CN105148285B - 用于活性试剂稳定化的方法和组合物 - Google Patents

用于活性试剂稳定化的方法和组合物 Download PDF

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CN105148285B
CN105148285B CN201510559840.6A CN201510559840A CN105148285B CN 105148285 B CN105148285 B CN 105148285B CN 201510559840 A CN201510559840 A CN 201510559840A CN 105148285 B CN105148285 B CN 105148285B
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vaccine
virus
composition
silk
section
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CN105148285A (zh
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戴维·L·卡普兰
菲奥伦佐·奥米内托
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Tufts University
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  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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CN201510559840.6A 2011-04-21 2012-04-23 用于活性试剂稳定化的方法和组合物 Active CN105148285B (zh)

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US (3) US20140287043A1 (https=)
EP (1) EP2699266B1 (https=)
JP (2) JP6170906B2 (https=)
CN (2) CN105148285B (https=)
AU (6) AU2012245198B2 (https=)
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Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5896743B2 (ja) 2008-10-09 2016-03-30 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ グリセロールを含有する改変された絹フィルム
BR112013027057A2 (pt) 2011-04-21 2020-08-11 Trustees Of Tufts College composições e métodos para a estabilização de agentes ativos
US9884027B2 (en) 2012-01-12 2018-02-06 Nanofiber Solutions, Inc. Nanofiber scaffolds for biological structures
JP2015510818A (ja) 2012-03-20 2015-04-13 トラスティーズ オブ タフツ カレッジ 薬物送達のための絹リザーバー
JP2015512944A (ja) 2012-04-13 2015-04-30 トラスティーズ・オブ・タフツ・カレッジTrustees Of Tufts College 絹マイクロスフェアを調製するための方法および組成物
HK1207977A1 (en) 2012-04-25 2016-02-19 Trustees Of Tufts College Silk microspheres and methods for surface lubrication
US20150368417A1 (en) 2013-02-15 2015-12-24 Tufts University Silk-based nanoimprinting
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US10464361B2 (en) 2013-03-15 2019-11-05 Tufts University Silk water lithography
WO2014152097A1 (en) * 2013-03-15 2014-09-25 Banner Pharmacaps Inc. Silk-based capsules
US11009792B2 (en) 2013-03-15 2021-05-18 Tufts University All water-based nanopatterning
AU2014233480B2 (en) * 2013-03-15 2018-08-09 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
ITMI20131255A1 (it) * 2013-07-26 2015-01-27 Ct Tessile Serico Societa Co Nsortile Per A Composizioni farmaceutiche nebulizzabili a base di fibroina per il trattamento di lesioni cutanee
EP3041504B1 (en) * 2013-09-03 2021-08-25 Georgia Tech Research Corporation Thermally stable vaccine formulations and microneedles
EP3046956B1 (en) * 2013-09-19 2019-08-28 Microvention, Inc. Polymer films
AU2014321277B2 (en) 2013-09-19 2017-07-20 Terumo Corporation Polymer particles
SG10201907426UA (en) 2013-09-30 2019-09-27 Evolved By Nature Inc Silk protein fragment compositions and articles manufactured therefrom
EP3065719A4 (en) 2013-11-08 2017-08-09 Terumo Corporation Polymer particles
AU2015241514A1 (en) * 2014-04-04 2016-11-03 Nanofiber Solutions, Inc. Electrospun biocompatible fiber compositions
PE20171791A1 (es) 2014-12-02 2017-12-28 Silk Therapeutics Inc Prendas de vestir de seda y productos de alto rendimiento y metodos para elaborarla
US10213378B2 (en) * 2015-03-10 2019-02-26 Sporos Therapeutics, LLC Single dose non-adjuvanted cutaneous tetanus vaccine and uses thereof
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
