CN106039087B - Traditional Chinese medicine composition for treating porcine circovirus disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating porcine circovirus disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of animal medicine, in particular to a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-20 parts of gypsum, 5-10 parts of fructus forsythiae, 15-20 parts of honeysuckle, 15-20 parts of radix isatidis, 10-15 parts of common andrographis herb, 10-15 parts of radix zanthoxyli, 10-15 parts of wrinkled gianthyssop herb, 5-10 parts of fructus cannabis, 5-10 parts of rice sprout, 5-10 parts of angelica sinensis, 5-10 parts of liquorice and 5-10 parts of astragalus membranaceus; according to the traditional theory of Chinese veterinarian, twelve traditional Chinese medicines are preferably selected, the traditional Chinese medicines are wide in material availability and low in cost, and clinical application proves that the prepared traditional Chinese medicine composition has an obvious curative effect on porcine circovirus disease, and the cure rate is over 90 percent through scientific and reasonable compatibility of the traditional Chinese medicines.
Description
Technical Field
The invention relates to the technical field of animal medicine, in particular to a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof.
Background
In the 90 s of the 20 th century, people worldwide detected a novel porcine ringlet virus in sick pigs and some pigs without obvious clinical symptoms, unlike the known PCV separated by PK-15 cell culture contamination, the original PCV is named as circovirus type I (PCV-1), the newly appeared PCV related to clinical diseases is named as circovirus type II (PCV-2), the infection of PCV-2 can cause the postweaning Piglet Multisystemic Wasting Syndrome (PMWS), porcine dermatitis nephrotic syndrome (PNDS), porcine respiratory mixed disease, reproductive failure syndrome and the like, the meaning of the present porcine circovirus disease (PCVD) refers to the group disease or the disease related to PCV-2, VD in PCVD, PMWS is the most harmful to the swine industry, and causes losses in the swine industry of about 6 billion euros each year in Europe.
At present, a large number of traditional Chinese medicine formula researches are reported for treating porcine circovirus disease, and certain effects are obtained, for example, application number CN201310581614.9, a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof, discloses a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof, and the traditional Chinese medicine composition is prepared by mixing the following components in parts by weight: 15-35 parts of gentiana scabra bunge, 15-35 parts of artemisia anomala, 15-45 parts of asiatic moonseed rhizome, 15-35 parts of Chinese holly, 10-40 parts of poplar flower, 10-35 parts of cardamom, 15-45 parts of radix zanthoxyli, 15-35 parts of fructus evodiae, 15-35 parts of tree peony bark and 15-45 parts of liquorice; for example, application number CN201210305975.6 "a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof" discloses a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof, wherein the traditional Chinese medicine compound of the composition comprises the following components: the traditional Chinese medicine formula comprises astragalus membranaceus, isatis root, fructus forsythiae, honeysuckle, cordyceps sinensis polysaccharide, codonopsis pilosula, rhizoma atractylodis, angelica sinensis, fresh rehmannia root, coptis chinensis, grifola, poria cocos, bighead atractylodes rhizome, pericarpium citri reticulatae and herba epimedii, and although the traditional Chinese medicine formula has a curative effect on the porcine circovirus disease, the traditional Chinese medicine formula is unreasonable, and raw material components are inappropriate, so that the porcine circovirus disease is low in cure rate and easy to relapse.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof to solve the technical problems.
The method is realized by the following technical scheme:
a traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 15-20 parts of gypsum, 5-10 parts of fructus forsythiae, 15-20 parts of honeysuckle, 15-20 parts of radix isatidis, 10-15 parts of common andrographis herb, 10-15 parts of radix zanthoxyli, 10-15 parts of wrinkled gianthyssop herb, 5-10 parts of fructus cannabis, 5-10 parts of rice sprout, 5-10 parts of angelica sinensis, 5-10 parts of liquorice and 5-10 parts of astragalus membranaceus.
Preferably, the feed comprises the following raw materials in parts by weight: 18 parts of gypsum, 8 parts of fructus forsythiae, 17 parts of honeysuckle, 18 parts of isatis root, 13 parts of common andrographis herb, 12 parts of shinyleaf pricklyash root, 13 parts of wrinkled gianthyssop herb, 8 parts of fructus cannabis, 8 parts of rice sprout, 8 parts of Chinese angelica, 8 parts of liquorice and 7 parts of astragalus membranaceus.
Further, the traditional Chinese medicine composition is an oral preparation.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 100-120 ℃ until the water content is 7-9%, crushing to the particle size of 0.5mm to obtain crushed materials, adding rapeseed oil accounting for 1-3% of the weight of the crushed materials, stirring uniformly, adding an acidifying agent, and adjusting the pH value of an aqueous solution to 5-6.5.
Further, the acidulant is prepared by mixing citric acid and 0.8-1.2% of H2SO4 according to the volume ratio of 0.4-0.6: 0.1-0.3.
Further, the application method of the traditional Chinese medicine composition comprises the following steps: the traditional Chinese medicine composition is taken once in the morning and once in the evening, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.03-0.05: 1 each time.
The raw materials used in the invention have the following effects:
fructus forsythiae: clearing away heart-fire, relieving fever, relieving swelling, resolving hard mass, having antibacterial, antiviral and diuretic effects, having the greatest antibacterial effect on staphylococcus aureus and shigella dysenteriae, also having stronger antibacterial effect on hemolytic streptococcus, diplococcus pneumoniae, typhoid bacillus and the like, and also having obvious inhibiting effect on the growth of tubercle bacillus.
Honeysuckle flower: clearing away heat and toxic materials, has antibacterial, antiviral, antifungal, astringent, and diuretic effects, and can be used for inhibiting Staphylococcus aureus, hemolytic streptococcus, dysentery bacillus, typhoid bacillus, meningococcus, and pneumococcus.
Radix isatidis: has antibacterial and antiviral effects, and can be used for treating influenza, fever with speckle, tonsillitis, parotitis, epidemic encephalitis, enteritis, and bacillary dysentery.
Andrographis paniculata: has effects in clearing away heat and toxic materials, resisting infection, relieving inflammation and pain, and removing snake venom.
Two-side needle: has effects of promoting blood circulation for removing blood stasis, activating qi-flowing, relieving pain, dispelling pathogenic wind, dredging collaterals, removing toxic substance and detumescence, and can be used for treating traumatic injury, stomach ache, toothache, rheumatalgia, venomous snake bite, and external treatment of burn and scald.
Agastache rugosus: agastache rugosus has antibacterial effect, has effects of eliminating turbid pathogen with aromatics, regulating the middle warmer, relieving vomit, relieving exterior syndrome of summer-heat and dampness, and can be used for treating damp turbidity obstruction in middle warmer, epigastric fullness and emesis, summer-heat and dampness exterior syndrome, early stage of damp-warm disease, fever and lassitude, chest distress and discomfort, cold-dampness and summer-heat retention, abdominal pain, vomiting and diarrhea, nasosinusitis and headache.
Fructus cannabis: has laxative effect, and is a lubricant laxative, and the contained fatty oil has lubricating effect on intestinal wall and feces, softens feces, and is easy to discharge, has no side effect of intestinal colic, and can not cause constipation after diarrhea.
Rice sprout: has effects of promoting appetite, eliminating stagnation, and promoting digestion, and can be used for treating dyspepsia, inappetence, etc.
Chinese angelica: has effects in replenishing blood, promoting blood circulation, moisturizing intestine, regulating menstruation, tranquilizing mind, relieving pain, promoting urination, and inhibiting dysentery bacillus, typhoid bacillus, Escherichia coli, and hemolytic streptococcus.
Licorice root: has effects of invigorating spleen and qi, clearing away heat and toxic materials, moistening lung, relieving cough, removing toxic substances, relieving spasm, inhibiting gastric acid secretion, and eliminating phlegm.
