IN2014DE01467A - - Google Patents
Info
- Publication number
- IN2014DE01467A IN2014DE01467A IN1467DE2014A IN2014DE01467A IN 2014DE01467 A IN2014DE01467 A IN 2014DE01467A IN 1467DE2014 A IN1467DE2014 A IN 1467DE2014A IN 2014DE01467 A IN2014DE01467 A IN 2014DE01467A
- Authority
- IN
- India
- Prior art keywords
- hot
- melt
- temperature
- drug
- melt extrusion
- Prior art date
Links
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 abstract 5
- 238000009474 hot melt extrusion Methods 0.000 abstract 5
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 239000012943 hotmelt Substances 0.000 abstract 4
- -1 hydroxypropoxy Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 230000009849 deactivation Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B13/00—Preparation of cellulose ether-esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/201—Pre-melted polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/32—Cellulose ether-esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
- C08J2301/08—Cellulose derivatives
- C08J2301/32—Cellulose ether-esters
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013116836 | 2013-06-03 | ||
| JP2013246178 | 2013-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DE01467A true IN2014DE01467A (enExample) | 2015-07-24 |
Family
ID=50842156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1467DE2014 IN2014DE01467A (enExample) | 2013-06-03 | 2014-06-03 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10016508B2 (enExample) |
| EP (2) | EP2810660B1 (enExample) |
| JP (2) | JP6126555B2 (enExample) |
| KR (2) | KR102228157B1 (enExample) |
| CN (2) | CN105283203B (enExample) |
| IN (1) | IN2014DE01467A (enExample) |
| PT (2) | PT2810660T (enExample) |
| WO (1) | WO2014196519A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105283203B (zh) * | 2013-06-03 | 2018-12-28 | 信越化学工业株式会社 | 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 |
| JP6203702B2 (ja) | 2014-11-18 | 2017-09-27 | 信越化学工業株式会社 | ヒプロメロース酢酸エステルコハク酸エステルを用いたスプレードライ用溶液及び固体分散体の製造方法 |
| EP3998258A1 (en) | 2014-12-18 | 2022-05-18 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl- 1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
| CN107567462B (zh) * | 2015-05-15 | 2020-10-16 | 陶氏环球技术有限责任公司 | 用于制造具有极高分子量和低粘度的酯化纤维素醚的方法 |
| JP6737810B2 (ja) * | 2015-05-15 | 2020-08-12 | ダウ グローバル テクノロジーズ エルエルシー | 高分子量のエステル化セルロースエーテルを調製するプロセス |
| KR20180036724A (ko) * | 2015-07-28 | 2018-04-09 | 다우 글로벌 테크놀로지스 엘엘씨 | 에스테르화된 셀룰로오스 에테르의 분산물을 생성하는 방법 |
| EP3596132B1 (en) | 2017-03-17 | 2021-05-05 | Nutrition & Biosciences USA 1, LLC | Process for recovering an esterified cellulose ether from a reaction product mixture |
| WO2018170083A1 (en) | 2017-03-17 | 2018-09-20 | Dow Global Technologies Llc | Process for recovering an esterified cellulose ether from a reaction product mixture |
| WO2018170060A1 (en) | 2017-03-17 | 2018-09-20 | Dow Global Technologies Llc | Process for recovering an esterified cellulose ether from a reaction product mixture |
| US20180282527A1 (en) * | 2017-03-30 | 2018-10-04 | Shin-Etsu Chemical Co., Ltd. | Injection molding composition containing hypromellose acetate succinate and method for producing same |
| CN109078186B (zh) * | 2017-06-14 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种胃漂浮组合物及其制备方法 |
| TR201722852A2 (tr) * | 2017-12-29 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Mesalazi̇ni̇n oral farmasöti̇k kompozi̇syonlari |
| WO2020131801A1 (en) | 2018-12-18 | 2020-06-25 | DDP Specialty Electronic Materials US, Inc. | A sustained release composition comprising a hydroxypropyl methylcellulose acetate succinate |
| JP7050714B2 (ja) * | 2019-04-04 | 2022-04-08 | 信越化学工業株式会社 | 腸溶性コーティング用組成物及び固形製剤の製造方法 |
| JP7273691B2 (ja) | 2019-11-01 | 2023-05-15 | 信越化学工業株式会社 | ヒドロキシプロピルメチルセルロースフタレートの製造方法 |
| JP7252882B2 (ja) * | 2019-11-01 | 2023-04-05 | 信越化学工業株式会社 | ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法 |
| WO2021118915A1 (en) | 2019-12-09 | 2021-06-17 | Nutrition & Biosciences Usa 1, Llc | Hydroxypropyl alkyl cellulose acetate succinate heteropolymers |
| EP4196096A1 (en) | 2020-08-13 | 2023-06-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant high-strength formulation containing posaconazole |
| JP7399060B2 (ja) * | 2020-10-01 | 2023-12-15 | 信越化学工業株式会社 | ヒドロキシプロピルメチルセルロースアセテートサクシネートの製造方法 |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
| CN115581678B (zh) * | 2022-11-04 | 2023-09-12 | 北京鑫开元医药科技有限公司 | 一种瑞派替尼片组合物及其制备方法 |
| CN115651085B (zh) * | 2022-11-14 | 2023-11-17 | 乳源东阳光药业有限公司 | 一种醋酸羟丙甲纤维素琥珀酸酯的纯化方法 |
| KR102945795B1 (ko) * | 2023-10-16 | 2026-03-30 | 강원대학교산학협력단 | 서방형 약물전달체를 유효성분으로 포함하는 염증성 장질환의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852421A (en) | 1970-03-23 | 1974-12-03 | Shinetsu Chemical Co | Excipient and shaped medicaments prepared therewith |
| US4226981A (en) | 1977-09-28 | 1980-10-07 | Shin-Etsu Chemical Co., Ltd. | Ether-ester derivatives of cellulose and their applications |
| JPS5951562B2 (ja) | 1977-10-25 | 1984-12-14 | 信越化学工業株式会社 | セルロ−スエ−テルの酸性サクシニルおよび脂肪族モノアシル混成エステルの製造方法 |
| US4266981A (en) | 1978-03-08 | 1981-05-12 | Purdue Research Corporation | Process for recovering and utilizing cellulose using sulfuric acid |
| DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
| JPWO2003077827A1 (ja) | 2002-03-19 | 2005-07-14 | 日本新薬株式会社 | 医薬固体分散体の製造方法 |
| KR100454394B1 (ko) | 2002-03-27 | 2004-10-26 | 이원희 | 맥파검출장치 |
| JP4344914B2 (ja) | 2003-02-28 | 2009-10-14 | 信越化学工業株式会社 | アルカリ溶解性カルボン酸エステル系セルロース誘導体及び該誘導体からなるフィルム |
| EP1753402B1 (en) * | 2004-05-28 | 2008-10-01 | Pfizer Products Incorporated | Pharmaceutical compositions with enhanced performance comprising a hpmca polymer |
| CA2621800A1 (en) | 2005-09-06 | 2007-03-15 | Astellas Pharma Inc. | Fine particles of poorly soluble drug having enteric base material adsorbed on the surface thereof |
| JP5576922B2 (ja) * | 2006-04-20 | 2014-08-20 | 信越化学工業株式会社 | 腸溶性固体分散体を含んでなる固形製剤 |
| JP5070618B2 (ja) * | 2006-06-16 | 2012-11-14 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
| JP5052051B2 (ja) * | 2006-06-16 | 2012-10-17 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
| CA2666670A1 (en) | 2006-10-20 | 2008-05-02 | Dow Global Technologies Inc. | Uses of water-soluble cellulose derivatives for preventing or treating metabolic syndrome |
| EP2278957A2 (en) | 2008-04-15 | 2011-02-02 | Schering Corporation | Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas |
| WO2009129300A2 (en) | 2008-04-15 | 2009-10-22 | Schering Corporation | High density compositions containing posaconazole and formulations comprising the same |
| EP2927720B1 (en) | 2010-02-03 | 2018-10-17 | Tyco Electronics Nederland B.V. | Enclosure assembly for a connector, strain relief element, and method |
| WO2011159626A1 (en) | 2010-06-14 | 2011-12-22 | Bend Research, Inc. | Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution |
| US8409560B2 (en) | 2011-03-08 | 2013-04-02 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| WO2012122279A1 (en) * | 2011-03-08 | 2012-09-13 | Zalicus Pharmaceuticals Ltd. | Solid dispersion formulations and methods of use thereof |
| US20120251588A1 (en) * | 2011-03-30 | 2012-10-04 | Miyuki Fukasawa | Coating Composition, Solid Preparation Coated Therewith, and Method for Preparing Solid Preparation |
| JP2013116836A (ja) | 2011-12-02 | 2013-06-13 | Sharp Corp | シリコン端材の再利用方法並びに原料シリコン、多結晶シリコン材料及び多結晶シリコン太陽電池の製造方法 |
| DE102012010430A1 (de) | 2012-05-29 | 2013-12-05 | Krohne Ag | Durchflussmessgerät |
| BR112015002055A2 (pt) | 2012-08-24 | 2017-07-04 | Dow Global Technologies Llc | acetato succinato de hidroxialquil metil celulose, composição, dispersão sólida, processo para produzir uma dispersão sólida, forma de dosagem e cápsula de envoltório |
| CN105283203B (zh) * | 2013-06-03 | 2018-12-28 | 信越化学工业株式会社 | 用于热熔挤出的组合物以及通过使用该组合物制备热熔挤出物的方法 |
-
2014
- 2014-06-03 CN CN201480030211.8A patent/CN105283203B/zh active Active
- 2014-06-03 US US14/294,258 patent/US10016508B2/en active Active
- 2014-06-03 PT PT141708636T patent/PT2810660T/pt unknown
- 2014-06-03 CN CN201410242677.6A patent/CN104208713B/zh active Active
- 2014-06-03 IN IN1467DE2014 patent/IN2014DE01467A/en unknown
- 2014-06-03 JP JP2014114900A patent/JP6126555B2/ja active Active
- 2014-06-03 EP EP14170863.6A patent/EP2810660B1/en active Active
- 2014-06-03 PT PT148069453T patent/PT3006049T/pt unknown
- 2014-06-03 JP JP2015521450A patent/JP6007322B2/ja active Active
- 2014-06-03 US US14/892,421 patent/US10646573B2/en active Active
- 2014-06-03 KR KR1020157034116A patent/KR102228157B1/ko active Active
- 2014-06-03 WO PCT/JP2014/064711 patent/WO2014196519A1/ja not_active Ceased
- 2014-06-03 KR KR1020140067370A patent/KR101918327B1/ko active Active
- 2014-06-03 EP EP14806945.3A patent/EP3006049B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2810660B1 (en) | 2017-07-26 |
| KR20160015234A (ko) | 2016-02-12 |
| JP2015127316A (ja) | 2015-07-09 |
| EP3006049A1 (en) | 2016-04-13 |
| US20160095928A1 (en) | 2016-04-07 |
| PT2810660T (pt) | 2017-08-16 |
| JPWO2014196519A1 (ja) | 2017-02-23 |
| CN105283203B (zh) | 2018-12-28 |
| EP3006049B1 (en) | 2018-02-28 |
| EP3006049A4 (en) | 2017-02-22 |
| US20140357681A1 (en) | 2014-12-04 |
| US10646573B2 (en) | 2020-05-12 |
| WO2014196519A1 (ja) | 2014-12-11 |
| EP2810660A1 (en) | 2014-12-10 |
| CN105283203A (zh) | 2016-01-27 |
| JP6126555B2 (ja) | 2017-05-10 |
| US10016508B2 (en) | 2018-07-10 |
| PT3006049T (pt) | 2018-03-20 |
| KR102228157B1 (ko) | 2021-03-17 |
| CN104208713B (zh) | 2018-04-27 |
| CN104208713A (zh) | 2014-12-17 |
| JP6007322B2 (ja) | 2016-10-12 |
| KR101918327B1 (ko) | 2018-11-13 |
| KR20140142173A (ko) | 2014-12-11 |
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