CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

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Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
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China
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compound
formula
pharmaceutically acceptable
acceptable salt
idd
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Expired - Fee Related
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CN201380068062.XA
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English (en)
Chinese (zh)
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CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Country Status (22)

Country Link
US (2) US9777038B2 (OSRAM)
EP (1) EP2912013B1 (OSRAM)
JP (1) JP6272888B2 (OSRAM)
KR (1) KR102068381B1 (OSRAM)
CN (2) CN108250264A (OSRAM)
AU (1) AU2013334122B2 (OSRAM)
BR (1) BR112015009395A2 (OSRAM)
CA (1) CA2889592A1 (OSRAM)
CY (1) CY1119731T1 (OSRAM)
DK (1) DK2912013T3 (OSRAM)
ES (1) ES2655034T3 (OSRAM)
HK (1) HK1253301A1 (OSRAM)
HU (1) HUE036887T2 (OSRAM)
IL (1) IL238454B (OSRAM)
MX (1) MX361653B (OSRAM)
NO (1) NO2968302T3 (OSRAM)
NZ (2) NZ707389A (OSRAM)
PL (1) PL2912013T3 (OSRAM)
PT (1) PT2912013T (OSRAM)
SG (1) SG11201503247UA (OSRAM)
SM (1) SMT201700602T1 (OSRAM)
WO (1) WO2014066819A1 (OSRAM)

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KR102068381B1 (ko) 2012-10-26 2020-01-20 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체의 제조 방법
EP3149019B1 (en) 2014-05-29 2019-12-04 Bar Pharmaceuticals S.r.l. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
CN107108688B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇
TWI688571B (zh) 2014-11-19 2020-03-21 英商Ｎｚｐ英國有限公司 化合物（四）
WO2016079518A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators
PL3221331T3 (pl) 2014-11-19 2020-03-31 NZP UK Limited Steroidy, 6-alkilo-7-hydroksy-4-en-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
CN107405325B (zh) 2015-02-06 2021-11-12 英特塞普特医药品公司 用于组合疗法的药物组合物
US11072631B2 (en) * 2015-09-24 2021-07-27 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation bile acid derivatives
WO2017079062A1 (en) * 2015-11-06 2017-05-11 Intercept Pharmaceuticals, Inc. Methods for the preparation of obeticholic acid and derivatives thereof
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
IL262342B (en) 2016-04-13 2022-08-01 Intercept Pharmaceuticals Inc An fxr agonist for use as a medicament for the treatment or prevention of hepatocellular carcinoma
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
KR20190057108A (ko) * 2016-09-30 2019-05-27 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체의 결정형
CA3070837A1 (en) * 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
JP7308811B2 (ja) * 2017-07-26 2023-07-14 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ステロイド系誘導体ｆｘｒアゴニストの製造方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CA3142358A1 (en) 2019-05-30 2020-12-03 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
BR112022017039A2 (pt) 2020-02-28 2022-11-16 Kallyope Inc Agonistas de gpr40
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
CN116249536A (zh) 2020-09-18 2023-06-09 首尔大学校产学协力团 牛磺脱氧胆酸钠的批量生产方法

Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

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US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
AU2002308295B2 (en) * 2001-03-12 2007-08-23 Intercept Pharmaceuticals, Inc. Steroids as agonists for FXR
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
EP2040713B1 (en) * 2006-06-27 2014-06-18 Intercept Pharmaceuticals Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions
WO2010036427A1 (en) * 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
EP3150620B1 (en) * 2008-11-19 2020-01-08 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
KR102068381B1 (ko) 2012-10-26 2020-01-20 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체의 제조 방법

Patent Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

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An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis;Norinder, Jakob等;《 Organic Letters》;20071231;第9卷(第24期);第5095-5098页 *
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
NZ745013A (en) 2019-08-30
PT2912013T (pt) 2018-01-03
NO2968302T3 (OSRAM) 2018-02-03
CN108250264A (zh) 2018-07-06
PL2912013T3 (pl) 2018-05-30
US10202414B2 (en) 2019-02-12
US20180079776A1 (en) 2018-03-22
SG11201503247UA (en) 2015-06-29
EP2912013A4 (en) 2016-06-01
EP2912013B1 (en) 2017-10-11
AU2013334122B2 (en) 2017-11-02
AU2013334122A1 (en) 2015-05-14
JP6272888B2 (ja) 2018-01-31
WO2014066819A1 (en) 2014-05-01
HK1253301A1 (zh) 2019-06-14
CN105102425A (zh) 2015-11-25
EP2912013A1 (en) 2015-09-02
MX2015005286A (es) 2015-10-29
IL238454B (en) 2018-11-29
CA2889592A1 (en) 2014-05-01
IL238454A0 (en) 2015-06-30
KR102068381B1 (ko) 2020-01-20
CY1119731T1 (el) 2018-06-27
KR20150074062A (ko) 2015-07-01
US9777038B2 (en) 2017-10-03
NZ707389A (en) 2018-08-31
SMT201700602T1 (it) 2018-03-08
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
JP2015533852A (ja) 2015-11-26
ES2655034T3 (es) 2018-02-16
MX361653B (es) 2018-12-13
US20150291653A1 (en) 2015-10-15
DK2912013T3 (en) 2018-01-15
BR112015009395A2 (pt) 2017-07-04

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