CN105358699A - 包含结合至鞘脂的抗体的农用化学组合物 - Google Patents

包含结合至鞘脂的抗体的农用化学组合物 Download PDF

Info

Publication number
CN105358699A
CN105358699A CN201480037515.7A CN201480037515A CN105358699A CN 105358699 A CN105358699 A CN 105358699A CN 201480037515 A CN201480037515 A CN 201480037515A CN 105358699 A CN105358699 A CN 105358699A
Authority
CN
China
Prior art keywords
seq
region
cdr1
cdr2
cdr3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480037515.7A
Other languages
English (en)
Chinese (zh)
Inventor
彼得·维尔希森
克里斯·德容格
英奇·埃洛迭·旺达勒
米格尔·弗朗切斯科·科利塔·德博勒
若昂·菲利佩·维洛佐·维埃拉
布鲁诺·卡穆埃
卡林·特维森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Agrosavfe NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agrosavfe NV filed Critical Agrosavfe NV
Priority to CN202211371382.XA priority Critical patent/CN116076508A/zh
Publication of CN105358699A publication Critical patent/CN105358699A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/14—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/10—Animals; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201480037515.7A 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物 Pending CN105358699A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211371382.XA CN116076508A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817170P 2013-04-29 2013-04-29
US61/817,170 2013-04-29
PCT/EP2014/058771 WO2014177595A1 (en) 2013-04-29 2014-04-29 Agrochemical compositions comprising antibodies binding to sphingolipids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211371382.XA Division CN116076508A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物

Publications (1)

Publication Number Publication Date
CN105358699A true CN105358699A (zh) 2016-02-24

Family

ID=50736046

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201480037515.7A Pending CN105358699A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物
CN202210433845.4A Pending CN114732017A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物
CN201480037506.8A Active CN105358698B (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物
CN202211371382.XA Pending CN116076508A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202210433845.4A Pending CN114732017A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物
CN201480037506.8A Active CN105358698B (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物
CN202211371382.XA Pending CN116076508A (zh) 2013-04-29 2014-04-29 包含结合至鞘脂的抗体的农用化学组合物

Country Status (16)

Country Link
US (5) US9803003B2 (https=)
EP (3) EP2992101B1 (https=)
JP (4) JP6967347B2 (https=)
CN (4) CN105358699A (https=)
AU (3) AU2014273418B2 (https=)
BR (2) BR112015027430B1 (https=)
CA (2) CA2910874C (https=)
DK (1) DK2992100T3 (https=)
ES (2) ES2762151T3 (https=)
HR (1) HRP20192182T1 (https=)
HU (1) HUE047580T2 (https=)
PL (2) PL2992101T3 (https=)
PT (1) PT2992100T (https=)
TR (1) TR201819577T4 (https=)
WO (2) WO2014177595A1 (https=)
ZA (2) ZA201507757B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112513277A (zh) * 2019-04-08 2021-03-16 Dna2.0股份有限公司 使用来自螟蛾属的转座酶将核酸构建体转座入真核基因组
CN113121692A (zh) * 2021-04-29 2021-07-16 中国科学技术大学 结合人rage胞外域的羊驼源抗体
CN119661667A (zh) * 2025-02-21 2025-03-21 南京农业大学三亚研究院 一种药物靶标蛋白MoFrd1及其在农业病害防治中的应用

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2795480C (en) 2010-04-06 2021-10-26 Vrije Universiteit Brussel Specific delivery of agrochemicals
US20180222966A1 (en) * 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
EP2992101B1 (en) 2013-04-29 2018-10-10 Agrosavfe N.V. Agrochemical compositions comprising antibodies binding to sphingolipids
JP6376798B2 (ja) * 2014-03-27 2018-08-22 三菱重工業株式会社 洗濯排水生物処理製剤を用いた洗濯排水処理装置及び方法
US10858666B2 (en) 2014-11-05 2020-12-08 Biotalys Transgenic plants expressing a variable domain of a heavy chain antibody (VHH) that binds to a sphingolipid of a fungus
EP3415010A1 (en) * 2017-06-13 2018-12-19 Agrosavfe Nv Insect-controlling polypeptides and methods
AU2018313810B2 (en) * 2017-08-09 2025-05-15 Orionis Biosciences BV Clec9A binding agents and use thereof
US10017560B1 (en) 2017-11-16 2018-07-10 King Saud University Nanobody against begomoviruses
KR102877915B1 (ko) 2018-02-05 2025-10-29 오리오니스 바이오사이언시즈 인코포레이티드 섬유아세포 결합제 및 이의 용도
MX2021000184A (es) * 2018-07-05 2021-05-12 Novobind Livestock Therapeutics Inc Anticuerpos contra agentes patogenos en aves de corral y sus aplicaciones.
CN109081870B (zh) * 2018-09-21 2021-12-03 成都阿帕克生物科技有限公司 一种抗人促绒毛膜促性腺激素β亚单位的纳米抗体及核酸分子和应用
US12410225B2 (en) 2018-11-08 2025-09-09 Orionis Biosciences, Inc Modulation of dendritic cell lineages
WO2020144164A1 (en) 2019-01-07 2020-07-16 Bactolife Aps Pathogen binding proteins
US12351614B2 (en) 2019-03-28 2025-07-08 Orionis Biosciences, Inc. CLEC9A-based chimeric protein complexes
JP7773372B2 (ja) 2019-03-28 2025-11-19 オリオニス バイオサイエンシズ，インコーポレイテッド 線維芽細胞活性化タンパク質結合物質およびその使用
CN113939279A (zh) * 2019-04-13 2022-01-14 旗舰创业创新六公司 包封多肽的植物信使包及其用途
CN110205252A (zh) * 2019-06-20 2019-09-06 江苏大学 喷雾干燥制备拮抗酵母固体制剂的方法
EP4041297A4 (en) * 2019-10-11 2024-02-28 The Trustees of The University of Pennsylvania COMPOSITIONS AND METHODS FOR TARGETING CD13 AND TIM-3 WITH CAR-T CELLS FOR TREATING ACUTE MYELOID LEUKEMIA
CA3160506A1 (en) 2019-11-11 2021-05-20 Ibi-Ag Innovative Bio Insecticides Ltd. Insect control nanobodies and uses thereof
WO2021198396A1 (en) * 2020-03-31 2021-10-07 Biotalys NV Anti-fungal polypeptides
WO2021226204A2 (en) * 2020-05-05 2021-11-11 Oncorus, Inc. Anti-dll3 antibodies and methods of use
CA3178663A1 (en) * 2020-05-15 2021-11-18 Alejandro Rojas One-step fast gradient method for nanoantibody generation
WO2022023584A1 (en) 2020-07-31 2022-02-03 Biotalys NV Methods of increasing recombinant protein yields
EP4015041A1 (en) * 2020-12-15 2022-06-22 Universidad De Zaragoza Treatment of fungal infections or diseases
EP4473119A1 (en) 2022-02-02 2024-12-11 Biotalys NV Modified microbial cells and uses thereof
EP4473108A1 (en) 2022-02-02 2024-12-11 Biotalys NV Methods for genome editing
EP4490168A1 (en) * 2022-03-08 2025-01-15 Molecular Templates, Inc. Ctla-4 binding molecules comprising shiga toxin a subunit scaffolds and uses thereof
CN114478757B (zh) * 2022-03-31 2022-07-05 深圳市人民医院 靶向新冠病毒的纳米抗体及其制备方法和应用
EP4638735A1 (en) 2022-12-22 2025-10-29 Biotalys NV Methods for genome editing
US20260026500A1 (en) 2022-12-29 2026-01-29 Biotalys NV Agrochemical compositions
WO2024141641A2 (en) 2022-12-30 2024-07-04 Biotalys NV Secretion signals
WO2024141645A1 (en) 2022-12-30 2024-07-04 Biotalys N.V. Agglomerate
EP4642232A1 (en) 2022-12-30 2025-11-05 Biotalys NV Self-emulsifiable concentrate
CN116267297B (zh) * 2023-02-21 2024-09-06 广西壮族自治区农业科学院 一种通过水分管理预防甘蔗白条病的方法
CN120058934B (zh) * 2023-11-30 2026-01-16 科弈(浙江)药业科技有限公司 靶向egfr的纳米抗体、药物偶联物及其用途
US12378306B2 (en) * 2023-12-22 2025-08-05 Biotalys NV Anti-fungal VHH antibodies
WO2025154058A1 (en) 2024-01-21 2025-07-24 Ibi-Ag Innovative Bio Insecticides Ltd. Anti-insect hsp70 nanobodies and uses thereof
WO2025154056A1 (en) 2024-01-21 2025-07-24 Ibi-Ag Innovative Bio Insecticides Ltd. Anti-insect cda nanobodies and uses thereof
CN117866903B (zh) * 2024-03-12 2024-06-04 北京贝来药业有限公司 单域抗体修饰的干细胞及其在疾病治疗中用途
WO2026008785A1 (en) 2024-07-03 2026-01-08 Biotalys NV Agrochemical compositions
CN119462912B (zh) * 2025-01-15 2025-08-19 中国人民解放军军事科学院军事医学研究院 抗埃博拉病毒vp40蛋白的纳米抗体及在病毒检测中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009398A1 (en) * 1994-09-19 1996-03-28 Rijkslandbouwuniversiteit Wageningen Gene constructs encoding crop-protecting agents, as well as transformed plants containing and expressing such constructs, and methods of controlling plague organisms and pathogens in crops
WO2011023522A1 (en) * 2009-08-24 2011-03-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Antibody fusion-mediated plant resistance against oomycota
WO2012025602A1 (en) * 2010-08-26 2012-03-01 Vib Vzw Insect binding antibodies
WO2012025621A1 (en) * 2010-08-26 2012-03-01 Vib Vzw Compositions for seed treatment

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02128697A (ja) * 1988-11-09 1990-05-17 Hoechst Japan Ltd 抗フコシルセラミドモノクローナル抗体
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
ES2162863T3 (es) 1993-04-29 2002-01-16 Unilever Nv Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae.
FR2708622B1 (fr) 1993-08-02 1997-04-18 Raymond Hamers Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
ES2294799T3 (es) 1996-06-27 2008-04-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana.
AU3596599A (en) 1998-01-26 1999-08-09 Unilever Plc Method for producing antibody fragments
WO2000002996A2 (en) 1998-07-10 2000-01-20 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
ES2246093T3 (es) 1998-10-16 2006-02-01 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Patogenicida molecular que induce una resistencia a la enfermedad en las plantas.
EP1141711A1 (en) 1999-01-05 2001-10-10 Unilever Plc Binding of antibody fragments to solid supports
DK1144616T4 (da) 1999-01-19 2009-03-30 Unilever Nv Fremgangsmåde til fremstilling af antistoffragmenter
CA2370351A1 (en) 1999-04-22 2000-11-02 Unilever Plc Inhibition of viral infection using monovalent antigen-binding proteins
CN1279172C (zh) 1999-07-22 2006-10-11 独立行政法人农业生物资源研究所 转化水稻植物的方法
US6479280B1 (en) 1999-09-24 2002-11-12 Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
ES2331051T3 (es) 1999-11-29 2009-12-21 Bac Ip B.V. Inmovilizacion de moleculas de union de antigenos de un dominio.
WO2001040310A2 (en) 1999-11-29 2001-06-07 Unilever Plc Immobilisation of proteins using a polypeptide segment
EP1118669A3 (en) 1999-12-17 2001-08-29 Unilever Plc Production of camelid antibodies in plants
ES2324280T3 (es) 2000-03-14 2009-08-04 Unilever N.V. Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos.
US20030190598A1 (en) 2000-05-26 2003-10-09 Jasmid Tanha Single-domain antigen-binding antibody fragments derived from llama antibodies
ATE513854T1 (de) 2000-12-13 2011-07-15 Bac Ip B V Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen
GB0110029D0 (en) * 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
US20060073141A1 (en) 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
JP4213586B2 (ja) * 2001-09-13 2009-01-21 株式会社抗体研究所 ラクダ抗体ライブラリーの作製方法
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
EP1456410A2 (en) 2001-12-11 2004-09-15 AlgoNomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
EP1456237A2 (en) 2001-12-21 2004-09-15 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Method for cloning of variable domain sequences
CA2471645A1 (en) 2002-01-03 2003-07-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Immunoconjugates useful for treatment of tumours
US7531522B2 (en) 2002-04-22 2009-05-12 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
DE10234116A1 (de) * 2002-07-26 2004-02-12 Land Rheinland-Pfalz vertreten durch die Staatliche Lehr- und Forschungsanstalt für Landwirtschaft, Weinbau und Gartenbau (SLFA) Verfahren zur Expression von gegen virale Proteine gerichtete scFv-Fragmenten in Pflanzen und deren Verwendung
EP1558645B1 (en) 2002-11-08 2011-07-27 Ablynx N.V. Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
WO2004041863A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor
JP2006517789A (ja) 2003-01-10 2006-08-03 アブリンクス エン．ヴェー． 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用
JP4283127B2 (ja) * 2003-06-20 2009-06-24 独立行政法人科学技術振興機構 転写因子を転写抑制因子に変換するペプチド及びこれをコードするポリヌクレオチド、並びにその利用
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
US20080014192A1 (en) * 2006-05-23 2008-01-17 Poeta Maurizio D Methods For The Diagnosis And Treatment of Fungal Infections Caused By Microorganisms Producing Glucosylceramide
US20090083880A1 (en) 2007-04-20 2009-03-26 Hexima Ltd. Modified plant defensin
NZ580505A (en) 2007-04-20 2011-03-31 Hexima Ltd Modified plant defensin comprising a signal peptide, a mature domain from a Class I defensin and a C-terminal propeptide tail from a Class II plant defensin
CU23688A1 (es) 2008-03-28 2011-07-11 Ct Ingenieria Genetica Biotech Secuencias de ácido nucleico y aminoácidos para el control de agentes patógenos
EP2143735A1 (en) * 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
WO2010019442A1 (en) 2008-08-12 2010-02-18 Plant Health Care, Inc. Production, formulation, and uses of stable liquid harpin protein formulations
WO2010066740A1 (en) 2008-12-08 2010-06-17 Complix Nv Single-chain antiparallel coiled coil proteins
UY32663A (es) * 2009-05-28 2010-12-31 Glaxo Group Ltd Proteinas de union a antigeno
WO2011085070A2 (en) 2010-01-06 2011-07-14 Virginia Tech Intellectual Properties, Inc. Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts
CA2795480C (en) 2010-04-06 2021-10-26 Vrije Universiteit Brussel Specific delivery of agrochemicals
WO2012011396A1 (ja) * 2010-07-20 2012-01-26 国立大学法人東京大学 ナノ抗体を発現するトランスジェニックイネ
WO2012047076A2 (ko) 2010-10-08 2012-04-12 한국생명공학연구원 파라고무나무 유래의 라텍스 분비 조직 특이적 ｓｒｐｐ 프로모터 및 이의 용도
JP2012157315A (ja) * 2011-02-02 2012-08-23 Gekkeikan Sake Co Ltd ラクダ科動物抗体の重鎖可変ドメイン（ｖｈｈ）の生産方法
US20150087517A1 (en) 2011-10-06 2015-03-26 Agrosavfe N.V. Manufacturing of specifically targeting microcapsules
EP2992101B1 (en) 2013-04-29 2018-10-10 Agrosavfe N.V. Agrochemical compositions comprising antibodies binding to sphingolipids
US20180222966A1 (en) 2013-04-29 2018-08-09 Agrosavfe N.V. Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
US10858666B2 (en) 2014-11-05 2020-12-08 Biotalys Transgenic plants expressing a variable domain of a heavy chain antibody (VHH) that binds to a sphingolipid of a fungus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009398A1 (en) * 1994-09-19 1996-03-28 Rijkslandbouwuniversiteit Wageningen Gene constructs encoding crop-protecting agents, as well as transformed plants containing and expressing such constructs, and methods of controlling plague organisms and pathogens in crops
WO2011023522A1 (en) * 2009-08-24 2011-03-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Antibody fusion-mediated plant resistance against oomycota
WO2012025602A1 (en) * 2010-08-26 2012-03-01 Vib Vzw Insect binding antibodies
WO2012025621A1 (en) * 2010-08-26 2012-03-01 Vib Vzw Compositions for seed treatment

