CN104971390A - 用于控制体内压力的装置和方法 - Google Patents

用于控制体内压力的装置和方法 Download PDF

Info

Publication number
CN104971390A
CN104971390A CN201510226589.1A CN201510226589A CN104971390A CN 104971390 A CN104971390 A CN 104971390A CN 201510226589 A CN201510226589 A CN 201510226589A CN 104971390 A CN104971390 A CN 104971390A
Authority
CN
China
Prior art keywords
pressure
diverter
flow control
control device
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201510226589.1A
Other languages
English (en)
Other versions
CN104971390B (zh
Inventor
丹.罗滕伯格
奥尔.布朗
阿夫拉哈姆.阿巴扎凯
阿舍.什马尔维茨
约拉姆.罗齐
加德.克伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atria Medical Inc
Original Assignee
Atria Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atria Medical Inc filed Critical Atria Medical Inc
Priority claimed from CNA2005800107351A external-priority patent/CN101415452A/zh
Publication of CN104971390A publication Critical patent/CN104971390A/zh
Application granted granted Critical
Publication of CN104971390B publication Critical patent/CN104971390B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2476—Valves implantable in the body not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2493—Transmyocardial revascularisation [TMR] devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A61B2017/00252—Making holes in the wall of the heart, e.g. laser Myocardial revascularization for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00592—Elastic or resilient implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B2017/1139—Side-to-side connections, e.g. shunt or X-connections

Abstract

本发明公开了用于控制体内压力的装置和方法。本发明提供一种差动压力调节装置来控制体内，特别是心脏内的压力。该装置可包括一分流器，其位于体内两个或多个内腔之间以使得液体能够在所述两个内腔之间流动；和一可调整的流量调节机构，其被设置为可选择性地覆盖所述分流器的开口以与所述体内腔之间压力差有关地调节流过所述分流器的液流。在一些实施例中，可提供一控制机构，其与可调整的流量调节机构相连接以遥控启动该可调整的流量调节机构。

Description

用于控制体内压力的装置和方法
本申请是申请人为：V波有限公司，申请日为：2005年2月3日，申请号为：200580010735.1，名称为：用于控制体内压力的装置和方法的发明的分案申请。
技术领域
本发明涉及用于降低或调节血液循环系统内压力，特别是调节心脏血液压力的装置和方法。
背景技术
充血性心力衰竭(CHF)在西方社会被认为是导致住院治疗和大量死亡的最普遍的原因，其对生活质量有严重的影响。CHF是一种低系统灌注和心脏机能低下的病症。CHF的原因可包括由于肌肉萎缩而导致的心肌损伤、心肌症和其它病症。与CHF直接相关的病理生理的机理包括心脏输出量减少，心脏充盈压力增加，流量积累，这些可以导致例如，肺充血和呼吸困难。心脏收缩机能的损伤可能导致左心室收缩减弱和心输出量减少，这些可以产生的临床症状包括：不耐力症(effort intolerance)，呼吸困难，寿命减少，浮肿(肺或体表)和疼痛。心脏收缩机能紊乱的病人通常有一个较大的左心室，这是由于为了保持足够心搏量出现了心脏重塑的现象。这种病理生理的机理是与心房压力和左心室充盈压力的增高有关。伴随心脏舒张机能异常，由于异常放松而导致在正常压力下心脏充盈不充分，左心室可能变得僵硬而且局部明显缺乏顺应性。在较高充盈压力下要保持适当的心脏充盈可能需要维持心输出量。这种为保持心脏充盈和输出量的强制性的充盈压升高会导致肺静脉高血压和肺气肿。
目前用于治疗CHF的方法通常分为三种：(1)药理学，例如利尿剂；(2)辅助系统，例如泵；以及(3)手术治疗。关于药物治疗，血管舒张药已被用于通过降低全身血管阻力来降低心脏的工作负荷，利用利尿剂来阻止液体积累和浮肿发生，同时降低心脏充盈压力。
用来治疗CHF的辅助设备可包括，例如，机械泵。机械泵通过全部或部分地完成正常情况下由心脏所作的泵功能而减少了心脏的负载。目前，机械泵被用于例如当病人可得到用于移植的捐献心脏的同时，对病人进行维持。还有许多起搏器也用来治疗CHF。再同步(Resysnchronization)起搏器也已经用来治疗CHF。最后，至少还有三种极端侵入性和复杂的外科手术方法用于治疗心力衰竭：(1)心脏移植；(2)动态心肌成形术；和(3)Batista左心室局部切除术。
在极端紧急状况时，临时性辅助仪器和大动脉内的气囊可以是有帮助的。心脏移植和长期性左心室辅助仪(LVAD)的植入通常可被用作最后的手段。然而，目前使用的所有辅助仪器目的都是增加心脏泵容量和增加心输出量来达到与正常的生活一致的状态，减少充盈压和/或防止形成浮肿。最终，心脏移植可以被用来治疗极端的心脏功能紊乱病症。然而这个手段有很高的侵害性，并且受到了捐助心脏可获得性的限制。机械装置可以允许推进大量的血液(公升/分)，然而这个也是它们的主要局限。对电源的需要，相当大的泵以及溶血和传染的可能性所有这些都要考虑到。
发明内容
本发明可以提供调节体内压力的方法和器械。根据本发明的一些实施例，差动压力调节装置可包括位于体内两个或多个内腔之间的分流器，以使得液体能够在这些内腔之间流动，以及一个被设置为可选择性地盖住分流器开口的可调节流量调节机构，以调节穿过分流器的与体内腔之间压差有关的液流的。
根据一些实施例，压力调节装置可包括位于心脏两个或多个内腔之间的分流器，以使得液体能够在这些内腔之间流动，一被设置为可选择性地盖住分流器开口，以调节穿过分流器的液流的可调节流量调节机构，以及一与可调节流量调节机构相连的控制机构，以遥控启动该可调节流量调节机构。
在另一个装置中提供了一种控制体内压力的方法，该方法包括将一差动压力调节装置植入体内，该压力调节装置包括一位于体内两个或多个内腔的分流器，配置一个流量调节机构，以及根据这些内腔之间压差的变化来控制流量调节机构的设置。
在本发明的另一个实施例中提供了一种控制体内压力的方法，该方法包括采用已植入体内的控制机构来控制一流量调节机构的设置，该流量调节机构被放置在包括一分流器的差动压力调节装置，该分流器例如，放在两个或多个内腔之间，如心脏左心房和右心房之间。
附图说明
本发明的主题在说明书结论部分被特别指出并且清楚地提出了主张。然而，通过项目的详细描述并参考阅读附图，本发明的结构和操作方法两方面以及它们的特性和优点都可以得到最好的理解。附图其中：
图1A示意性说明了根据本发明典型实施例的一差动压力调节装置(DPRD)；
图1B-1I示意性说明了根据本发明一些实施例的差动压力调节装置(DPRD)的其它实施例；
图1J是根据本发明典型实施例的描述压力曲线的一个实例的示意图，该示意图涉及两个内腔间压差的变化，流过流量控制机构的流量以及孔口面积之间的关系；
图2A和2B分别示意性说明了根据本发明一典型实施例可调节分流器、管或其它结构的横截面图和侧面图；
图3示意性说明了根据本发明另一典型实施例的分流管；
图4示意性说明了根据本发明一典型实施例的包含流量调节机构(FRM)的分流器；
图5示意性说明了根据本发明典型实施例的图4中的分流器，其结合有打开状态的FRM；
图6示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合；
图7示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合；
图8示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合；
图9示意性说明了根据本发明另一典型实施例的在心脏内部的FRM。
图10示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合。
图11示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合；
图12示意性说明了根据本发明另一典型实施例的FRM，其可用于与例如图1中的DPRD、图2A-2B中的分流器，或者图3中的分流器相结合；
图13A示意性说明了根据本发明的一些实施例用于遥控DPRD的装置；
图13B-E示意性说明了根据本发明的一些实施例用于遥控DPRD的机构；
图14示意性说明了根据本发明的一些实施例用于说明控制压力，例如心脏血压的方法的流程图。
应该理解的是为了简单和清楚地说明，图中所示的元件没有必要地按比例画。例如，为了清楚起见，一些元件的尺寸相对于其它元件被夸大了。进一步，在适当的地方，参考数字在这些附图中可以重复使用以表示相应的或类似的元件。
具体实施方式
为了完整地理解本发明，在下列的详述中，阐述了多个具体细节。然而，本领域普通技术人员将认识到没有这些具体细节也可实施本发明。在其它例子中，可能没有具体描述公知的方法、过程、部件及结构，以免与本发明混淆。
应该意识到，尽管为了示意的目的，此处部分讨论涉及到心脏、心内腔和/或心房，但是本发明实施方式并不限于这方面，其可以用于各种各样其它的血管、内腔室、器官或身体部位。例如本发明的实施例可包括在脑内腔之间、所选器官之间、血管等之间(例如，在大动脉和内腔静脉之间)，和/或其它的合适的内腔之间，比如，在身体内的带、内腔、器官、导管、区域或地区之间调节液体转移。
本发明的一些实施例包括，例如，一种通过减少或别的方式控制两个或两个以上身体部位，例如心脏的两个内腔(如，左心房和右心房)之间的压力差来控制体内压力的方法和装置。例如，这样的压力控制可以用来帮助解决具有充血性心力衰竭和突出的心脏舒张性功能紊乱的病人心脏充盈压力增高的问题，从而帮助尽量减少或阻止肺部液体积聚、水肿形成和临床呼吸困难疾病。另一个例子是，压力控制可以用来减少左心室充盈压。本发明的一些实施例可以包括差动压力调节装置(DPRD)，例如，包括分流器、管或其它具有孔口、管或开口的结构以液体地连接两个或更多内腔，如连接心脏的左右心房。根据本发明的一些实施例，该DPRD可包括一个调整装置或调节装置，其能够校正、改变或用其它方式调节例如孔口的横截面，例如与第一和第二内腔之间压力差变化有关的孔口的横截面，从而增加和/或减小这两个内腔之间的血液流速。
本发明的一些实施例可用来，例如消除充血性心力衰竭(CHF)病人左心室的额外充盈压，以及潜在地防止或减少肺气肿的发生。
本发明的一些装置包括，例如，在两个心内腔，例如左心房和右心房之间的壁内植入一个可调节的DPRD。这个压力调节装置可以，例如容许一选定的血液量从左心房流向右心房，这与左右心房之间的压差有关。该压力调节装置例如可进行调节，以选择性地改变开口的大小和形状、允许流过的血液量等等。
在一些实施例中，该压力调节装置可设计为保持两个或多个内腔之间，例如左右心房之间有一连续流量。又如，一分流器、管或其它结构可连接到一盖子，阀孔，阀杆，或其它可设置为连续半开的流量调节机构上，以使得所选的最小量液体能够在体内两个内腔，例如两个心内腔之间持续流动。随后可调节所述盖子，例如进一步打开或关闭盖子来控制内腔之间的液体量。流过DPRD的液体可以根据两个内腔之间的压力或压差的变化而增加或减少。例如，当左心房的压力相对于右心房的压力增大或减小时，盖子可以打开和/或关闭。在一些实施例中，DPRD可如此设计以使得孔口盖与分流器的开口不直接接触，以使对复原的帮助最小化或阻止组织在孔盖上或孔盖周围的生长。这样一个构造可使连续的液体流过DPRD，并且可以阻止或减少血液凝结、生物膜形成或其它不想要的生长的发生。在一些实施例中，DPRD可以被用来冲洗或清洁分流器和/或分流器盖等。
参见图1A，其示意性地说明根据本发明典型实施例植入心脏109中的DPRD101。DPRD101可以被植入两个或多个体内腔之间，例如，植入左心房102和右心房103之间。采用不同的心内腔排列方式，DPRD101可以植入其它心内腔，和/或被植入其它体内腔内或植在体内腔之间。一些实施例中，使用例如安装在导管远端的穿孔或切口仪器或其它合适的穿孔装置，可在两个体内腔之间的壁内，例如，左心房102和右心房103之间的隔膜105内，形成一开口、穿孔或其它结构。然后用导管或其它的输送装置将DPRD101放置于穿孔中。在一些实施例中，一个或多个组织固定元件，例如，支撑臂106可以将DPRD101支撑在生成孔或穿孔中所需要的位置。
DPRD101可以包括，例如一个可调节的分流器，管子或通道107，使得液体在两体内腔之间、器官之间、部位或区域等之间流动，比如在左心房102和右心房103之间流动。DPRD101可以包括一个在此所述的流量调节器(FRM)108，例如流体阀、盖子，阀孔，阀杆或帽，以对分流管107的参数进行所选择的改变，例如，通过改变分流器107开口的横截面或分流器形状等，从而调节从左心房102自右心房103的血流量。在一些实施例FRM108可设置为连续半开位置以使左右心房之间有一连续血流量。例如，FRM108可有目的地处于半开以使得一选择的血液量连续在心内腔之间流动。随后可通过选择地改变开孔的大小和形状，血液的容许流过量，来调节FRM108，使得分流器107开口和FRM108周围的区域能够受到限制和/或扩张，从而影响分流器107的有效流通，同时能够控制各内腔之间的血流量。DPRD101可以包括一个或多个控制设备110，例如，导线、弹簧、绳索等，使得FRM108能够被动地或主动地受到控制。在一个实施例中，例如，通过被预加载一选定的拉力，弹簧可以用来使得FRM108依照压差的变化而动作，以一个可控方式响应一个或多个压力阈值的变化。
FRM108可以设置为响应所选的压力分布，从而提供一个已知的压力释放分布。举例来说，FRM108可以预调、预校准和/或预配置，以根据左右心房之间压力差的变化而改变其设置，调整其配置或位置，和/或改变其孔口宽度或流量等。FRM108可以对于例如连续可变设置进行连续调节，例如响应于环境条件和/或外部控制。在至少这些方式中，DPRD101可以在两个或多个体内腔或区域之间提供一选择的、可预知的和/或有保证的液流。在一些实施例中，FRM108的静止或缺省设置，开口大小，流量水平或位置可以通过例如预先设置好的参数和/或遥控机构来改变。在一些实施例中持续打开或半开的FRM108可以帮助阻止分流器107的堵塞。
在一些实施例中，在低于某一压力或压差时，阀门或仪器可以完全关闭；然而在其它一些实施例中，在低于某一压力或压差时，阀门不能完全闭合或者处于微开的状态。例如，阀门可有一个最小打开尺度。
在一些实施例中，DPRD的一个或多个性能，例如，压力调节装置的横截面开口大小可能取决于左右心房之间的血压差。因此，在一些实施例中，左右心房之间的血流可能受到左右心房之间血压差变化的影响。
根据本发明一些实施例的DPRD可以通过减少心房压力而使得心室的压力减少。
在一些实施例中，DPRD可以用于心膜炎(ASD)病人，例如那些不能耐受完全不受控制的心房关闭过程的人，以有选择地关闭隔膜中的孔或间隙。
在一些实施例中，DPRD可以用于将液体从左心房移到右心房，例如救护肺动脉高血压病人。在这些例子中，DPRD可以与FRM108一起放置在左心房中。根据本发明的一些实施例，FRM108可以是单向的或双向的。
在一些装置中，可将多个DPRD植入一个壁或其它结构内，例如，帮助提供备份，以植入设置范围不同的仪器来获得更高水平的开口控制，和/或能够增加另外的仪器。当两个或多个更小直径的DPRD可被输送时，植入多个DPRD可减小输送导管的直径。
在其它的实施例中，FRM108可以包括盖子、帽或其它合适的具有多种形式的机构，以使FRM 108能够部分或完全关闭。现在参见图1B-1G。图1B中，FRM108可以包括两个或多个臂120，上述臂可设置为在分流器122的开口125处连续或恒定地保持微开。举例来说，FRM108可设置为至少局部地连续保持与分流器107分离，以容许左心房102和右心房103之间有一持续液流量。臂120可以响应心内腔间的压差的变化而进一步地打开和/或关闭。臂120可以由柔韧的聚合物或其它合适材料构成。在臂末端130臂处120可具有，例如圆形形状，以帮助防止血液停滞。
在图1C中，FRM108可包括分流器122，以及两个或多个柔性膜135，该膜可设置为在开口125处恒定地半开状态，以使血液能持续流过分流器122。例如，在这里讨论的多种实施例中，一设备可如此安置使得无论心内腔之间的压力或压差是多少，都可以设置最小的开口大小或可以产生流量。膜135可以包括至少一个弹簧机构，以响应心内腔间压差的变化，帮助膨胀或收缩所述膜135。
在图1D中，FRM 108可以包括分流器122，以及一个或多个柔韧的或弹簧为基础的帽、膜或叶状物150，其通过弹簧或其它合适的压力敏感机构155与分流器122可选择地相连。在一个实施例中，压力敏感机构155可利用一可控方式响应一个或多个压力阈值的变化被预加载。帽150可设置为在开口125处持续微开，来使得血液能够持续流过分流器122。FRM 108可包括一个或多个凸起区域160，例如，棘状物或其它合适形状的物体以帮助阻止盖子150与分流器122完全接触。
在图1E中，FRM108可以包括分流器122，以及一个或多个有角度的柔性膜或叶状物165，其设置为在开口125处持续微开以使血液能够持续流过分流器122。在一个实施例中，叶状物165可在选定张力下预加载以用可控方式响应一个或多个压力阈值的变化。叶状物165可以包括至少一个弹簧机构或其它合适的机构以响应心内腔之间的压差变化，帮助关闭和/或打开叶状物165。叶状物165可以包括至少一个磁铁或电磁铁170或其它合适的机构以远距离地帮助叶状物165关闭和/或打开。导线172或其它合适的机构可用于启动磁铁或电磁铁170。
在图1F中，FRM108可以包括分流管122、和罩、阀孔、阀杆或其它流量调节机构175，其设置为在开口125处一直保持半开以使血液能够持续流过分流器122。罩175可以和弹簧177或其它合适的压力敏感机构连接在一起。在一个实施例中，弹簧177可在选定张力下预加载以用一可控方式响应一个或多个压力阈值的变化。FRM 108可以包括一个或多个罩的活动限制器179。FRM 108可以包括一个固定的极化磁铁181以及带有一个或多个导体185的电磁线圈183。罩175可响应心内腔之间压差的变化，和/或通过遥控启动磁铁181和/或电磁线圈183而打开和/或关闭。例如，当磁铁181启动时，罩175可以进一步地打开，而当线圈183启动时，罩175可以进一步地关闭。
如图1G所示，FRM 108可以包括分流器122，以及罩175，其设置为在开口125处一直保持半开以使血液能够持续流过管道122。罩175可通过连接臂185与分流器相连接。罩175可包括切口，狭槽，凹槽或裂缝187等以使血能够连续流过分流器。狭槽187可具有不同的大小、深度、宽度或密度，这可帮助指示罩175的各种区域是较结实和柔韧性较差，还是较软弱和较柔韧，因此可以根据体内腔间压差的变化而做出不同地反应。举例来说，在具有更多或更深侵入的区域中，该区域可以是比较软弱和有柔韧性的，从而使罩175至少局部打开，允许压力相对低的血流流过分流器122。在具有较少或较浅侵入的区域，该区域可以相对结实且缺乏柔韧性，因此仅仅使罩175至少局部打开，允许压力相对高的血流流过分流器122。
在图1H和1I所示，FRM108可包括分流器122和罩175，其可以设置为在开口125处保持一直半开的状态以使得血液能够连续流过分流器122。罩175可以与弹簧190或其它适合的血压感应装置相连接。弹簧190和罩175可以与一活塞或泵机构192相连接。如图1I所示,罩175可以响应于心内腔之间压力差的变化，和/或通过活塞192激活弹簧190，延长和/或扩大罩175而被打开和或者关闭，从而改变了开口125的大小。
根据本发明的一些实施例，使用DPRD101能够生成一压力曲线，该曲线涉及两个内腔间压差的变化，流过流量控制装置的流量和孔口面积之间的关系。可采用任何所需或所选的设计参数。现在参照图1J，该图表示了这种压力曲线的一个例子。在图1J中可以看到，在12毫米汞柱压力差以下，开口或孔口的大小可以相对稳定，而流量主要受压差影响。当压差上升到大约12毫米汞柱以上20毫米汞柱以下时，流量可按一较高速度增长，这时它既受孔口面积增加的影响，也受压差增长的影响。当压差上升到大约20毫米汞柱以上时，由于孔口区域可能已经达到了其最大横截面，因此流速以较低速度增长，流量主要受压差的影响。压差可受孔口面积的线形和/或非线性变化的影响。可采用其它的压差，流量和/或孔口面积水平，各种关系，以及相互关系，作为其它参数，变量，最小和最大限制等。
参见图2A和2B，它们分别示意性说明了根据本发明的典型实施例可调节DPRD 201的横截面图和侧视图。DPRD 201可包括例如一个框架220，该框架与一个或多个支撑臂，例如，支撑臂211-216相连接。框架220可包括例如一个柔性固定架，环或管。框架220由柔性材料，例如柔性金属，超柔性合金，和/或形状记忆材料做成，形状记忆合金采用例如镍钛诺(Nitinol)或其它合适的材料。
尽管在这里为示意的目的，将DPRD201描述为有着六个臂或附肢211-216，但本发明的装置并不受到此限制，且可包括不同数量的臂，例如一个臂、两个臂、十个臂等等。
为了获得期望的功能，臂或附肢211-216可以是柔韧的和/或预先塑形的。例如，臂211-216在插入过程中，例如在插入一合适的输送管中时可以被折叠起来。在一些实施例中，臂211-216可以由超弹性材料，例如形状记忆合金(SMA)制成，该记忆合金如镍钛(NiTi)合金。其它合适的材料可以包括，例如，金属、不锈钢，和/或其它合适的材料。至少部分臂211-216或所选的其它DPRD201元件可以被涂敷和/或被赋予某种结构，以增加它们的生物相容性和/或增加这些元件可选择性地成为内皮细胞状的等级，如在某些移植条件中所要求的。
DPRD201可包括，例如，FRM 250，又如，包括一个盖子、阀口、阀杆，或其它的带有一个或多个预设位置的流量调整设备，以有选择性地覆盖由于DPRD201的展开而造成的开口。FRM将在下面详细描述。
如图2B所示，DPRD201可有两个侧面，这里分别指近侧251和远侧252。例如DPRD 201可被植入心脏109中，这样DPRD201的近侧251可面对着右心房103，而DPRD201的远侧252可面对着左心房102。可使用其它方向的侧面251和252，同样可使用其它数目的侧面。
在有些实施例中，DPRD201的远侧252可与远端的一组臂或附肢相连，例如，臂211-213，而DPRD201的近侧251可与近端的一组臂或附肢相连，例如，臂214-216。因此，当DPRD201植入心脏109时，远端的一组臂211-213可首先在例如左心房102内放开，进入图1中隔膜105的右侧，从病人的透视图看，将DPRD201支持在隔膜105的左侧。然后，随着DPRD201插入过程的完成，例如通过收回运载DPRD201的导管或输送管，近端的一组臂214-216在右心房103内放开，例如进入图1中隔膜105的左侧，从病人的透视图看，因此支持隔膜105的右侧。用这种方式，支撑臂211-216可以将DPRD201的框架220支撑在左心房102和右心房103之间所期望的位置。
现在参见图3，其示意性说明了根据本发明另一实施例DPRD301。DPRD301可包括，例如框架302，该框架连接到一个或多个臂或附肢，例如臂303和304。
框架302可包括，例如由柔性材料构成的柔性固定架，该柔性材料如柔性金属，该柔性金属例如为镍钛诺如或镍钛诺丝。框架302可具有如图3所示的通常螺旋形状，并可与框架302每个末端的弯臂303和304一体成型，如图3所示。其它合适的形状也可以被采用。臂303和304可以是柔性的并且能够预先塑形以实现想要的功能。举例来说，臂303和304在插入过程，可以被折叠在例如一合适的输送管内，以便随后放开将框架302定位到小孔中。根据本发明的一些实施例，DPRD301也包括FRM305，比如这里详细介绍的FRM。
同样参见图4，其示意性说明了根据本发明实施例包括DPRD405的DPRD401。DPRD405可以作为FRM250和FRM350的例子。尽管DPRD405可以用于结合DPRD301或其它合适的分流管或医疗器械，但为了示意的目的，这里仅仅展示了DPRD405与DPRD401相结合，其中DPRD401可与DPRD201相似。
DPRD405可包括例如一通过弹簧433连接到环431上的盘432。盘432可由生物相容性材料，比如，由热解碳(Pyrolitic carbon)或不锈钢形成。弹簧433可包括一个或多个旋转弹簧、螺旋弹簧或任何其它弹性元件，当DPRD401的两侧，比如图2B中DPRD201的近侧251与远侧252之间没有很大压差时，这些弹簧将盘432托在环431内部。
响应于DPRD401两侧之间的压差，盘432可以离开压力相对较高的心房，典型地如左心房，接着弯曲弹簧433，这会对盘432的移动施加一反作用力，从而打开和/或扩大血液会从中流过的内腔室。弹簧433所施加的反作用力取决于DPRD401两侧之间的压差，例如当一个心室内的压力迫使弹簧433压缩，这样通过DPRD401的压差越高，则允许通过从高压侧向低压侧流动的液体来释放这个压差的开口就越大。以这种方式，DPRD401的远端与近端之间的压差可根据一个或多个所选水平进行控制。在一些实施例中，这里描述的DPRD的各种各样的配置可容许随着压力差而不断改变的开口大小和流速。
要理解的是，当DPRD401两侧之间基本没有压差，或者当压差相当小时，盘432可能会完全闭合，或者另外不会完全阻塞通过DPRD450，比如通过盘432和环431之间区域的血流。举例来说，盘432可以选择在环431和盘432之间设置间隙，这样盘432可作为漏泄阀使得血液持续地流过穿孔。连续自由流过DPRD401的流体可以，例如阻止在盘432内部和/或周围形成血液凝结和/或血栓。
在一些实施例中，环432可以是不对称的，例如它可具有相对较宽的上部451和相对较窄的下部452。这样可以允许，例如当盘432在增加的压力下倾斜期间，血液以相对小的流速经过，直到盘432弯曲到超过环431上部位，从而提供一压力或压差阈值，在此阈值下阀门打开或开始打开，以增加通过血管的血流截面。压力阈值可以是一组连续(比如无限变化的)的压力点，在这些压力点，阀门打开或允许一根据该压力的压流。例如，在达到某一压力之前，阀门可保持闭合或者微微张开，然后在高于那个压力时不断地打开直到达到一更高压力，在该更高压力下阀门完全打开。要注意根据本发明的实施例，可使用不对称环432或其它不对称部件来得到与各种FRMs，DPRDs，分流管和/或仪器相类似的功能。
在一些实施例中，环431可以由合适的金属形成。在一些实施例中，环431可以结合在框架220内，或者环431与框架220可以采用整体的环-框部件来实现。环431和/或框架220可以由合适的线和管组成。环431和/或臂211-216可以由合适的线和管组成，例如，相同的线和管和/或相同的材料。
参见图5，其示意性说明了根据本发明实施例植入心脏109的DPRD401，其结合有打开状态的DPRD450。一压差可存在于左心房102和右心房103之间，例如左心房102的压力大于右心室103的压力。压差可以引起所述盘432朝着右心房103移动并使弹簧433弯曲，从而产生一个扩大的开口，通过这个开口更多的血液可从左心房102流向右心房103。随着血液流向右心房103，左心房102的压力会降低，同时右心房103的压力会升高，从而降低了左心房102和右心房103之间的压差，并且允许弹簧433朝着闭合或基本上闭合位置拉回盘432。也可以使用其它能够使盘432移动的设备。
图6示意性地说明了依照本发明另一个实施例的DPRD 650。DPRD650可以是FRM 108、FRM250或FRM350的一个例子。DPRD650可包括，例如环431和预先塑形的线634。线634可包括一柔性金属线，例如该金属线由镍钛诺或其它合适材料形成。在一种实施例中线634可以被弯曲成马蹄形、舌形或其它适合的形状。在一些实施例中，线634的末端可以与环431连接，或者线634和环431由相同的线、管或其它合适的材料形成。
线634可以通过或连接到一盖子或者板635的方式被覆盖，该盖子或板可包括，例如，一生物相容性材料的平板，该材料例如为与人工阀叶片一起使用的生物组织材料。板635可以采用例如一或多根缝合线636与线634相连。
DPRD 650包括在植入心脏内的DPRD 201或DPRD 301中。在左心房102和右心房间存在一压差，比如，左心房102的压力可大于右心室103。利用线634的弹性，该压差能够引起板635移动，从而形成一个内腔，血液可通过该内腔从左心房102流向右心房103。当血液以此方向流动时，左心房102的压力会降低，同时右心房103的压力会增加，从而降低了左心房102和右心房103之间的压差，并且允许板635朝向关闭或基本上关闭位置或朝向板635在边上打开的位置移动。
要注意的是，当左心房102和右心房103之间没有压差，或者压差相当小时，板635可能不完全阻塞穿过DPRD650，例如穿过板635周围，或板635和环431之间区域的血流。这可以，例如阻止在板635或DPRD之内和/或周围形成血液凝结和/或血栓。然而，如在此讨论的其它配置一样，在其它实施例中，开口或阀门可以在某一压差下完全关闭。
图7示意性说明了依照本发明另一个实施例的FRM750。FRM750可包括，例如采用一或多个弹簧738与锥体737相连接的环431。锥体737可以放在环431内，且可以例如由生物相容性材料制成，该生物相容性材料如，热解碳或不锈钢。锥体737可以有合适的形状，比如，矩形、方形、圆形、椭圆形、梯形、锥形或其它合适的形状。
FRM750可包括在植入心脏109中的分流管，例如，DPRD201或DPRD301中。弹簧738可包括一个或多个压缩弹簧，以及例如当左心房102和右心房103之间基本不存在压差时，将锥体737保持在环431内。
当左心房102和右心房103之间存在压差，比如，当左心房102的压力大于右心室103时，FRM750能允许血液从左心房102流向右房室103。该压差可以引起锥体737向弹簧738的反方向后退，从而打开或扩大了一个内腔，血液可穿过该内腔从左心房102流向右心房103。随着血液沿该方向流动，左心房102的压力会降低，同时右心房103的压力会增加，从而降低了左心房102和右心房103之间的压差，并且允许锥体737朝着关闭或基本上关闭位置退回。
要注意的是，当左心房102和右心房103之间没有压差，或者压差相当小时，锥体737可能不完全阻塞穿过FRM750，例如穿过FRM750周围，或FRM750和环431之间区域的血流。这样可以，例如阻止在锥体737或FRM750之内和/或周围形成血液凝结和/或血栓。
图8示意性说明了依照本发明另一个实施例的FRM850。FRM850可包括例如一与环431连接并放在其内的柔性阀门839。阀门839例如可由生物相容性材料制成，例如该生物相容性材料为聚亚胺酯或硅树脂。通过例如在环431内粘合或缝合阀门839的底部840，阀门839可与环431相连接。阀门839可包括一个或多个小叶片，例如，小叶片841与842能够移动并建立或扩大一个开口843。在一些实施例中，开口843的大小会与施加在小叶片841与842上的压力有关。
FRM850可包括在植入心脏109内的分流管、导管或管道例如，DPRD201或DPRD301中。当左心房102和右心房103之间存在压差，比如，当左心房102的压力大于右心室103时，FRM850能允许血液从左心房102流向右房室103。该压差可能延伸、展开或推动叶片841和/或842，从而增加它们之间的距离并且扩大了开口843，血液可通过该开口843从左心室102流向右心室103。随着血液沿该方向流动，左心房102的压力会降低，同时右心房103的压力会增加，并且允许叶片841和/或843朝着关闭或基本上关闭的位置退回。
要注意的是，当左心房102和右心房103之间没有压差，或者压差相当小时，阀门839、叶片841和843可能不完全阻塞穿过FRM850，例如穿过开口843的血流。这样可以，例如阻止在阀门839或FRM850之内和/或周围形成血液凝结和/或血栓。
图9示意性说明了根据本发明另一个实施例在心脏109内部的DPRD950。DPRD950可包括大量通过一个或多个管子内部相连的气囊或液囊，比如，一不柔软气囊943通过管子944与柔软气囊945相连接。不柔软气囊943可放在左心房102和/或刺孔内，而柔软气囊945可放在右心房103内。在一些实施例中，不柔软气囊943和/或柔软气囊945连接到一环(例如环431)。在一些实施例中，不柔软气囊943和/或柔软气囊945含有液体920。
液体920可以例如从气囊943流向气囊945或反之亦然，这与左心房102和右心房103之间的压差有关。举例而言，当左心室102的压力相对较大时，液体920可通过管子944从不柔软气囊943流向柔软气囊945，从而缩小了不柔软气囊943和膨胀了气囊945。要注意的是柔软气囊945比不柔软气囊943更柔软，从而允许柔软气囊945作为一弹簧装置来控制不柔软气囊943的缩小。
图10示意性说明了根据本发明另一个实施例的DPRD1050。DPRD1050可包括，例如环431和带有孔1047的柔性盘1046。在一些实施例中，孔1047可以是大体上圆形的并且位于例如大体上柔性盘1046中心的位置。柔性盘1046可例如由柔性聚合材料形成，例如硅橡胶或聚亚胺酯。
DPRD1050可以植入心脏109，孔1047可以随着左心房102和右心房103之间的压差而改变直径。例如，压差可以向后推或伸展柔性盘1046，从而扩大孔1047，同时允许血液可从左心房102穿过一较大区域流向右心房103。
要注意的是，当左心房102和右心房103之间没有压差，或者压差相当小时，孔1047仍可以打开并具有一相当小的直径，柔性盘1046不能完全阻止血液通过DPRD1050。这样可以，例如阻止在DPRD1050之内和/或周围形成血液凝结和/或血栓。
图11示意性说明了根据本发明另一个实施例的DPRD1150。DPRD1150可包括，例如一气囊或液囊1148，如象含有液体的不柔软气囊。气囊1148可放在或连接在环1131内，其可包括，例如类似于环431和/或框架的环。一管1149可将气囊1148连接到容器1155上，该容器可包括一或多个活塞1151，该活塞能够抵抗压缩弹簧1152而运动。弹簧1152例如可以由金属或合适的弹性材料构成。
DPRD1150可植入心脏109中，而气囊1148的体积可随着左心房102和右心房103之间的压差而改变。例如，该压差可以推动或缩小气囊1148，从而造成液体1120从气囊1148流向容器1155。这可以形成或扩大环1131内的开口，血液可以通过该开口从左心房102流到右心房103。
图12示意性说明了根据本发明另一个实施例的DPRD1250。DPRD1250可包括，例如气囊1148，如象含有液体的不柔软气囊。气囊1148可放在或连接在环1131内，其可包括，例如类似于环431和/或框架的环。一管1149可将气囊1148连接到容器1155上，该容器可包括一或多个能够运动的活塞1151。该活塞可以通过使用一发动机1153来运动，该发动机可包括一电动机，如步进电动机或其它合适的电动机。发动机1153可以移动、推或拉所述活塞1151，从而使液体1120从气囊1148流到容器1155，反之亦然。这可以改变气囊1148的体积，从而增大或减小环1131内的开口的尺度，通过该孔血液可以从左心房102流到右心房103。
根据本发明另一个实施例，可以例如通过病人或医疗服务提供者主动地控制DPRD1250。在一种实施例中DPRD可采用外部和/或人工提供的指令来进行操作。例如，发动机1153可根据外部和/或人工提供的指令运转。附带地或可替换地，发动机1153可根据左心房102和右心房103之间的压差来运转。例如可采用结合有一个或多个压力传感器1254的与压力有关的闭环1260。该压力传感器1254可测量一个或多个心内腔中，例如左心房102和右心房103的绝对压力，或者测量两心内腔之间，例如左心房102和右心房103之间的压力差。基于该压力信息，发动机1153可以运转并移动、推或拉所述活塞1151。
在另一个实施例中可以采用一个或多个电动机构、机械机构、无线机构、气动机构或其它合适的机构遥控操作DPRD。例如可将一金属线、线、弹簧、钉、电缆、钩、销、发动机或磁铁连接到DPRD以使得可由病人和/或医疗服务提供者遥控DPRD。如图13A所示，至少一根线或控制导线1320可以将DPRD1300连接到例如一控制盒的控制机构1310上。例如，控制导线1320可通过穿孔或孔1335从血管1330出来。控制机构1310可包括，例如一机械接口、电子接口、拉/推线，弹簧、磁铁或其它合适的元件或机构以使DPRD1300能被遥控。
控制机构1310可以是一个可放在外部或内部的微型机构，例如它可以放进病人皮下的组织中，以为医疗服务提供者提供一外通道，或者它可以内部地放在最接近于使医疗服务提供者用最小侵入技术就可进入的部位。
在一个实施例中，DPRD1300可以由以外部“发射”单元无线控制。例如控制信号可以在病人体外采用遥测，局部无线电频率(RF)发射，局部超声发射，外磁场，局部加热或其它合适的信号发生装置。在这种实施例中DPRD1300可包括一“接收”单元。该接收单元可包括一内部电源(如电池)，或可以从控制信号或其它所发射信号接收激励动力。该接收单元例如可经由一植入插头连接到一外电源，或者可直接连接到临时基地的DPRD1300(例如在医生办公室)，所植入的插头可转送指令信号和/或电源以启动DPRD 1300。
现在参见图13B，其表示被布置在皮肤表面1360下的控制机构1310的例子。在一个例子中，控制线1320可通过采用传统针或注射器1365，例如通过作一小切口进入病人来放入。可在外部或内部地控制一根或一些控制线1320以使得DPRD 1300能够被控制。在某些实施例中，一个(或一些)线1320可在管，例如在硅压管1370内操作。控制机构1310可包括例如一远程阀打开/关闭机构以使得能够监测心脏压力，监测DPRD功能等。在一种实施例中，控制机构1310可用于响应阀的位置来监测血流变化。控制机构1310可使得在临床需要的情况下，能够人工地减少心脏压力或某一内腔体或心脏中的血压。控制机构1310可以以选定间隔，通过例如增加内部血压或液体压力的方式冲洗或清洁DPRD1300。在另一个实施例中能够采用冲洗或清洁液，例如在选定压力下，食盐水可以进入控制导管1320而对所述孔口进行清洁或冲洗。这种清洁可以帮助减少与DPRD1300有关的不想要的生长、感染等。
控制机构1310可包覆一种或几种物质以防止血栓或其它病症。DPRD1300可包括尖、刺或其它结构以避免FRM与分流器完全接触或保证FRM与分流器之间只有最小接触。控制机构1310可使DPRD的多个部分能够远距离地被替换、清洁、维修或进行其它操作。控制机构1310可使预先配置或设计的漏洞能够根据临床需要而被远距离地打开、关闭或进行其它改变。控制机构1310能够阻塞DPRD的孔或内腔，例如通过远距离在孔内安放栓塞以终止DPRD的作用。上述的一种或多种性能可使得公共医疗卫生服务提供者能够远程控制DPRD1300的功能。
如图13C所示的实施例中，控制机构1310可包括可以用手指或其它合适器具控制的一或多个揿下旋钮1340或其它合适的控制器或机构。例如，多个揿下旋钮1340可单独、同时和/或以多种其它结合方式被揿下以在DPRD1300中达到所期望的效果。在一个实施例中控制机构1310可包括，例如一个或多个杆或导电体1350以帮助控制DPRD1300。在一个实施例中控制机构1310可包括，例如一个或多个安全机构1345，如锁定钮以帮助防止不需要的改变被加到DPRD1300的操作上。在另一个实施例中控制机构1310可包括，例如一个或多个与杆1350和DPRD1300连接的弹簧或其它合适的控制机构。
如图13D所示的实施例中，控制机构1310可用于控制DPRD1300，例如采用一个或多个杆或线1375等在管1370内可选择地操作。DPRD1300可包括一盖1377，例如柔性或非柔性盖，其例如可保持恒定微开，以形成一间隙1379。在一个实施例中，盖1377可由刚性材料构造并可以刚性方式被装配或连接到一锁定机构1380。一旦盖1377通过锁定机构1380一直固定在选定位置，那么它就保持稳定，例如不受血压变化的影响，直到盖1377重新定位。在这种情况下，盖1377只能用控制机构1310，如信号线，或其它合适的通讯线路通过有意识的和受控制的行动进行调整。
锁定机构1380可使盖1377遥控地被设置在一个或多个位置上。锁定机构1380可包括，例如一个或多个弹簧、插销、控制杆、凹口、槽、钩、滑轨或其它合适的锁定机构。例如位置#1可以是一较低位置，例如在此位置钩子1325固定在所示的抓钩机构1332上；位置#2可以是一中间位置，例如在此位置钩子1325固定在所示的抓钩机构1333上；位置#3可以是一较高位置，例如在此位置钩子1325固定在所示的抓钩机构1334上。也可采用其它的设置、开口大小、流动水平、位置和位置数目。控制机构1310可包括例如安全部件，以帮助防止未经授权人员启动DPRD1300(如特殊工具和磁铁，编码序列、密码等)。
如图13E所示的实施例中，控制机构1310可用于控制DPRD1300，例如采用辅助液力系统。控制机构1310例如可经由一个或多个管1390连接到该液力系统，上述管可帮助控制通过DPRD1390供给的液体的压力和/或流速。DPRD1390可在需要时连接到一液压系统，或者可永久地连接到一液压系统。在一个实施例中，管1390例如可增加DPRD1300的液体压力，以在分流器上或分流器内提供一显著的力。管1390可附加地或可替换地用于“维护”，例如通过迫使液体如经由分流器底部1392流过分流器，来冲洗、清洁和/或润滑分流器和/或FRM1396，和/或来释放EPRD的运动部件以便保持DPRD1300处于所需的运行条件或状态。在一个实施例中，一种物质(如盐溶液)可注射进所述管1390或从中进行抽取，以改变底部1392的压力并且从而使活塞膜1394活动起来。活塞膜1394可被伸展和/或扩大从而引起FRM1396动作起来，例如来打开和/或关闭FRM1396，以允许液体选择性地流过DPRD1300。管1390可被连接到管1320上(见图13A和13B)和/或与适合于穿刺进入病人皮肤与管1390连接的针头1366或其它器械相连。在一个实施例中，液压机构可以在DPRD1300放置到体内以后使用，例如来检验DPRD1300的可操作性。在另一个实施例中，液压机构可以在DPRD1300放置到体内后检查DPRD1300可操作性的时候使用。
要理解的是，本发明的某些实施例可采用例如一个或多个阈值、预定参数、条件和/或标准，以触发分流器、DPRD或FRM起作用或不起作用。
根据本发明的一实施例，可以采用各种植入一个装置的合适的技术。按照某些实施例，可采用最小侵入手术，例如采用经皮导入的方法将压力调节装置导入和植入病人体内。在这种实施例中，该装置可固定在一导管导入系统上并经由小切口插入身体。一旦该装置位于体内的正确部位，则它就可被操作者布置、扩大和锁定在合适位置。由导管传导的装置可以例如被收缩或折叠成小尺度，该装置在布置时可自张开。在另一个实施例中该压力调整装置可采用侵入性外科手术被导入，例如外科医生在体内作一较大开口以便实现与该装置植入部位更直接的接触。
在本发明的一实施例中，如2001年4月提交的，名称为“降低局部血液循环系统压力的方法和装置”的美国专利09/839643，特别是图3-5中所描述的，一组横膈膜针头可被推入右前房隔膜壁(Right atrial septum)。可以从股静脉制造一入口，同时该装置穿过下内腔静脉推进并进入右心房。一旦横膈膜穿刺已完成，则一引导线可交换针头部件，然后进入左心房。用横膈膜穿刺的方式将导管安装进入左心房的方法是本领域公知的。当横膈膜护套定位于左心房之后，如上所述，可以开始放置根据本发明的实施例所作的分流器。
扩张器和线可随后从该护套中抽回，该护套现在可以从病人腹股沟的股静脉入口点伸出来进入左心房、穿过股静脉、髂静脉、下内腔静脉、右心房和前房隔膜等。输送导管可以在荧光镜显影下穿过该护套。为了定位一些特殊的点可以在该导管以及护套上提供不透射线的标志物。输送导管可以小心地和缓慢地前进，因此左心房固定元件的最远部分从导管的远端开口被放出并进入左心房的内腔室。该固定元件可由类似弹簧的材料构成和/或可以是超弹性形状记忆合金，因此当它脱离该输送导管内部区域的限制时，它就变成预先设置的完全成形的形状。然后护套和输送导管的组件可缓慢地整体缩回以便朝着前房隔膜抽回固定元件。当通过荧光镜显影以及通过触觉反应很清楚该固定元件已靠着前房隔膜被固定时，医生可停止这种收回。在那个点，护套可单独被缩回，露出分流器并将其定位于前房隔膜内已形成的开口中。然后护套可进一步缩回，允许右前房的固定元件变成其完全成形的形状。整个分流器组件和DPRD可随后与输送导管系统分离。在输送导管内部该DPRD可通过长控制线进行控制，该控制线在导管区域内部有独立的移动控制。这种连接可通过任何传统方法来构成，如焊接或粘接，或者在规定张力水平下可机械地分离的类似方式进行连接，所述张力水平由医生在坚决收回该控制线的过程中被超过。DPRD和/或FRM的其它应用方法也可以采用。
现在参见图14，其示出了根据本发明的一些实施例，将DPRD和/或FRM输送到体内，例如左心房和右心房之间的心脏隔膜的方法。将一设备植入隔膜内可包括下列步骤中的一个或多个：a)识别用于植入的精确部位；b)将该设备对准所选定部位；和c)确保植入的精确性和完整性。理想的植入位置可以例如由专业医生通过使隔膜成像并分析隔膜的解剖结构(如用TEE)而进行选择。所述对准可包括采用“绘制”隔膜位置的已知工具识别该精确设备输送工具的位置。可将标记物加到该输送工具和设备(如金的标记物)。一旦已识别该位置并且已经配置该设备，专业医生可检查和测试该设备安装,可选择地在完全取回该输送系统之前进行。例如，专业医生可采用例如身体挑动(physically challenging)的直接接触或拉整个设备(如通过轻拉该设备以确保正确地锚定)。该锚定可通过非接触装置来测试(如采用电磁成像、回波、X-线，用造影材料的血管造影术等)。
在框140，可采用例如导管将DPRD植入体内两个或多个室、内腔、器官、区域、带等之间。在框141，FRM可配置在例如所选定部位或位置以使在两个或多个内腔之间能够有一连续的液流，并且可根据这些内腔之间压力差的变化而选择性地起作用或不起作用。在框142，FRM例如可响应于这些内腔之间压力差的变化而被控制(如被动地)，FRM可响应压力的变化被进一步地打开和/或关闭。可选择地，在框143，DPRD和/或FRM可被遥控以帮助控制这些内腔之间的液流。在某些实施例中，DPRD和/或FRM的遥控能够清洁DPRD和/或FRM、使DPRD和/或FRM功能停止、改变DPRD和/或FRM的部件等。上述步骤中的任意组合可以被实现。进一步地，可以采用其它一些步骤或步骤系列。
为了说明和描述的目的，已经介绍了前面所述的本发明的这些实施例。这并不意味着是穷举或将本发明限制为所精确公开的方式。本领域技术人员应该认识到根据上述的教导有可能存在许多改进、变形、替代或变化以及等价物。因此要理解的是，所附的权利要求书意图包括所有在本发明真实精神内的这样的改进和变型。

