CN105030950B - 防治高血脂的微生态制剂及其制备方法和应用 - Google Patents
防治高血脂的微生态制剂及其制备方法和应用 Download PDFInfo
- Publication number
- CN105030950B CN105030950B CN201510477288.6A CN201510477288A CN105030950B CN 105030950 B CN105030950 B CN 105030950B CN 201510477288 A CN201510477288 A CN 201510477288A CN 105030950 B CN105030950 B CN 105030950B
- Authority
- CN
- China
- Prior art keywords
- probiotics
- parts
- freeze
- fermented soybean
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 81
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 81
- 208000031226 Hyperlipidaemia Diseases 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 54
- 244000068988 Glycine max Species 0.000 claims abstract description 43
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 43
- 239000000203 mixture Substances 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 34
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 15
- 230000002265 prevention Effects 0.000 claims abstract description 15
- 230000035622 drinking Effects 0.000 claims abstract description 14
- 235000008216 herbs Nutrition 0.000 claims abstract description 14
- 230000010354 integration Effects 0.000 claims abstract description 14
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims abstract description 13
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 13
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 13
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 13
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 13
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 13
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 13
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 13
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 13
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 13
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 13
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 13
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims abstract description 12
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 12
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims abstract description 12
- 229940072205 lactobacillus plantarum Drugs 0.000 claims abstract description 12
- 241000186604 Lactobacillus reuteri Species 0.000 claims abstract description 11
- 229940001882 lactobacillus reuteri Drugs 0.000 claims abstract description 11
- 239000002775 capsule Substances 0.000 claims abstract description 6
- 238000009472 formulation Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 18
- 229960005486 vaccine Drugs 0.000 claims description 14
- 241001092040 Crataegus Species 0.000 claims description 12
- 238000000855 fermentation Methods 0.000 claims description 10
- 230000004151 fermentation Effects 0.000 claims description 10
- 239000003223 protective agent Substances 0.000 claims description 9
- 239000003390 Chinese drug Substances 0.000 claims description 7
- 238000002224 dissection Methods 0.000 claims description 4
- 235000020183 skimmed milk Nutrition 0.000 claims description 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 241000218628 Ginkgo Species 0.000 claims 3
- 241000186660 Lactobacillus Species 0.000 claims 1
- 229940039696 lactobacillus Drugs 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 244000194101 Ginkgo biloba Species 0.000 abstract description 12
- 238000002474 experimental method Methods 0.000 abstract description 6
- 230000000968 intestinal effect Effects 0.000 abstract description 6
- 238000009098 adjuvant therapy Methods 0.000 abstract description 3
- 239000013022 formulation composition Substances 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 21
- 239000008280 blood Substances 0.000 description 21
- 235000013557 nattō Nutrition 0.000 description 20
- 230000000694 effects Effects 0.000 description 19
- 241000700159 Rattus Species 0.000 description 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- 241000894006 Bacteria Species 0.000 description 11
- 150000002632 lipids Chemical class 0.000 description 11
- 244000063299 Bacillus subtilis Species 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 108010023302 HDL Cholesterol Proteins 0.000 description 9
- 235000014469 Bacillus subtilis Nutrition 0.000 description 8
- 230000001603 reducing effect Effects 0.000 description 8
- 108010028554 LDL Cholesterol Proteins 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 239000013641 positive control Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 7
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- 208000026106 cerebrovascular disease Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 229930003935 flavonoid Natural products 0.000 description 6
- 235000017173 flavonoids Nutrition 0.000 description 6
- 150000002215 flavonoids Chemical class 0.000 description 6