CN104940981B (zh) * 2015-05-21 2018-11-30 重庆市畜牧科学院 具有生物活性的外用敷料及其制备方法
AU2016294611B2 (en) 2015-07-14 2022-08-11 Evolved By Nature, Inc. Silk performance apparel and products and methods of preparing the same
CN105903027A (zh) * 2016-05-31 2016-08-31 福建傲农生物科技集团股份有限公司 一种常温下长期保存抗生素的方法
US20210322537A1 (en) * 2016-06-07 2021-10-21 Aridis Pharmaceuticals, Inc. Method For Preparation of Quick Dissolving Thin Films Containing Bioactive Material With Enhanced Thermal Stability
CN106362223B (zh) * 2016-08-26 2019-05-03 南通纺织丝绸产业技术研究院 多孔丝素蛋白微针给药装置及其制备方法
GB201614799D0 (en) * 2016-09-01 2016-10-19 Glaxosmithkline Biologicals Sa Compositions
US20190275136A1 (en) * 2016-09-19 2019-09-12 Vaxess Technologies, Inc. Vaccine formulations with increased stability
EP3518983B1 (en) 2016-09-28 2024-04-24 Terumo Corporation Polymer particles
US10857262B2 (en) 2016-10-31 2020-12-08 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
US10898608B2 (en) 2017-02-02 2021-01-26 Nanofiber Solutions, Llc Methods of improving bone-soft tissue healing using electrospun fibers
WO2019067745A1 (en) 2017-09-27 2019-04-04 Silk, Inc. SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR
WO2019094702A1 (en) 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
US11911457B2 (en) * 2018-02-07 2024-02-27 Bharat Biotech International Limited Process for enterovirus purification and inactivation and vaccine compositions obtained thereof
WO2020023906A2 (en) * 2018-07-27 2020-01-30 Vaxess Technologies, Inc. Polymer-based biospecimen collection devices and uses thereof
AU2019336940B2 (en) * 2018-09-06 2025-09-11 Bavarian Nordic A/S Storage improved poxvirus compositions
GB2596413A (en) 2018-12-10 2021-12-29 Cambridge Crops Inc Compositions and methods for polymer based shelf life extension
TWI691531B (zh) * 2019-02-11 2020-04-21 南臺學校財團法人南臺科技大學 蠶絲蛋白膜的製造方法
CA3142608A1 (en) 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
CN110627899A (zh) * 2019-10-09 2019-12-31 山东天牧生物科技有限公司 一种呼肠孤病毒和细小病毒卵黄抗体锭及其制备方法
US11738174B2 (en) 2019-10-15 2023-08-29 Sofregen Medical, Inc. Delivery devices for delivering and methods of delivering compositions
BR112022009082A2 (pt) * 2019-11-18 2022-07-26 Elanco Us Inc Bolo liofilizado em frasco de parede reta
WO2021263282A1 (en) * 2020-06-24 2021-12-30 Trustees Of Tufts College Edible cell based vaccines
WO2022101877A1 (pt) * 2020-11-13 2022-05-19 Targetalent, Lda Composição de criopreservação de amostras biológicas para pcr
GB2615462A (en) * 2020-11-20 2023-08-09 Team Medical Llc RNA stabilization
WO2022187346A1 (en) * 2021-03-02 2022-09-09 Georgia Tech Research Corporation Hydrogel materials and methods of making and transport using the same
US11976196B2 (en) 2021-04-14 2024-05-07 Cambridge Crops, Inc. Silk packaging applications
EP4149277A4 (en) 2021-05-21 2024-11-20 Cambridge Crops, Inc. d/b/a Mori SYSTEMS AND METHODS FOR MANUFACTURING SILK FIBROIN SOLUTION AND POWDERS CONTAINING SILK FIBROIN
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
CN116421734A (zh) * 2021-12-30 2023-07-14 深圳复诺健生物科技有限公司 适用于溶瘤病毒的冻干保护剂及其应用
EP4499051A1 (en) 2022-03-30 2025-02-05 Bioneedle Drug Delivery B.V. A process for storing biologically active constructs in a biodegradable material
CN115227863A (zh) * 2022-07-01 2022-10-25 浙江大学 一种搭载噬菌体的复合水凝胶及其制备方法
AU2023373016A1 (en) * 2022-10-31 2025-05-15 National Agriculture And Food Research Organization Oral-administration-type vaccine composition containing fibroin-containing nanoparticles