Astragalus root: has effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, removing toxic substance, expelling pus, resisting bacteria, inducing diuresis, resisting nephritis, lowering blood pressure, resisting Shigella shigella, hemolytic streptococcus, Diplococcus pneumoniae, Staphylococcus aureus, etc., and radix astragali has effects of protecting liver and preventing reduction of glycogen.
In conclusion, the beneficial effects of the invention are as follows: according to the traditional theory of Chinese veterinarian, twelve traditional Chinese medicines are preferably selected, the traditional Chinese medicines are wide in material availability and low in cost, and clinical application proves that the prepared traditional Chinese medicine composition has an obvious curative effect on porcine circovirus disease, and the cure rate is over 90 percent through scientific and reasonable compatibility of the traditional Chinese medicines.
The invention crushes the raw materials to certain granularity, is favorable for the absorption of pigs, adds the vegetable oil, is more favorable for the absorption of the raw materials by the pigs, wherein, the acidification treatment can play a role of appetizing to the pigs, so that the drug effect can be better exerted.
The efficacy of the present invention will be further illustrated with respect to the efficacy test
1. Toxicity test study of the Chinese medicinal composition
Test subjects: 100 healthy mice with half male and female bodies and 12-18 g weight are selected, the mice are raised and observed for 2d under the conditions of artificial lighting for 24h and good ventilation conditions, the mice are randomly divided into 5 groups, the mice are prohibited from eating but not being prohibited from water within 12h before administration and 4h after administration, and one group is a blank control group.
The test method comprises the following steps: after 2 days, the traditional Chinese medicine compositions with the dosages of 100ml/kg, 200ml/kg, 300ml/kg and 400ml/kg are respectively administrated to the other 4 groups of white mice except for the blank group, and the white mice of the control group are not fed with the composition for 15-20 days.
As a result: all white mice are healthy and alive, no abnormality is observed in the aspects of spirit, appetite, secretion, respiration, eyes and the like of all the white mice, and the white mice have no abnormality compared with a control group, which indicates that the traditional Chinese medicine preparation is safe and nontoxic to the mice.
2. Research on treatment test of porcine circovirus disease by using traditional Chinese medicine composition
Test subjects: 200 healthy mice with half male and female bodies and 20-25 g weight are selected, the mice are bred and observed for 2d under the conditions of artificial lighting for 24h and good ventilation conditions, the mice are prohibited from eating but not from water within 12h before and 4h after administration and are randomly divided into 2 groups, wherein one group is a blank control group.
The test method comprises the following steps: after 2d, inoculating porcine circovirus disease to two groups of mice, wherein the inoculation amount is 10-20 ml/kg, the test group is drenched with the traditional Chinese medicine composition, the control group is drenched with the conventional medicine for treating porcine circovirus disease, the traditional Chinese medicine composition is drenched once every day, the dosage is 30-50 ml/kg, the survival rate, the mental state and the recurrence rate of the two groups of mice are counted after the mice are administrated for 10-15 d, and the results are shown in table 1:
TABLE 1
3. Clinical research experiment on pig
(1) The sick pigs in a certain pig farm are weak in spirit, rough and disorganized in hair, anorexia or fasting, rhinoscope cyanosis and cold, a large number of red and purplish red bean-like spots appear on two ears, back and even abdomen, the kidney is enlarged and becomes khaki after autopsy, renal cortex atrophy, renal papillary bleeding and mesenteric lymph node enlargement are grayish white, after the pig farm is used for 5 days according to the formula, the sick pigs are better in spirit, the appetite is recovered, no dead pig continues to die, the skin red spots are removed after 7 days, the cure rate of the sick pigs in the whole pig farm is counted, and the cure rate of the porcine circovirus disease is 93%.
(2) 100 fattening pigs are newly purchased in a certain pig farm, part of newly purchased pigs show anorexia, mental depression, slow movement, rough hair, dyspnea and cough one week after entering the pig farm, after the newly purchased pigs are used for 6-7 days according to the formula, the sick pigs are improved in spirit, recovered in appetite and negative after 10-12 days of serum antibody examination, the researchers count the treatment condition of the sick pigs, and the cure rate of the porcine circovirus disease is 94%
Detailed Description
The following is a detailed description of the embodiments of the present invention, but the present invention is not limited to these embodiments, and any modifications or substitutions in the basic spirit of the embodiments are included in the scope of the present invention as claimed in the claims.