Claims (11)

1.一种用于心脏的装置，包括：
一具有两个端的分流器，所述分流器适合于以这样的方式被定位于心脏的左心房和右心房之间的前房隔膜中，使得经由分流器从左心房到右心房能够进行液流，而每端各自面对相应的心房；和
一被动控制的流量调节机构，适合于通过相对于心脏的左心房和右心房之间压力差的变化调整通过所述分流器的液流横截面积，来调整通过所述分流器的液流，该被动控制的流量调节机构位于分流器的被构造成用于植入右心房的一端部，从而当植入该装置时，被动控制的流量调节机构完全处于右心房内并且与前房隔膜分隔开。
2.如权利要求1的装置，其中所述流量调节机构还适合于响应穿过所述流量调节机构的压力差而打开或关闭。
3.如权利要求1或2的装置，其中流量调节机构适合于相对于压力差的变化而选择性地改变液流横截面积的尺寸或形状或者改变允许流经其的血液量。
4.如权利要求1或2的装置，其中在达到一压力差阈值之前，所述流量调节机构适合于保持闭合或者微微张开，然后在高于该压力差阈值时不断地打开直到达到一更高压力差，在该更高压力下流量调节机构完全打开。
5.如权利要求4的装置，其中压力差阈值大致为12mmHg。
6.如权利要求1或2的装置，其中所述流量调节机构连续地允许通过所述分流器的液流。
7.如权利要求1或2的装置，其中所述流量调节机构包括一双向阀。
8.如权利要求1或2的装置，其中所述流量调节机构包括一个盘，所述盘适合于从分流器具有高压的一端移开，允许液流从高压端流向低压端。
9.如权利要求1或2的装置，其中所述分流器包括固定架、环或管。
10.如权利要求1的装置，其中流量调节机构被预配置，以根据心脏的左心房和右心房之间压力差的变化而调整其配置。
11.如权利要求1的装置，其中流量调节机构包括一个或多个有角度的柔性膜或叶状物。
CN201510226589.1A 2004-02-03 2005-02-03 用于控制体内压力的装置和方法 Active CN104971390B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54126704P 2004-02-03 2004-02-03
US60/541,267 2004-02-03
US57337804P 2004-05-24 2004-05-24
US60/573,378 2004-05-24
CNA2005800107351A CN101415452A (zh) 2004-02-03 2005-02-03 用于控制体内压力的装置和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800107351A Division CN101415452A (zh) 2004-02-03 2005-02-03 用于控制体内压力的装置和方法

Publications (2)

Publication Number Publication Date
CN104971390A true CN104971390A (zh) 2015-10-14
CN104971390B CN104971390B (zh) 2018-03-16

Family

ID=34841124

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510226589.1A Active CN104971390B (zh) 2004-02-03 2005-02-03 用于控制体内压力的装置和方法

Country Status (8)

Country Link
US (13) US20050148925A1 (zh)
EP (1) EP1771132B1 (zh)
JP (1) JP2007527742A (zh)
CN (1) CN104971390B (zh)
AU (1) AU2005211243A1 (zh)
CA (1) CA2554595C (zh)
ES (1) ES2725721T3 (zh)
WO (1) WO2005074367A2 (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105709286A (zh) * 2016-01-18 2016-06-29 暨南大学 与双心室体外辅助循环血泵室配套使用的无级调控装置
CN107106749A (zh) * 2015-01-07 2017-08-29 恩莫德斯有限公司 用于在血液和气体/混合气之间进行物质交换的装置
CN108030483A (zh) * 2017-12-06 2018-05-15 深圳市星河泉新材料有限公司五金配件分厂 一种加压结构、血压检测模块以及血压智能检测设备
WO2019015617A1 (zh) * 2017-07-18 2019-01-24 杭州诺生医疗科技有限公司 一种适用于心房间的压力调节装置
CN110168626A (zh) * 2016-11-14 2019-08-23 米兰综合工科大学 用于模拟心脏手术和/或介入式心脏病手术和/或过程的测试台组件
CN110402113A (zh) * 2017-01-11 2019-11-01 维兰德.K.沙马 心脏分流装置和输送系统
CN112971876A (zh) * 2021-05-14 2021-06-18 上海心瑞医疗科技有限公司 一种心房分流装置
CN113694277A (zh) * 2021-08-18 2021-11-26 苏州才豪电子科技有限公司 一种多级调压式血液滤过装置

