CN105246884B - 用作激酶抑制剂的脲衍生物 - Google Patents
用作激酶抑制剂的脲衍生物 Download PDFInfo
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- CN105246884B CN105246884B CN201480031484.4A CN201480031484A CN105246884B CN 105246884 B CN105246884 B CN 105246884B CN 201480031484 A CN201480031484 A CN 201480031484A CN 105246884 B CN105246884 B CN 105246884B
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- amino
- bases
- oxygroup
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- phenyl
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- 0 C*C(C)C(C*(C)I)N Chemical compound C*C(C)C(C*(C)I)N 0.000 description 11
- ZRKRJSAOOWCHOM-UHFFFAOYSA-N CC(C=CC(N)=C1)=CC1OC Chemical compound CC(C=CC(N)=C1)=CC1OC ZRKRJSAOOWCHOM-UHFFFAOYSA-N 0.000 description 1
- NSTCXWDUXNZMCN-GDLZYMKVSA-N C[C@H](COCCOCCOC)NC(c1cc(C#C)cc(Nc2cc(Oc(c3c4cccc3)ccc4NC(Nc(cc(C(C)(C)C)cc3NS(C)(=O)=O)c3OC)=O)ccn2)c1)=O Chemical compound C[C@H](COCCOCCOC)NC(c1cc(C#C)cc(Nc2cc(Oc(c3c4cccc3)ccc4NC(Nc(cc(C(C)(C)C)cc3NS(C)(=O)=O)c3OC)=O)ccn2)c1)=O NSTCXWDUXNZMCN-GDLZYMKVSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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- Pyridine Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201305945A GB201305945D0 (en) | 2013-04-02 | 2013-04-02 | New compounds |
| GB1305945.6 | 2013-04-02 | ||
| GBGB1322678.2A GB201322678D0 (en) | 2013-12-20 | 2013-12-20 | New compounds |
| GB1322678.2 | 2013-12-20 | ||
| GB201402647A GB201402647D0 (en) | 2014-02-14 | 2014-02-14 | New compounds |
| GB1402647.0 | 2014-02-14 | ||
| PCT/GB2014/051022 WO2014162126A1 (en) | 2013-04-02 | 2014-04-01 | Urea derivatives useful as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105246884A CN105246884A (zh) | 2016-01-13 |
| CN105246884B true CN105246884B (zh) | 2018-05-22 |
Family
ID=50434228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480031484.4A Expired - Fee Related CN105246884B (zh) | 2013-04-02 | 2014-04-01 | 用作激酶抑制剂的脲衍生物 |
| CN201480031577.7A Expired - Fee Related CN105408315B (zh) | 2013-04-02 | 2014-04-01 | 激酶抑制剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480031577.7A Expired - Fee Related CN105408315B (zh) | 2013-04-02 | 2014-04-01 | 激酶抑制剂 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8927563B2 (enExample) |
| EP (2) | EP2981526B1 (enExample) |
| JP (2) | JP6464384B2 (enExample) |
| KR (3) | KR102283883B1 (enExample) |
| CN (2) | CN105246884B (enExample) |
| AU (2) | AU2014246870C1 (enExample) |
| BR (2) | BR112015024678B1 (enExample) |
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| UA105763C2 (uk) | 2007-12-19 | 2014-06-25 | Кансер Рісерч Текнолоджі Лімітед | 8-ЗАМІЩЕНІ ПІРИДО[2,3-b]ПІРАЗИНИ ТА ЇХ ЗАСТОСУВАННЯ |
| NZ706154A (en) | 2010-02-01 | 2016-09-30 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| JP2014528404A (ja) | 2011-10-03 | 2014-10-27 | レスピバート・リミテツド | p38MAPキナーゼ阻害剤としての1−ピラゾリル−3−(4−((2−アニリノピリミジン−4−イル)オキシ)ナフタレン−1−イル)尿素 |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| EP2890695A2 (en) | 2012-08-29 | 2015-07-08 | Respivert Limited | Kinase inhibitors |
| EP2890460B1 (en) | 2012-08-29 | 2017-02-22 | Respivert Limited | Kinase inhibitors |
| US9783556B2 (en) | 2012-08-29 | 2017-10-10 | Respivert Limited | Kinase inhibitors |
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| WO2014140582A1 (en) | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
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| EP3394059B1 (en) | 2015-12-23 | 2020-11-25 | Chiesi Farmaceutici S.p.A. | 1-(3-tert-butyl-phenyl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro- naphthalen-1-yl)-urea derivatives and their use as p38 mapk inhibitors |
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| CN110878055B (zh) * | 2018-09-06 | 2021-02-05 | 中国科学院化学研究所 | 一种制备羰基杂环类化合物的方法 |
| CA3122371A1 (en) | 2018-12-07 | 2020-06-11 | University Of Maryland, Baltimore | Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors |
| IL306101A (en) * | 2021-03-23 | 2023-11-01 | Gen1E Lifesciences Inc | Naphthyl-mutated p38 alpha mitogen-activated protein kinase inhibitors |
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