- 108010073682 nattokinase Proteins 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 230000002526 effect on cardiovascular system Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- YXHVCZZLWZYHSA-FPLPWBNLSA-N Ginkgoic acid Chemical compound CCCCCC\C=C/CCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-FPLPWBNLSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000011149 active material Substances 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 235000021050 feed intake Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 4
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 4
- 235000008696 isoflavones Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940086319 nattokinase Drugs 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 201000001320 Atherosclerosis Diseases 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000034189 Sclerosis Diseases 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 229930184727 ginkgolide Natural products 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000726221 Gemma Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 206010057249 Phagocytosis Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 229930003448 Vitamin K Natural products 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 208000011775 arteriosclerosis disease Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000008782 phagocytosis Effects 0.000 description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 238000002203 pretreatment Methods 0.000 description 2
- 108700022737 rat Fat1 Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 108010048734 sclerotin Proteins 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 235000007586 terpenes Nutrition 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 235000019168 vitamin K Nutrition 0.000 description 2
- 239000011712 vitamin K Substances 0.000 description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 description 2
- 229940046010 vitamin k Drugs 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 description 1
- BVPWJMCABCPUQY-UHFFFAOYSA-N 4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1CCN(CC=2C=CC=CC=2)CC1 BVPWJMCABCPUQY-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002388 Angina unstable Diseases 0.000 description 1
- 102000040350 B family Human genes 0.000 description 1
- 108091072128 B family Proteins 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 201000000057 Coronary Stenosis Diseases 0.000 description 1
- 206010011089 Coronary artery stenosis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010057178 Osteoarthropathies Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 208000037062 Polyps Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 206010072810 Vascular wall hypertrophy Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000036523 atherogenesis Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000002391 femur head Anatomy 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- LVPMIMZXDYBCDF-UHFFFAOYSA-N isocinchomeronic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)N=C1 LVPMIMZXDYBCDF-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- GJAWHXHKYYXBSV-UHFFFAOYSA-N pyridinedicarboxylic acid Natural products OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
组别 | CK组 | PS | SY1 | SY2 | SY3 |
采食量 | 165.36±8.65 | 155.90±8.24 | 166.83±16.86 | 167.55±9.18 | 161.62±23.56 |
增重 | 37.003±9.825 | 35.905±2.555 | 35.013±3.688 | 35.488±7.024 | 33.055±4.057 |
组别 | CK组 | PS | SY1 | SY2 | SY3 |
料肉比 | 4.418±0.319 | 4.342±0.599 | 5.142±1.050 | 4.591±1.000 | 5.048±0.892 |
组别 | CK | PS | SY1 | SY2 | SY3 |
肝指数 | 3.376±0.211bc | 3.737±0.168a | 3.379±0.194a | 3.643±0.215ab | 3.585±0.139c |
脾指数 | 0.209±0.030a | 0.191±0.038ab | 0.198±0.036ab | 0.199±0.028b | 0.205±0.032ab |
肾指数 | 0.579±0.059 | 0.601±0.040 | 0.589±0.042 | 0.595±0.032 | 0.601±0.036 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510477288.6A CN105030950B (zh) | 2015-08-06 | 2015-08-06 | 防治高血脂的微生态制剂及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510477288.6A CN105030950B (zh) | 2015-08-06 | 2015-08-06 | 防治高血脂的微生态制剂及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105030950A CN105030950A (zh) | 2015-11-11 |
CN105030950B true CN105030950B (zh) | 2019-01-18 |
Family
ID=54438313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510477288.6A Active CN105030950B (zh) | 2015-08-06 | 2015-08-06 | 防治高血脂的微生态制剂及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105030950B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105747113A (zh) * | 2016-02-29 | 2016-07-13 | 武汉大学 | 一种具有溶栓降血脂功效的纳豆益生菌组合物及其制备方法与应用 |
CN107523526B (zh) | 2017-10-17 | 2020-05-12 | 无限极(中国)有限公司 | 一种罗伊氏乳杆菌及其用途 |
CN109123680A (zh) * | 2018-09-10 | 2019-01-04 | 富益元(东莞)生物科技有限公司 | 一种具有调节肠道菌群功能的乳酸菌组合物及其制备方法 |
CN110090284A (zh) * | 2019-05-13 | 2019-08-06 | 北京南亚医学研究院 | 一种中药微生态制剂及其制备方法和应用 |
CN110679949A (zh) * | 2019-09-30 | 2020-01-14 | 山东晶辉生物技术有限公司 | 一种减肥组合物及其制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709165A (zh) * | 2005-06-23 | 2005-12-21 | 亥比布勒·哈迪尔 | 调脂稳压保健茶及其制备方法 |
CN101933627A (zh) * | 2009-06-29 | 2011-01-05 | 董丙华 | 一种具有降压、降血脂、降糖、软化血管功能的保健面条 |
CN102423070A (zh) * | 2011-10-13 | 2012-04-25 | 胡鲸波 | 纳豆胶囊及其制备方法 |
CN103223033A (zh) * | 2013-05-22 | 2013-07-31 | 武汉真福医药科技发展有限公司 | 一种新型纳豆保健组合物及其制备方法与应用 |
CN103416741A (zh) * | 2012-05-18 | 2013-12-04 | 于兰荣 | 一种降血脂的绿豆糕 |
CN103461882A (zh) * | 2013-08-15 | 2013-12-25 | 鲁杨 | 一种蔬菜降血脂保健香肠及其加工方法 |
CN103584078A (zh) * | 2012-08-16 | 2014-02-19 | 浙江劲膳美生物科技有限公司 | 一种冠心病食疗组合物 |
CN102872306B (zh) * | 2012-09-25 | 2014-04-09 | 深圳市安美信生物医药科技有限公司 | 治疗心脑血管疾病的复方富硒中药组合物及其制备方法 |
-
2015
- 2015-08-06 CN CN201510477288.6A patent/CN105030950B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1709165A (zh) * | 2005-06-23 | 2005-12-21 | 亥比布勒·哈迪尔 | 调脂稳压保健茶及其制备方法 |
CN101933627A (zh) * | 2009-06-29 | 2011-01-05 | 董丙华 | 一种具有降压、降血脂、降糖、软化血管功能的保健面条 |
CN102423070A (zh) * | 2011-10-13 | 2012-04-25 | 胡鲸波 | 纳豆胶囊及其制备方法 |
CN103416741A (zh) * | 2012-05-18 | 2013-12-04 | 于兰荣 | 一种降血脂的绿豆糕 |
CN103584078A (zh) * | 2012-08-16 | 2014-02-19 | 浙江劲膳美生物科技有限公司 | 一种冠心病食疗组合物 |
CN102872306B (zh) * | 2012-09-25 | 2014-04-09 | 深圳市安美信生物医药科技有限公司 | 治疗心脑血管疾病的复方富硒中药组合物及其制备方法 |
CN103223033A (zh) * | 2013-05-22 | 2013-07-31 | 武汉真福医药科技发展有限公司 | 一种新型纳豆保健组合物及其制备方法与应用 |
CN103461882A (zh) * | 2013-08-15 | 2013-12-25 | 鲁杨 | 一种蔬菜降血脂保健香肠及其加工方法 |
Also Published As
Publication number | Publication date |
---|---|
CN105030950A (zh) | 2015-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105030950B (zh) | 防治高血脂的微生态制剂及其制备方法和应用 | |
CN106173773A (zh) | 一种酵素益生菌固体饮料及其制备方法 | |
JP5000066B2 (ja) | 腸内共生生物の共発酵培養による天然薬の転換および修飾 | |
CN105167072A (zh) | 一种功能性枸杞酵素及其制品的生产方法 | |
CN106798252B (zh) | 一种具有调理肠胃降血脂溶血栓功效的纳豆产品 | |
CN112425767A (zh) | 一种美容养颜益生菌发酵粉及其生产方法 | |
CN105146614A (zh) | 一种功能性钙果酵素、酵素饮料及其生产方法 | |
CN109125525B (zh) | 防治心血管疾病的组合物及其制备方法和应用 | |
CN101760478A (zh) | 一种葛根红曲的制造方法 | |
CN106420847A (zh) | 辅助保护胃黏膜和/或缓解胃胀的组合物及其微生态制剂 | |
CN106265763A (zh) | 具有延缓衰老和美容养颜功能的组合物及其应用 | |
CN112999261A (zh) | 一种舒缓动脉硬化的纳豆发酵组合物及其制备方法和应用 | |
CN109528814B (zh) | 一种乳酸菌发酵黄芪的微生态制剂及其制备方法和应用 | |
CN107692219A (zh) | 一种降血糖的水果发酵液及其制备方法 | |
CN103892390A (zh) | 富硒锗螺旋藻灵芝谷物蔬菜天然饮料 | |
CN108785331A (zh) | 一种具有气血双补的组合物及其制备方法和应用 | |
CN102362627A (zh) | 虫草保健咖啡 | |
CN102742653B (zh) | 一种健脑安神益生菌羊奶片及其制备方法 | |
CN106798755B (zh) | 一种具有调理乳腺增生功能的益生菌组合物及其应用 | |
JP7042544B2 (ja) | 脱毛治療用組成物の調製方法 | |
CN105685972A (zh) | 具有减脂瘦身功能的益生菌组合物及其制备方法与应用 | |
CN102246956A (zh) | 一种含有松花粉的保健食品及其制备方法 | |
CN106072133A (zh) | 一种具有抗氧化和脂质代谢调节作用的复合浆果精粉的制备方法 | |
CN108795823A (zh) | 一种改善女性孕产妇肠道菌群的益生菌的培养方法和应用 | |
CN105595351A (zh) | 一种具有稳态化调控血糖的营养产品及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 271099 No. 17 Huayuan Road, Taishan District, Tai'an City, Shandong Province Patentee after: Shandong Fenghuang Biotechnology Co.,Ltd. Address before: 271000 No. 28 Chuangye street, Taishan District, Tai'an City, Shandong Province Patentee before: SHANDONG PHOENIX BIO-TECH. Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Microecological preparation for preventing and treating hyperlipidemia and its preparation method and Application Effective date of registration: 20211229 Granted publication date: 20190118 Pledgee: Taian Bank Co.,Ltd. Daizong sub branch Pledgor: Shandong Fenghuang Biotechnology Co.,Ltd. Registration number: Y2021980016806 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221206 Granted publication date: 20190118 Pledgee: Taian Bank Co.,Ltd. Daizong sub branch Pledgor: Shandong Fenghuang Biotechnology Co.,Ltd. Registration number: Y2021980016806 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Microecological preparation for prevention and treatment of hyperlipidemia and its preparation method and application Effective date of registration: 20221212 Granted publication date: 20190118 Pledgee: Taian Bank Co.,Ltd. Daizong sub branch Pledgor: Shandong Fenghuang Biotechnology Co.,Ltd. Registration number: Y2022980026535 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231213 Granted publication date: 20190118 Pledgee: Taian Bank Co.,Ltd. Daizong sub branch Pledgor: Shandong Fenghuang Biotechnology Co.,Ltd. Registration number: Y2022980026535 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Microecological preparations for the prevention and treatment of hyperlipidemia, their preparation methods and applications Effective date of registration: 20231227 Granted publication date: 20190118 Pledgee: Taian Bank Co.,Ltd. Daizong sub branch Pledgor: Shandong Fenghuang Biotechnology Co.,Ltd. Registration number: Y2023980074803 |