CN105848665A - 用于预防或治疗卒中或神经变性疾病的包含作为活性成分的葛根和黄芩的复合提取物的组合物 - Google Patents
用于预防或治疗卒中或神经变性疾病的包含作为活性成分的葛根和黄芩的复合提取物的组合物 Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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KR1020130119726A KR101548050B1 (ko) | 2013-10-08 | 2013-10-08 | 갈근 및 황금의 복합 추출물을 유효성분으로 함유하는 뇌졸중 및 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 |
KR10-2013-0119726 | 2013-10-08 | ||
PCT/KR2014/009484 WO2015053561A1 (ko) | 2013-10-08 | 2014-10-08 | 갈근 및 황금의 복합 추출물을 유효성분으로 함유하는 뇌졸중 또는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
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US (1) | US11446349B2 (ko) |
EP (1) | EP3056209B1 (ko) |
KR (1) | KR101548050B1 (ko) |
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JP2004536600A (ja) * | 2001-06-26 | 2004-12-09 | ニュー ヨーク ステイト オフィス オブ メンタル ヘルス | 細胞に基づいた高スループットスクリーニング法 |
KR20030007111A (ko) * | 2001-07-11 | 2003-01-23 | 주식회사 유젠바이오 | 황금추출물을 함유하는 신경세포 보호 및 재생용 조성물 |
WO2006080590A1 (en) * | 2005-01-25 | 2006-08-03 | University-Industry Cooperation Group Of Kyung Hee University | Composition comprising the extract of crude drug complex having neuroprotective activity for preventing and treating stroke and neurodegenerative diseases |
KR20070002279A (ko) * | 2005-06-30 | 2007-01-05 | 고려대학교 산학협력단 | 뇌 신경세포 콜린아세틸트랜스퍼라제 활성화 기능을 갖는칡 추출물 |
US8017147B2 (en) * | 2008-04-07 | 2011-09-13 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
US20080241084A1 (en) * | 2007-03-29 | 2008-10-02 | Shaklee Corporation | Compositions and methods for inhibiting melanogenesis |
KR20100022128A (ko) * | 2008-08-13 | 2010-03-02 | (주)한중보건연구원 | 활락대기능단 |
KR101189191B1 (ko) * | 2010-06-24 | 2012-10-09 | 한국과학기술연구원 | 용안육 추출물 또는 이를 포함하는 혼합 추출물을 함유하는 퇴행성 뇌신경질환의 예방 또는 치료용 조성물 |
CN102380045A (zh) * | 2010-09-01 | 2012-03-21 | 方谅军 | 一种治疗因肾阴亏损而中风的中药组方 |
CN102335352B (zh) * | 2011-11-11 | 2013-06-19 | 姚传斌 | 一种治疗缺血性脑中风的中药组合物 |
CN103127286A (zh) * | 2011-12-05 | 2013-06-05 | 鲍力恒 | 用于治疗或减轻忧郁症或神经退化性疾病的医药组成物 |
CN103169786A (zh) * | 2011-12-20 | 2013-06-26 | 王永刚 | 治疗颈动脉粥样硬化防治缺血性脑中风的通脉胶囊 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101040928A (zh) * | 2007-04-11 | 2007-09-26 | 李发有 | 治疗型灵芝组合茶 |
Non-Patent Citations (4)
Title |
---|
[日]井上胜也编 齐宏业译: "《痴呆》", 31 January 2002, 辽宁科学技术出版社 * |
南京中医药大学 编著: "《中药大辞典(第二版)》", 31 March 2006, 上海科学技术出版社 * |
国家食品药品监督管理局执业药师资格认证中心组织编写 李大魁主编: "《药学综合知识与技能》", 31 March 2008, 中国医药科技出版社 * |
崔明宇等: "葛芩片提取纯化工艺的研究", 《中成药》 * |
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EP3056209B1 (en) | 2018-08-01 |
EP3056209A4 (en) | 2017-03-22 |
WO2015053561A1 (ko) | 2015-04-16 |
US11446349B2 (en) | 2022-09-20 |
KR20150041331A (ko) | 2015-04-16 |
KR101548050B1 (ko) | 2015-08-27 |
EP3056209A1 (en) | 2016-08-17 |
US20160243181A1 (en) | 2016-08-25 |
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