CN105555265A - 大麻素的生物合成 - Google Patents

大麻素的生物合成 Download PDF

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Publication number
CN105555265A
CN105555265A CN201480023902.5A CN201480023902A CN105555265A CN 105555265 A CN105555265 A CN 105555265A CN 201480023902 A CN201480023902 A CN 201480023902A CN 105555265 A CN105555265 A CN 105555265A
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cannabinoid
aryl
chain
straight chain
optionally substituted
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CN201480023902.5A
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Chinese (zh)
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罗伯特·温尼茨基
马克·东斯基
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Full Spectrum Laboratories Ltd
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Full Spectrum Laboratories Ltd
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/28—Cannabaceae, e.g. cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03007—Tetrahydrocannabinolic acid synthase (1.21.3.7)
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    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03008—Cannabidiolic acid synthase (1.21.3.8)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01206—3,5,7-Trioxododecanoyl-CoA synthase (2.3.1.206)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01102—Geranyl-pyrophosphate—olivetolic acid geranyltransferase (2.5.1.102)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201480023902.5A 2013-02-28 2014-02-27 大麻素的生物合成 Pending CN105555265A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361770766P 2013-02-28 2013-02-28
US61/770,766 2013-02-28
PCT/US2014/018944 WO2014134281A1 (en) 2013-02-28 2014-02-27 Biosynthesis of cannabinoids

Publications (1)

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CN105555265A true CN105555265A (zh) 2016-05-04

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US (8) US9359625B2 (enExample)
EP (1) EP2961402B1 (enExample)
JP (3) JP6581509B2 (enExample)
CN (1) CN105555265A (enExample)
AU (2) AU2014223458A1 (enExample)
BR (1) BR112015020332A2 (enExample)
CA (2) CA3012383C (enExample)
IL (1) IL240830B (enExample)
WO (1) WO2014134281A1 (enExample)

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CN109641022A (zh) * 2016-06-15 2019-04-16 奥海能量公益公司 用于减少氧化应激的方法和组合物
CN109734591A (zh) * 2018-12-26 2019-05-10 江苏暨明医药科技有限公司 一种大麻二酚中间体及其制备方法与及应用
CN110914416A (zh) * 2017-04-27 2020-03-24 加州大学董事会 产生大麻素和大麻素衍生物的微生物和方法
CN114599787A (zh) * 2019-10-11 2022-06-07 新加坡国立大学 利用酿酒酵母（Saccharomyces Cerevisiae）从简单前体原料可持续生产大麻素
CN114616326A (zh) * 2019-10-11 2022-06-10 新加坡国立大学 使用新型大麻素合成酶由大麻萜酚酸生物合成大麻素
CN114729337A (zh) * 2019-05-22 2022-07-08 德美崔克斯公司 优化的大麻素合酶多肽

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WO2019070876A2 (en) 2017-10-03 2019-04-11 The Regents Of The University Of Colorado METHOD FOR DIFFERENTIATING CANNABIS PLANT CULTIVARS BASED ON CANNABINOID SYNTHASE PARALOGUES
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