CN105073725A - 作为激酶抑制剂的吡唑基-脲 - Google Patents
作为激酶抑制剂的吡唑基-脲 Download PDFInfo
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- CN105073725A CN105073725A CN201380054166.5A CN201380054166A CN105073725A CN 105073725 A CN105073725 A CN 105073725A CN 201380054166 A CN201380054166 A CN 201380054166A CN 105073725 A CN105073725 A CN 105073725A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106771117A (zh) * | 2016-11-25 | 2017-05-31 | 王婧 | 一种中性粒细胞抗原底片的制备方法 |
| CN114573510A (zh) * | 2015-12-16 | 2022-06-03 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
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| KR20130121196A (ko) * | 2003-01-22 | 2013-11-05 | 센주 세이야꾸 가부시키가이샤 | 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환 치료약의 눈의 국소 조직으로의 이행 방법 |
| EA019974B1 (ru) | 2007-12-19 | 2014-07-30 | Кансер Рисерч Текнолоджи Лимитед | 8-ЗАМЕЩЕННЫЕ ПИРИДО[2,3-b]ПИРАЗИНЫ И ИХ ПРИМЕНЕНИЕ |
| CN102906090B (zh) | 2010-02-01 | 2015-06-24 | 癌症研究技术有限公司 | 1-(5-叔丁基-2-苯基-2h-吡唑-3-基)-3-[2-氟-4-(1-甲基-2-氧代-2,3-二氢-1h-咪唑并[4,5-b]吡啶-7-基氧基)-苯基]-脲和相关化合物及它们在治疗中的应用 |
| PT2763984T (pt) | 2011-10-03 | 2016-07-25 | Respivert Ltd | 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureias como inibidores da map cinase p38 |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
| WO2014033449A1 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| WO2014033447A2 (en) | 2012-08-29 | 2014-03-06 | Respivert Limited | Kinase inhibitors |
| US9732063B2 (en) | 2012-11-16 | 2017-08-15 | Respivert Limited | Kinase inhibitors |
| US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
| EP2981534B1 (en) * | 2013-04-02 | 2017-07-19 | Topivert Pharma Limited | Kinase inhibitors based upon n-alkyl pyrazoles |
| KR102283883B1 (ko) * | 2013-04-02 | 2021-07-29 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제 |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| CA2934199A1 (en) | 2013-12-20 | 2015-06-25 | Respivert Limited | Urea derivatives useful as kinase inhibitors |
| US9447076B2 (en) | 2014-02-14 | 2016-09-20 | Respivert Ltd. | Inhibitor of p38 map kinase |
| MA40775A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
| EP4566638A3 (en) * | 2015-05-29 | 2025-08-27 | Allergan, Inc. | Implant for treatment of an ocular condition |
| CA3015978A1 (en) | 2016-04-06 | 2017-10-12 | Topivert Pharma Limited | Kinase inhibitors |
| JP2019515925A (ja) * | 2016-04-29 | 2019-06-13 | エンセラドゥス ファーマセウティカルス べー．フェー． | 炎症性病変又は領域に局所注射するためのリポソーム化コルチコステロイド |
| CA3127373A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
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| RU2505539C2 (ru) | 2008-12-23 | 2014-01-27 | Эбботт Лэборетриз | Антивирусные соединения |
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| GB0921730D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
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| CN102892752B (zh) | 2010-03-15 | 2015-03-25 | 宇部兴产株式会社 | 制备酰胺化合物的方法 |
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| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
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| GB201010193D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
| CN105968110B (zh) | 2011-12-09 | 2018-04-27 | 奇斯药制品公司 | 激酶抑制剂 |
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| US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
| KR102283883B1 (ko) | 2013-04-02 | 2021-07-29 | 옥슬러 액퀴지션즈 리미티드 | 키나제 저해제 |
| EP2981534B1 (en) | 2013-04-02 | 2017-07-19 | Topivert Pharma Limited | Kinase inhibitors based upon n-alkyl pyrazoles |
| US9447076B2 (en) | 2014-02-14 | 2016-09-20 | Respivert Ltd. | Inhibitor of p38 map kinase |
| MA40775A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
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- 2013-08-16 BR BR112015003218A patent/BR112015003218A2/pt not_active IP Right Cessation
- 2013-08-16 AU AU2013303922A patent/AU2013303922A1/en not_active Abandoned
Patent Citations (5)
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|---|---|---|---|---|
| CN102333770A (zh) * | 2008-12-11 | 2012-01-25 | 瑞斯比维特有限公司 | P38map激酶抑制剂 |
| WO2011124930A1 (en) * | 2010-04-08 | 2011-10-13 | Respivert Limited | P38 map kinase inhibitors |
| WO2011158042A2 (en) * | 2010-06-17 | 2011-12-22 | Respivert Limited | Methods |
| WO2013050757A1 (en) * | 2011-10-03 | 2013-04-11 | Respivert Limited | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
| WO2013050756A1 (en) * | 2011-10-03 | 2013-04-11 | Respivert Limited | L-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p3i map kinase inhibitors |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114573510A (zh) * | 2015-12-16 | 2022-06-03 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| CN114634447A (zh) * | 2015-12-16 | 2022-06-17 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| CN114634447B (zh) * | 2015-12-16 | 2024-11-15 | 洛克索肿瘤学股份有限公司 | 可用作激酶抑制剂的化合物 |
| CN106771117A (zh) * | 2016-11-25 | 2017-05-31 | 王婧 | 一种中性粒细胞抗原底片的制备方法 |
| CN106771117B (zh) * | 2016-11-25 | 2018-09-14 | 王婧 | 一种中性粒细胞抗原底片的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150056777A (ko) | 2015-05-27 |
| US9701670B2 (en) | 2017-07-11 |
| BR112015003218A2 (pt) | 2019-09-24 |
| CA2881914A1 (en) | 2014-02-20 |
| WO2014027209A1 (en) | 2014-02-20 |
| JP2015524837A (ja) | 2015-08-27 |
| EA201590391A1 (ru) | 2015-06-30 |
| US20150218137A1 (en) | 2015-08-06 |
| EP2885284A1 (en) | 2015-06-24 |
| US20140057915A1 (en) | 2014-02-27 |
| MX2015002044A (es) | 2016-01-22 |
| GB201214750D0 (en) | 2012-10-03 |
| EA025393B1 (ru) | 2016-12-30 |
| EP2885284B1 (en) | 2016-11-02 |
| AU2013303922A1 (en) | 2015-02-19 |
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