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8808A (en) 1852-03-16 Planiwg-machiete
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3832253A (en) 1973-03-21 1974-08-27 Baxter Laboratories Inc Method of making an inflatable balloon catheter
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4667014A (en) 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
CA1200416A (en) 1983-05-13 1986-02-11 Societe Des Produits Nestle S.A. Food process
JPH0652268B2 (ja) * 1985-07-03 1994-07-06 鐘紡株式会社 固定化抗原
CN86100565A (zh) * 1986-04-30 1987-11-11 华东化工学院 一种共价活化的固定化酶载体
JPH07121871B2 (ja) * 1986-10-09 1995-12-25 国立予防衛生研究所長 インフルエンザワクチン凍結乾燥製剤
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
IE61575B1 (en) * 1987-05-04 1994-11-16 Merck & Co Inc A stable lyophilized live herpes virus vaccine
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
JP2750306B2 (ja) * 1989-05-24 1998-05-13 ポーラ化成工業株式会社 固定化低分子プロテインaの製造法
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5245012A (en) 1990-04-19 1993-09-14 The United States Of America As Represented By The Secretary Of The Army Method to achieve solubilization of spider silk proteins
JPH04167172A (ja) 1990-10-31 1992-06-15 Nec Corp ベクトルプロセッサ
ATE207080T1 (de) 1991-11-25 2001-11-15 Enzon Inc Multivalente antigen-bindende proteine
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5346481A (en) 1993-10-14 1994-09-13 Merck & Co., Inc. Vaccine delivery system
US5900238A (en) 1995-07-27 1999-05-04 Immunex Corporation Vaccine delivery system
IL123398A0 (en) 1995-08-22 1998-09-24 Agricola Tech Inc Cloning methods for high strength spider silk proteins
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
CA2274755A1 (en) * 1996-12-20 1998-07-02 Su-Pi Sheu Stabilizers for lyophilized vaccines
JP3101711B2 (ja) * 1997-11-20 2000-10-23 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子からなる吸着体/徐放体及びその製造方法
ATE290364T1 (de) 1999-08-18 2005-03-15 Microchips Inc Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
EP2308522A3 (en) 1999-11-17 2012-02-29 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
WO2002055058A2 (en) 2001-01-09 2002-07-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
RU21271U1 (ru) * 2001-08-06 2002-01-10 Алкацева Надежда Ильинична Основа для косметических средств
AR040819A1 (es) 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
JP2005097229A (ja) * 2002-12-04 2005-04-14 Toray Ind Inc ワクチンおよび抗原タンパク質の製造方法
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
US7060260B2 (en) * 2003-02-20 2006-06-13 E.I. Du Pont De Nemours And Company Water-soluble silk proteins in compositions for skin care, hair care or hair coloring
EP1613796B1 (en) 2003-04-10 2017-03-22 Tufts University Concentrated aqueous silk fibroin solution and use thereof
US20050123550A1 (en) * 2003-05-12 2005-06-09 Laurent Philippe E. Molecules enhancing dermal delivery of influenza vaccines
US7588774B2 (en) * 2003-05-12 2009-09-15 Becton, Dickinson And Company Molecules enhancing dermal delivery of influenza vaccines
WO2005044366A2 (en) 2003-10-31 2005-05-19 Alza Corporation System and method for transdermal vaccine delivery
AU2004292953A1 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
CN1243059C (zh) * 2004-03-04 2006-02-22 苏州大学 纳米丝素颗粒的制造方法
GB0405787D0 (en) * 2004-03-15 2004-04-21 Chiron Srl Low dose vaccines
WO2006062685A2 (en) 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
US7960509B2 (en) 2005-01-14 2011-06-14 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
ATE526378T1 (de) * 2005-08-02 2011-10-15 Tufts College Verfahren zur stufenweisen ablagerung von seidenfibroinbeschichtungen
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
WO2008127403A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer optofluidic device and method of manufacturing the same
CA2704768A1 (en) * 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
US8187616B2 (en) 2007-05-29 2012-05-29 Trustees Of Tufts College Method for silk fibroin gelation using sonication
WO2009048607A1 (en) * 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5795166B2 (ja) * 2007-11-28 2015-10-14 オルガノジェネシス インク. 生命工学による組織コンストラクト並びに生産及び使用のための方法
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
JP5896743B2 (ja) 2008-10-09 2016-03-30 タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ グリセロールを含有する改変された絹フィルム
WO2010057142A2 (en) 2008-11-17 2010-05-20 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti adhesion barriers and anti thrombotic materials
AU2010257120A1 (en) * 2009-03-04 2011-10-27 Trustees Of Tufts College Silk fibroin systems for antibiotic delivery
WO2011005381A2 (en) 2009-06-01 2011-01-13 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
US8293486B2 (en) 2009-07-21 2012-10-23 Trustees Of Tufts College Functionalization of silk material by avidin-biotin interaction
IN2012DN02358A (https=) * 2009-09-29 2015-08-21 Tufts College
EP3495015B1 (en) * 2010-10-19 2022-12-07 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
CN102085173B (zh) * 2011-01-26 2012-05-30 上海交通大学 以天然蚕丝蛋白为乳化剂的生物活性乳液及其制备方法
BR112013027057A2 (pt) 2011-04-21 2020-08-11 Trustees Of Tufts College composições e métodos para a estabilização de agentes ativos

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