CN105188791B - 填充有治疗剂制剂的中空支架 - Google Patents

填充有治疗剂制剂的中空支架 Download PDF

Info

Publication number
CN105188791B
CN105188791B CN201480024997.2A CN201480024997A CN105188791B CN 105188791 B CN105188791 B CN 105188791B CN 201480024997 A CN201480024997 A CN 201480024997A CN 105188791 B CN105188791 B CN 105188791B
Authority
CN
China
Prior art keywords
acid
therapeutic agent
metal ion
support
stabilizing agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480024997.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN105188791A (zh
Inventor
斯蒂芬·D·帕塞蒂
尼·丁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Inc
Original Assignee
Abbott Vascular Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Vascular Inc filed Critical Abbott Vascular Inc
Publication of CN105188791A publication Critical patent/CN105188791A/zh
Application granted granted Critical
Publication of CN105188791B publication Critical patent/CN105188791B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/143—Stabilizers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/4998—Combined manufacture including applying or shaping of fluent material
    • Y10T29/49993—Filling of opening

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Mechanical Engineering (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480024997.2A 2013-05-06 2014-05-01 填充有治疗剂制剂的中空支架 Expired - Fee Related CN105188791B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361820155P 2013-05-06 2013-05-06
US61/820,155 2013-05-06
PCT/US2014/036427 WO2014182542A1 (fr) 2013-05-06 2014-05-01 Endoprothèse creuse remplie avec une formulation d'agent thérapeutique

Publications (2)

Publication Number Publication Date
CN105188791A CN105188791A (zh) 2015-12-23
CN105188791B true CN105188791B (zh) 2018-01-12

Family

ID=50897923

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480024997.2A Expired - Fee Related CN105188791B (zh) 2013-05-06 2014-05-01 填充有治疗剂制剂的中空支架

Country Status (5)

Country Link
US (1) US9901663B2 (fr)
EP (1) EP2994174A1 (fr)
JP (1) JP2016523588A (fr)
CN (1) CN105188791B (fr)
WO (1) WO2014182542A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190022073A1 (en) * 2015-09-03 2019-01-24 Nippon Kayaku Kabushiki Kaisha Pharmaceutical composition comprising rapamycin or derivative thereof
US20200390943A1 (en) * 2017-12-25 2020-12-17 Lifetech Scientific (Shenzhen) Co., Ltd Absorbable iron-based implantable device
CN109568652A (zh) * 2018-12-26 2019-04-05 粤肽生物科技(珠海)有限公司 促进伤口快速愈合的敷料组合物
CN114533352A (zh) * 2022-03-23 2022-05-27 苏州卓欣雅科技有限公司 颈动脉3d打印可降解支架