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119737A1 (en) * 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US8091556B2 (en) 2001-04-20 2012-01-10 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
US20050148925A1 (en) 2001-04-20 2005-07-07 Dan Rottenberg Device and method for controlling in-vivo pressure
US20030225439A1 (en) * 2002-05-31 2003-12-04 Cook Alonzo D. Implantable product with improved aqueous interface characteristics and method for making and using same
IL154531A (en) * 2003-02-19 2006-04-10 Yair Tal Method and system for regulating blood flow
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US8086315B2 (en) 2004-02-12 2011-12-27 Asap Medical, Inc. Cardiac stimulation apparatus and method for the control of hypertension
US20060206049A1 (en) * 2005-03-14 2006-09-14 Rodgers M S MEMS flow module with piston-type pressure regulating structure
US7384550B2 (en) * 2004-02-24 2008-06-10 Becton, Dickinson And Company Glaucoma implant having MEMS filter module
US20060036207A1 (en) * 2004-02-24 2006-02-16 Koonmen James P System and method for treating glaucoma
US7226540B2 (en) * 2004-02-24 2007-06-05 Becton, Dickinson And Company MEMS filter module
US7544176B2 (en) * 2005-06-21 2009-06-09 Becton, Dickinson And Company Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation
US7364564B2 (en) * 2004-03-02 2008-04-29 Becton, Dickinson And Company Implant having MEMS flow module with movable, flow-controlling baffle
US20060173399A1 (en) * 2005-02-01 2006-08-03 Rodgers M S MEMS flow module with pivoting-type baffle
US20060219627A1 (en) * 2005-03-31 2006-10-05 Rodgers M S MEMS filter module with concentric filtering walls
WO2005082025A2 (en) * 2004-02-25 2005-09-09 Wolf Erich W System for transcutaneous monitoring of intracranial pressure (icp) using near infrared (nir) telemetry
US8057422B2 (en) * 2004-02-25 2011-11-15 Wolf Ii Erich W Transcutaneous telemetry of cerebrospinal fluid shunt programmable-valve pressure using near-infrared (NIR) light
US8165674B2 (en) 2005-03-02 2012-04-24 Backbeat Medical, Inc. Methods and apparatus to increase secretion of endogenous naturetic hormones
US9681948B2 (en) * 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US8758333B2 (en) 2006-04-04 2014-06-24 The Spectranetics Corporation Laser-assisted guidewire having a variable stiffness shaft
CN101466299B (zh) * 2006-04-26 2011-11-02 东弗吉尼亚医学院 用于监视和控制眼睛或身体部分的内部压力的系统
US7869874B2 (en) 2006-09-25 2011-01-11 G&L Consulting, Llc Methods and apparatus to stimulate heart atria
US10413284B2 (en) 2006-11-07 2019-09-17 Corvia Medical, Inc. Atrial pressure regulation with control, sensing, monitoring and therapy delivery
US8882697B2 (en) 2006-11-07 2014-11-11 Dc Devices, Inc. Apparatus and methods to create and maintain an intra-atrial pressure relief opening
US10624621B2 (en) * 2006-11-07 2020-04-21 Corvia Medical, Inc. Devices and methods for the treatment of heart failure
US8745845B2 (en) 2006-11-07 2014-06-10 Dc Devices, Inc. Methods for mounting a prosthesis onto a delivery device
US20110257723A1 (en) 2006-11-07 2011-10-20 Dc Devices, Inc. Devices and methods for coronary sinus pressure relief
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US8460372B2 (en) 2006-11-07 2013-06-11 Dc Devices, Inc. Prosthesis for reducing intra-cardiac pressure having an embolic filter
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US8979828B2 (en) 2008-07-21 2015-03-17 The Spectranetics Corporation Tapered liquid light guide
US9421065B2 (en) 2008-04-02 2016-08-23 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US8340763B2 (en) 2008-09-08 2012-12-25 Backbeat Medical, Inc. Methods and apparatus to stimulate heart atria
WO2010042058A1 (en) 2008-10-10 2010-04-15 Milux Holding S.A. An improved artificial valve
US8900177B2 (en) * 2009-03-13 2014-12-02 Stanley Batiste Self adjusting venous equalizing graft
US8460168B2 (en) * 2009-03-27 2013-06-11 Circulite, Inc. Transseptal cannula device, coaxial balloon delivery device, and methods of using the same
CA2760207C (en) * 2009-04-28 2014-08-12 Dc Devices, Inc. Devices, systems and methods to treat heart failure
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US20230285133A1 (en) * 2009-05-04 2023-09-14 V-Wave Ltd. Shunt for redistributing atrial blood volume
US20210161637A1 (en) 2009-05-04 2021-06-03 V-Wave Ltd. Shunt for redistributing atrial blood volume
EP2427143B1 (en) * 2009-05-04 2017-08-02 V-Wave Ltd. Device for regulating pressure in a heart chamber
US10076403B1 (en) * 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US8956389B2 (en) 2009-06-22 2015-02-17 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US9642993B2 (en) 2011-12-22 2017-05-09 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having selectable flow rates
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
US8715300B2 (en) * 2009-12-05 2014-05-06 Integrated Sensing Systems, Inc. Delivery system, method, and anchor for medical implant placement
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
CA2785041A1 (en) 2010-01-29 2011-08-04 Dc Devices, Inc. Devices and methods for reducing venous pressure
US20110224785A1 (en) 2010-03-10 2011-09-15 Hacohen Gil Prosthetic mitral valve with tissue anchors
US8398610B2 (en) * 2010-04-13 2013-03-19 Medtronic Vascular, Inc. Catheter with distensible and frangible cap
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9247942B2 (en) 2010-06-29 2016-02-02 Artventive Medical Group, Inc. Reversible tubal contraceptive device
WO2012002944A1 (en) 2010-06-29 2012-01-05 Artventive Medical Group, Inc. Reducing flow through a tubular structure
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9149277B2 (en) 2010-10-18 2015-10-06 Artventive Medical Group, Inc. Expandable device delivery
US9457186B2 (en) 2010-11-15 2016-10-04 Bluewind Medical Ltd. Bilateral feedback
US11083870B2 (en) 2011-04-11 2021-08-10 The Spectranetics Corporation Hypotube based support catheter
US9162038B2 (en) 2011-04-11 2015-10-20 The Spectranetics Corporation Needle and guidewire holder
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
US11135054B2 (en) 2011-07-28 2021-10-05 V-Wave Ltd. Interatrial shunts having biodegradable material, and methods of making and using same
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8852272B2 (en) * 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US8855783B2 (en) 2011-09-09 2014-10-07 Enopace Biomedical Ltd. Detector-based arterial stimulation
US8923973B2 (en) 2011-11-10 2014-12-30 Rainbow Medical Ltd. Blood flow control element
US9386991B2 (en) 2012-02-02 2016-07-12 Rainbow Medical Ltd. Pressure-enhanced blood flow treatment
US9005155B2 (en) 2012-02-03 2015-04-14 Dc Devices, Inc. Devices and methods for treating heart failure
US10588611B2 (en) 2012-04-19 2020-03-17 Corvia Medical Inc. Implant retention attachment and method of use
US8858491B2 (en) * 2012-05-23 2014-10-14 Alcon Research, Ltd. Pre-biased membrane valve
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9649480B2 (en) 2012-07-06 2017-05-16 Corvia Medical, Inc. Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
US9008769B2 (en) 2012-12-21 2015-04-14 Backbeat Medical, Inc. Methods and systems for lowering blood pressure through reduction of ventricle filling
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US8984733B2 (en) 2013-02-05 2015-03-24 Artventive Medical Group, Inc. Bodily lumen occlusion
US9095344B2 (en) 2013-02-05 2015-08-04 Artventive Medical Group, Inc. Methods and apparatuses for blood vessel occlusion
US9775636B2 (en) 2013-03-12 2017-10-03 Corvia Medical, Inc. Devices, systems, and methods for treating heart failure
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP2999412B1 (en) 2013-05-21 2020-05-06 V-Wave Ltd. Apparatus for delivering devices for reducing left atrial pressure
US10149968B2 (en) 2013-06-14 2018-12-11 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
US9636116B2 (en) 2013-06-14 2017-05-02 Artventive Medical Group, Inc. Implantable luminal devices
US9737308B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
US9737306B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Implantable luminal devices
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
ITBS20130176A1 (it) * 2013-11-25 2015-05-26 Corrado Tamburino Dispositivo e sistema endoluminale per la creazione di un flusso ematico bidirezionale per il trattamento dell'insufficienza cardiaca
KR102323562B1 (ko) * 2013-12-19 2021-11-09 백비트 메디컬 인크 심방 압력을 조절하여 혈압을 조절하는 방법 및 시스템
US10675450B2 (en) 2014-03-12 2020-06-09 Corvia Medical, Inc. Devices and methods for treating heart failure
US10363043B2 (en) 2014-05-01 2019-07-30 Artventive Medical Group, Inc. Treatment of incompetent vessels
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9814483B2 (en) 2014-06-13 2017-11-14 InterShunt Technologies, Inc. Method and catheter for creating an interatrial aperture
US10993735B2 (en) 2014-06-13 2021-05-04 InterShunt Technologies, Inc. Method and catheter for creating an interatrial aperture
US11369405B2 (en) 2014-06-13 2022-06-28 InterShunt Technologies, Inc. Method and septostomy device for creating an interatrial aperture
US20160270810A1 (en) 2014-06-13 2016-09-22 InterShunt Technologies, Inc. Method and catheter for creating an interatrial aperture
US10667931B2 (en) * 2014-07-20 2020-06-02 Restore Medical Ltd. Pulmonary artery implant apparatus and methods of use thereof
CA2955389C (en) 2014-07-23 2023-04-04 Corvia Medical, Inc. Devices and methods for treating heart failure
WO2016016899A1 (en) 2014-07-30 2016-02-04 Mitraltech Ltd. Articulatable prosthetic valve
US20170274128A1 (en) * 2014-12-16 2017-09-28 Corrado TAMBURINO Pumping systems, endoluminal devices and systems for creating two-way blood flow
EP3244940B1 (en) 2015-01-15 2018-12-19 Rainbow Medical Ltd. Pump for right atrium
WO2016126921A1 (en) * 2015-02-04 2016-08-11 Boston Scientific Scimed, Inc. A novel concept to reduce left atrial pressure in systolic and diastolic hf patients to treat pulmonary edema and reduce hospitalization rates
CA3162308A1 (en) 2015-02-05 2016-08-11 Cardiovalve Ltd. Prosthetic valve with axially-sliding frames
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US10940296B2 (en) 2015-05-07 2021-03-09 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Temporary interatrial shunts
US20160338706A1 (en) * 2015-05-20 2016-11-24 Edwards Lifesciences Corporation Atrial septal closure device for re-access
US10342982B2 (en) 2015-09-11 2019-07-09 Backbeat Medical, Inc. Methods and systems for treating cardiac malfunction
US9789294B2 (en) 2015-10-07 2017-10-17 Edwards Lifesciences Corporation Expandable cardiac shunt
WO2017106713A1 (en) 2015-12-18 2017-06-22 Boston Scientific Scimed, Inc. Heart tissue anchors
DE202017007326U1 (de) 2016-01-29 2020-10-20 Neovasc Tiara Inc. Klappenprothese zum Verhindern einer Abflussobstruktion
US10265059B2 (en) * 2016-02-04 2019-04-23 Edwards Lifesciences Corporation Trans-septal closure and port device
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10813644B2 (en) 2016-04-01 2020-10-27 Artventive Medical Group, Inc. Occlusive implant and delivery system
US10485658B2 (en) 2016-04-22 2019-11-26 Backbeat Medical, Inc. Methods and systems for controlling blood pressure
CN105997158B (zh) * 2016-05-06 2018-10-12 广州新诚生物科技有限公司 一种心脏缺损封堵器
US10835394B2 (en) 2016-05-31 2020-11-17 V-Wave, Ltd. Systems and methods for making encapsulated hourglass shaped stents
US20170340460A1 (en) 2016-05-31 2017-11-30 V-Wave Ltd. Systems and methods for making encapsulated hourglass shaped stents
US11304698B2 (en) 2016-07-25 2022-04-19 Virender K. Sharma Cardiac shunt device and delivery system
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US11771434B2 (en) 2016-09-28 2023-10-03 Restore Medical Ltd. Artery medical apparatus and methods of use thereof
USD810941S1 (en) 2016-10-06 2018-02-20 Edwards Lifesciences Corporation Cardiac shunt
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. METHODS AND SYSTEMS FOR RAPID RETRACTION OF A TRANSCATHETER HEART VALVE DELIVERY SYSTEM
AU2018228451B2 (en) * 2017-03-03 2022-12-08 V-Wave Ltd. Shunt for redistributing atrial blood volume
US11291807B2 (en) 2017-03-03 2022-04-05 V-Wave Ltd. Asymmetric shunt for redistributing atrial blood volume
WO2018217919A1 (en) * 2017-05-23 2018-11-29 Harmony Development Group, Inc. Tethered implantable device having an apical base plate with a hydraulic intracardiac adjusting mechanism
EP3624704A4 (en) 2017-06-05 2021-03-10 Restore Medical Ltd DOUBLE WALL FIXED LENGTH ENDOPROTHESIS DEVICE AND ITS PROCEDURES FOR USE
US10940002B2 (en) 2017-06-28 2021-03-09 Harmony Development Group, Inc. Force transducting inflatable implant system including a dual force annular transduction implant
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
WO2019036810A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT
DE102017125600A1 (de) * 2017-11-02 2019-05-02 Universität Zu Lübeck Steuerbarer interatrialer kathetergestützter temporärer rechts-links Shunt zur Entlastung des rechten Ventrikels
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
US10898698B1 (en) 2020-05-04 2021-01-26 V-Wave Ltd. Devices with dimensions that can be reduced and increased in vivo, and methods of making and using the same
US11744589B2 (en) 2018-01-20 2023-09-05 V-Wave Ltd. Devices and methods for providing passage between heart chambers
US11458287B2 (en) 2018-01-20 2022-10-04 V-Wave Ltd. Devices with dimensions that can be reduced and increased in vivo, and methods of making and using the same
US11167122B2 (en) 2018-03-05 2021-11-09 Harmony Development Group, Inc. Force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
DE102018114856A1 (de) * 2018-06-20 2019-12-24 Fresenius Medical Care Deutschland Gmbh Implantat zur Bereitstellung eines Shunts mit verstellbarem Durchfluss
JP2022501113A (ja) * 2018-09-19 2022-01-06 エヌエックスティー バイオメディカル, エルエルシーNxt Biomedical, Llc 生物学的構造の腔と管との間の接続およびシャントを形成するための方法および技術
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
EP3886761A1 (en) 2018-11-29 2021-10-06 V-Wave Ltd. Systems and methods for making encapsulated hourglass shaped stents
JP2022514517A (ja) 2018-12-13 2022-02-14 エヌエックスティー バイオメディカル，エルエルシー 血液酸素化治療方法および装置
AU2019404588B2 (en) 2018-12-21 2022-12-15 W. L. Gore & Associates, Inc. Implantable medical device with adjustable blood flow
CN113677298A (zh) 2019-02-06 2021-11-19 Inqb8医疗科技有限责任公司 心内左心房以及双支持系统
CN114025716A (zh) 2019-02-07 2022-02-08 Nxt生物医疗有限责任公司 铆钉分流器和部署方法
WO2020198694A1 (en) * 2019-03-28 2020-10-01 Shifamed Holdings, Llc Implantable sensors and associated systems and methods
EP3946163A4 (en) 2019-04-01 2022-12-21 Neovasc Tiara Inc. ADJUSTABLE VALVE PROSTHESIS
US11612385B2 (en) 2019-04-03 2023-03-28 V-Wave Ltd. Systems and methods for delivering implantable devices across an atrial septum
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020215090A1 (en) * 2019-04-18 2020-10-22 NXT Biomedical Temporary shunt for post-operative atrial fibrillation
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
US11865282B2 (en) * 2019-05-20 2024-01-09 V-Wave Ltd. Systems and methods for creating an interatrial shunt
EP3986331A4 (en) * 2019-06-18 2023-06-21 Shifamed Holdings, LLC ADJUSTABLE INTERAURICULAR SHUNTS AND RELATED SYSTEMS AND METHODS
AU2020295566B2 (en) 2019-06-20 2023-07-20 Neovasc Tiara Inc. Low profile prosthetic mitral valve
US20220249285A1 (en) 2019-07-08 2022-08-11 Shifamed Holdings, Llc Treatment systems with adjustable flow shunts and sensors, and associated devices and methods
CN114667117A (zh) 2019-09-09 2022-06-24 施菲姆德控股有限责任公司 可调整分流器和相关联的系统和方法
JP2023504548A (ja) * 2019-12-05 2023-02-03 シファメド・ホールディングス・エルエルシー 植込み式シャントシステム及び方法
US20230118243A1 (en) * 2020-02-05 2023-04-20 Shifamed Holdings, Llc Intracardiac pressure sensor with clip structure
WO2021212011A2 (en) * 2020-04-16 2021-10-21 Shifamed Holdings, Llc Adjustable interatrial devices, and associated systems and methods
EP4138649A4 (en) 2020-04-23 2024-04-17 Shifamed Holdings Llc INTRACARDIAC SENSORS WITH SWITCHABLE CONFIGURATIONS AND RELATED SYSTEMS AND METHODS
US11395910B2 (en) 2020-05-20 2022-07-26 Rainbow Medical Ltd. Passive pump
US11219754B2 (en) 2020-05-20 2022-01-11 Rainbow Medical Ltd. Passive pump
EP4203847A4 (en) 2020-08-25 2024-02-28 Shifamed Holdings Llc ADJUSTABLE IN-EAR SHUNTS, AND RELATED SYSTEMS AND METHODS
CN116723800A (zh) * 2020-11-02 2023-09-08 瑞科罗斯有氧运动公司 闭塞装置
EP4243915A1 (en) 2020-11-12 2023-09-20 Shifamed Holdings, LLC Adjustable implantable devices and associated methods
US11234702B1 (en) 2020-11-13 2022-02-01 V-Wave Ltd. Interatrial shunt having physiologic sensor
US20230099881A1 (en) * 2021-09-27 2023-03-30 Medtronic, Inc. Interatrial shunting devices, systems and methods
US11484700B1 (en) 2021-10-25 2022-11-01 Yossi Gross Mechanical treatment of heart failure
US11357629B1 (en) 2021-10-25 2022-06-14 Rainbow Medical Ltd. Diastolic heart failure treatment
WO2023144778A1 (en) 2022-01-28 2023-08-03 V-Wave Ltd. Interatrial shunt having physiologic sensor
WO2023166447A1 (en) * 2022-03-02 2023-09-07 Revascardio Ltd. Devices, systems, and methods for revascularization of the myocardium
US11813386B2 (en) 2022-04-14 2023-11-14 V-Wave Ltd. Interatrial shunt with expanded neck region
US11883030B2 (en) 2022-04-29 2024-01-30 inQB8 Medical Technologies, LLC Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature
GB2621355A (en) * 2022-08-09 2024-02-14 Imperial College Innovations Ltd Fail safe interatrial shunt device

Family Cites Families (389)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3852334A (en) 1973-12-17 1974-12-03 American Cyanamid Co Substituted carbazic acid esters
US3952334A (en) 1974-11-29 1976-04-27 General Atomic Company Biocompatible carbon prosthetic devices
FR2550583B1 (fr) * 1983-08-08 1986-03-28 Delecroix Michel Dispositif de regulation d'une pompe
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US4484955A (en) 1983-12-12 1984-11-27 Hochstein Peter A Shape memory material and method of treating same
US4617932A (en) 1984-04-25 1986-10-21 Elliot Kornberg Device and method for performing an intraluminal abdominal aortic aneurysm repair
US4705507A (en) * 1984-05-02 1987-11-10 Boyles Paul W Arterial catheter means
US4601309A (en) * 1985-04-23 1986-07-22 The United States Of America As Represented By The United States Department Of Energy Valve and dash-pot assembly
JPS63238872A (ja) 1987-03-25 1988-10-04 テルモ株式会社 管状器官内腔の内径確保用器具
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
JPS6446477A (en) 1987-08-13 1989-02-20 Terumo Corp Catheter
US4979955A (en) * 1988-06-06 1990-12-25 Smith Robert M Power assisted prosthetic heart valve
US4988339A (en) 1988-12-30 1991-01-29 Vadher Dinesh L Retractable needle/syringe devices for blood collection, catheterization, and medicinal injection procedures
US4995857A (en) * 1989-04-07 1991-02-26 Arnold John R Left ventricular assist device and method for temporary and permanent procedures
US5186431A (en) 1989-09-22 1993-02-16 Yehuda Tamari Pressure sensitive valves for extracorporeal circuits
US5035706A (en) 1989-10-17 1991-07-30 Cook Incorporated Percutaneous stent and method for retrieval thereof
US5267940A (en) * 1989-11-29 1993-12-07 The Administrators Of The Tulane Educational Fund Cardiovascular flow enhancer and method of operation
US5221261A (en) 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5035702A (en) 1990-06-18 1991-07-30 Taheri Syde A Method and apparatus for providing an anastomosis
US5234447A (en) 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US5197978B1 (en) 1991-04-26 1996-05-28 Advanced Coronary Tech Removable heat-recoverable tissue supporting device
BR9206005A (pt) 1991-05-16 1994-08-02 Mures Cardiovascular Research Válvula cardíaca, processo para formar uma válvula cardiaca artificial, tecido flexível para a formação de uma válvula cardíaca, e, conjunto para formar membranas trapezoidais de pericárdio para a formação de uma válvula cardiaca
US5584803A (en) * 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
JP3393383B2 (ja) 1992-01-21 2003-04-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 中隔欠損閉鎖装置
US5578008A (en) 1992-04-22 1996-11-26 Japan Crescent, Inc. Heated balloon catheter
WO1993022986A1 (en) 1992-05-08 1993-11-25 Schneider (Usa) Inc. Esophageal stent and delivery tool
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5290227A (en) 1992-08-06 1994-03-01 Pasque Michael K Method of implanting blood pump in ascending aorta or main pulmonary artery
US5312341A (en) 1992-08-14 1994-05-17 Wayne State University Retaining apparatus and procedure for transseptal catheterization
US5429144A (en) * 1992-10-30 1995-07-04 Wilk; Peter J. Coronary artery by-pass method
US5409019A (en) 1992-10-30 1995-04-25 Wilk; Peter J. Coronary artery by-pass method
US5326374A (en) * 1992-12-01 1994-07-05 Michael N. Ilbawi Body-implantable device for controlling the size of a fluid passageway
US5713950A (en) 1993-11-01 1998-02-03 Cox; James L. Method of replacing heart valves using flexible tubes
US5531759A (en) 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5597377A (en) 1994-05-06 1997-01-28 Trustees Of Boston University Coronary sinus reperfusion catheter
WO1995031945A1 (en) 1994-05-19 1995-11-30 Scimed Life Systems, Inc. Improved tissue supporting devices
ES2239322T3 (es) 1994-06-27 2005-09-16 Bard Peripheral Vascular, Inc. Politetrafluoretileno radialmente expandible y stents endovasculares expandibles formados con esta materia.
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5725552A (en) 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5545210A (en) 1994-09-22 1996-08-13 Advanced Coronary Technology, Inc. Method of implanting a permanent shape memory alloy stent
US5989244A (en) 1994-11-15 1999-11-23 Gregory; Kenton W. Method of use of a sheet of elastin or elastin-based material
NL9500147A (nl) 1995-01-26 1996-09-02 Industrial Res Bv Werkwijze voor het uit foliemateriaal vervaardigen van een hulsvormige stent, en stent verkregen onder toepassing van deze werkwijze.
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5904697A (en) * 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6451047B2 (en) 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
US6039755A (en) 1997-02-05 2000-03-21 Impra, Inc., A Division Of C.R. Bard, Inc. Radially expandable tubular polytetrafluoroethylene grafts and method of making same
US6579314B1 (en) 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
US6124523A (en) 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
US6264684B1 (en) 1995-03-10 2001-07-24 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Helically supported graft
WO1996029957A1 (en) 1995-03-29 1996-10-03 CV DYNAMICS, INC., doing business as MEDICAL INCORPORATED Bileaflet heart valve
EP0819014B1 (en) 1995-03-30 2003-02-05 Heartport, Inc. Endovascular cardiac venting catheter
US5556386A (en) * 1995-04-03 1996-09-17 Research Medical, Inc. Medical pressure relief valve
US6027518A (en) 1995-05-30 2000-02-22 Gaber; Benny Seizing instrument
US5662711A (en) * 1995-06-07 1997-09-02 Douglas; William Flow adjustable artery shunt
US6214039B1 (en) 1995-08-24 2001-04-10 Impra, Inc., A Subsidiary Of C. R. Bard, Inc. Covered endoluminal stent and method of assembly
US6562052B2 (en) 1995-08-24 2003-05-13 Sutura, Inc. Suturing device and method
US6117144A (en) 1995-08-24 2000-09-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
US5702412A (en) * 1995-10-03 1997-12-30 Cedars-Sinai Medical Center Method and devices for performing vascular anastomosis
US5779716A (en) 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
IL125416A0 (en) 1996-02-02 1999-03-12 Transvascular Inc Methods and apparatus for connecting openings formed in adjacent blood vessels or other anatomical structures
US6039759A (en) * 1996-02-20 2000-03-21 Baxter International Inc. Mechanical prosthetic valve with coupled leaflets
US5810836A (en) 1996-03-04 1998-09-22 Myocardial Stents, Inc. Device and method for trans myocardial revascularization (TMR)
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5655548A (en) 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US6447539B1 (en) * 1996-09-16 2002-09-10 Transvascular, Inc. Method and apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion
US6086610A (en) 1996-10-22 2000-07-11 Nitinol Devices & Components Composite self expanding stent device having a restraining element
US6165188A (en) 1996-12-02 2000-12-26 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having controlled cutting depth and methods of use
JP2001505807A (ja) * 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション 人工血管弁
CN1626048B (zh) 1997-01-24 2012-09-12 帕拉贡知识产权有限责任公司 具有双稳态弹簧结构的可膨胀的装置
US6111520A (en) 1997-04-18 2000-08-29 Georgia Tech Research Corp. System and method for the wireless sensing of physical properties
US5795307A (en) * 1997-04-29 1998-08-18 Krueger; John A. Shunt tap apparatus and method
US5957949A (en) * 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
JP2000514958A (ja) 1997-05-16 2000-11-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ シリコンゲルマニウム半導体デバイスとその製造方法
JP3645399B2 (ja) 1997-06-09 2005-05-11 住友金属工業株式会社 血管内ステント
US6120534A (en) 1997-10-29 2000-09-19 Ruiz; Carlos E. Endoluminal prosthesis having adjustable constriction
US5910144A (en) 1998-01-09 1999-06-08 Endovascular Technologies, Inc. Prosthesis gripping system and method
US6589198B1 (en) * 1998-01-29 2003-07-08 David Soltanpour Implantable micro-pump assembly
AU1923999A (en) 1998-01-30 1999-08-16 Vascular Science Inc. Medical graft connector or plug structures, and methods of making and installingsame
US6638303B1 (en) * 1998-03-13 2003-10-28 Carbomedics, Inc. Heart valve prosthesis
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6278379B1 (en) 1998-04-02 2001-08-21 Georgia Tech Research Corporation System, method, and sensors for sensing physical properties
US7083588B1 (en) 1998-05-26 2006-08-01 Medtronic Vascular, Inc. Apparatus for providing coronary retroperfusion and methods of use
US5941850A (en) 1998-06-29 1999-08-24 Shah; Binod Safety cannula
GB9816173D0 (en) * 1998-07-25 1998-09-23 Huntleigh Technology Plc Pneumatic systems
US7169160B1 (en) 1998-07-28 2007-01-30 Medtronic, Inc. Device for anchoring tubular element
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US6406488B1 (en) * 1998-08-27 2002-06-18 Heartstent Corporation Healing transmyocardial implant
US7118600B2 (en) 1998-08-31 2006-10-10 Wilson-Cook Medical, Inc. Prosthesis having a sleeve valve
EP1112043B1 (en) * 1998-09-10 2006-04-05 Percardia, Inc. Tmr shunt
US6641610B2 (en) 1998-09-10 2003-11-04 Percardia, Inc. Valve designs for left ventricular conduits
US6254564B1 (en) * 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
EP1726271B1 (en) 1998-09-30 2012-07-25 Bard Peripheral Vascular, Inc. Selective adherence of stentgraft coverings, mandrel and method of making stent-graft device
US6547814B2 (en) 1998-09-30 2003-04-15 Impra, Inc. Selective adherence of stent-graft coverings
DE19855422A1 (de) * 1998-12-01 2000-06-08 Basf Ag Hartstoff-Sinterformteil mit einem nickel- und kobaltfreien, stickstoffhaltigen Stahl als Binder der Hartstoffphase
US6217541B1 (en) 1999-01-19 2001-04-17 Kriton Medical, Inc. Blood pump using cross-flow principles
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
WO2000050100A1 (en) 1999-02-26 2000-08-31 Advanced Cardiovascular Systems, Inc. Composite super elastic/shape memory alloy and malleable alloy stent
US6210318B1 (en) 1999-03-09 2001-04-03 Abiomed, Inc. Stented balloon pump system and method for using same
US6695859B1 (en) * 1999-04-05 2004-02-24 Coalescent Surgical, Inc. Apparatus and methods for anastomosis
US6287335B1 (en) 1999-04-26 2001-09-11 William J. Drasler Intravascular folded tubular endoprosthesis
US6712836B1 (en) 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6790229B1 (en) * 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6344022B1 (en) 1999-07-19 2002-02-05 Robert Jarvik Right ventricular bypass devices and methods of their use during heart surgery
US6485507B1 (en) 1999-07-28 2002-11-26 Scimed Life Systems Multi-property nitinol by heat treatment
US6890350B1 (en) 1999-07-28 2005-05-10 Scimed Life Systems, Inc. Combination self-expandable, balloon-expandable endoluminal device
US7892246B2 (en) * 1999-07-28 2011-02-22 Bioconnect Systems, Inc. Devices and methods for interconnecting conduits and closing openings in tissue
US6302892B1 (en) 1999-08-04 2001-10-16 Percardia, Inc. Blood flow conduit delivery system and method of use
WO2001010314A2 (en) 1999-08-05 2001-02-15 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
AU5812299A (en) 1999-09-07 2001-04-10 Microvena Corporation Retrievable septal defect closure device
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US20070043435A1 (en) 1999-11-17 2007-02-22 Jacques Seguin Non-cylindrical prosthetic valve system for transluminal delivery
US6277078B1 (en) 1999-11-19 2001-08-21 Remon Medical Technologies, Ltd. System and method for monitoring a parameter associated with the performance of a heart
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US8298150B2 (en) 2000-01-11 2012-10-30 Cedars-Sinai Medical Center Hemodynamic waveform-based diagnosis and treatment
US6970742B2 (en) 2000-01-11 2005-11-29 Savacor, Inc. Method for detecting, diagnosing, and treating cardiovascular disease
HUP0204398A2 (en) 2000-01-27 2003-03-28 3F Therapeutics Prosthetic heart valve
US6475136B1 (en) 2000-02-14 2002-11-05 Obtech Medical Ag Hydraulic heartburn and reflux treatment
US6406422B1 (en) 2000-03-02 2002-06-18 Levram Medical Devices, Ltd. Ventricular-assist method and apparatus
US6468303B1 (en) * 2000-03-27 2002-10-22 Aga Medical Corporation Retrievable self expanding shunt
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US7056294B2 (en) * 2000-04-13 2006-06-06 Ev3 Sunnyvale, Inc Method and apparatus for accessing the left atrial appendage
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US6527698B1 (en) * 2000-05-30 2003-03-04 Abiomed, Inc. Active left-right flow control in a two chamber cardiac prosthesis
US6358277B1 (en) * 2000-06-21 2002-03-19 The International Heart Institute Of Montana Foundation Atrio-ventricular valvular device
US6572652B2 (en) * 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
AU1129902A (en) 2000-09-29 2002-04-08 Cordis Corp Coated medical devices
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
MXPA03004395A (es) 2000-11-22 2004-04-20 Bard Peripheral Vascular Inc Estructura tubular de politetrafluoroetileno expandido de micropared de alta densidad.
DE60115280T2 (de) 2000-12-15 2006-08-10 Angiomed Gmbh & Co. Medizintechnik Kg Stent mit herzklappe
US6544208B2 (en) * 2000-12-29 2003-04-08 C. Ross Ethier Implantable shunt device
US6802846B2 (en) 2001-02-12 2004-10-12 Ams Research Corporation Foreign body retrieval device and method
US6562066B1 (en) 2001-03-02 2003-05-13 Eric C. Martin Stent for arterialization of the coronary sinus and retrograde perfusion of the myocardium
US6632169B2 (en) 2001-03-13 2003-10-14 Ltk Enterprises, L.L.C. Optimized pulsatile-flow ventricular-assist device and total artificial heart
US20050148925A1 (en) * 2001-04-20 2005-07-07 Dan Rottenberg Device and method for controlling in-vivo pressure
US8091556B2 (en) * 2001-04-20 2012-01-10 V-Wave Ltd. Methods and apparatus for reducing localized circulatory system pressure
GB2378760A (en) * 2001-04-20 2003-02-19 Marconi Medical Systems Uk Ltd Surgical Probe
JP2005506112A (ja) 2001-04-26 2005-03-03 バスキュラー イノベイション，インコーポレイティド 管腔内装置及びそれを作製する方法
WO2002094363A2 (en) * 2001-05-21 2002-11-28 Medtronic,Inc. Trans-septal catheter with retention mechanism
WO2002098296A1 (en) 2001-06-05 2002-12-12 Apex Medical, Inc. Pressure sensing endograft
US6685664B2 (en) 2001-06-08 2004-02-03 Chf Solutions, Inc. Method and apparatus for ultrafiltration utilizing a long peripheral access venous cannula for blood withdrawal
FR2827153A1 (fr) * 2001-07-12 2003-01-17 Younes Boudjemline Dispositif pour fermer les defauts septaux
US7288105B2 (en) 2001-08-01 2007-10-30 Ev3 Endovascular, Inc. Tissue opening occluder
US20030036698A1 (en) 2001-08-16 2003-02-20 Robert Kohler Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US6629988B2 (en) 2001-08-28 2003-10-07 Ethicon, Inc. Composite staple for completing an anastomosis
US20070129755A1 (en) 2005-12-05 2007-06-07 Ovalis, Inc. Clip-based systems and methods for treating septal defects
US20030176914A1 (en) 2003-01-21 2003-09-18 Rabkin Dmitry J. Multi-segment modular stent and methods for manufacturing stents
US6978176B2 (en) 2001-12-08 2005-12-20 Lattouf Omar M Treatment for patient with congestive heart failure
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
ATE460902T1 (de) 2001-12-20 2010-04-15 Trivascular2 Inc Verfahren und vorrichtung zur herstellung eines endovaskulären transplantatabschnitts
US20030139819A1 (en) 2002-01-18 2003-07-24 Beer Nicholas De Method and apparatus for closing septal defects
US7699059B2 (en) 2002-01-22 2010-04-20 Cardiomems, Inc. Implantable wireless sensor
US7311690B2 (en) 2002-02-25 2007-12-25 Novashunt Ag Implantable fluid management system for the removal of excess fluid
US6638257B2 (en) 2002-03-01 2003-10-28 Aga Medical Corporation Intravascular flow restrictor
US7270675B2 (en) 2002-05-10 2007-09-18 Cordis Corporation Method of forming a tubular membrane on a structural frame
US7621879B2 (en) 2002-05-14 2009-11-24 Pacesetter, Inc. System for calibrating implanted sensors
US7862513B2 (en) 2002-05-14 2011-01-04 Pacesetter, Inc. Apparatus for minimally invasive calibration of implanted pressure transducers
EP1538994A4 (en) 2002-06-05 2008-05-07 Nmt Medical Inc DEVICE FOR CLOSING A PATENT FORAMS OVALE (PFO) WITH RADIAL AND COMPLEMENTARY SUPPORT
US7390310B2 (en) 2002-07-10 2008-06-24 Codman & Shurtleff, Inc. Shunt valve locking mechanism
TW547058U (en) * 2002-07-23 2003-08-11 Nien Made Entpr Co Ltd Sectional curtain
US7025777B2 (en) 2002-07-31 2006-04-11 Unison Therapeutics, Inc. Flexible and conformable stent and method of forming same
US7147604B1 (en) 2002-08-07 2006-12-12 Cardiomems, Inc. High Q factor sensor
US8303511B2 (en) 2002-09-26 2012-11-06 Pacesetter, Inc. Implantable pressure transducer system optimized for reduced thrombosis effect
EP1549394B1 (en) 2002-09-26 2011-12-07 Pacesetter, Inc. Cardiovascular anchoring device
US7615010B1 (en) 2002-10-03 2009-11-10 Integrated Sensing Systems, Inc. System for monitoring the physiologic parameters of patients with congestive heart failure
US7169172B2 (en) 2002-11-01 2007-01-30 Counter Clockwise, Inc. Method and apparatus for caged stent delivery
US7608067B2 (en) 2002-11-06 2009-10-27 Aram Bonni Patient-adjustable incontinence device (AID)
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US6923829B2 (en) 2002-11-25 2005-08-02 Advanced Bio Prosthetic Surfaces, Ltd. Implantable expandable medical devices having regions of differential mechanical properties and methods of making same
US20040162514A1 (en) * 2003-02-14 2004-08-19 Scout Medical Technologies System and method for controlling differential pressure in a cardio-vascular system
EP1603492B1 (en) * 2003-03-12 2009-12-23 Cook Incorporated Prosthetic valve that permits retrograde flow
WO2004082528A2 (en) 2003-03-17 2004-09-30 Cook Incorporated Vascular valve with removable support component
US7967769B2 (en) 2003-04-08 2011-06-28 Rox Medical Inc. Implantable arterio-venous shunt devices and methods for their use
US20040267306A1 (en) 2003-04-11 2004-12-30 Velocimed, L.L.C. Closure devices, related delivery methods, and related methods of use
US8372112B2 (en) 2003-04-11 2013-02-12 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US7175656B2 (en) 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
US20050003327A1 (en) 2003-05-12 2005-01-06 Nicolas Elian Drilling system and method for dental implants
US20030216803A1 (en) 2003-05-28 2003-11-20 Ledergerber Walter J. Textured and drug eluting stent-grafts
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US7317951B2 (en) * 2003-07-25 2008-01-08 Integrated Sensing Systems, Inc. Anchor for medical implant placement and method of manufacture
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
JP2007527272A (ja) 2003-10-10 2007-09-27 コヒーレックス メディカル インコーポレイテッド 卵円孔開存（ｐｆｏ）閉鎖装置、送出装置、並びに関連する方法およびシステム
IL158960A0 (en) 2003-11-19 2004-05-12 Neovasc Medical Ltd Vascular implant
US20050165344A1 (en) 2003-11-26 2005-07-28 Dobak John D.Iii Method and apparatus for treating heart failure
US7261732B2 (en) 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US7988724B2 (en) 2003-12-23 2011-08-02 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US7311730B2 (en) 2004-02-13 2007-12-25 Shlomo Gabbay Support apparatus and heart valve prosthesis for sutureless implantation
US20050267524A1 (en) 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
EP1753374A4 (en) 2004-04-23 2010-02-10 3F Therapeutics Inc IMPLANTABLE PROSTHESIS VALVE
US7842069B2 (en) 2004-05-07 2010-11-30 Nmt Medical, Inc. Inflatable occluder
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
EP1604697A1 (en) 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
US8313524B2 (en) 2004-08-31 2012-11-20 C. R. Bard, Inc. Self-sealing PTFE graft with kink resistance
US8764848B2 (en) 2004-09-24 2014-07-01 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US7993383B2 (en) 2004-09-28 2011-08-09 William A. Cook Australia Pty. Ltd. Device for treating aortic dissection
US7794473B2 (en) 2004-11-12 2010-09-14 C.R. Bard, Inc. Filter delivery system
US7905901B2 (en) 2004-11-29 2011-03-15 Cardia, Inc. Self-centering occlusion device
US20060122522A1 (en) 2004-12-03 2006-06-08 Abhi Chavan Devices and methods for positioning and anchoring implantable sensor devices
US7524329B2 (en) 2005-02-08 2009-04-28 Wilson-Cook Medical Inc. Self contracting stent
US20060174712A1 (en) 2005-02-10 2006-08-10 Cardiomems, Inc. Hermetic chamber with electrical feedthroughs
CA2599965C (en) 2005-03-04 2014-05-06 Cardiomems, Inc. Communicating with an implanted wireless sensor
US8025625B2 (en) 2005-04-12 2011-09-27 Cardiomems, Inc. Sensor with electromagnetically coupled hermetic pressure reference
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
US8025668B2 (en) 2005-04-28 2011-09-27 C. R. Bard, Inc. Medical device removal system
US7376006B2 (en) 2005-05-13 2008-05-20 International Business Machines Corporation Enhanced programming performance in a nonvolatile memory device having a bipolar programmable storage element
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
JP2009501027A (ja) 2005-06-17 2009-01-15 シー・アール・バード・インコーポレイテツド 締付後のよじれ耐性を有する血管移植片
US20070021739A1 (en) 2005-07-24 2007-01-25 Lascor Gmbh Inter-atrial Transseptal Laser Puncture (TLP) Procedure
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
DE102005056532A1 (de) 2005-11-28 2007-05-31 Mnemoscience Gmbh Entfernung von tubulären Gewebestützen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US8834912B2 (en) 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
EP1979023B1 (en) 2006-01-17 2015-07-22 Transcend Medical, Inc. Glaucoma treatment device
US9681948B2 (en) 2006-01-23 2017-06-20 V-Wave Ltd. Heart anchor device
US8235916B2 (en) * 2006-02-03 2012-08-07 Pacesetter, Inc. System and method for manipulating insertion pathways for accessing target sites
US20110022057A1 (en) 2006-02-03 2011-01-27 Pacesetter, Inc. Apparatus and methods for transferring an implanted elongate body to a remote site
US7402899B1 (en) 2006-02-03 2008-07-22 Pacesetter, Inc. Hermetically sealable silicon system and method of making same
CA2643720A1 (en) 2006-02-28 2007-09-07 Debra A. Bebb Flexible stretch stent-graft
EP1849440A1 (en) 2006-04-28 2007-10-31 Younes Boudjemline Vascular stents with varying diameter
ATE543267T1 (de) 2006-09-08 2012-02-15 Cardiomems Inc System zur erfassung und verwaltung physiologischer daten zur verwendung in einem implantierten funksensor
US8876894B2 (en) 2006-09-19 2014-11-04 Medtronic Ventor Technologies Ltd. Leaflet-sensitive valve fixation member
JP2010505597A (ja) 2006-10-10 2010-02-25 セロノバ バイオサイエンシーズ， インコーポレイテッド ポリホスファゼンを用いたバイオ人工心臓弁
US20080269774A1 (en) 2006-10-26 2008-10-30 Chestnut Medical Technologies, Inc. Intracorporeal Grasping Device
US8745845B2 (en) 2006-11-07 2014-06-10 Dc Devices, Inc. Methods for mounting a prosthesis onto a delivery device
US10413284B2 (en) 2006-11-07 2019-09-17 Corvia Medical, Inc. Atrial pressure regulation with control, sensing, monitoring and therapy delivery
US20110257723A1 (en) 2006-11-07 2011-10-20 Dc Devices, Inc. Devices and methods for coronary sinus pressure relief
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US8882697B2 (en) 2006-11-07 2014-11-11 Dc Devices, Inc. Apparatus and methods to create and maintain an intra-atrial pressure relief opening
US8460372B2 (en) 2006-11-07 2013-06-11 Dc Devices, Inc. Prosthesis for reducing intra-cardiac pressure having an embolic filter
US10624621B2 (en) * 2006-11-07 2020-04-21 Corvia Medical, Inc. Devices and methods for the treatment of heart failure
US7552853B2 (en) 2007-01-24 2009-06-30 Medtronic Vascular, Inc. Low-profile vascular closure systems and methods of using same
US9504568B2 (en) 2007-02-16 2016-11-29 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
CN101842061A (zh) 2007-06-25 2010-09-22 微排放器公司 自扩展假体
EP2420205B1 (en) 2007-06-26 2014-04-09 St. Jude Medical, Inc. Apparatus for implanting collapsible/expandable prosthetic heart valves
US8147545B2 (en) 2007-06-26 2012-04-03 Galit Avior Eustachian tube device
US8142363B1 (en) 2007-07-11 2012-03-27 Pacesetter, Inc. Cardiac rhythm management lead with omni-directional pressure sensing
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8192351B2 (en) 2007-08-13 2012-06-05 Paracor Medical, Inc. Medical device delivery system having integrated introducer
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
US8734483B2 (en) 2007-08-27 2014-05-27 Cook Medical Technologies Llc Spider PFO closure device
WO2009052188A1 (en) 2007-10-15 2009-04-23 Edwards Lifesciences Corporation Transcatheter heart valve with micro-anchors
BRPI0819217B8 (pt) 2007-10-25 2021-06-22 Symetis Sa válvula de substituição para uso dentro de um corpo humano, sistema para substituir uma válvula dentro de um corpo humano e sistema de liberação da válvula cardíaca com stent
US7806921B2 (en) 2007-11-08 2010-10-05 Cook Incorporated Monocusp valve design
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8157853B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US9138213B2 (en) 2008-03-07 2015-09-22 W.L. Gore & Associates, Inc. Heart occlusion devices
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
US20100022940A1 (en) 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Percutaneously Introduceable Shunt Devices and Methods
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
DE102008041815A1 (de) * 2008-09-04 2010-04-15 Carl Zeiss Nts Gmbh Verfahren zur Analyse einer Probe
JP2012501806A (ja) 2008-09-12 2012-01-26 ボストン サイエンティフィック サイムド，インコーポレイテッド ステントの層単位製造
JP4649506B2 (ja) 2008-09-16 2011-03-09 有限会社日本エレクテル 高周波加温バルーンカテーテル
EP2340075B1 (en) 2008-10-10 2013-03-06 Sadra Medical, Inc. Medical devices and delivery systems for delivering medical devices
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US8021420B2 (en) 2009-03-12 2011-09-20 Medtronic Vascular, Inc. Prosthetic valve delivery system
CN101919752B (zh) 2009-03-30 2014-04-09 苏州杰成医疗科技有限公司 带有活动连接瓣膜扣的人工瓣膜
US8257251B2 (en) 2009-04-08 2012-09-04 Ethicon Endo-Surgery, Inc. Methods and devices for providing access into a body cavity
US8414644B2 (en) 2009-04-15 2013-04-09 Cardiaq Valve Technologies, Inc. Vascular implant and delivery system
CA2760207C (en) 2009-04-28 2014-08-12 Dc Devices, Inc. Devices, systems and methods to treat heart failure
EP2427143B1 (en) 2009-05-04 2017-08-02 V-Wave Ltd. Device for regulating pressure in a heart chamber
US9034034B2 (en) 2010-12-22 2015-05-19 V-Wave Ltd. Devices for reducing left atrial pressure, and methods of making and using same
US10076403B1 (en) 2009-05-04 2018-09-18 V-Wave Ltd. Shunt for redistributing atrial blood volume
US20100292779A1 (en) 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
JP5535313B2 (ja) 2009-05-29 2014-07-02 エックスルミナ， インコーポレイテッド 隣接する組織層にわたってステントを展開するための装置および方法
JP6245805B2 (ja) 2009-08-07 2017-12-13 スマーター アロイズ インコーポレーテッド 形状記憶材料の処理方法および形状記憶材料の処理装置
US20110054515A1 (en) 2009-08-25 2011-03-03 John Bridgeman Device and method for occluding the left atrial appendage
US9642993B2 (en) 2011-12-22 2017-05-09 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having selectable flow rates
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
WO2011037866A1 (en) 2009-09-22 2011-03-31 Cook Incorporated Vessel closure device
US8114149B2 (en) 2009-10-20 2012-02-14 Svelte Medical Systems, Inc. Hybrid stent with helical connectors
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
AU2010311811B2 (en) 2009-11-02 2015-09-17 Symetis Sa Aortic bioprosthesis and systems for delivery thereof
US9757263B2 (en) 2009-11-18 2017-09-12 Cook Medical Technologies Llc Stent graft and introducer assembly
US8715300B2 (en) 2009-12-05 2014-05-06 Integrated Sensing Systems, Inc. Delivery system, method, and anchor for medical implant placement
US20110152923A1 (en) 2009-12-18 2011-06-23 Ethicon Endo-Surgery, Inc. Incision closure device
CA2785041A1 (en) 2010-01-29 2011-08-04 Dc Devices, Inc. Devices and methods for reducing venous pressure
PL3335670T3 (pl) 2010-03-05 2022-09-05 Edwards Lifesciences Corporation Mechanizmy ustalające do zastawek protetycznych
US8512401B2 (en) 2010-04-12 2013-08-20 Medtronic, Inc. Transcatheter prosthetic heart valve delivery system with funnel recapturing feature and method
US8524132B2 (en) 2010-04-14 2013-09-03 Abbott Cardiovascular Systems Inc. Method of fabricating an intraluminal scaffold with an enlarged portion
WO2011139746A1 (en) 2010-04-27 2011-11-10 Medtronic Inc. Transcatheter prosthetic heart valve delivery device with passive trigger release
US8419767B2 (en) 2010-05-04 2013-04-16 Mustafa H. Al-Qbandi Steerable atrial septal occluder implantation device with flexible neck
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
EP2387951B1 (en) 2010-05-23 2012-12-26 Occlutech Holding AG Braided medical device and manufacturing method therefore
US9510973B2 (en) 2010-06-23 2016-12-06 Ivantis, Inc. Ocular implants deployed in schlemm's canal of the eye
EP4098227A1 (en) 2010-07-23 2022-12-07 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8597225B2 (en) 2010-07-26 2013-12-03 The Cleveland Clinic Foundation Method for increasing blood flow in or about a cardiac or other vascular or prosthetic structure to prevent thrombosis
US20120046528A1 (en) 2010-08-17 2012-02-23 Pacesetter, Inc. System and method for detecting and treating cardiovascular disease
US20120190991A1 (en) 2011-01-24 2012-07-26 Pacesetter, Inc. System and Method for Detecting a Clinically-Significant Pulmonary Fluid Accumulation Using an Implantable Medical Device
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9522064B2 (en) 2011-05-16 2016-12-20 Hlt, Inc. Inversion delivery device and method for a prosthesis
WO2012175483A1 (en) 2011-06-20 2012-12-27 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
US9629715B2 (en) 2011-07-28 2017-04-25 V-Wave Ltd. Devices for reducing left atrial pressure having biodegradable constriction, and methods of making and using same
US11135054B2 (en) 2011-07-28 2021-10-05 V-Wave Ltd. Interatrial shunts having biodegradable material, and methods of making and using same
EP2755562B8 (en) 2011-09-12 2017-01-25 Highlife SAS Treatment catheter system
CN102462565B (zh) 2011-10-25 2014-03-26 张石江 可回收可调节血管内缩窄介入支架
US8845684B2 (en) 2011-11-30 2014-09-30 Abbott Cardiovascular Systems, Inc. Tissue closure device with resilient arms
US20140350669A1 (en) 2011-12-01 2014-11-27 The Trustees if The University of Pennsylvania Percutaneous valve replacement devices
EP2785277B1 (en) 2011-12-04 2017-04-05 Endospan Ltd. Branched stent-graft system
US8894701B2 (en) 2011-12-23 2014-11-25 Cook Medical Technologies Llc Hybrid balloon-expandable/self-expanding prosthesis for deployment in a body vessel and method of making
JP2013153810A (ja) 2012-01-27 2013-08-15 Terumo Corp 瘤治療デバイス及び瘤治療方法
US9005155B2 (en) 2012-02-03 2015-04-14 Dc Devices, Inc. Devices and methods for treating heart failure
WO2013119630A1 (en) 2012-02-06 2013-08-15 Cook Medical Technologies Llc Artificial device deployment apparatus
US8882798B2 (en) 2012-02-13 2014-11-11 Apollo Endosurgery, Inc. Endoscopic tools for the removal of balloon-like intragastric devices
US9067050B2 (en) 2012-03-30 2015-06-30 Medtronic Vascular, Inc. Arteriovenous shunt having a flow control mechanism
US10588611B2 (en) 2012-04-19 2020-03-17 Corvia Medical Inc. Implant retention attachment and method of use
CA2873440C (en) 2012-05-14 2020-06-02 C.R. Bard, Inc. Uniformly expandable stent
WO2013175468A2 (en) 2012-05-20 2013-11-28 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
US9649480B2 (en) 2012-07-06 2017-05-16 Corvia Medical, Inc. Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention
CN104508864B (zh) 2012-07-30 2017-04-19 帝人株式会社 非水电解质电池用隔膜及非水电解质电池
US9649212B2 (en) 2012-08-30 2017-05-16 Biotronik Ag Release device for releasing a medical implant from a catheter and catheter comprising a release device
US9023099B2 (en) 2012-10-31 2015-05-05 Medtronic Vascular Galway Limited Prosthetic mitral valve and delivery method
EP2922592B1 (en) 2012-11-21 2022-09-21 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic heart valves
US10098551B2 (en) 2013-01-31 2018-10-16 Pacesetter, Inc. Wireless MEMS left atrial pressure sensor
US10413401B2 (en) 2013-02-01 2019-09-17 Medtronic CV Luxembourg S.a.r.l. Anti-paravalvular leakage component for a transcatheter valve prosthesis
US9844435B2 (en) 2013-03-01 2017-12-19 St. Jude Medical, Cardiology Division, Inc. Transapical mitral valve replacement
US9867697B2 (en) 2013-03-12 2018-01-16 St. Jude Medical, Cardiology Division, Inc. Self-actuating sealing portions for a paravalvular leak protection
US9775636B2 (en) 2013-03-12 2017-10-03 Corvia Medical, Inc. Devices, systems, and methods for treating heart failure
US9220429B2 (en) 2013-03-15 2015-12-29 Pacesetter, Inc. Systems and methods to determine HR, RR and classify cardiac rhythms based on atrial IEGM and atrial pressure signals
US20140277054A1 (en) 2013-03-15 2014-09-18 Dc Devices, Inc. Devices, systems, and methods for percutaneous trans-septal puncture
US10105103B2 (en) 2013-04-18 2018-10-23 Vectorious Medical Technologies Ltd. Remotely powered sensory implant
EP2999412B1 (en) 2013-05-21 2020-05-06 V-Wave Ltd. Apparatus for delivering devices for reducing left atrial pressure
WO2014197498A1 (en) 2013-06-04 2014-12-11 Boston Scientific Scimed, Inc. Tissue spreader for accessing papilla, and related methods of use
US11911258B2 (en) 2013-06-26 2024-02-27 W. L. Gore & Associates, Inc. Space filling devices
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
US10123870B2 (en) 2013-09-12 2018-11-13 St. Jude Medical, Cardiology Division, Inc. Alignment of an implantable medical device
WO2015057838A1 (en) 2013-10-15 2015-04-23 Boston Scientific Scimed, Inc. Methods and systems for loading and delivering a stent
US20150112383A1 (en) 2013-10-21 2015-04-23 Cook Medical Technologies Llc Closure device
US20150119796A1 (en) 2013-10-26 2015-04-30 Dc Devices, Inc. Anti-Lockup Thread Attachment Mechanism and Method of Use Thereof
US9775591B2 (en) 2013-11-21 2017-10-03 Edwards Lifesciences Corporation Sealing devices and related delivery apparatuses
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9907641B2 (en) 2014-01-10 2018-03-06 W. L. Gore & Associates, Inc. Implantable intraluminal device
WO2015112494A1 (en) 2014-01-23 2015-07-30 St. Jude Medical, Cardiology Division, Inc. Medical devices including high strength bond joints and methods of making same
US10675450B2 (en) 2014-03-12 2020-06-09 Corvia Medical, Inc. Devices and methods for treating heart failure
US10149758B2 (en) 2014-04-01 2018-12-11 Medtronic, Inc. System and method of stepped deployment of prosthetic heart valve
WO2015157116A1 (en) 2014-04-08 2015-10-15 Boston Scientific Scimed, Inc. Endoscopic closure device
US11712230B2 (en) 2014-05-02 2023-08-01 W. L. Gore & Associates, Inc. Occluder and anastomosis devices
US9814483B2 (en) 2014-06-13 2017-11-14 InterShunt Technologies, Inc. Method and catheter for creating an interatrial aperture
JP2017527694A (ja) 2014-07-14 2017-09-21 スマーター アロイズ インコーポレーテッド 複記憶材料、システム、方法及びその応用
CA2955389C (en) 2014-07-23 2023-04-04 Corvia Medical, Inc. Devices and methods for treating heart failure
WO2016030767A1 (en) 2014-08-27 2016-03-03 Distalmotion Sa Surgical system for microsurgical techniques
EP3193791B1 (en) 2014-09-09 2018-08-22 Occlutech Holding AG A flow regulating device in the heart
US10111741B2 (en) 2014-10-29 2018-10-30 W. L. Gore & Associates, Inc. Intralumenal stent graft fixation
US10932786B2 (en) 2014-11-04 2021-03-02 Corvia Medical, Inc. Devices and methods for treating patent ductus arteriosus
CN111437068B (zh) 2014-12-04 2023-01-17 爱德华兹生命科学公司 用于修复心脏瓣膜的经皮夹具
WO2016115375A1 (en) 2015-01-16 2016-07-21 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10201417B2 (en) 2015-02-03 2019-02-12 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
US20170224444A1 (en) 2015-04-06 2017-08-10 Smarter Alloys Inc. Systems and methods for orthodontic archwires for malocclusions
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10940296B2 (en) 2015-05-07 2021-03-09 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Temporary interatrial shunts
US9789294B2 (en) 2015-10-07 2017-10-17 Edwards Lifesciences Corporation Expandable cardiac shunt
US10463477B2 (en) 2015-11-09 2019-11-05 Corvia Medical, Inc. Retrievable devices for treating heart failure
WO2017118920A1 (en) 2016-01-04 2017-07-13 Cardiopass Ltd. Cutting device with expandable anvil
US10265059B2 (en) 2016-02-04 2019-04-23 Edwards Lifesciences Corporation Trans-septal closure and port device
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10207807B2 (en) 2016-04-13 2019-02-19 The Boeing Company Condensate removal system of an aircraft cooling system
US20170340460A1 (en) 2016-05-31 2017-11-30 V-Wave Ltd. Systems and methods for making encapsulated hourglass shaped stents
US10835394B2 (en) 2016-05-31 2020-11-17 V-Wave, Ltd. Systems and methods for making encapsulated hourglass shaped stents
US10531941B2 (en) 2016-11-09 2020-01-14 Boston Scientific Scimed, Inc. Stent including anti-migration capabilities
EP3568089B1 (en) 2017-01-11 2021-09-15 Virender K. Sharma Cardiac shunt device and delivery system
US11135410B2 (en) 2017-02-26 2021-10-05 Corvia Medical, Inc. Devices and methods for treating heart failure
US11291807B2 (en) 2017-03-03 2022-04-05 V-Wave Ltd. Asymmetric shunt for redistributing atrial blood volume
AU2018228451B2 (en) 2017-03-03 2022-12-08 V-Wave Ltd. Shunt for redistributing atrial blood volume
WO2018220589A1 (en) 2017-06-02 2018-12-06 HemoDynamx Technologies, Ltd. Flow modification in body lumens
CN209059540U (zh) 2017-07-18 2019-07-05 杭州诺生医疗科技有限公司 心房间的压力调节装置
EP3705154A4 (en) 2017-10-31 2020-12-23 Hangzhou Noya Medtech Co., Ltd AURICULAR SEPTOSTOMY DEVICE, AURICULAR SEPTOSTOMY SYSTEM, THEIR OPERATING PROCESS AND OPENING CREATION PROCESS
CN111432743A (zh) 2017-11-30 2020-07-17 阿列维安特医疗公司 用于心房间吻合的经导管装置
US10898698B1 (en) 2020-05-04 2021-01-26 V-Wave Ltd. Devices with dimensions that can be reduced and increased in vivo, and methods of making and using the same
US11744589B2 (en) 2018-01-20 2023-09-05 V-Wave Ltd. Devices and methods for providing passage between heart chambers
WO2019179447A1 (zh) 2018-03-19 2019-09-26 杭州诺生医疗科技有限公司 经导管介入的房间隔造口装置
EP3794260A4 (en) 2018-05-16 2022-06-22 Smarter Alloys Inc. SHAPE MEMORY ALLOY VALVE AND METHOD OF PRODUCTION THEREOF
JP2022501113A (ja) 2018-09-19 2022-01-06 エヌエックスティー バイオメディカル, エルエルシーNxt Biomedical, Llc 生物学的構造の腔と管との間の接続およびシャントを形成するための方法および技術
AU2019404588B2 (en) 2018-12-21 2022-12-15 W. L. Gore & Associates, Inc. Implantable medical device with adjustable blood flow
US11612385B2 (en) 2019-04-03 2023-03-28 V-Wave Ltd. Systems and methods for delivering implantable devices across an atrial septum
US11865282B2 (en) 2019-05-20 2024-01-09 V-Wave Ltd. Systems and methods for creating an interatrial shunt
CN114667117A (zh) 2019-09-09 2022-06-24 施菲姆德控股有限责任公司 可调整分流器和相关联的系统和方法

