CN105101803A - 具有改进特异性的修饰的t淋巴细胞 - Google Patents

具有改进特异性的修饰的t淋巴细胞 Download PDF

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Publication number
CN105101803A
CN105101803A CN201480020004.4A CN201480020004A CN105101803A CN 105101803 A CN105101803 A CN 105101803A CN 201480020004 A CN201480020004 A CN 201480020004A CN 105101803 A CN105101803 A CN 105101803A
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antigen
lymphocyte
modification
polypeptide
domain
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CN201480020004.4A
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English (en)
Chinese (zh)
Inventor
毕涛·梁
斯图尔特·阿博特
伟·刘
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Celgene Corp
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Anthrogenesis Corp
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Priority to CN201710991379.0A priority Critical patent/CN107988165A/zh
Priority to CN202011174721.6A priority patent/CN113005091A/zh
Publication of CN105101803A publication Critical patent/CN105101803A/zh
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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CN201480020004.4A 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞 Pending CN105101803A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201710991379.0A CN107988165A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞
CN202011174721.6A CN113005091A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361761548P 2013-02-06 2013-02-06
US61/761,548 2013-02-06
PCT/US2014/015113 WO2014124143A1 (en) 2013-02-06 2014-02-06 Modified t lymphocytes having improved specificity

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CN202011174721.6A Division CN113005091A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞
CN201710991379.0A Division CN107988165A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞

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CN201480020004.4A Pending CN105101803A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞
CN201710991379.0A Pending CN107988165A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞
CN202011174721.6A Pending CN113005091A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞

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CN202011174721.6A Pending CN113005091A (zh) 2013-02-06 2014-02-06 具有改进特异性的修饰的t淋巴细胞

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US (2) US20150368360A1 (enExample)
EP (3) EP2953475B1 (enExample)
JP (3) JP6467661B2 (enExample)
KR (2) KR102417657B1 (enExample)
CN (3) CN105101803A (enExample)
AU (3) AU2014214850C1 (enExample)
CA (2) CA3115383A1 (enExample)
ES (2) ES2748398T3 (enExample)
HK (1) HK1254962A1 (enExample)
NZ (2) NZ750426A (enExample)
SG (2) SG10201810087QA (enExample)
WO (1) WO2014124143A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106635998A (zh) * 2016-09-14 2017-05-10 深圳市默赛尔生物医学科技发展有限公司 抗体调控的双抗原特异性t细胞及其制备方法和应用
CN108220238A (zh) * 2018-01-09 2018-06-29 郑州大学第附属医院 一种减少cd8+t细胞凋亡并增强其功能的培养方法
CN108463229A (zh) * 2016-01-11 2018-08-28 斯坦福大学托管董事会 嵌合蛋白和免疫治疗方法
WO2019052562A1 (zh) * 2017-09-15 2019-03-21 科济生物医药（上海）有限公司 Il-4r的融合蛋白及其应用
CN109988242A (zh) * 2018-01-02 2019-07-09 武汉波睿达生物科技有限公司 联合嵌合抗原受体、表达载体、慢病毒及t细胞

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104853766A (zh) 2012-10-02 2015-08-19 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
ES2949648T3 (es) 2012-12-20 2023-10-02 Purdue Research Foundation Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
EP2953475B1 (en) * 2013-02-06 2019-07-03 Celgene Corporation Modified t lymphocytes having improved specificity
EP2958943B1 (en) 2013-02-20 2019-09-11 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
US9944898B2 (en) * 2013-03-11 2018-04-17 Case Western Reserve University Method of generating tumor-specific T cells
US11071754B2 (en) 2013-03-11 2021-07-27 Case Western Reserve University Method of generating tumor-specific T cells
HK1220205A1 (zh) 2013-03-15 2017-04-28 Celgene Corporation 修饰的t淋巴细胞
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