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429717A (en) 1965-05-24 1969-02-25 Grace W R & Co Flexible film wrapper
US3993622A (en) 1970-10-08 1976-11-23 Ciba-Geigy Corporation Bis-salicyloyl-hydrazine as stabilizer for polymers
US4374669A (en) 1975-05-09 1983-02-22 Mac Gregor David C Cardiovascular prosthetic devices and implants with porous systems
US4401804A (en) 1982-05-24 1983-08-30 Eastman Kodak Company Deactivation of polyester catalyst residues
US5006281A (en) 1985-03-26 1991-04-09 Century Laboratories, Inc. Process for the production of a marine animal oil
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
ATE121954T1 (de) 1988-08-24 1995-05-15 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US5344425A (en) 1990-09-14 1994-09-06 Interface Biomedical Laboratories, Corp. Intravascular stent and method for conditioning the surfaces thereof
US5163952A (en) 1990-09-14 1992-11-17 Michael Froix Expandable polymeric stent with memory and delivery apparatus and method
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
US5338822A (en) 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
GB2281161B (en) 1993-08-04 1997-05-28 Fulcrum Communications Limited Optical data communications networks
US5629077A (en) 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
CA2178541C (fr) 1995-06-07 2009-11-24 Neal E. Fearnot Dispositif medical implantable
US5618866A (en) 1996-01-22 1997-04-08 General Electric Company Neo diol phosphite esters and polymeric compositions thereof
WO1997033552A1 (fr) 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Bioprecurseurs de paclitaxel solubles dans l'eau
US5713949A (en) 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
SE9602352D0 (sv) 1996-06-14 1996-06-14 Astra Ab Catheter package
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
WO1998041559A1 (fr) 1997-03-20 1998-09-24 Eastman Chemical Company Procede servant a modifier une matiere fondue de polyester utilisee dans un procede de fusion pour preformage en continu
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6037022A (en) 1997-09-16 2000-03-14 International Paper Company Oxygen-scavenging filled polymer blend for food packaging applications
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5992000A (en) 1997-10-16 1999-11-30 Scimed Life Systems, Inc. Stent crimper
US6264596B1 (en) 1997-11-03 2001-07-24 Meadox Medicals, Inc. In-situ radioactive medical device
JPH11299901A (ja) 1998-04-16 1999-11-02 Johnson & Johnson Medical Kk ステント及びその製造方法
CA2326828C (fr) 1998-05-05 2008-07-22 Scimed Life Systems, Inc. Extenseur possedant des extremites lisses
AU5054499A (en) 1998-07-21 2000-02-14 Biocompatibles Limited Coating
US6206915B1 (en) 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
US6358276B1 (en) 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6592814B2 (en) 1998-10-02 2003-07-15 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US6120847A (en) 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
ATE291446T1 (de) 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
ATE250056T1 (de) 1999-07-09 2003-10-15 Dimensional Pharm Inc Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel
US6287628B1 (en) 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
US6379381B1 (en) * 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
US20020081228A1 (en) 1999-12-21 2002-06-27 Hui Henry K. Monitoring sterilant concentration in diffusion-restricted regions as a basis for parametric release
US6908624B2 (en) 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US20040009229A1 (en) 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
US6309383B1 (en) 2000-01-20 2001-10-30 Isostent, Inc. Stent crimper apparatus with radiation shied
IT1318423B1 (it) 2000-03-24 2003-08-25 Great Lakes Chemical Europ Miscele stabilizzanti per polimeri organici.
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US20020022144A1 (en) 2000-05-19 2002-02-21 Hu Yang Enhanced oxygen barrier performance from modification of ethylene vinyl alcohol copolymers (EVOH)
AU2001263408A1 (en) 2000-05-23 2001-12-03 The Rockefeller University C1 bacteriophage lytic system
US7101624B2 (en) 2000-06-22 2006-09-05 Cello-Foil Products, Inc. Laminate antioxidant film
US6485950B1 (en) 2000-07-14 2002-11-26 Council Of Scientific And Industrial Research Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions
US7192395B1 (en) 2000-09-08 2007-03-20 The Trustees Of Columbia University In The City Of New York Modification of polymer surfaces as radioisotope carriers
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6727300B2 (en) 2000-11-03 2004-04-27 Cytec Technology Corp. Polymeric articles containing hindered amine light stabilizers based on multi-functional carbonyl compounds
US6875400B2 (en) 2000-12-22 2005-04-05 Cryovac, Inc. Method of sterilizing and initiating a scavenging reaction in an article
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US20030215564A1 (en) 2001-01-18 2003-11-20 Heller Phillip F. Method and apparatus for coating an endoprosthesis
US20040220660A1 (en) 2001-02-05 2004-11-04 Shanley John F. Bioresorbable stent with beneficial agent reservoirs
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
US6743462B1 (en) 2001-05-31 2004-06-01 Advanced Cardiovascular Systems, Inc. Apparatus and method for coating implantable devices
EP1273314A1 (fr) * 2001-07-06 2003-01-08 Terumo Kabushiki Kaisha Stent
US20060224234A1 (en) * 2001-08-29 2006-10-05 Swaminathan Jayaraman Drug eluting structurally variable stent
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
US7175874B1 (en) 2001-11-30 2007-02-13 Advanced Cardiovascular Systems, Inc. Apparatus and method for coating implantable devices
WO2003050266A2 (fr) 2001-12-11 2003-06-19 Cytograft Tissue Engineering, Inc. Feuillets cellulaires traites par genie tissulaire, leurs procedes de fabrication et leur utilisation
US6607795B1 (en) 2001-12-19 2003-08-19 Chevron Phillips Chemical Company Lp Oxygen scavenging compositions comprising polymers derived from aromatic difunctional monomers
US6949254B2 (en) 2002-01-30 2005-09-27 Bmg Incorporated Bio-decomposable polymer composition showing good thermal decomposition
US6746622B2 (en) 2002-02-08 2004-06-08 Chevron Phillips Chemical Company Lp Oxygen scavenging compositions comprising polymers derived from tetrahydrofurfuryl monomers
US7022258B2 (en) 2002-02-14 2006-04-04 Chevron Phillips Chemical Company, Lp Oxygen scavenging compositions comprising polymers derived from benzenedimethanol monomers
JP2003253031A (ja) 2002-02-28 2003-09-10 Toray Ind Inc 生分解性樹脂架橋発泡体
US20030204239A1 (en) 2002-04-26 2003-10-30 Wenda Carlyle Endovascular stent with a preservative coating
DE60303705T2 (de) 2002-05-14 2006-10-19 Terumo K.K. Beschichteter Stent für die Freisetzung aktiver Substanzen
AU2003250913A1 (en) 2002-07-08 2004-01-23 Abbott Laboratories Vascular Enterprises Limited Drug eluting stent and methods of manufacture
US6962714B2 (en) 2002-08-06 2005-11-08 Ecolab, Inc. Critical fluid antimicrobial compositions and their use and generation
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US20050070989A1 (en) 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
AU2003293082A1 (en) 2002-11-27 2004-06-23 Tufts University Antioxidant-functionalized polymers
CA2519711C (fr) 2003-03-28 2012-01-17 Conor Medsystems, Inc. Dispositif medical implantable a gradient de concentration d'agent utile
US7662864B2 (en) * 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
US20050037048A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices containing antioxidant and therapeutic agent
CA2556212C (fr) 2004-02-13 2013-05-28 Conor Medsystems, Inc. Systeme de liberation de medicament implantable comprenant des filaments ou des fils
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US8007737B2 (en) 2004-04-14 2011-08-30 Wyeth Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices
US20060246109A1 (en) * 2005-04-29 2006-11-02 Hossainy Syed F Concentration gradient profiles for control of agent release rates from polymer matrices
GB0410749D0 (en) * 2004-05-14 2004-06-16 Dow Corning Ireland Ltd Coating apparatus
KR20070063511A (ko) 2004-08-13 2007-06-19 세타곤 인코포레이티드 나노 다공성 층을 구비하는 의료 장치 및 그 제조 방법
KR20070095916A (ko) * 2004-11-26 2007-10-01 스텐토믹스 인코포레이티드 의료용 임플란트에 킬레이트화 및 결합하는 화합물
MX2007009430A (es) 2005-02-03 2007-08-17 Cinv Ag Materiales para suministro de farmacos producidos mediante la tecnologia de sol/gel.
DE102005008434A1 (de) 2005-02-24 2006-09-07 Forschungszentrum Jülich GmbH Verfahren zur Modifizierung eines Substrats
WO2007005910A2 (fr) 2005-06-30 2007-01-11 Mc3, Inc. Revetements d'oxyde nitrique pour dispositifs medicaux
US8394446B2 (en) 2005-07-25 2013-03-12 Abbott Cardiovascular Systems Inc. Methods of providing antioxidants to implantable medical devices
US7785647B2 (en) 2005-07-25 2010-08-31 Advanced Cardiovascular Systems, Inc. Methods of providing antioxidants to a drug containing product
WO2007021749A1 (fr) 2005-08-10 2007-02-22 Med Institute, Inc. Dispositif intraluminal a structure creuse
US8309671B2 (en) 2005-10-24 2012-11-13 Lucite International, Inc. Extrudable acrylic compositions
US10029034B2 (en) 2005-12-15 2018-07-24 CARDINAL HEALTH SWITZERLAND 515 GmbH Drug-eluting articles with improved drug release profiles
US20070173923A1 (en) 2006-01-20 2007-07-26 Savage Douglas R Drug reservoir stent
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US7482818B2 (en) 2006-04-17 2009-01-27 Greenwald Technologies, Llc Systems and methods for detecting the presence and/or absence of a solid liquid or gas
US20070259101A1 (en) 2006-05-02 2007-11-08 Kleiner Lothar W Microporous coating on medical devices
US20070258903A1 (en) 2006-05-02 2007-11-08 Kleiner Lothar W Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US8506984B2 (en) 2006-07-26 2013-08-13 Cordis Corporation Therapeutic agent elution control process
EP2061526B1 (fr) 2006-09-13 2015-07-29 DSM IP Assets B.V. Dispositifs médicaux revêtus
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US8187255B2 (en) 2007-02-02 2012-05-29 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
WO2008098927A2 (fr) 2007-02-13 2008-08-21 Cinvention Ag Implants dégradables à réservoir
EP2111193A1 (fr) 2007-02-13 2009-10-28 Cinvention Ag Implants et stents à réservoir
TW200840553A (en) 2007-04-12 2008-10-16 Jung-Tang Huang A fabrication method for drug-eluting stent with medicine-compatible filling mechanism
US7901726B2 (en) 2007-08-31 2011-03-08 Boston Scientific Scimed, Inc. Porous medical articles for therapeutic agent delivery
US8016880B2 (en) 2007-11-16 2011-09-13 Medtronic Vascular, Inc. Stent having spiral channel for drug delivery
US20090240323A1 (en) 2008-03-20 2009-09-24 Medtronic Vascular, Inc. Controlled Degradation of Magnesium Stents
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
WO2009155328A2 (fr) 2008-06-18 2009-12-23 Boston Scientific Scimed, Inc. Revêtement d'endoprothèse
US20090319031A1 (en) 2008-06-19 2009-12-24 Yunbing Wang Bioabsorbable Polymeric Stent With Improved Structural And Molecular Weight Integrity
DE102008040356A1 (de) * 2008-07-11 2010-01-14 Biotronik Vi Patent Ag Stent mit biodegradierbaren Stentstreben und Wirkstoffdepots
WO2010144499A2 (fr) * 2009-06-09 2010-12-16 Medolution Limited Dérivés d'urée comme inhibiteurs de kinase
US8207240B2 (en) 2009-09-14 2012-06-26 Abbott Cardiovascular Systems Inc Method to minimize molecular weight drop of poly(L-lactide) stent during processing
US8381774B2 (en) * 2009-09-20 2013-02-26 Medtronic Vascular, Inc. Methods for loading a drug eluting medical device
US8678046B2 (en) 2009-09-20 2014-03-25 Medtronic Vascular, Inc. Apparatus and methods for loading a drug eluting medical device
WO2011097563A1 (fr) 2010-02-08 2011-08-11 Board Of Regents Of The University Of Nebraska Liposomes se liant aux biominéraux et aux métaux, leur synthèse et leurs procédés d'utilisation
IT1402654B1 (it) 2010-09-20 2013-09-13 Cid S R L Composizione per il rilascio di principi attivi da dispositivi di impianto
US9238514B2 (en) 2011-02-25 2016-01-19 Abbott Cardiovascular Systems Inc. Vacuum chamber and apparatus for loading material into a stent strut
US9585780B2 (en) 2011-02-25 2017-03-07 Abbott Cardiovascular Systems Inc. Pressure chamber and apparatus for loading material into a stent strut
US8757219B2 (en) * 2011-02-25 2014-06-24 Abbott Cardiovascular Systems Inc. Suction pump and apparatus for loading material into a stent strut
US20120219696A1 (en) 2011-02-25 2012-08-30 Abbott Cardiovascular Systems Inc. Methods Of Loading A Hollow Stent Using A Solvent
US20120216908A1 (en) 2011-02-25 2012-08-30 Abbott Cardiovascular Systems Inc. Methods Of Drug Loading A Hollow Stent By Immersion
US8733408B2 (en) 2011-02-25 2014-05-27 Abbott Cardiovascular Systems Inc. Cover sleeve and apparatus for loading material into a stent strut
US8927047B2 (en) 2011-02-25 2015-01-06 Abbott Cardiovascular Systems Inc. Methods of drug loading a hollow stent with a high viscosity formulation
US8936827B2 (en) 2011-02-25 2015-01-20 Abbott Cardiovascular Systems Inc. Methods of loading a hollow stent with a drug or drug formulation
US8772273B2 (en) * 2011-10-04 2014-07-08 Quretino Therapeutics, Inc. Formulations and uses of retinoic acid receptor selective agonists
CN102670333A (zh) * 2012-06-08 2012-09-19 同济大学 一种带冠状动脉的主动脉瓣膜支架及其输送器
US20140102049A1 (en) 2012-10-17 2014-04-17 Abbott Cardiovascular Systems Inc. Method Of Fabrication Of Implantable Medical Device Comprising Macrocyclic Triene Active Agent And Antioxidant

