CN1056372C - 噻唑烷二酮衍生物,它们的制备方法和用途 - Google Patents

噻唑烷二酮衍生物,它们的制备方法和用途 Download PDF

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Publication number
CN1056372C
CN1056372C CN93121754A CN93121754A CN1056372C CN 1056372 C CN1056372 C CN 1056372C CN 93121754 A CN93121754 A CN 93121754A CN 93121754 A CN93121754 A CN 93121754A CN 1056372 C CN1056372 C CN 1056372C
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CN
China
Prior art keywords
methyl
compound
reference example
phenyl
ethyl acetate
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN93121754A
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English (en)
Chinese (zh)
Other versions
CN1094726A (zh
Inventor
左右田隆
池田衡
今井佐知子
百濑祐
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
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Publication of CN1094726A publication Critical patent/CN1094726A/zh
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Publication of CN1056372C publication Critical patent/CN1056372C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN93121754A 1992-12-28 1993-12-28 噻唑烷二酮衍生物,它们的制备方法和用途 Expired - Fee Related CN1056372C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP348568/1992 1992-12-28
JP348568/92 1992-12-28
JP34856892 1992-12-28
JP180996/93 1993-07-22
JP18099693 1993-07-22
JP180996/1993 1993-07-22

Publications (2)

Publication Number Publication Date
CN1094726A CN1094726A (zh) 1994-11-09
CN1056372C true CN1056372C (zh) 2000-09-13

Family

ID=26500340

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93121754A Expired - Fee Related CN1056372C (zh) 1992-12-28 1993-12-28 噻唑烷二酮衍生物,它们的制备方法和用途

Country Status (21)

Country Link
US (1) US5489602A (enExample)
EP (1) EP0605228B1 (enExample)
JP (1) JP3741452B2 (enExample)
KR (1) KR100292363B1 (enExample)
CN (1) CN1056372C (enExample)
AT (1) ATE190052T1 (enExample)
AU (1) AU666414B2 (enExample)
CA (1) CA2112283A1 (enExample)
CZ (1) CZ288363B6 (enExample)
DE (1) DE69327944T2 (enExample)
DK (1) DK0605228T3 (enExample)
ES (1) ES2142852T3 (enExample)
FI (1) FI935887L (enExample)
GR (1) GR3033487T3 (enExample)
HU (1) HUT69383A (enExample)
MX (1) MX9400190A (enExample)
MY (1) MY110142A (enExample)
NO (1) NO300735B1 (enExample)
PT (1) PT605228E (enExample)
RU (1) RU2129553C1 (enExample)
TW (1) TW245716B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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IL113112A (en) * 1994-03-28 2000-06-01 Nissan Chemical Ind Ltd Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising them
WO1996005186A1 (en) * 1994-08-10 1996-02-22 Takeda Chemical Industries, Ltd. Thiazolidinedione derivatives, their production and use
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
AU744518B2 (en) 1996-07-01 2002-02-28 Dr. Reddy's Laboratories Limited Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) * 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
WO1997041097A2 (en) * 1996-12-31 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
JP2000514041A (ja) * 1996-07-26 2000-10-24 ドクター・レディーズ・リサーチ・ファウンデーション 抗糖尿病、低脂血、抗高血圧特性を有するチアゾリジンジオン化合物、それらの調製法、及びその薬学的組成物
TW577875B (en) * 1997-01-31 2004-03-01 Shionogi & Co Pyrrolidine derivatives with inhibitory activity for phospholipase A2
EP0981526B1 (en) * 1997-05-02 2004-02-25 Dr. Reddy's Laboratories Ltd. Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
GB9726568D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
UA75569C2 (en) * 1998-12-01 2006-05-15 Reddys Lab Ltd Dr Pharmaceutical composition of thiadiazolidinedione and method for its manufacture
JP4316787B2 (ja) * 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20050107387A1 (en) * 2003-05-13 2005-05-19 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a peroxisome proliferator activated receptor agonist for the treatment of ischemic mediated central nervous system disorders
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2011079274A1 (en) * 2009-12-23 2011-06-30 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
CN101824032B (zh) * 2010-04-23 2015-09-09 浙江华海药业股份有限公司 一种制备盐酸吡格列酮的工艺改进方法
BR112014010563B1 (pt) 2011-11-04 2021-01-12 Jasco Pharmaceuticals, LLC compostos inibidores da aminopirimidina quinase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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JPS5364586A (en) * 1976-11-19 1978-06-09 Takeda Chemical Industries Ltd Emission driving device for blood detector
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5564586A (en) * 1978-11-09 1980-05-15 Takeda Chem Ind Ltd Thiazolidine derivative
US4296237A (en) * 1979-09-11 1981-10-20 Merck & Co., Inc. 4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
WO1986006069A1 (fr) * 1985-04-09 1986-10-23 Takeda Chemical Industries, Ltd. Derives de thiazolidinedione, leur procede de preparation et composition medicinale les contenant
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
RU2066322C1 (ru) * 1991-06-28 1996-09-10 Киевский Государственный Университет Им.Т.Г.Шевченко 3-(4-метил-2-тиазолил)-6-пропил-7-(1-метил-1-этоксикарбонил)метоксихромон, обладающий гипогликемическим, гиполипидемическим действием и аналептическим действием

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C.A 117:48397W J.MED CHEM.1992.35(14)2617-26 1992.8.1 Studies on antialia betic agents *
C.A 117:48397W J.MED CHEM.1992.35(14)2617-26 1992.8.1 Studies on antialia betic agents;CA 117:48397W J MED CHEM 1992,35(14)2617-2619 1992.8.1 STUDIES ON AHTIDIABETIC AGENTS *
CA 117:48397W J MED CHEM 1992,35(14)2617-2619 1992.8.1 STUDIES ON AHTIDIABETIC AGENTS *

Also Published As

Publication number Publication date
NO934833D0 (no) 1993-12-27
US5489602A (en) 1996-02-06
KR100292363B1 (ko) 2001-09-17
DK0605228T3 (da) 2000-06-05
RU2129553C1 (ru) 1999-04-27
MY110142A (en) 1998-02-28
AU5261393A (en) 1994-07-07
DE69327944D1 (de) 2000-04-06
CN1094726A (zh) 1994-11-09
GR3033487T3 (en) 2000-09-29
JPH0782269A (ja) 1995-03-28
CZ287693A3 (en) 1994-12-15
FI935887A7 (fi) 1994-06-29
HUT69383A (en) 1995-09-28
AU666414B2 (en) 1996-02-08
FI935887A0 (fi) 1993-12-27
KR940014392A (ko) 1994-07-18
CZ288363B6 (en) 2001-06-13
JP3741452B2 (ja) 2006-02-01
EP0605228B1 (en) 2000-03-01
DE69327944T2 (de) 2000-10-19
ES2142852T3 (es) 2000-05-01
EP0605228A1 (en) 1994-07-06
MX9400190A (es) 1994-07-29
CA2112283A1 (en) 1994-06-29
TW245716B (enExample) 1995-04-21
NO934833L (no) 1994-06-29
NO300735B1 (no) 1997-07-14
HU9303757D0 (en) 1994-04-28
PT605228E (pt) 2000-06-30
FI935887L (fi) 1994-06-29
ATE190052T1 (de) 2000-03-15

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee