JP2016506962A - スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 - Google Patents

スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 Download PDF

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JP2016506962A
JP2016506962A JP2015556106A JP2015556106A JP2016506962A JP 2016506962 A JP2016506962 A JP 2016506962A JP 2015556106 A JP2015556106 A JP 2015556106A JP 2015556106 A JP2015556106 A JP 2015556106A JP 2016506962 A JP2016506962 A JP 2016506962A
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JP2016506962A5 (enExample
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ロウ，ジョン，エー．
カーン，エム．，アミン
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Naurex Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015556106A 2013-01-29 2014-01-29 スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 Withdrawn JP2016506962A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757942P 2013-01-29 2013-01-29
US61/757,942 2013-01-29
PCT/US2014/013639 WO2014120800A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

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JP2016506962A true JP2016506962A (ja) 2016-03-07
JP2016506962A5 JP2016506962A5 (enExample) 2017-03-02

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JP2015556106A Withdrawn JP2016506962A (ja) 2013-01-29 2014-01-29 スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用

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US (2) US9708335B2 (enExample)
EP (1) EP2951185B1 (enExample)
JP (1) JP2016506962A (enExample)
KR (1) KR20150110784A (enExample)
CN (1) CN105308049A (enExample)
AU (1) AU2014212501A1 (enExample)
BR (1) BR112015018094A2 (enExample)
CA (1) CA2899191A1 (enExample)
EA (1) EA201591405A1 (enExample)
ES (1) ES2618421T3 (enExample)
IL (1) IL240164A0 (enExample)
MX (1) MX2015009785A (enExample)
PE (1) PE20151436A1 (enExample)
PH (1) PH12015501598A1 (enExample)
SG (1) SG11201505862TA (enExample)
WO (1) WO2014120800A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019527234A (ja) * 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
JP2021512098A (ja) * 2018-01-31 2021-05-13 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用

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JP6531042B2 (ja) 2013-01-29 2019-06-12 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
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MX2015009773A (es) 2013-01-29 2016-08-05 Aptinyx Inc Moduladores de receptores nmda de espiro-lactama y sus usos.
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BR112015018087B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
JP2019527234A (ja) * 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
JP7032378B2 (ja) 2016-08-01 2022-03-08 アプティニックス インコーポレイテッド スピロ－ラクタムｎｍｄａ受容体修飾因子及びその使用
JP2021512098A (ja) * 2018-01-31 2021-05-13 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用
JP7210599B2 (ja) 2018-01-31 2023-01-23 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用

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BR112015018094A2 (pt) 2017-07-18
MX2015009785A (es) 2016-04-04
US20180127430A1 (en) 2018-05-10
EA201591405A1 (ru) 2017-05-31
WO2014120800A1 (en) 2014-08-07
PH12015501598A1 (en) 2015-10-19
US10316041B2 (en) 2019-06-11
US20150368254A1 (en) 2015-12-24
IL240164A0 (en) 2015-09-24
EP2951185B1 (en) 2016-12-21
CN105308049A (zh) 2016-02-03
CA2899191A1 (en) 2014-08-07
KR20150110784A (ko) 2015-10-02
EP2951185A1 (en) 2015-12-09
SG11201505862TA (en) 2015-08-28
US9708335B2 (en) 2017-07-18
AU2014212501A1 (en) 2015-07-30
ES2618421T3 (es) 2017-06-21
PE20151436A1 (es) 2015-10-10

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