CN105495258B - 一种有助降尿酸的水果饮料 - Google Patents
一种有助降尿酸的水果饮料 Download PDFInfo
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- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims abstract description 54
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Abstract
本发明一种有助降低尿酸的水果饮料，属于水果饮料技术领域。由以下质量份数的组分组成：樱桃粉10份‑20份，山楂粉10份‑20份，番茄粉1份‑10份，桑叶粉1份‑5份，抗性糊精1份‑10份，维生素C1份‑5份，赤藓糖醇20份‑50份，魔芋粉0.5份‑1份，三氯蔗糖0.05份‑0.1份，磷酸三钙0.5份‑1份。本发明适于痛风患者，有助于降低尿酸，缓解痛风症状。酸甜可口，生津开胃。饮料中添加无热量的赤藓糖醇，搭配三氯蔗糖，使得饮料的甜度宜人，不会导致龋齿，也不会引起血糖升高。
Description
技术领域
本发明属于水果饮料技术领域，涉及一种有助降低人体中尿酸含量的水果固体饮料，对缓解痛风人群的症状具有积极的作用。
背景技术
痛风以嘌呤代谢紊乱，尿酸排泄失常所致血尿酸增高，并伴有结缔组织内尿酸钠结晶沉着为特征的疾病。临床上表现为高尿酸血症、痛风性急性关节炎反复发作、痛风石沉积、特征性慢性关节炎和关节炎畸形，常累及肾脏引起慢性间质性肾炎和肾尿酸结石形成，并可出现关节致残及肾功能不全。急性痛风性关节炎是痛风最常见的首发症状。随着人们生活水平的提高及饮食结构的改变。谷类食物减少而肉类食物增多，导致痛风患病率迅速升高，痛风发病年龄呈年轻化趋势。发病率男性高于女性，男性多于中年发病，女性均于绝经后发病，这可能是由于雌激素有促进尿酸排泄的作用。
痛风原因之一是由于嘌呤代谢紊乱导致尿酸生成增多所引起。目前，治疗痛风的方法主要包括秋水仙碱、非甾醇类抗炎药、抑制尿酸生成药、促进尿酸排泄药、糖皮质激素以及一些中医治疗方法。人们在经历了长期化学药物治疗疾病的过程中，逐渐认识到对痛风用化学药物治疗虽然作用迅速，效果明显，但目前常用治疗痛风的化学药物不良反应较多，常见恶心、呕吐、腹泻、过敏反应、肝肾损害等。如秋水仙碱治疗痛风的有效剂量与其引起胃肠道症状的剂量相近。传统的非甾体抗炎药(NSAIDs)通过抑制环氧化酶-1和环氧化酶-2来发挥其抗炎作用，而NSAIDs的大部分副作用，尤其是胃肠道毒性，则是环氧化酶-1受抑制的作用。皮质激素类药物治疗痛风的效果明显，但撤药后易生“反跳”。黄嘌呤氧化酶抑制剂别嘌呤醇是当前治疗痛风的一线药物，但大约 2%的患者对此药过敏。苯溴马隆可致重症肝炎，日本己对抗痛风药物提出安全警告。
鉴于目前降尿酸药物较少，且存在安全性、有效性和经济性缺陷，以及人们日常饮食中有众多食物具有降尿酸的作用，尚无有相关的食品见于市面，开发一种有助于降低尿酸的健康食品具有重大的意义。近年来，国内外研究初步证明我们日常所接触的很多食品确有促进尿酸排泄和治疗痛风性关节炎的作用，展示了这一领域内较广阔的前景。有学者认为低脂奶对痛风有保护作用，低脂奶可以降低血尿酸，其机制可能是牛奶中的酪蛋白和乳清蛋白可增加尿酸的排泄，从而降低血尿酸。最近有研究发现高剂量的维生素C有促进尿酸排泄的作用，连续2个月，每天摄取维生素C500mg，血尿酸就可以减少0.5mg/dl。樱桃粉中含有高活性樱桃黄酮素和大樱桃素，抑制尿酸合成，有助尿酸排泄，止疼消炎。山楂利尿促进尿酸排出，还可以可以降低痛风并发症发生。西红柿是碱性食物，可促进尿酸的排泄。因尿变成碱性后，就易于溶解尿酸，从而将尿酸顺利排出。香港中文大学医学院研究发现桑叶及桑枝有效治疗痛风。多数痛风患者伴有代谢综合征，食用膳食纤维可改善代谢综合征，进而改善痛风患者的整体代谢情况。
发明内容
本发明涉及一种有助降低人体中尿酸含量的水果固体饮料，对缓解痛风人群的症状具有积极的作用。
本发明要解决上述问题所采用技术方案是这样实现的：
一种有助降低尿酸的水果固体饮料，由以下质量份数的组分组成：
樱桃粉 10份-20份，
山楂粉 10份-20份，
番茄粉 1份-10份，
桑叶粉 1份-5份，
抗性糊精 1份-10份，
维生素C 1份-5份，
赤藓糖醇 20份-50份，
魔芋粉 0.5份-1份，
三氯蔗糖 0.05份-0.1份，
磷酸三钙 0.5份-1份。
樱桃粉按照下述步骤制备得到：挑选新鲜樱桃为原料，经过缓冻、切割、装盘、速冻、升华干燥、粉碎、过筛后制得的冻干粉。
番茄粉按照下述步骤制备得到：挑选新鲜番茄为原料，经过缓冻、切割、装盘、速冻、升华干燥、粉碎、过筛后制得的冻干粉。
山楂粉按照下述步骤制备得到：挑选新鲜山楂为原料，经过粉碎、磨浆、过滤、调配、喷雾干燥、过筛后制得的干粉。
桑叶粉按照下述步骤制备得到：挑选新鲜桑叶为原料，经过粉碎、磨浆、过滤、调配、喷雾干燥、过筛后制得的干粉。
本发明的优点：1、适于痛风患者，有助于降低尿酸，缓解痛风症状。2、酸甜可口，生津开胃。3、饮料中添加0热量的赤藓糖醇，搭配三氯蔗糖，使得饮料的甜度宜人，不会导致龋齿，也不会引起血糖升高。
具体实施方式
通过以下实施实例将更加详细的说明本发明。以下实施例仅是说明性的，本发明并不受这些实施实例的限制。
实施例1：本发明所提供有助于降低尿酸的水果固体饮料对高尿酸血症模型老鼠的影响。
（1）样品的制备：水果固体饮料按下述配方进行配备，
一种有助降低尿酸的水果固体饮料，由以下质量份数的组分组成：
樱桃粉 10份，
山楂粉 10份，
番茄粉 1份，
桑叶粉 1份，
抗性糊精 1份，
维生素C 1份，
赤藓糖醇 20份，
魔芋粉 0.5份，
三氯蔗糖 0.05份，
磷酸三钙 0.5份；加6倍水进行冲调。
（2）氧嗪酸钾盐用灭菌热蒸馏水配成1.5g/100ml的混悬液，按照300mg/kg体质量的剂量一次性腹腔注射。苯溴马隆：将药片压碎，加蒸馏水溶解、混匀、配成 100mg/100ml,按照 16mg/kg体质量的剂量每日灌胃 1次。
（3）雄性ICR大鼠随机分为4组，每组10个(包括正常对照组、模型组、试验组及阳性药物组（苯溴马隆组）。第1天，除对照组外，其余各组在首次喂食前1h予氧嗪酸钾盐300mg/kg小鼠腹腔注射。1h后各组灌胃喂食，正常对照组和模型组灌胃生理盐水，试验组按 0.1g/kg浓度灌胃喂食，阳性药物组按20mg/kg灌胃给药,每日1次,连续 7天。末次喂食1h后各组小鼠摘眼球取血，水浴（37℃）中静置至分层后，1800r/min离心10min，取血清测定血尿酸值，进行组间差异性比较。实验结果见表1。
表1 有助于降低尿酸的水果固体饮料对小鼠高尿酸血症模型血尿酸的影响
| 组别 | 血尿酸值（U/L） |
| 对照组 | 125.52±16.23 |
| 模型组 | 204.11±24.14 |
| 试验组 | 193.65±12.85 |
| 阳性药物组 | 149.51±23.26 |
模型组与空白组比较，血尿酸值极明显升高，证明模型非常成功。试验组与模型组比较，血尿酸值有一定程度下降。证明有助于降低尿酸的水果固体饮料对尿酸酶抑制剂所致的小鼠血尿酸有降低作用。但效果不如阳性药物组。
实施例2：本发明所提供有助于降低尿酸的水果固体饮料对高尿酸血症模型老鼠的影响。
（1）样品的制备：水果固体饮料按下述配方进行配备，
一种有助降低尿酸的水果固体饮料，由以下质量份数的组分组成：
樱桃粉 20份，
山楂粉 20份，
番茄粉 10份，
桑叶粉 5份，
抗性糊精 10份，
维生素C 5份，
赤藓糖醇 50份，
魔芋粉 1份，
三氯蔗糖 0.1份，
磷酸三钙 1份；加6倍水进行冲调。
（2）氧嗪酸钾盐用灭菌热蒸馏水配成1.5g/100ml的混悬液，按照300mg/kg体质量的剂量一次性腹腔注射。苯溴马隆：将药片压碎，加蒸馏水溶解、混匀、配成 100mg/100ml,按照 16mg/kg体质量的剂量每日灌胃 1次。
（3）高尿酸模型的制备：采用腹腔注射氧嗪酸钾盐（3000mg/kg）方法在ICR小鼠建立高尿酸血症动物模型
（4）分组：雄性ICR大鼠随机分为4组，每组10个(包括正常对照组、模型组、试验组及阳性药物组（苯溴马隆组）。正常对照组和模型组灌胃生理盐水，试验组按 0.2g/kg浓度灌胃喂食，阳性药物组按20mg/kg灌胃给药，每日1次，连续 7天。于第7天，除对照组外，其余各组在末次喂食前1h予氧嗪酸钾盐300mg/kg小鼠腹腔注射，1h后各组灌胃喂食，1h后各组小鼠摘眼球取血，水浴（37℃）中静置至分层后，1800r/min离心10min，取血清测定血尿酸值，进行组间差异性比较。实验结果见表2
表2 有助于降低尿酸的水果固体饮料对小鼠高尿酸血症模型血尿酸的影响
| 组别 | 血尿酸值（U/L） |
| 对照组 | 125.52±16.23 |
| 模型组 | 204.11±24.14 |
| 试验组 | 170.65±19.85 |
| 阳性药物组 | 149.51±23.26 |
模型组与空白组比较，血尿酸值极明显升高，证明模型非常成功。试验组与模型组比较，血尿酸值有下降。证明有助于降低尿酸的水果固体饮料对尿酸酶抑制剂所致的小鼠血尿酸有降低作用。但效果不如阳性药物组。
实施例3：本发明所提供有助于降低尿酸的水果固体饮料对高尿酸血症模型老鼠的影响。
（1）样品的制备：水果固体饮料按前述配方进行配备，
一种有助降低尿酸的水果固体饮料，由以下质量份数的组分组成：
樱桃粉 15份，
山楂粉 15份，
番茄粉 5份，
桑叶粉 2份，
抗性糊精 5份，
维生素C 2份，
赤藓糖醇 30份，
魔芋粉 0.8份，
三氯蔗糖 0.06份，
磷酸三钙 0.8份；加6倍水进行冲调。
（2）氧嗪酸钾盐用灭菌热蒸馏水配成1.5g/100ml的混悬液，按照300mg/kg体质量的剂量一次性腹腔注射。苯溴马隆：将药片压碎，加蒸馏水溶解、混匀、配成 100mg/100ml，按照 16mg/kg体质量的剂量每日灌胃 1次。
（3）高尿酸模型的制备：采用腹腔注射氧嗪酸钾盐（3000mg/kg）方法在ICR小鼠建立高尿酸血症动物模型
（4）分组：雄性ICR大鼠随机分为4组，每组10个(包括正常对照组、模型组、试验组及阳性药物组（苯溴马隆组）。正常对照组和模型组灌胃生理盐水，试验组按 0.5g/kg浓度灌胃喂食，阳性药物组按20mg/kg灌胃给药,每日1次,连续 7天。于第7天，除对照组外，其余各组在末次喂食前1h予氧嗪酸钾盐300mg/kg小鼠腹腔注射，1h后各组灌胃喂食，1h后各组小鼠摘眼球取血，水浴（37℃）中静置至分层后，1800r/min离心10min，取血清测定血尿酸值，进行组间差异性比较。
实验结果见表3
表3 有助于降低尿酸的水果固体饮料对小鼠高尿酸血症模型血尿酸的影响
| 组别 | 血尿酸值（U/L） |
| 对照组 | 125.52±16.23 |
| 模型组 | 204.11±24.14 |
| 试验组 | 167.31±29.75 |
| 阳性药物组 | 149.51±23.26 |
模型组与空白组比较，血尿酸值极明显升高，证明模型非常成功。试验组与模型组比较，血尿酸值有较明显下降。证明有助于降低尿酸的水果固体饮料对尿酸酶抑制剂所致的小鼠血尿酸有降低作用。但效果不如阳性药物组。
Claims (1)
1.一种有助降低尿酸的水果饮料，其特征在于由以下质量份数的组分组成：
樱桃粉 10份-20份，
山楂粉 10份-20份，
番茄粉 1份-10份，
桑叶粉 1份-5份，
抗性糊精 1份-10份，
维生素C 1份-5份，
赤藓糖醇 20份-50份，
魔芋粉 0.5份-1份，
三氯蔗糖 0.05份-0.1份，
磷酸三钙 0.5份-1份；
樱桃粉按照下述步骤制备得到：挑选新鲜樱桃为原料，经过缓冻、切割、装盘、速冻、升华干燥、粉碎、过筛后制得的冻干粉；
山楂粉按照下述步骤制备得到：挑选新鲜山楂为原料，经过粉碎、磨浆、过滤、调配、喷雾干燥、过筛后制得的干粉；
番茄粉按照下述步骤制备得到：挑选新鲜番茄为原料，经过缓冻、切割、装盘、速冻、升华干燥、粉碎、过筛后制得的冻干粉；
桑叶粉按照下述步骤制备得到：桑叶粉按照下述步骤制备得到：挑选新鲜桑叶为原料，经过粉碎、磨浆、过滤、调配、喷雾干燥、过筛后制得的干粉。
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