CN105283203B - 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 - Google Patents

用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 Download PDF

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CN105283203B
CN105283203B CN201480030211.8A CN201480030211A CN105283203B CN 105283203 B CN105283203 B CN 105283203B CN 201480030211 A CN201480030211 A CN 201480030211A CN 105283203 B CN105283203 B CN 105283203B
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hot
hpmcas
drug
melt
melt extruded
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CN105283203A (zh
Inventor
藁品彰吾
草木史枝
菊池辉
菊池一辉
尾原荣
丸山直亮
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Shin Etsu Chemical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/201—Pre-melted polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/32—Cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/32—Cellulose ether-esters

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480030211.8A 2013-06-03 2014-06-03 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 Active CN105283203B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013116836 2013-06-03
JP2013-116836 2013-06-03
JP2013-246178 2013-11-28
JP2013246178 2013-11-28
PCT/JP2014/064711 WO2014196519A1 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

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CN105283203A CN105283203A (zh) 2016-01-27
CN105283203B true CN105283203B (zh) 2018-12-28

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CN201480030211.8A Active CN105283203B (zh) 2013-06-03 2014-06-03 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法
CN201410242677.6A Active CN104208713B (zh) 2013-06-03 2014-06-03 用于热熔挤出的组合物以及用其制备热熔挤出产品的方法

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US (2) US10646573B2 (enExample)
EP (2) EP2810660B1 (enExample)
JP (2) JP6007322B2 (enExample)
KR (2) KR102228157B1 (enExample)
CN (2) CN105283203B (enExample)
IN (1) IN2014DE01467A (enExample)
PT (2) PT2810660T (enExample)
WO (1) WO2014196519A1 (enExample)

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MX2017008077A (es) 2014-12-18 2017-09-28 Merck Sharp & Dohme Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
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CN107567463A (zh) * 2015-05-15 2018-01-09 陶氏环球技术有限责任公司 制备高分子量酯化纤维素醚的工艺
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JP7252882B2 (ja) * 2019-11-01 2023-04-05 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法
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CN115581678B (zh) * 2022-11-04 2023-09-12 北京鑫开元医药科技有限公司 一种瑞派替尼片组合物及其制备方法
CN115651085B (zh) * 2022-11-14 2023-11-17 乳源东阳光药业有限公司 一种醋酸羟丙甲纤维素琥珀酸酯的纯化方法

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Also Published As

Publication number Publication date
KR20140142173A (ko) 2014-12-11
US20160095928A1 (en) 2016-04-07
EP2810660A1 (en) 2014-12-10
US10016508B2 (en) 2018-07-10
CN104208713A (zh) 2014-12-17
US20140357681A1 (en) 2014-12-04
JP2015127316A (ja) 2015-07-09
EP2810660B1 (en) 2017-07-26
PT3006049T (pt) 2018-03-20
JPWO2014196519A1 (ja) 2017-02-23
KR20160015234A (ko) 2016-02-12
JP6007322B2 (ja) 2016-10-12
US10646573B2 (en) 2020-05-12
IN2014DE01467A (enExample) 2015-07-24
PT2810660T (pt) 2017-08-16
EP3006049B1 (en) 2018-02-28
CN105283203A (zh) 2016-01-27
CN104208713B (zh) 2018-04-27
JP6126555B2 (ja) 2017-05-10
EP3006049A1 (en) 2016-04-13
EP3006049A4 (en) 2017-02-22
KR101918327B1 (ko) 2018-11-13
WO2014196519A1 (ja) 2014-12-11
KR102228157B1 (ko) 2021-03-17

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