Also Published As

Publication number Publication date
EP2994174A1 (fr) 2016-03-16
CN105188791A (zh) 2015-12-23
US20140330365A1 (en) 2014-11-06
US9901663B2 (en) 2018-02-27
WO2014182542A1 (fr) 2014-11-13
JP2016523588A (ja) 2016-08-12

Similar Documents

Publication Publication Date Title
US11850333B2 (en) Coatings containing multiple drugs
ES2432746T3 (es) Polímeros purificados para revestimientos de dispositivos médicos implantables
JP5443336B2 (ja) 生分解性層を有するステント
AU2010202640B2 (en) Sustained drug-releasing stent
JP6955553B2 (ja) 薬物溶出ステントおよび機能的内皮細胞層の回復を可能とするためのその使用方法
MXPA03002873A (es) Dispositivos medicos revestidos y esterilizacion de los mismos.
PT1986711E (pt) Dispositivo médico implantável com revestimento de poliéster de erosão superficial para entrega de fármacos
JP6387359B2 (ja) ラパマイシン誘導体を含む埋め込み型医療用デバイスの製造方法
CN105188791B (zh) 填充有治疗剂制剂的中空支架
JP2006051364A (ja) 手術室内で医療用装置に医薬コーティングを適用するキット
JP2004222953A (ja) 生体留置用ステント
US20120239140A1 (en) Medical product comprising an active coating
KR101595267B1 (ko) 재협착과 염증 조절을 위한 순차적 약물 방출 스텐트의 제조방법
JP6820745B2 (ja) 薬剤溶出型ステント
AU2011232760B2 (en) Polymer coatings containing drug powder of controlled morphology
JP2021122748A (ja) 生分解性層を有するステント

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180112

Termination date: 20210501