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106749A (zh) * 2015-01-07 2017-08-29 恩莫德斯有限公司 用于在血液和气体/混合气之间进行物质交换的装置
CN107106749B (zh) * 2015-01-07 2020-04-14 恩莫德斯有限公司 用于在血液和气体/混合气之间进行物质交换的装置
CN105709286A (zh) * 2016-01-18 2016-06-29 暨南大学 与双心室体外辅助循环血泵室配套使用的无级调控装置
CN110168626B (zh) * 2016-11-14 2021-07-16 米兰综合工科大学 用于模拟心脏手术或介入式心脏病手术的测试台组件
CN110168626A (zh) * 2016-11-14 2019-08-23 米兰综合工科大学 用于模拟心脏手术和/或介入式心脏病手术和/或过程的测试台组件
CN110402113B (zh) * 2017-01-11 2023-02-17 维兰德.K.沙马 心脏分流装置和输送系统
CN110402113A (zh) * 2017-01-11 2019-11-01 维兰德.K.沙马 心脏分流装置和输送系统
WO2019015617A1 (zh) * 2017-07-18 2019-01-24 杭州诺生医疗科技有限公司 一种适用于心房间的压力调节装置
CN108030483A (zh) * 2017-12-06 2018-05-15 深圳市星河泉新材料有限公司五金配件分厂 一种加压结构、血压检测模块以及血压智能检测设备
CN108030483B (zh) * 2017-12-06 2023-12-29 深圳市星河泉新材料有限公司 一种加压结构、血压检测模块以及血压智能检测设备
CN112971876A (zh) * 2021-05-14 2021-06-18 上海心瑞医疗科技有限公司 一种心房分流装置
CN112971876B (zh) * 2021-05-14 2021-08-31 上海心瑞医疗科技有限公司 一种心房分流装置
CN113694277A (zh) * 2021-08-18 2021-11-26 苏州才豪电子科技有限公司 一种多级调压式血液滤过装置

Also Published As

Publication number Publication date
US8070708B2 (en) 2011-12-06
EP1771132A2 (en) 2007-04-11
EP1771132B1 (en) 2019-03-27
US20070282157A1 (en) 2007-12-06
ES2725721T3 (es) 2019-09-26
AU2005211243A1 (en) 2005-08-18
CN104971390B (zh) 2018-03-16
US20110218479A1 (en) 2011-09-08
JP2007527742A (ja) 2007-10-04
US10463490B2 (en) 2019-11-05
US20140163449A1 (en) 2014-06-12
US20210154012A1 (en) 2021-05-27
US20110218480A1 (en) 2011-09-08
EP1771132A4 (en) 2009-12-16
US9724499B2 (en) 2017-08-08
US20220183838A1 (en) 2022-06-16
CA2554595A1 (en) 2005-08-18
US20220338989A1 (en) 2022-10-27
US20200276016A1 (en) 2020-09-03
US10912645B2 (en) 2021-02-09
CA2554595C (en) 2016-03-29
US11266501B2 (en) 2022-03-08
WO2005074367A3 (en) 2008-12-31
US20110218481A1 (en) 2011-09-08
US20170325956A1 (en) 2017-11-16
US20200060825A1 (en) 2020-02-27
US11382747B2 (en) 2022-07-12
US20180250131A9 (en) 2018-09-06
WO2005074367A2 (en) 2005-08-18
US20050148925A1 (en) 2005-07-07

Similar Documents

Publication Publication Date Title
CN104971390A (zh) 用于控制体内压力的装置和方法
US11253353B2 (en) Heart anchor device
CN104812439B (zh) 介入式医疗系统、工具和组件
CN105592885B (zh) 用于可植入医疗装置的工具及其组件
US10596357B2 (en) Endovascular cerebrospinal fluid shunt
US20060293698A1 (en) Retainer device for mitral valve leaflets
CN101415452A (zh) 用于控制体内压力的装置和方法
US20190298977A1 (en) Endovascular cerebrospinal fluid shunt
CN113164661A (zh) 用于经由身体引流或注射进行治疗的系统和方法
US11883030B2 (en) Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature
US20230414360A1 (en) Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant