CN105188781A - 用于制备微粒脱细胞组织的方法 - Google Patents

用于制备微粒脱细胞组织的方法 Download PDF

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Publication number
CN105188781A
CN105188781A CN201480025727.3A CN201480025727A CN105188781A CN 105188781 A CN105188781 A CN 105188781A CN 201480025727 A CN201480025727 A CN 201480025727A CN 105188781 A CN105188781 A CN 105188781A
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CN
China
Prior art keywords
tissue
cell
particulate acellular
hydrostatic pressure
particulate
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Pending
Application number
CN201480025727.3A
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English (en)
Chinese (zh)
Inventor
岸田晶夫
木村刚
根岸淳
日渡谦一郎
田崎晃子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adeka Corp
Tokyo Medical and Dental University NUC
Original Assignee
Tokyo Medical and Dental University NUC
Asahi Denka Kogyo KK
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Application filed by Tokyo Medical and Dental University NUC, Asahi Denka Kogyo KK filed Critical Tokyo Medical and Dental University NUC
Publication of CN105188781A publication Critical patent/CN105188781A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
CN201480025727.3A 2013-05-07 2014-05-02 用于制备微粒脱细胞组织的方法 Pending CN105188781A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013-097402 2013-05-07
JP2013097402 2013-05-07
PCT/JP2014/062149 WO2014181767A1 (fr) 2013-05-07 2014-05-02 Procédé de production d'un tissu décellularisé particulaire

Publications (1)

Publication Number Publication Date
CN105188781A true CN105188781A (zh) 2015-12-23

Family

ID=51867247

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480025727.3A Pending CN105188781A (zh) 2013-05-07 2014-05-02 用于制备微粒脱细胞组织的方法

Country Status (6)

Country Link
US (1) US20160058910A1 (fr)
EP (2) EP3556406B1 (fr)
JP (2) JP6515304B2 (fr)
KR (1) KR102240373B1 (fr)
CN (1) CN105188781A (fr)
WO (1) WO2014181767A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102339700B1 (ko) * 2013-05-07 2021-12-14 케이엠 바이올로직스 가부시키가이샤 입자상 탈세포화 조직을 포함하는 하이브리드 겔
JP6666898B2 (ja) * 2015-02-27 2020-03-18 株式会社Adeka 脱細胞化組織
CN104740685A (zh) * 2015-04-16 2015-07-01 烟台隽秀生物科技有限公司 一种神经修复膜及其制备方法
JP2021027803A (ja) * 2019-08-09 2021-02-25 国立研究開発法人国立長寿医療研究センター 象牙質再生用細胞培養物
CN112826983A (zh) * 2019-11-22 2021-05-25 中国科学院大连化学物理研究所 一种心脏脱细胞基质修饰仿生膜及其制备和应用
CN112472870A (zh) * 2020-12-03 2021-03-12 中国人民解放军陆军军医大学第一附属医院 一种人工微粒皮的制备方法及应用
TW202306575A (zh) * 2021-06-23 2023-02-16 日商Ａｄｅｋａ股份有限公司 去細胞化細胞結構體

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
JP2002518319A (ja) * 1998-06-19 2002-06-25 ライフセル コーポレイション 粒状無細胞組織マトリックス
JP2010227246A (ja) * 2009-03-26 2010-10-14 Tokyo Medical & Dental Univ 脱細胞化生体組織の調製方法
CN102238970A (zh) * 2008-10-13 2011-11-09 亚洲大学校产学协力团 利用动物组织粉末制造多孔立体支架的方法及其多孔立体支架
CN102470149A (zh) * 2009-08-18 2012-05-23 生命细胞公司 用于处理组织的方法
US20130028981A1 (en) * 2010-02-26 2013-01-31 Decell Technologies Inc. Methods for tissue decellularization
JP2013042677A (ja) * 2011-08-22 2013-03-04 Tokyo Medical & Dental Univ 脱細胞処理液、脱細胞化角膜の調製方法、及び脱細胞化角膜を備える移植片

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ZA843751B (en) 1983-06-10 1984-12-24 University Patents Inc Body implants of extracellular matrix and means and methods of making and using such implants
WO1994003584A1 (fr) * 1992-08-07 1994-02-17 Tissue Engineering, Inc. Production de tissu de greffe a partir d'une matrice extracellulaire
JP2002507907A (ja) 1997-06-27 2002-03-12 バーダー、アウグスチヌス 生合成移植片及びその製造方法
US6933326B1 (en) * 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
DE69922228T2 (de) 1998-09-30 2005-12-01 Medtronic, Inc., Minneapolis Verfahren zur Reduzierung der Mineralisierung von Gewebe zum Gebrauch bei Transplantationen
US8882850B2 (en) * 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US7153518B2 (en) * 2001-08-27 2006-12-26 Regeneration Technologies, Inc. Processed soft tissue for topical or internal application
JP2004094552A (ja) 2002-08-30 2004-03-25 Sumitomo Chem Co Ltd 病理組織画像解析方法および病理組織画像解析システム
JP4092397B2 (ja) 2002-09-10 2008-05-28 国立循環器病センター総長 超高静水圧印加による移植用生体組織の処理方法
WO2008111530A1 (fr) 2007-03-09 2008-09-18 National University Corporation, Tokyo Medical And Dental University Procédé de préparation d'un tissu mou décellularisé, d'une greffe et d'un matériau de culture
JP5869219B2 (ja) * 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
JP2002518319A (ja) * 1998-06-19 2002-06-25 ライフセル コーポレイション 粒状無細胞組織マトリックス
CN102238970A (zh) * 2008-10-13 2011-11-09 亚洲大学校产学协力团 利用动物组织粉末制造多孔立体支架的方法及其多孔立体支架
JP2010227246A (ja) * 2009-03-26 2010-10-14 Tokyo Medical & Dental Univ 脱細胞化生体組織の調製方法
CN102470149A (zh) * 2009-08-18 2012-05-23 生命细胞公司 用于处理组织的方法
US20130028981A1 (en) * 2010-02-26 2013-01-31 Decell Technologies Inc. Methods for tissue decellularization
JP2013042677A (ja) * 2011-08-22 2013-03-04 Tokyo Medical & Dental Univ 脱細胞処理液、脱細胞化角膜の調製方法、及び脱細胞化角膜を備える移植片

Also Published As

Publication number Publication date
JP2019030332A (ja) 2019-02-28
KR20160005712A (ko) 2016-01-15
JPWO2014181767A1 (ja) 2017-02-23
KR102240373B1 (ko) 2021-04-13
EP2995325B1 (fr) 2020-01-15
US20160058910A1 (en) 2016-03-03
EP2995325A1 (fr) 2016-03-16
JP6515304B2 (ja) 2019-05-22
EP3556406B1 (fr) 2021-12-22
JP6623333B2 (ja) 2019-12-25
EP2995325A4 (fr) 2016-12-21
WO2014181767A1 (fr) 2014-11-13
EP3556406A1 (fr) 2019-10-23

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Application publication date: 20151223