Example 1
A traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 15kg of gypsum, 5kg of fructus forsythiae, 15kg of honeysuckle, 15kg of isatis root, 10kg of common andrographis herb, 10kg of shinyleaf pricklyash root, 10kg of wrinkled gianthyssop herb, 5kg of fructus cannabis, 5kg of rice sprout, 5kg of angelica, 5kg of liquorice and 5kg of astragalus membranaceus.
The traditional Chinese medicine composition is an oral preparation.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 100 deg.C until water content is 7%, pulverizing to particle size of 0.5mm to obtain pulverized material, adding 1% rapeseed oil, stirring, adding acidifying agent, and adjusting pH of water solution to 5.
The acidulant is prepared by mixing citric acid and 0.8% of H2SO4 according to the volume ratio of 0.4: 0.1.
The application method of the traditional Chinese medicine composition comprises the following steps: the composition is taken once a morning and a night, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.03: 1 each time.
Example 2
A traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 20kg of gypsum, 10kg of fructus forsythiae, 20kg of honeysuckle, 20kg of isatis root, 15kg of common andrographis herb, 15kg of shinyleaf pricklyash root, 15kg of wrinkled gianthyssop herb, 10kg of fructus cannabis, 10kg of rice sprout, 10kg of angelica, 10kg of liquorice and 10kg of astragalus membranaceus.
The traditional Chinese medicine composition is an oral preparation.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 120 deg.C until water content is 9%, pulverizing to particle size of 0.5mm to obtain pulverized material, adding 3% rapeseed oil by weight of pulverized material, stirring, adding acidifying agent, and adjusting pH of aqueous solution to 6.5.
The acidulant is prepared by mixing citric acid and 1.2% H2SO4 according to the volume ratio of 0.6: 0.3.
The application method of the traditional Chinese medicine composition comprises the following steps: the traditional Chinese medicine composition is taken once in the morning and one night, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.05: 1 by weight ratio.
Example 3
A traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 18kg of gypsum, 8kg of fructus forsythiae, 17kg of honeysuckle, 18kg of isatis root, 13kg of common andrographis herb, 12kg of shinyleaf pricklyash root, 13kg of wrinkled gianthyssop herb, 8kg of fructus cannabis, 8kg of rice sprout, 8kg of Chinese angelica, 8kg of liquorice and 7kg of astragalus membranaceus.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 110 deg.C until water content is 8%, pulverizing to particle size of 0.5mm to obtain pulverized material, adding 2% rapeseed oil, stirring, adding acidifying agent, and adjusting pH of aqueous solution to 6.
The acidulant is prepared by mixing citric acid and 1% H2SO4 according to the volume ratio of 0.5: 0.2.
The application method of the traditional Chinese medicine composition comprises the following steps: the composition is taken once a morning and a night, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.04: 1 each time.
Example 4
A traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 20kg of gypsum, 5kg of fructus forsythiae, 15kg of honeysuckle, 20kg of isatis root, 13kg of common andrographis herb, 14kg of shinyleaf pricklyash root, 10kg of wrinkled gianthyssop herb, 10kg of fructus cannabis, 10kg of rice sprout, 5kg of angelica, 5kg of liquorice and 5kg of astragalus membranaceus.
The traditional Chinese medicine composition is an oral preparation.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 120 deg.C until water content is 9%, pulverizing to particle size of 0.5mm to obtain pulverized material, adding 3% rapeseed oil by weight of the pulverized material, stirring, adding acidifying agent, and adjusting pH of aqueous solution to 5.
The acidulant is prepared by mixing citric acid and 0.8% of H2SO4 according to the volume ratio of 0.6: 0.1.
The application method of the traditional Chinese medicine composition comprises the following steps: the composition is taken once a morning and a night, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.03: 1 each time.
Example 5
A traditional Chinese medicine composition for treating porcine circovirus disease and a preparation method thereof comprise the following raw materials in parts by weight: 20kg of gypsum, 10kg of fructus forsythiae, 15kg of honeysuckle, 15kg of isatis root, 15kg of common andrographis herb, 10kg of shinyleaf pricklyash root, 10kg of wrinkled gianthyssop herb, 5kg of fructus cannabis, 8kg of rice sprout, 9kg of angelica, 5kg of liquorice and 5kg of astragalus membranaceus.
The traditional Chinese medicine composition is an oral preparation.
The preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 120 deg.C until water content is 8%, pulverizing to particle size of 0.5mm to obtain pulverized material, adding 2% rapeseed oil, stirring, adding acidifying agent, and adjusting pH of water solution to 6.
The acidulant is prepared by mixing citric acid and 1.2% H2SO4 according to the volume ratio of 0.5: 0.3.
The application method of the traditional Chinese medicine composition comprises the following steps: the composition is taken once a morning and a night, and the prepared traditional Chinese medicine composition and the pig feed are mixed according to the weight ratio of 0.04: 1 each time.
Claims (3)
1. The traditional Chinese medicine composition for treating porcine circovirus disease is characterized by being prepared from the following raw materials in parts by weight: 15-20 parts of gypsum, 5-10 parts of fructus forsythiae, 15-20 parts of honeysuckle, 15-20 parts of radix isatidis, 10-15 parts of common andrographis herb, 10-15 parts of radix zanthoxyli, 10-15 parts of wrinkled gianthyssop herb, 5-10 parts of fructus cannabis, 5-10 parts of rice sprout, 5-10 parts of angelica sinensis, 5-10 parts of liquorice and 5-10 parts of astragalus membranaceus;
the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing raw material components, drying at 100-120 ℃ until the water content is 7-9%, crushing to the particle size of 0.5mm to obtain crushed materials, adding rapeseed oil accounting for 1-3% of the weight of the crushed materials, uniformly stirring, adding an acidifying agent, and adjusting the pH value of an aqueous solution to 5-6.5;
the acidifier is prepared by mixing citric acid and 0.8-1.2% of H2SO4According to the weight ratio of 0.4-0.6: mixing at a volume ratio of 0.1-0.3.
2. The traditional Chinese medicine composition for treating porcine circovirus disease of claim 1, wherein the raw materials comprise, by weight: 18 parts of gypsum, 8 parts of fructus forsythiae, 17 parts of honeysuckle, 18 parts of isatis root, 13 parts of common andrographis herb, 12 parts of shinyleaf pricklyash root, 13 parts of wrinkled gianthyssop herb, 8 parts of fructus cannabis, 8 parts of rice sprout, 8 parts of Chinese angelica, 8 parts of liquorice and 7 parts of astragalus membranaceus.
3. The traditional Chinese medicine composition for treating porcine circovirus disease of claim 1 or 2, wherein the traditional Chinese medicine composition is an oral preparation.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104922410A (en) * | 2015-06-30 | 2015-09-23 | 矦泽宏 | TCM (traditional Chinese medicine) preparation for treating porcine circovirus disease |
| CN105079177A (en) * | 2014-05-13 | 2015-11-25 | 重庆美德实业集团有限公司 | Chinese herbal preparation capable of preventing and controlling porcine cytomegaloviral disease and porcine circovirus disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105079177A (en) * | 2014-05-13 | 2015-11-25 | 重庆美德实业集团有限公司 | Chinese herbal preparation capable of preventing and controlling porcine cytomegaloviral disease and porcine circovirus disease |
| CN104922410A (en) * | 2015-06-30 | 2015-09-23 | 矦泽宏 | TCM (traditional Chinese medicine) preparation for treating porcine circovirus disease |
Non-Patent Citations (1)
| Title |
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| "中西医结合治疗猪圆环病毒病";黄希忠;《农业与技术》;20130430(第4期);第155页第2点 * |
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