CN105831731A - 具有清咽润肺、去除口腔异味功效的双层片及其制备方法 - Google Patents
具有清咽润肺、去除口腔异味功效的双层片及其制备方法 Download PDFInfo
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Abstract
具有清咽润肺、去除口腔异味功效的双层片及其制备方法,由原料按以下重量百分比制备而成,罗汉果提取物12‑28%、冬凌草提取物10‑15%、薰衣草提取物10‑15%、黑木耳提取物5‑8%、山梨糖醇30‑40%、木糖醇1.5‑2.0%、茶多酚0.2‑0.8%、溶菌酶0.2‑0.5%、柠檬酸0.25‑0.28%、甜菊糖0.02‑0.05%;其制备方法的步骤为:步骤1、原料预处理;步骤2、清咽润肺速溶颗粒的制备;步骤3、口气清新缓释颗粒的制备;步骤4、压片。本发明的具有清咽润肺、去除口腔异味功效的双层片,产品口感良好、适合口含,具有清咽润肺、去除口腔异味、清新口气、调节肠胃的功效。
Description
技术领域
本发明涉及食品加工领域,特别是涉及一种具有清咽润肺、去除口腔异味功效的双层片及其制备方法。
背景技术
咽喉疾患为常见多发性炎症性疾病,尤其是在两个季节交替的时期,往往也是咽喉疾病发病率高的时期。过度吸烟、饮酒等诱发因素的刺激,就更容易导致突发性咽喉肿痛,咽炎患者急剧增加。如果不及时治疗,容易引发慢性咽炎,临床以咽部有异物感、干燥、发痒、灼热、微痫等各种不适感为主要表现,其病程时间长,症状顽固,吸烟是肺气肿和慢性气道阻塞的主要诱因之一。
实验研究发现,长期吸烟可使支气管粘膜的纤毛受损、变短,影响纤毛的清除功能。此外,粘膜下腺体增生、肥大,粘液分泌增多,成分也有改变,容易阻塞细支气管。吸烟者患慢性气管炎较不吸烟者高2-4倍,患者往往有慢性咳嗽、咯痰和活动时呼吸困难。肺功能检查显示呼吸道阻塞,肺顺应性、通气功能和弥散功能降低及动脉血氧分压下降。即使年轻的无症状的吸烟者也有轻度肺功能减退。此外雾霾天气也会导致肺功能收到严重影响,也是肺癌高发的诱因。
研究还表明,肠胃不好,抽烟人群,口腔疾病都会导致口臭,而口臭势必产生口腔异味。口臭气味的主要成份是挥发性硫化物,其中90%为硫化氢( H2S)和甲硫醇( CH3SH)。大量研究证明,口腔微生物与口臭及口气中硫化物关系密切, 其中螺旋体是与口腔中挥发含硫化物及口臭的产生有关的口腔微生物之一。有口臭的疾患,则会在社交和生活中给自己或他人带来诸多困扰,这种难言之隐非常尴尬,造成很大的心理压力。因此, 要使口气清新, 必须要清除口臭。此外消化道疾病也是引起口臭的主要原因,凡是引起肠道内容物潴留的疾病都会因气味反流引起口臭。消化道狭窄的疾病,如先天性食管狭窄、食管失弛缓症、胃扭转、十二指肠梗塞、肠梗阻等,因食物、分泌物潴留、发酵,加上腐败菌的作用,会引发口臭;消化道炎症,如食管炎、慢性胃炎、慢性肠炎、溃疡性结肠炎等,消化道动力障碍,肠道内容物潴留、反流而易出现口臭;便秘的病人,因粪便中有粪臭素、氨气、硫化氢等物,也可因气味反流到口腔,发生口臭。另外,消化道肿瘤,如食管癌、胃癌、肠癌等,因占位病变,影响排空,发生内容物潴留,都会出现口腔异味。
现在市面上的清咽润肺多为药品,普通食品产品几乎没有,并且一般的药品并不带有清除口腔异味、清新口气的作用,大多数药品还存在着药味重、入口苦涩、服食口感差、功效单一等缺点,此外,药品通常都带有一定的副作用,长期服用,会对人体健康埋下隐患。
发明内容
本发明的目的是提供一种具有清咽润肺、去除口腔异味功效的双层片及其制备方法,产品口感良好、适合口含,具有清咽润肺、去除口腔异味、清新口气、调节肠胃的功效。
本发明的目的通过以下技术方案来实现:
具有清咽润肺、去除口腔异味功效的双层片,由原料按以下重量百分比制备而成,罗汉果提取物12-28%、冬凌草提取物10-15%、薰衣草提取物10-15%、黑木耳提取物5-8%、山梨糖醇30-40%、木糖醇1.5-2.0%、茶多酚0.2-0.8%、溶菌酶0.2-0.5%、柠檬酸0.25-0.28%、甜菊糖0.02-0.05%。
优选方案1:
原料优选重量百分比,罗汉果提取物25%、冬凌草提取物12%、薰衣草提取物13%、黑木耳提取物7%、山梨糖醇40%、木糖醇2.0%、茶多酚0.4%、溶菌酶0.3%、柠檬酸0.274%、甜菊糖0.026%。
优选方案2:
原料优选重量百分比,罗汉果提取物28%、冬凌草提取物15%、薰衣草提取物15%、黑木耳提取物8%、山梨糖醇30.9%、木糖醇1.5%、茶多酚0.8%、溶菌酶0.5%、柠檬酸0.28%、甜菊糖0.02%。
优选方案3:
原料优选重量百分比,罗汉果提取物27%、冬凌草提取物14.3%、薰衣草提取物14%、黑木耳提取物6%、山梨糖醇36%、木糖醇1.7%、茶多酚0.3%、溶菌酶0.4%、柠檬酸0.25%、甜菊糖0.05%。
其制备方法的步骤为:
步骤1、原料预处理:
(1)罗汉果、冬凌草、薰衣草的提取
a
、按重量百分比,称取优质的罗汉果、冬凌草、薰衣草,混合置于煎煮容器内,加水提取3次,第一次加10倍的水提取2小时,第二次加8倍的水提取1.5小时,第三次加6倍的水提取1小时,合并三次提取液,得混合提取液;
b
、将混合提取液采用三层无纺布过滤,滤液薄膜浓缩,得混合浓缩液;
c
、将混合浓缩液置于喷雾干燥机中进行喷雾干燥,得混合干粉;
d
、将混合干粉置于万能粉碎机中进行粉碎,过80目筛,得罗汉果、冬凌草、薰衣草的混合提取物,备用;
(2)黑木耳的提取
按重量百分比,称取干燥黑木耳,置于万能粉碎机中粉碎,得黑木耳粗粉;取黑木耳粗粉,加30倍的水浸泡24小时,调节PH5.0,加入质量为黑木耳水溶液1.1%的果胶酶,55℃保温酶解80分钟,然后迅速升温至85℃灭酶,灭酶后热水浸提2小时,无纺布过滤,薄膜浓缩,喷雾干燥得黑木耳干粉,置于万能粉碎机中进行粉碎,粉碎过80目筛,得黑木耳提取物,备用;
(3)称量
按重量百分比,称取优质的山梨糖醇、木糖醇、茶多酚、溶菌酶、柠檬酸、甜菊糖,备用;
步骤2、清咽润肺速溶颗粒的制备:
(1)混合
a
、按重量百分比,称取罗汉果、冬凌草、薰衣草的混合提取物与黑木耳提取物;
b
、按重量百分比,称取甜菊糖、柠檬酸,再称取五分之一备用的山梨糖醇,置于混合容器内,充分混合均匀,备用;
c
、将黑木耳提取物加入至罗汉果、冬凌草、薰衣草的混合提取物中,充分混合均匀;再加入混合后的甜菊糖、柠檬酸、山梨糖醇,混合搅拌均匀,得总混物料,备用;
(2)制粒
a
、取总混物料,加入适量5%PVPK30乙醇溶液,80%乙醇水溶液,制软材;
b
、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得清咽润肺速溶颗粒,备用;
步骤3、口气清新缓释颗粒的制备:
(1)混合
按重量百分比,取备用的溶菌酶、茶多酚、木糖醇,混合搅拌均匀,再加入剩余五分之四备用的山梨糖醇,充分混合均匀,得总混料;
(2)制粒
a
、取步骤3(1)混合均匀的总混料,加入适量1%PVPK乙醇溶液,80%乙醇水溶液,制软材;
b
、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得口气清新缓释颗粒,备用;
步骤4、压片
取步骤2制得的清咽润肺速溶颗粒与步骤3制得的口气清新缓释颗粒,先以较小的压力将清咽润肺速溶颗粒压制成清咽润肺片,再在清咽润肺片的基础上,压制口气清新缓释颗粒,压制双层片,无菌包装,制得成品。
在原料中:
冬凌草:苦、甘、微寒,清热、解毒、活血止痛,用于咽喉肿痛、扁桃体炎、蛇虫咬伤、风湿骨痛等。主要成分有挥发油和二萜类、冬凌夏草甲素、乙素、丙素、丁素、戊素、辛素以及α一香树脂醇,还有5个未知结构成分。还含有无机元素铁、锌、硒等。主要作用有:抗肿瘤、抗菌作用和解热降燥等功效。
冬凌草的抗瘤作用,在民间主要用来防治食管癌。实验动物移植性肿癌,如艾氏腹水癌、肝癌、网状细胞肉瘤等均有抑制作用;能防止亚硝酸胺所引起的大鼠食管上皮增生转变为癌;对多种球菌及杆菌有明显的抗菌作用临床实验证明,冬凌草对食管癌、贲门癌、原发性肝癌及乳癌等有明显缓解症状作用,有稳定和缩小瘤体及延长病人生命的效果。与化疗合用,可减轻化疗药物的不良反应,提高疗效,对食管上皮重度增生也有一定的疗效。另外,对急性喉炎、急性化脓性扁桃体炎有显著疗效,对慢性支气管炎及慢性咽炎等也有良好效果。
研究发现冬凌草还具有解热、降燥润喉、降血脂、降血压等功效。对感冒发热、口舌生疮、焦热上火等都有较好的预防和治疗作用。
罗汉果,葫芦科多年生藤本植物的果实。别名拉汗果、假苦瓜、光果木鳖、金不换、罗汉表、裸龟巴,被人们誉为“神仙果”,罗汉果为卫生部首批公布的药食两用名贵中药材,其所含罗汉果甜甙比蔗糖甜300倍,不产生热量,是饮料、糖果行业的名贵原料,是蔗糖的最佳替代品。常饮罗汉果茶,可防多种疾病,现代医学证明,罗汉果对支气管炎、高血压等疾病有显著疗效,还是起到防治冠心病、血管硬化、肥胖症的作用。营养价值高,有清热解暑、化痰止咳、凉血舒骨、清肺润肠和生津止渴等功效;可治急慢性气管炎、咽喉炎、支气管哮喘、百日咳、胃热、便秘、急性扁桃体炎等症,糖尿病患者亦宜服用。
中医药学认为,罗汉果甘、酸、性凉、有清热凉血、生津止咳、滑肠排毒、嫩肤益颜、润肺化痰等功效,可用于益寿延年、驻颜悦色及治疗痰热咳嗽、咽喉肿痛、大便秘结、消渴烦躁诸症。
黑木耳为大型真菌木耳科植物木耳的子实体,始见于东汉《神农本草经》,别名云耳术耳又叫木菌。黑木耳生长在朽木上,没有枝叶,受湿热余气而生。各种树木都能生木耳,它的良毒也由木性而决定。黑木耳实体丛生,常覆瓦状叠生。耳状。叶状或近林状,边缘波状,薄,宽2-6cm,最大者可达12cm,厚2mm左右,以侧生的短柄或狭细的基部固着于基质上。初期为柔软的胶质,粘而富弹性,以后稍带软骨质,干后强烈收缩,变为黑色硬而脆的角质至近革质。《药性论》:“蕈耳,古槐、桑树上者良。能治风,破血,益力,次柘木者良。”《纲目》:木耳性甘平,主治益气不饥等,有补气益智,润肺补脑,降低血压,活血止血之功效;《全国中草药汇编》:色泽黑褐,质地柔软,味道鲜美,营养丰富,具有显著的治疗血栓高血脂等作用,并可防治缺铁性贫血。
黑木耳是一种药食同源的真菌类物质,黑木耳主要化学成分为多糖、蛋白质、黑木耳腺苷、维生素、及微量元素。其中多糖,腺苷及铁是黑木耳主要活性物质。
