JP6007322B2 - 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法 - Google Patents

加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法 Download PDF

Info

Publication number
JP6007322B2
JP6007322B2 JP2015521450A JP2015521450A JP6007322B2 JP 6007322 B2 JP6007322 B2 JP 6007322B2 JP 2015521450 A JP2015521450 A JP 2015521450A JP 2015521450 A JP2015521450 A JP 2015521450A JP 6007322 B2 JP6007322 B2 JP 6007322B2
Authority
JP
Japan
Prior art keywords
drug
hpmcas
hot melt
temperature
melt extrusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015521450A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2014196519A1 (ja
Inventor
彰吾 藁品
彰吾 藁品
史枝 草木
史枝 草木
一輝 菊池
一輝 菊池
栄 尾原
栄 尾原
直亮 丸山
直亮 丸山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Etsu Chemical Co Ltd
Original Assignee
Shin Etsu Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50842156&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6007322(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shin Etsu Chemical Co Ltd filed Critical Shin Etsu Chemical Co Ltd
Application granted granted Critical
Publication of JP6007322B2 publication Critical patent/JP6007322B2/ja
Publication of JPWO2014196519A1 publication Critical patent/JPWO2014196519A1/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/201—Pre-melted polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/32—Cellulose ether-esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/32—Cellulose ether-esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015521450A 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法 Active JP6007322B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013116836 2013-06-03
JP2013116836 2013-06-03
JP2013246178 2013-11-28
JP2013246178 2013-11-28
PCT/JP2014/064711 WO2014196519A1 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Publications (2)

Publication Number Publication Date
JP6007322B2 true JP6007322B2 (ja) 2016-10-12
JPWO2014196519A1 JPWO2014196519A1 (ja) 2017-02-23

Family

ID=50842156

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015521450A Active JP6007322B2 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法
JP2014114900A Active JP6126555B2 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014114900A Active JP6126555B2 (ja) 2013-06-03 2014-06-03 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Country Status (8)

Country Link
US (2) US10646573B2 (enExample)
EP (2) EP2810660B1 (enExample)
JP (2) JP6007322B2 (enExample)
KR (2) KR102228157B1 (enExample)
CN (2) CN105283203B (enExample)
IN (1) IN2014DE01467A (enExample)
PT (2) PT2810660T (enExample)
WO (1) WO2014196519A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015127316A (ja) * 2013-06-03 2015-07-09 信越化学工業株式会社 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6203702B2 (ja) 2014-11-18 2017-09-27 信越化学工業株式会社 ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
MX2017008077A (es) 2014-12-18 2017-09-28 Merck Sharp & Dohme Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
JP6725534B2 (ja) * 2015-05-15 2020-07-22 ダウ グローバル テクノロジーズ エルエルシー 極めて高い分子量及び低い粘度のエステル化セルロースエーテルの生成プロセス
CN107567463A (zh) * 2015-05-15 2018-01-09 陶氏环球技术有限责任公司 制备高分子量酯化纤维素醚的工艺
EP3328899B1 (en) * 2015-07-28 2019-06-19 Dow Global Technologies LLC Process for producing dispersion of esterified cellulose ether
WO2018170062A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
WO2018170083A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
WO2018170060A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
US20180282527A1 (en) * 2017-03-30 2018-10-04 Shin-Etsu Chemical Co., Ltd. Injection molding composition containing hypromellose acetate succinate and method for producing same
CN109078186B (zh) * 2017-06-14 2021-09-03 江苏恒瑞医药股份有限公司 一种胃漂浮组合物及其制备方法
TR201722852A2 (tr) * 2017-12-29 2019-07-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari
WO2020131801A1 (en) 2018-12-18 2020-06-25 DDP Specialty Electronic Materials US, Inc. A sustained release composition comprising a hydroxypropyl methylcellulose acetate succinate
JP7050714B2 (ja) * 2019-04-04 2022-04-08 信越化学工業株式会社 腸溶性コーティング用組成物及び固形製剤の製造方法
JP7252882B2 (ja) * 2019-11-01 2023-04-05 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法
JP7273691B2 (ja) 2019-11-01 2023-05-15 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースフタレートの製造方法
WO2021118915A1 (en) 2019-12-09 2021-06-17 Nutrition & Biosciences Usa 1, Llc Hydroxypropyl alkyl cellulose acetate succinate heteropolymers
WO2022034232A1 (en) 2020-08-13 2022-02-17 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Gastro-resistant high-strength formulation containing posaconazole
JP7399060B2 (ja) * 2020-10-01 2023-12-15 信越化学工業株式会社 ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法
EP4091604B1 (en) 2021-11-25 2024-04-03 Alfred E. Tiefenbacher (GmbH & Co. KG) Granules containing posaconazole
CN115581678B (zh) * 2022-11-04 2023-09-12 北京鑫开元医药科技有限公司 一种瑞派替尼片组合物及其制备方法
CN115651085B (zh) * 2022-11-14 2023-11-17 乳源东阳光药业有限公司 一种醋酸羟丙甲纤维素琥珀酸酯的纯化方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3852421A (en) 1970-03-23 1974-12-03 Shinetsu Chemical Co Excipient and shaped medicaments prepared therewith
US4226981A (en) 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
JPS5951562B2 (ja) 1977-10-25 1984-12-14 信越化学工業株式会社 セルロ−スエ−テルの酸性サクシニルおよび脂肪族モノアシル混成エステルの製造方法
US4266981A (en) 1978-03-08 1981-05-12 Purdue Research Corporation Process for recovering and utilizing cellulose using sulfuric acid
DE19504832A1 (de) * 1995-02-14 1996-08-22 Basf Ag Feste Wirkstoff-Zubereitungen
AR038375A1 (es) 2002-02-01 2005-01-12 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
JPWO2003077827A1 (ja) 2002-03-19 2005-07-14 日本新薬株式会社 医薬固体分散体の製造方法
KR100454394B1 (ko) 2002-03-27 2004-10-26 이원희 맥파검출장치
JP4344914B2 (ja) * 2003-02-28 2009-10-14 信越化学工業株式会社 アルカリ溶解性カルボン酸エステル系セルロース誘導体及び該誘導体からなるフィルム
WO2005115330A2 (en) 2004-05-28 2005-12-08 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
CA2621800A1 (en) * 2005-09-06 2007-03-15 Astellas Pharma Inc. Fine particles of poorly soluble drug having enteric base material adsorbed on the surface thereof
JP5576922B2 (ja) * 2006-04-20 2014-08-20 信越化学工業株式会社 腸溶性固体分散体を含んでなる固形製剤
JP5052051B2 (ja) * 2006-06-16 2012-10-17 トーアエイヨー株式会社 腸溶性顆粒剤及びその製造方法
JP5070618B2 (ja) * 2006-06-16 2012-11-14 トーアエイヨー株式会社 腸溶性顆粒剤及びその製造方法
US20090093442A1 (en) 2006-10-20 2009-04-09 Lynch Stephanie K Uses of water-soluble cellulose derivatives for preventing or treating metabolic syndrome
WO2009129301A2 (en) 2008-04-15 2009-10-22 Schering Corporation Oral pharmaceutical compositions in a molecular solid dispersion
TWI388324B (zh) 2008-04-15 2013-03-11 Schering Corp 含有泊沙康唑（ｐｏｓａｃｏｎａｚｏｌｅ）之高密度組合物及包含該組合物之調配物
EP2927720B1 (en) 2010-02-03 2018-10-17 Tyco Electronics Nederland B.V. Enclosure assembly for a connector, strain relief element, and method
BR112012031667A2 (pt) 2010-06-14 2016-11-08 Dow Global Technologies Llc composição
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8591944B2 (en) * 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US20120251588A1 (en) * 2011-03-30 2012-10-04 Miyuki Fukasawa Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation
JP2013116836A (ja) 2011-12-02 2013-06-13 Sharp Corp シリコン端材の再利用方法並びに原料シリコン、多結晶シリコン材料及び多結晶シリコン太陽電池の製造方法
DE102012010430A1 (de) 2012-05-29 2013-12-05 Krohne Ag Durchflussmessgerät
JP6215945B2 (ja) 2012-08-24 2017-10-18 ダウ グローバル テクノロジーズ エルエルシー 新規ヒドロキシアルキルメチルセルロースアセテートサクシネート
US10646573B2 (en) * 2013-06-03 2020-05-12 Shin-Etsu Chemical Co., Ltd. Composition for hot melt extrusion and method for producing hot melt extrudate by using same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015127316A (ja) * 2013-06-03 2015-07-09 信越化学工業株式会社 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法

Also Published As

Publication number Publication date
KR20140142173A (ko) 2014-12-11
US20160095928A1 (en) 2016-04-07
EP2810660A1 (en) 2014-12-10
US10016508B2 (en) 2018-07-10
CN104208713A (zh) 2014-12-17
US20140357681A1 (en) 2014-12-04
JP2015127316A (ja) 2015-07-09
EP2810660B1 (en) 2017-07-26
PT3006049T (pt) 2018-03-20
JPWO2014196519A1 (ja) 2017-02-23
KR20160015234A (ko) 2016-02-12
US10646573B2 (en) 2020-05-12
IN2014DE01467A (enExample) 2015-07-24
PT2810660T (pt) 2017-08-16
EP3006049B1 (en) 2018-02-28
CN105283203A (zh) 2016-01-27
CN104208713B (zh) 2018-04-27
CN105283203B (zh) 2018-12-28
JP6126555B2 (ja) 2017-05-10
EP3006049A1 (en) 2016-04-13
EP3006049A4 (en) 2017-02-22
KR101918327B1 (ko) 2018-11-13
WO2014196519A1 (ja) 2014-12-11
KR102228157B1 (ko) 2021-03-17

Similar Documents

Publication Publication Date Title
JP6007322B2 (ja) 加熱溶融押出用組成物及びこれを用いた加熱溶融押出成型物の製造方法
JP6162662B2 (ja) 加熱溶融押出担体用ヒプロメロース酢酸エステルコハク酸エステル、加熱溶融押出用組成物及び加熱溶融押出成型物の製造方法
JP6203702B2 (ja) ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法
JP6522853B2 (ja) Ｓｏｍｃｌ−９１１２固体分散体、その製造方法およびそれを含むｓｏｍｃｌ−９１１２固体製剤
KR102265215B1 (ko) 용해 상태가 우수한 히프로멜로오스 아세트산에스테르 숙신산에스테르 분말 및 그의 제조 방법, 및 고체 분산체용 조성물, 코팅용 조성물, 약물 함유 입자 및 고형 제제의 각 제조 방법
KR20250152014A (ko) 비정질 고체 분산체를 포함하는 복합물

Legal Events

Date Code Title Description
TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160816

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160912

R150 Certificate of patent or registration of utility model

Ref document number: 6007322

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150