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ANDRE F.C. DA SILVA 等: "Glucosylceramides in colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelia cells", 《FEBS LETTERS》 *
JACK H. WONG 等: "Proteins with antifungal properties and other medicinal applications from plants and mushrooms", 《APPL MICROBIOL BIOTECHNOL》 *
JANUSZ WESOLOWSKI 等: "Single domain antibodies: and therapeutic tools in infection and immunitypromising experimental", 《MED MICROBIOL IMMUNOL》 *
KARIN THEVISSEN 等: "Defensins from Insects and Plants Interact with Fungal Glucosylceramides", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *
LEONARDO NIMRICHTER 等: "Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials", 《FRONTIERS IN MICROBIOLOGY》 *
S. VIJAYAN & LALITHA GURUPRASAD & P. B. KIRT: "Prokaryotic expression of a constitutively expressed Tephrosia villosa defensin and its potent antifungal activity", 《APPL MICROBIOL BIOTECHNOL》 *
吴诗光 等: "动物和植物体内的抗菌肽", 《生物学教学》 *
涂追: "基于单域重链抗体的天然噬菌体文库的构建及抗DON适配体的淘选", 《中国博士学位论文全文数据库 医药卫生科技辑》 *
王更如 等: "纳米抗体的研究进展", 《现代免疫学》 *
胡明 等: "抗真菌蛋白研究进展", 《生物技术通报》 *
陈惠黎 主编: "《糖复合物的结构和功能》", 30 June 1997, 上海医科大学出版社 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112513277A (zh) * 2019-04-08 2021-03-16 Dna2.0股份有限公司 使用来自螟蛾属的转座酶将核酸构建体转座入真核基因组
CN113121692A (zh) * 2021-04-29 2021-07-16 中国科学技术大学 结合人rage胞外域的羊驼源抗体
CN113121692B (zh) * 2021-04-29 2022-12-06 中国科学技术大学 结合人rage胞外域的羊驼源抗体
CN119661667A (zh) * 2025-02-21 2025-03-21 南京农业大学三亚研究院 一种药物靶标蛋白MoFrd1及其在农业病害防治中的应用
CN119661667B (zh) * 2025-02-21 2025-05-13 南京农业大学三亚研究院 一种药物靶标蛋白MoFrd1及其在农业病害防治中的应用

Also Published As

Publication number Publication date
CN114732017A (zh) 2022-07-12
US11028154B2 (en) 2021-06-08
CN105358698A (zh) 2016-02-24
CA2910874C (en) 2022-03-22
AU2014273418B2 (en) 2020-04-23
JP6967347B2 (ja) 2021-11-17
JP2019014715A (ja) 2019-01-31
PL2992100T3 (pl) 2020-04-30
EP3597758A1 (en) 2020-01-22
US20160075769A1 (en) 2016-03-17
BR112015027430A2 (pt) 2017-07-25
HUE047580T2 (hu) 2020-05-28
PL2992101T3 (pl) 2019-05-31
BR112015027430A8 (pt) 2019-12-24
BR112015027192A2 (https=) 2017-07-25
US9803003B2 (en) 2017-10-31
CA2910874A1 (en) 2014-11-06
AU2020205327B2 (en) 2023-02-23
EP2992101B1 (en) 2018-10-10
WO2014177595A1 (en) 2014-11-06
ZA201507757B (en) 2016-12-21
JP2016522186A (ja) 2016-07-28
CN105358698B (zh) 2024-02-20
WO2014191146A1 (en) 2014-12-04
HRP20192182T1 (hr) 2020-02-21
BR112015027430B1 (pt) 2022-09-06
PT2992100T (pt) 2019-12-16
ES2762151T3 (es) 2020-05-22
EP2992100A1 (en) 2016-03-09
AU2014273418A1 (en) 2015-11-05
CN116076508A (zh) 2023-05-09
EP2992100B1 (en) 2019-09-04
US20210253677A1 (en) 2021-08-19
AU2014261434B2 (en) 2020-04-16
TR201819577T4 (tr) 2019-01-21
US20190352379A1 (en) 2019-11-21
JP6388917B2 (ja) 2018-09-12
EP2992101A1 (en) 2016-03-09
US20180022791A1 (en) 2018-01-25
ZA201507758B (en) 2017-01-25
US20160145325A1 (en) 2016-05-26
AU2020205327A1 (en) 2020-08-06
US10400033B2 (en) 2019-09-03
JP2019178136A (ja) 2019-10-17
AU2014261434A1 (en) 2015-11-12
BR112015027192B1 (pt) 2022-05-10
CA2910632A1 (en) 2014-12-04
DK2992100T3 (da) 2019-12-09
ES2703192T3 (es) 2019-03-07
JP6720252B2 (ja) 2020-07-08
JP2016526015A (ja) 2016-09-01

Similar Documents

Publication Publication Date Title
JP6720252B2 (ja) ポリペプチドからなる農薬組成物
US20210340556A1 (en) Transgenic plant comprising a polynucleotide encoding a variable domain of heavy-chain antibody
US20230242629A1 (en) Transgenic plants expressing a variable domain of heavy-chain antibody (vhh) that binds to a sphingolipid of a fungus
CN115915939B (zh) 抗真菌多肽
US12378306B2 (en) Anti-fungal VHH antibodies

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: Belgium and the United States

Applicant after: Biocatalysis Co.

Address before: Belgium and the United States

Applicant before: AGROSAVFE N.V.

TA01 Transfer of patent application right
TA01 Transfer of patent application right

Effective date of registration: 20220801

Address after: Leuven

Applicant after: KATHOLIEKE UNIVERSITEIT LEUVEN

Address before: Belgium and the United States

Applicant before: Biocatalysis Co.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160224