现代药理研究表明,黑木耳提取物对细胞免疫和体液免疫功能具有良好的促进作用,具有抗白细胞降低、抗肿瘤、抗辐射、抗突变、抗炎症等细胞保护作用;具有降低血脂、胆固醇、血液粘度,抗血栓形成作用;具有降低血糖、抗糖尿病以及降低脂褐质含量,增强SOD活力,减少有害物质自由基产生的功能;还能促进核酸、蛋白质的生物合成和防治多种老年性疾病,同时因其含铁量高,可以及时为人体补充足够的铁质,所以它具有补血功能。
黑木耳还有较强的吸附作用,经常食用利于使体内产生的垃圾及时排出体外。黑木耳对胆结石、肾结石也有较好的化解功能,黑木耳的作用因为它所含的植物碱具有促进消化道、泌尿道各种腺体分泌的特性,植物碱能协同这些分泌物催化结石,润滑肠道。
茶多酚,又名抗氧灵、维多酚、防哈灵,是茶叶中所含的一类多羟基类化合物,简称TP,主要化学成分为儿茶素类、黄酮及黄酮醇类、花青素类、酚酸及缩酚酸类、聚合酚类等化合物的复合体。其中儿茶素类化合物为茶多酚的主体成分,占茶多酚总量的65%-80%。儿茶素类化合物主要包括儿茶素、没食子儿茶素、儿茶素没食子酸酯和没食子儿茶素没食子酸酯4种物质。
茶多酚具有较强的抗氧化作用,尤其酯型儿茶素EGCG,其还原性甚至可达L-异坏血酸的100倍。4种主要儿茶素化合物当中,抗氧化能力为EGCG>EGC>ECG>EC>BHA,且抗氧化性能随温度的升高而增强。茶多酚除具有抗氧化作用外,还具有抑菌作用,如对葡萄球菌、大肠杆菌、枯草杆菌等有抑制作用。茶多酚可吸附食品中的异味,因此具有一定的除臭作用。茶多酚可以杀死在齿缝中存在的乳酸菌及其他龋齿细菌,具有抑制葡萄糖聚合酶活性的作用,这样病菌就不能在牙上着床,有效的中断了使龋齿形成的过程。残留于齿缝中的蛋白质食物成为腐败细菌增殖的基质,茶多酚可以杀死此类细菌。
溶菌酶又称胞壁质酶或N-乙酰胞壁质聚糖水解酶,是一种能水解致病菌中黏多糖的碱性酶。主要通过破坏细胞壁中的N-乙酰胞壁酸和N-乙酰氨基葡糖之间的β-1,4糖苷键,使细胞壁不溶性黏多糖分解成可溶性糖肽,导致细胞壁破裂内容物逸出而使细菌溶解。溶菌酶还可与带负电荷的病毒蛋白直接结合,与DNA、RNA、脱辅基蛋白形成复盐,使病毒失活。因此,该酶具有抗菌、消炎、抗病毒等作用,可作为一种具有杀菌作用的天然抗感染物质。
本发明的有益效果:本发明的具有清咽润肺、去除口腔异味功效的双层片,内部含有冬凌草、罗汉果、黑木耳、薰衣草、溶菌酶、茶多酚、木糖醇等物质,具有清咽润肺、去除口腔异味、调节胃肠道、清新口气、化痰止咳,生津止咳、补虚润肺等多种功效;其可有效解决由于雾霾天气、长期吸烟等原因对咽喉及肺带来的伤害,也可通过预防口腔疾病,调节胃肠道功能来达到了口气清新的目的。
本发明采用双层缓释及速溶技术,同时实现了清咽润肺与去除口腔异味的双重功效,优于市场上目前的品种,
采用双层片压片工艺,将清咽润肺作为基础层,口气清新作为上面层,制成双层片剂,完美的达到了清咽润肺和去除口腔异味的效果,
适用于雾霾带来的不适、长期吸烟、口腔异味的各年龄阶段的人群食用,具有良好的经济效益。
本发明经两组临床验证,其中一组为治疗组服用本发明,每天服用本发明三次,7天为一个疗程,另一组对照组服用
清咽润肺茶
,每天使用一次,7天为一个疗程,每组选择门诊病人120例,其中男60例,女60例,最大年龄65岁,最小年龄15岁,临床表现为
咽部干燥、咽部异物感、咽喉肿痛、肺热咳喘
、
慢性胃炎、慢性肠炎、口腔异味
,表一为服用一个疗程后的对照数据:
