CN105829310B - 双环杂环化合物及其治疗用途 - Google Patents

双环杂环化合物及其治疗用途 Download PDF

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Publication number
CN105829310B
CN105829310B CN201480069940.4A CN201480069940A CN105829310B CN 105829310 B CN105829310 B CN 105829310B CN 201480069940 A CN201480069940 A CN 201480069940A CN 105829310 B CN105829310 B CN 105829310B
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methyl
compound
pyrrolo
dimethyl
fluorophenyl
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CN201480069940.4A
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Chinese (zh)
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CN105829310A (zh
Inventor
G.彻斯萨里
C.N.约翰逊
S.霍瓦德
J.E.H.戴
I.M.布克
C.M.格里菲斯-乔内斯
G.萨克斯蒂
E.塔马尼尼
N.E.维舍尔
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Astex Therapeutics Ltd
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Astex Therapeutics Ltd
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Priority claimed from GBGB1322755.8A external-priority patent/GB201322755D0/en
Priority claimed from GB201406986A external-priority patent/GB201406986D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Priority to CN201811129977.8A priority Critical patent/CN109336883B/zh
Priority to CN202210613741.1A priority patent/CN115368356B/zh
Publication of CN105829310A publication Critical patent/CN105829310A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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CN201480069940.4A 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途 Active CN105829310B (zh)

Priority Applications (2)

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CN201811129977.8A CN109336883B (zh) 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途
CN202210613741.1A CN115368356B (zh) 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1322755.8 2013-12-20
GBGB1322755.8A GB201322755D0 (en) 2013-12-20 2013-12-20 Bicyclic heterocycle compounds and their uses in therapy
GB1406986.8 2014-04-17
GB201406986A GB201406986D0 (en) 2014-04-17 2014-04-17 Bicyclic heterocycle compounds and their uses in therapy
PCT/GB2014/053778 WO2015092420A1 (en) 2013-12-20 2014-12-19 Bicyclic heterocycle compounds and their uses in therapy

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CN202210613741.1A Division CN115368356B (zh) 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途

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CN105829310A CN105829310A (zh) 2016-08-03
CN105829310B true CN105829310B (zh) 2019-04-12

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CN201480069940.4A Active CN105829310B (zh) 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途
CN201811129977.8A Active CN109336883B (zh) 2013-12-20 2014-12-19 双环杂环化合物及其治疗用途

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Cited By (1)

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CN115368356B (zh) * 2013-12-20 2025-05-09 阿斯特克斯治疗有限公司 双环杂环化合物及其治疗用途

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