CN105308049A - 螺-内酰胺nmda受体调节剂及其用途 - Google Patents

螺-内酰胺nmda受体调节剂及其用途 Download PDF

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Publication number
CN105308049A
CN105308049A CN201480018644.1A CN201480018644A CN105308049A CN 105308049 A CN105308049 A CN 105308049A CN 201480018644 A CN201480018644 A CN 201480018644A CN 105308049 A CN105308049 A CN 105308049A
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J·A·洛
M·A·卡恩
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Aptinyx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201480018644.1A 2013-01-29 2014-01-29 螺-内酰胺nmda受体调节剂及其用途 Pending CN105308049A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29
US61/757,942 2013-01-29
PCT/US2014/013639 WO2014120800A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

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CN105308049A true CN105308049A (zh) 2016-02-03

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US (2) US9708335B2 (enExample)
EP (1) EP2951185B1 (enExample)
JP (1) JP2016506962A (enExample)
KR (1) KR20150110784A (enExample)
CN (1) CN105308049A (enExample)
AU (1) AU2014212501A1 (enExample)
BR (1) BR112015018094A2 (enExample)
CA (1) CA2899191A1 (enExample)
EA (1) EA201591405A1 (enExample)
ES (1) ES2618421T3 (enExample)
IL (1) IL240164A0 (enExample)
MX (1) MX2015009785A (enExample)
PE (1) PE20151436A1 (enExample)
PH (1) PH12015501598A1 (enExample)
SG (1) SG11201505862TA (enExample)
WO (1) WO2014120800A1 (enExample)

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CN109661398A (zh) * 2016-08-01 2019-04-19 阿普廷伊克斯股份有限公司 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途
CN109843889A (zh) * 2016-08-01 2019-06-04 阿普廷伊克斯股份有限公司 螺-内酰胺nmda调节剂和使用其的方法
CN109890825A (zh) * 2016-08-01 2019-06-14 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CN109906218A (zh) * 2016-08-01 2019-06-18 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CN109937204A (zh) * 2016-08-01 2019-06-25 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CN111018746A (zh) * 2019-12-16 2020-04-17 山东金城柯瑞化学有限公司 一种氨曲南主环合成中间体n-苄氧羰基-l-苏氨酸酰胺的合成方法
CN112218866A (zh) * 2018-01-31 2021-01-12 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
US12167998B2 (en) 2013-01-29 2024-12-17 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam NMDA receptor modulators and uses thereof

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EP2331571B1 (en) 2008-09-18 2015-08-26 Northwestern University Nmda receptor modulators and uses thereof
AU2014212487C1 (en) * 2013-01-29 2018-10-25 Aptinyx, Inc. Spiro-lactam NMDA receptor modulators and uses thereof
ES2618421T3 (es) 2013-01-29 2017-06-21 Aptinyx Inc. Moduladores espiro-lactama del receptor NMDA y usos de los mismos
BR112015018095A2 (pt) 2013-01-29 2017-07-18 Naurex Inc moduladores de receptor nmda de espiro-lactama e usos dos mesmos
CN105408336B (zh) 2013-01-29 2018-06-26 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
JP2017516836A (ja) 2014-06-04 2017-06-22 リューゲン ホールディングス （ケイマン） リミテッド Ｎｒ２ｂｎｍｄａ受容体アンタゴニストとしてのジフルオロエチルピリジン誘導体
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KR102613179B1 (ko) 2015-06-01 2023-12-14 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 3,3-디플루오로피페리딘 카바메이트 헤테로사이클릭 화합물
WO2017136348A1 (en) * 2016-02-01 2017-08-10 Naurex, Inc. Processes for synthesis of dipyrrolidine peptide compounds
AU2017267708B2 (en) 2016-05-19 2020-02-20 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3544610A1 (en) 2016-11-22 2019-10-02 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2020249802A1 (en) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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Cited By (19)

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US12167998B2 (en) 2013-01-29 2024-12-17 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam NMDA receptor modulators and uses thereof
CN109843889B (zh) * 2016-08-01 2022-03-15 阿普廷伊克斯股份有限公司 螺-内酰胺nmda调节剂和使用其的方法
CN109906218B (zh) * 2016-08-01 2023-01-17 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CN109906218A (zh) * 2016-08-01 2019-06-18 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
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CN109843889A (zh) * 2016-08-01 2019-06-04 阿普廷伊克斯股份有限公司 螺-内酰胺nmda调节剂和使用其的方法
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