ATE250056T1 - Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel - Google Patents
Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittelInfo
- Publication number
- ATE250056T1 ATE250056T1 AT00960130T AT00960130T ATE250056T1 AT E250056 T1 ATE250056 T1 AT E250056T1 AT 00960130 T AT00960130 T AT 00960130T AT 00960130 T AT00960130 T AT 00960130T AT E250056 T1 ATE250056 T1 AT E250056T1
- Authority
- AT
- Austria
- Prior art keywords
- blood
- compounds
- inhibiting
- formation
- thrombin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14292999P | 1999-07-09 | 1999-07-09 | |
PCT/US2000/040332 WO2001004117A1 (en) | 1999-07-09 | 2000-07-07 | Heteroaryl protease inhibitors and diagnostic imaging agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE250056T1 true ATE250056T1 (de) | 2003-10-15 |
Family
ID=22501854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00960130T ATE250056T1 (de) | 1999-07-09 | 2000-07-07 | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel |
Country Status (6)
Country | Link |
---|---|
US (1) | US6420397B1 (de) |
EP (1) | EP1194428B1 (de) |
AT (1) | ATE250056T1 (de) |
CA (1) | CA2379416A1 (de) |
DE (1) | DE60005351D1 (de) |
WO (1) | WO2001004117A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU751412B2 (en) | 1997-11-26 | 2002-08-15 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
SI21097A (sl) | 2001-12-04 | 2003-06-30 | Univerza V Ljubljani | Inhibitorji trombina |
US7285287B2 (en) * | 2002-11-14 | 2007-10-23 | Synecor, Llc | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses |
US20040098106A1 (en) * | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
US6932930B2 (en) * | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
US9609861B2 (en) | 2011-05-17 | 2017-04-04 | Velico Medical Inc. | Platelet additive solution having a β-galactosidase inhibitor |
US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
AU2012255137A1 (en) | 2011-05-17 | 2013-12-12 | The Brigham And Women's Hospital, Inc. | Improved platelet storage using a sialidase inhibitor |
WO2014120886A1 (en) | 2013-01-30 | 2014-08-07 | Velico Medical, Inc. | Platelet additive solution having a self-assembling hydrogel-forming peptide |
JP2016523588A (ja) | 2013-05-06 | 2016-08-12 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 治療剤配合物が充填されている中空ステント |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4418052A (en) | 1980-08-12 | 1983-11-29 | Wong Dennis W | Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body |
US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
US4652440A (en) | 1984-05-03 | 1987-03-24 | Paik Chang H | Method of stably radiolabeling antibodies with technetium and rhenium |
US4980148A (en) | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
GB8506792D0 (en) | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
US5011686A (en) | 1987-09-21 | 1991-04-30 | Creative Biomolecules, Inc. | Thrombus specific conjugates |
US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US5024829A (en) | 1988-11-21 | 1991-06-18 | Centocor, Inc. | Method of imaging coronary thrombi |
US5122361A (en) | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
EP0604022A1 (de) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Mehrschichtiges resorbierbares Stent und Verfahren zu dessen Herstellung |
US5656600A (en) | 1993-03-25 | 1997-08-12 | Corvas International, Inc. | α-ketoamide derivatives as inhibitors of thrombosis |
GB9318637D0 (en) | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
US6087479A (en) | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
US5466811A (en) | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
WO1996011720A1 (en) | 1994-10-17 | 1996-04-25 | Kabushikikaisha Igaki Iryo Sekkei | Drug-releasing stent |
US5643580A (en) | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
NZ298699A (en) | 1994-12-13 | 2001-03-30 | Corvas Int Inc | 3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis |
US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
DE19514104C2 (de) | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
JPH11508558A (ja) | 1995-06-27 | 1999-07-27 | メルク エンド カンパニー インコーポレーテッド | ピリジノン トロンビン阻害剤 |
JP2000512616A (ja) | 1996-02-22 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | ピリジノントロンビンインヒビター |
US5891909A (en) | 1996-03-29 | 1999-04-06 | 3-Dimensional Pharmaceuticals, Inc. | Amidinohydrazones as protease inhibitors |
AU743735B2 (en) * | 1996-10-11 | 2002-02-07 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
AU751412B2 (en) | 1997-11-26 | 2002-08-15 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
-
2000
- 2000-07-07 DE DE60005351T patent/DE60005351D1/de not_active Expired - Lifetime
- 2000-07-07 EP EP00960130A patent/EP1194428B1/de not_active Expired - Lifetime
- 2000-07-07 US US09/612,591 patent/US6420397B1/en not_active Expired - Lifetime
- 2000-07-07 CA CA002379416A patent/CA2379416A1/en not_active Abandoned
- 2000-07-07 AT AT00960130T patent/ATE250056T1/de not_active IP Right Cessation
- 2000-07-07 WO PCT/US2000/040332 patent/WO2001004117A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO2001004117A1 (en) | 2001-01-18 |
CA2379416A1 (en) | 2001-01-18 |
EP1194428A1 (de) | 2002-04-10 |
US6420397B1 (en) | 2002-07-16 |
EP1194428B1 (de) | 2003-09-17 |
DE60005351D1 (de) | 2003-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998023565A3 (en) | Aminoguanidines and alkoxyguanidines as protease inhibitors | |
DK1086122T3 (da) | Pyrazinonproteaseinhibitorer | |
BR9815325A (pt) | Heteroaril, aminoguanidinas e alcóxiguanidinas eseu uso como inibidores da protease | |
DE60122546D1 (en) | Aminopyridinyl-, aminoguanidinyl- und alkoxyguanidinyl- substituierte phenylacetamide als protease inhibitoren | |
NO20004871D0 (no) | Benzamid- og sulfonamid-substituert aminoguanidiner og alkoksyguanidiner som protease inhibitorer | |
ATE338030T1 (de) | Amidine-inhibitoren der serine-proteasen | |
ATE250056T1 (de) | Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel | |
WO2002006248A3 (en) | Cyclic oxyguanidine pyrazinones as protease inhibitors | |
MXPA01008084A (es) | Heteroarilamidinas, metilamidinas y guanidinas como inhibidores de proteasa. | |
TW200508200A (en) | Substituted phenyl acetamides and their use as protease inhibitors | |
MXPA03000963A (es) | Inhibidores de oxiguanidina ciclica proteasa. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |