BR112014000735A2 - genes e proteína para a síntese de alcanoil-coa - Google Patents

genes e proteína para a síntese de alcanoil-coa

Info

Publication number
BR112014000735A2
BR112014000735A2 BR112014000735A BR112014000735A BR112014000735A2 BR 112014000735 A2 BR112014000735 A2 BR 112014000735A2 BR 112014000735 A BR112014000735 A BR 112014000735A BR 112014000735 A BR112014000735 A BR 112014000735A BR 112014000735 A2 BR112014000735 A2 BR 112014000735A2
Authority
BR
Brazil
Prior art keywords
alkanoyl
genes
protein
coa synthesis
coa
Prior art date
Application number
BR112014000735A
Other languages
English (en)
Inventor
m stout Jason
e page Jonathan
Original Assignee
Nat Res Council Canada
Univ Saskatchewan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Res Council Canada, Univ Saskatchewan filed Critical Nat Res Council Canada
Publication of BR112014000735A2 publication Critical patent/BR112014000735A2/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BR112014000735A 2011-07-13 2012-07-13 genes e proteína para a síntese de alcanoil-coa BR112014000735A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161507331P 2011-07-13 2011-07-13
PCT/CA2012/000656 WO2013006953A1 (en) 2011-07-13 2012-07-13 Genes and proteins for alkanoyl-coa synthesis

Publications (1)

Publication Number Publication Date
BR112014000735A2 true BR112014000735A2 (pt) 2017-06-13

Family

ID=47505453

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000735A BR112014000735A2 (pt) 2011-07-13 2012-07-13 genes e proteína para a síntese de alcanoil-coa

Country Status (16)

Country Link
US (1) US9546362B2 (pt)
EP (1) EP2732037B1 (pt)
JP (1) JP6177774B2 (pt)
KR (1) KR102031022B1 (pt)
CN (1) CN103842509B (pt)
AU (1) AU2012283708B2 (pt)
BR (1) BR112014000735A2 (pt)
CA (2) CA2851316C (pt)
CL (1) CL2014000096A1 (pt)
DK (1) DK2732037T3 (pt)
ES (1) ES2659526T3 (pt)
HK (1) HK1198298A1 (pt)
IL (1) IL230439B (pt)
MX (1) MX346923B (pt)
RU (1) RU2650766C2 (pt)
WO (1) WO2013006953A1 (pt)

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AU2015206358A1 (en) * 2014-01-17 2016-09-01 Conagen Inc. Methods of using capsaicin synthase for the microbial production of capsaicinoids
AU2015281729B2 (en) 2014-06-27 2021-11-25 National Research Council Of Canada (Nrc) Cannabichromenic acid synthase from cannabis sativa
WO2016010827A1 (en) 2014-07-14 2016-01-21 Librede Inc. Production of cannabinoids in yeast
US9394510B2 (en) 2014-08-25 2016-07-19 Full Spectrum Laboratories Limited Apparatus and methods for the simultaneous production of compounds
JP2018519853A (ja) * 2015-05-28 2018-07-26 ツイード・インコーポレイテッドTweed Inc. Thca合成酵素の発現を改変したアサ植物
KR20180101445A (ko) 2016-01-07 2018-09-12 코나겐 인크. 생합성 프로세스에 의해 캡시노이드를 제조하는 방법
AU2017232529B2 (en) * 2016-03-16 2021-06-10 William Marsh Rice University Microbial synthesis of isoprenoid precursors, isoprenoids and derivatives including prenylated aromatics compounds
US20190119694A1 (en) * 2016-04-14 2019-04-25 ebbu, Inc. Enhanced cannabis plants and methods of making and using the same
US10499584B2 (en) 2016-05-27 2019-12-10 New West Genetics Industrial hemp Cannabis cultivars and seeds with stable cannabinoid profiles
BR112019000895A2 (pt) 2016-07-19 2019-04-30 Conagen Inc. método para a produção microbiana de capsaicinoides naturais específicos
SG10201913280UA (en) * 2016-09-20 2020-03-30 22Nd Century Limited Llc Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
CN110325641B (zh) * 2016-12-30 2020-10-27 耐特希生物有限公司 基于无机多磷酸盐的能量再生的无细胞表达系统
JP2020507351A (ja) * 2017-02-17 2020-03-12 ヒヤシンス・バイオロジカルス・インコーポレイテッド 酵母における植物性カンナビノイド及び植物性カンナビノイドアナログの生成のための方法及び細胞株
BR112019019966A2 (pt) 2017-03-24 2020-04-28 Trait Biosciences Inc biossíntese in vivo de alto nível e isolamento de canabinoides solúveis em água em sistemas de plantas
AU2018256863A1 (en) 2017-04-27 2019-11-14 Regents Of The University Of California Microorganisms and methods for producing cannabinoids and cannabinoid derivatives
CN110869496A (zh) * 2017-05-10 2020-03-06 海湾医学公司 用于大麻素家族的戊烯化聚酮的重组生产系统
US11905543B2 (en) 2017-07-11 2024-02-20 Trait Biosceinces, Inc. In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures
US11946059B2 (en) 2017-07-11 2024-04-02 Trait Biosciences, Inc. In vivo generation of water-soluble cannabinoids in plant cell suspension cultures
WO2019014395A1 (en) 2017-07-11 2019-01-17 Trait Biosciences, Inc. GENERATION OF WATER-SOLUBLE CANNABINOID COMPOUNDS IN PLANT CELL SUSPENSION YEAST AND CROPS AND MATERIAL COMPOSITIONS
AU2018301828A1 (en) * 2017-07-12 2020-01-30 Biomedican, Inc. Production of cannabinoids in yeast
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
EP3864000A4 (en) 2018-10-10 2022-08-10 Treehouse Biosciences, Inc. CANNABIGEROL SYNTHESIS
WO2020102430A1 (en) * 2018-11-14 2020-05-22 Baymedica, Inc. Use of type i and type ii polyketide synthases for the production of cannabinoids and cannabinoid analogs
EP3931330A4 (en) 2019-02-25 2023-03-15 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
US20220186267A1 (en) * 2019-03-27 2022-06-16 Rynetech Bio, Inc. Biosynthetic Cannabidiol Production In Engineered Microorganisms
AU2020259500A1 (en) * 2019-04-19 2021-10-21 Genomatica, Inc. Olivetol synthase variants and methods for production of olivetolic acid and its analog compounds
US20230037234A1 (en) * 2019-11-27 2023-02-02 Genomatica, Inc. ENGINEERED CELLS FOR PRODUCTION OF CANNABINOIDS AND OTHER MALONYL-CoA-DERIVED PRODUCTS
CN110923242B (zh) * 2019-12-14 2021-04-13 厦门梓蔓生物科技有限公司 一种大麻腺毛中分离的转录因子CsAPL1及其应用
BR112023002818A2 (pt) * 2020-08-19 2023-04-25 Amyris Inc Produção microbiana de canabinoides
CN112489738B (zh) * 2020-11-30 2023-05-26 上海交通大学 高活性苯丙素类衍生物的定向设计及其生物合成方法
CN114196647B (zh) * 2021-09-10 2022-08-12 北京蓝晶微生物科技有限公司 一种橄榄醇合成酶变体r及其用途
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Also Published As

Publication number Publication date
NZ621037A (en) 2016-02-26
CA2851316C (en) 2021-10-19
CA2851316A1 (en) 2013-01-17
CA3130623A1 (en) 2013-01-17
EP2732037B1 (en) 2017-12-06
RU2014104668A (ru) 2015-08-20
WO2013006953A9 (en) 2014-04-03
WO2013006953A1 (en) 2013-01-17
CN103842509A (zh) 2014-06-04
MX2014000535A (es) 2015-05-12
HK1198298A1 (en) 2015-06-12
JP6177774B2 (ja) 2017-08-16
CN103842509B (zh) 2016-06-08
DK2732037T3 (en) 2018-02-26
MX346923B (es) 2017-04-05
JP2014521311A (ja) 2014-08-28
CL2014000096A1 (es) 2015-06-05
KR20140108210A (ko) 2014-09-05
US20140141476A1 (en) 2014-05-22
EP2732037A4 (en) 2015-01-14
AU2012283708B2 (en) 2017-02-23
AU2012283708A2 (en) 2014-04-10
RU2650766C2 (ru) 2018-04-17
IL230439A0 (en) 2014-03-31
ES2659526T3 (es) 2018-03-16
US9546362B2 (en) 2017-01-17
WO2013006953A8 (en) 2014-06-19
IL230439B (en) 2020-07-30
AU2012283708A1 (en) 2014-02-27
KR102031022B1 (ko) 2019-10-11
EP2732037A1 (en) 2014-05-21

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