表1服用前后两组疗程比较(单位:人)
治疗组和对照组有显著差异,从而可以看出本发明在临床上的应用有显著的疗效。
本发明的工艺优点在于:
1
、选择原料科学,生产工艺先进,其产品不但具有食用的价值,并且保健价值极高;
2
、产品纯天然、无毒副作用,不添加防腐剂,保持原料本身的风味和营养成份,易被人体吸收;
3
、原料来源广泛,加工艺线路短,产品易加工制造。
具体实施方式
下面详细阐述本发明优选的实施方式。
实施例1
具有清咽润肺、去除口腔异味功效的双层片,由原料按以下重量百分比制备而成,罗汉果提取物12-28%、冬凌草提取物10-15%、薰衣草提取物10-15%、黑木耳提取物5-8%、山梨糖醇30-40%、木糖醇1.5-2.0%、茶多酚0.2-0.8%、溶菌酶0.2-0.5%、柠檬酸0.25-0.28%、甜菊糖0.02-0.05%。
其制备方法的步骤为:
步骤1、原料预处理:
(1)罗汉果、冬凌草、薰衣草的提取
a
、按重量百分比,称取优质的罗汉果、冬凌草、薰衣草,混合置于煎煮容器内,加水提取3次,第一次加10倍的水提取2小时,第二次加8倍的水提取1.5小时,第三次加6倍的水提取1小时,合并三次提取液,得混合提取液;
b
、将混合提取液采用三层无纺布过滤,滤液薄膜浓缩,得混合浓缩液;
c
、将混合浓缩液置于喷雾干燥机中进行喷雾干燥,得混合干粉;
d
、将混合干粉置于万能粉碎机中进行粉碎,过80目筛,得罗汉果、冬凌草、薰衣草的混合提取物,备用;
(2)黑木耳的提取
按重量百分比,称取干燥黑木耳,置于万能粉碎机中粉碎,得黑木耳粗粉;取黑木耳粗粉,加30倍的水浸泡24小时,调节PH5.0,加入质量为黑木耳水溶液1.1%的果胶酶,55℃保温酶解80分钟,然后迅速升温至85℃灭酶,灭酶后热水浸提2小时,无纺布过滤,薄膜浓缩,喷雾干燥得黑木耳干粉,置于万能粉碎机中进行粉碎,粉碎过80目筛,得黑木耳提取物,备用;
(3)称量
按重量百分比,称取优质的山梨糖醇、木糖醇、茶多酚、溶菌酶、柠檬酸、甜菊糖,备用;
步骤2、清咽润肺速溶颗粒的制备:
(1)混合
a
、按重量百分比,称取罗汉果、冬凌草、薰衣草的混合提取物与黑木耳提取物;
b
、按重量百分比,称取甜菊糖、柠檬酸,再称取五分之一备用的山梨糖醇,置于混合容器内,充分混合均匀,备用;
c
、将黑木耳提取物加入至罗汉果、冬凌草、薰衣草的混合提取物中,充分混合均匀;再加入混合后的甜菊糖、柠檬酸、山梨糖醇,混合搅拌均匀,得总混物料,备用;
(2)制粒
a
、取总混物料,加入适量5%PVPK30乙醇溶液,80%乙醇水溶液,制软材;
b
、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得清咽润肺速溶颗粒,备用;
步骤3、口气清新缓释颗粒的制备:
(1)混合
按重量百分比,取备用的溶菌酶、茶多酚、木糖醇,混合搅拌均匀,再加入五分之四备用的山梨糖醇,充分混合均匀,得总混料;
(2)制粒
a
、取步骤3(1)混合均匀的总混料,加入适量1%PVPK乙醇溶液,80%乙醇水溶液,制软材;
b
、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得口气清新缓释颗粒,备用;
步骤4、压片:
取步骤2制得的清咽润肺速溶颗粒与步骤3制得的口气清新缓释颗粒,先以较小的压力将清咽润肺速溶颗粒压制成清咽润肺片,再在清咽润肺片的基础上,压制口气清新缓释颗粒,压制双层片,无菌包装,制得成品。
实施例2
具有清咽润肺、去除口腔异味功效的双层片,原料优选重量百分比,罗汉果提取物25%、冬凌草提取物12%、薰衣草提取物13%、黑木耳提取物7%、山梨糖醇40%、木糖醇2.0%、茶多酚0.4%、溶菌酶0.3%、柠檬酸0.274%、甜菊糖0.026%。
其制备方法同实施例1相同。
实施例3
具有清咽润肺、去除口腔异味功效的双层片,原料优选重量百分比,罗汉果提取物28%、冬凌草提取物15%、薰衣草提取物15%、黑木耳提取物8%、山梨糖醇30.9%、木糖醇1.5%、茶多酚0.8%、溶菌酶0.5%、柠檬酸0.28%、甜菊糖0.02%。
实施例4
具有清咽润肺、去除口腔异味功效的双层片,原料优选重量百分比,原料优选重量百分比,罗汉果提取物27%、冬凌草提取物14.3%、薰衣草提取物14%、黑木耳提取物6%、山梨糖醇36%、木糖醇1.7%、茶多酚0.3%、溶菌酶0.4%、柠檬酸0.25%、甜菊糖0.05%。
实施例5
具有清咽润肺、去除口腔异味功效的双层片的制备方法:
(1)称取罗汉果500g、冬凌草300g、薰衣草300g,加水煎煮,第一次加10倍水提取2小时,第二次加8倍水提取1.5小时,第三次加6倍水提取1小时,合并提取液,三层无纺布过滤,滤液薄膜浓缩,喷雾干燥得干粉,万能粉碎机粉碎过80目筛,备用;
(2)称取干燥黑木耳,万能粉碎机粉碎,加水30倍浸泡过夜,调节PH5.0,加入果胶酶1.1%,55℃保温酶解80min, 然后迅速升温至85℃灭酶、热水浸提2h,无纺布过滤,薄膜浓缩、喷雾干燥得干粉,万能粉碎机粉碎过80目筛,备用。
(3)称取冬凌草、罗汉果、薰衣草喷干粉418g,加入黑木耳喷干粉70g,充分混合均匀,然后加入100g山梨糖醇、1.5g甜菊糖、16g柠檬酸(这三种材料充分混合均匀),混匀,加入含有50gPVPK30乙醇(80%乙醇水溶液)溶液制成软材,24目制粒,60℃烘干,24目整粒,然后加入5g硬脂酸镁混匀,制备得清咽润肺速溶颗粒585g;
(4)称取溶菌酶1.2g、茶多酚1.6g、木糖醇8g混合,加入400g山梨糖醇,充分混匀,加入含有4gPVPK乙醇溶液(80%乙醇水溶液)制软材,24目制粒,烘干,24目整粒,外加2g硬脂酸镁混匀,制备得口气清新缓释颗粒415g。
(5)先以较小的压力压制清咽润肺片,再在清咽润肺片的基础上压制双层片;压制的双层片经无菌包装,即得;食用时、置于口中含服或咀嚼,一次1-3片(1片1g)。
本实施方式只是对本专利的示例性说明而并不限定它的保护范围,本领域人员还可以对其进行局部改变,只要没有超出本专利的精神实质,都视为对本专利的等同替换,都在本专利的保护范围之内。
Claims (5)
1.具有清咽润肺、去除口腔异味功效的双层片,其特征在于:由原料按以下重量百分比制备而成,罗汉果提取物12-28%、冬凌草提取物10-15%、薰衣草提取物10-15%、黑木耳提取物5-8%、山梨糖醇30-40%、木糖醇1.5-2.0%、茶多酚0.2-0.8%、溶菌酶0.2-0.5%、柠檬酸0.25-0.28%、甜菊糖0.02-0.05%。
2.根据权利要求1所述的具有清咽润肺、去除口腔异味功效的双层片,其特征在于:原料按优选重量百分比,罗汉果提取物25%、冬凌草提取物12%、薰衣草提取物13%、黑木耳提取物7%、山梨糖醇40%、木糖醇2.0%、茶多酚0.4%、溶菌酶0.3%、柠檬酸0.274%、甜菊糖0.026%。
3.根据权利要求1所述的具有清咽润肺、去除口腔异味功效的双层片,其特征在于:原料按优选重量百分比,罗汉果提取物28%、冬凌草提取物15%、薰衣草提取物15%、黑木耳提取物8%、山梨糖醇30.9%、木糖醇1.5%、茶多酚0.8%、溶菌酶0.5%、柠檬酸0.28%、甜菊糖0.02%。
4.根据权利要求1所述的具有清咽润肺、去除口腔异味功效的双层片,其特征在于:原料按优选重量百分比,罗汉果提取物27%、冬凌草提取物14.3%、薰衣草提取物14%、黑木耳提取物6%、山梨糖醇36%、木糖醇1.7%、茶多酚0.3%、溶菌酶0.4%、柠檬酸0.25%、甜菊糖0.05%。
5.根据权利要求1-4任意一项所述的具有清咽润肺、去除口腔异味功效的双层片,其特征在于:其制备方法的步骤为:
步骤1、原料预处理:
(1)罗汉果、冬凌草、薰衣草的提取
a、按重量百分比,称取优质的罗汉果、冬凌草、薰衣草,混合置于煎煮容器内,加水提取3次,第一次加10倍的水提取2小时,第二次加8倍的水提取1.5小时,第三次加6倍的水提取1小时,合并三次提取液,得混合提取液;
b、将混合提取液采用三层无纺布过滤,滤液薄膜浓缩,得混合浓缩液;
c、将混合浓缩液置于喷雾干燥机中进行喷雾干燥,得混合干粉;
d、将混合干粉置于万能粉碎机中进行粉碎,过80目筛,得罗汉果、冬凌草、薰衣草的混合提取物,备用;
(2)黑木耳的提取
按重量百分比,称取干燥黑木耳,置于万能粉碎机中粉碎,得黑木耳粗粉;取黑木耳粗粉,加30倍的水浸泡24小时,调节PH5.0,加入质量为黑木耳水溶液1.1%的果胶酶,55℃保温酶解80分钟,然后迅速升温至85℃灭酶,灭酶后热水浸提2小时,无纺布过滤,薄膜浓缩,喷雾干燥得黑木耳干粉,置于万能粉碎机中进行粉碎,粉碎过80目筛,得黑木耳提取物,备用;
(3)称量
按重量百分比,称取优质的山梨糖醇、木糖醇、茶多酚、溶菌酶、柠檬酸、甜菊糖,备用;
步骤2、清咽润肺速溶颗粒的制备:
(1)混合
a、按重量百分比,称取罗汉果、冬凌草、薰衣草的混合提取物与黑木耳提取物;
b、按重量百分比,称取甜菊糖、柠檬酸,再称取五分之一备用的山梨糖醇,置于混合容器内,充分混合均匀,备用;
c、将黑木耳提取物加入至罗汉果、冬凌草、薰衣草的混合提取物中,充分混合均匀;再加入混合后的甜菊糖、柠檬酸、山梨糖醇,混合搅拌均匀,得总混物料,备用;
(2)制粒
a、取总混物料,加入适量5%PVPK30乙醇溶液,80%乙醇水溶液,制软材;
b、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得清咽润肺速溶颗粒,备用;
步骤3、口气清新缓释颗粒的制备:
(1)混合
按重量百分比,取备用的溶菌酶、茶多酚、木糖醇,混合搅拌均匀,再加入剩余五分之四备用的山梨糖醇,充分混合均匀,得总混料;
(2)制粒
a、取步骤3(1)混合均匀的总混料,加入适量1%PVPK乙醇溶液,80%乙醇水溶液,制软材;
b、将软材置于摇摆制粒机中,过24目筛制粒,得湿粒,置于烘箱中,60℃烘干,烘干后过24目钢筛整粒,整粒外加适量硬脂酸镁混合均匀,制得口气清新缓释颗粒,备用;
步骤4、压片:
取步骤2制得的清咽润肺速溶颗粒与步骤3制得的口气清新缓释颗粒,先以较小的压力将清咽润肺速溶颗粒压制成清咽润肺片,再在清咽润肺片的基础上,压制口气清新缓释颗粒,压制双层片,无菌包装,制得成品。
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