CN104970224A - Composition and mixed feed for preventing and treating porcine epizootic diarrhea - Google Patents
Composition and mixed feed for preventing and treating porcine epizootic diarrhea Download PDFInfo
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Abstract
The invention discloses a composition for preventing and treating porcine epizootic diarrhea. The composition comprises the following raw materials in parts by weight: 0.1-0.8 part of probiotics, 0.02-0.04 part of N-carbamyl glutamic acid, 0.04-0.05 part of protease preparation, 0.2-0.3 part of glyceryl tributyrate, 0.2-0.3 part of acidifying agent and 0.03-0.05 part of egg yolk antibody. With the adoption of the composition disclosed in the invention, the amount of antibiotics used in pig industry is effectively reduced by more than 80 percent, and the porcine epizootic diarrhea caused by porcine epizootic diarrhea viruses can be effectively prevented and treated. In addition, the composition is safe and non-toxic. On the other hand, only a small amount of the composition is needed for adding in feeds, and the quality of the composition is stable. With the addition of the composition, the incidence of the porcine epizootic diarrhea can be reduced by 60-80 percent, and the immunity of the animals is greatly improved.
Description
Technical field
The present invention relates to pig feed field, specifically relate to a kind of composition for prevention and therapy pig epidemic diarrhea, and be added with the mixed feed of said composition.
Background technology
Pig epidemic diarrhea (Porcine epidemic diarrhea, PED) is a kind of acute infectious intestinal disease of piglet and the growing and fattening pigs caused by Porcine epidemic diarrhea virus (Porcineepidemic diarrhea virus, PEDV).This disease only betides pig, and the pig at various age can infection morbidity.The incidence of disease of suckling pig, feeder pig or fattening pig is very high, and be especially injured with suckling pig the most serious, the variation of the sow incidence of disease is very large, is about 15-90%.This disease is multiple is born in cold season.Mostly occur in 1 ~ February of annual December to next year in China, also have the report of morbidity summer.PED is very large to the harm of pig, and the pig at various age all can fall ill, but the most serious to the harm of suckling pig, and within 20 ages in days, the piglet death rate reaches more than 95% (Timoney J Fet al., 1988), and to raising pigs, industrial belt carrys out heavy economic losses.Can betide the pig at any age, the age is less, and symptom is heavier, and the death rate is high.
Porcine epidemic diarrhea virus (PEDV) Study on etiology progress PEDV belongs to coronaviridae, coronavirus genus.PED Late Cambrian also report is the Britain (Oldham, 1972) in 1971.1976 start, and China reports the generation (Cai Baoxiang, 1982 Ni Yan shows, 2001) of PED in succession, and it is one of sick that present PED has become the important virus diarrhea of the pig of world-wide prevalence.Up to the present, also do not find that this virus has different serotype.Pig infects PEDV and often causes the chordapsus of piglet and mortality watery diarrhea until dewater dead later, and its Clinical symptoms is mainly manifested in piglet vomiting, severe diarrhea and dehydration; The pig pathological change infecting PEDV is mainly manifested in the atrophy of the jejunum of pig and the intestinal villus of ileal segment and comes off.
Sick pig is major source of infection.Virus is present in intestinal villus epithelial cell and lymphonodi mesenterici, after discharging with ight soil, and contaminated environment, feed, drinking-water, the vehicles and apparatus etc. and infect.Main infection approach is alimentary canal.If a pig farm has many nest piglets to be born or wean successively, virus can constantly infect the weanling pig losing maternal antibody, makes this disease in endemicity, and in this breeding farm, pig epidemic diarrhea can cause the weaning period intractable diarrhea of 5-8 piglet in age in week.
After virus per os and nose infect, directly enter small intestine.By immunofluorescence and electron microscopy, copying of virus carries out in small intestine and colon villus epithelial cells slurry.Virus multiplication is not found in other organs.Because first virus multiplication causes the damage of organelle, then there is cell dysfunction.Intestinal villus atrophy, cause the minimizing that sorbent surface is long-pending, small intestinal mucosa content of alkaline phosphatase significantly reduces and then causes absorption of nutrient ingredients obstacle, and this is the main cause causing diarrhoea, belongs to osmotic diarrhea.Severe diarrhea causes dehydration, is to cause disease pig main causes of death.
PEDV is mainly through enteric infection pig, it has obvious intestinal tissue preferendum, except humoral immunity and cellular immunity play a role in the immunologic process of the anti-PEDV infection of pig, local intestinal mucosal immune system has also played important function, thus stimulate intestinal mucosa to produce specific sIgA, become one of key issue of development opposing PEDV vaccine.Correlation test find, in 7 ages in days piglet lose serious reason may be relevant slowly with enterocyte renewal speed.Piglet age in days is less, and enterocyte renewal speed is slower.PEDV causes Apoptosis after infecting intestinal epithelial cell, and the age is less, and enterocyte upgrades slower, causes intestinal mucosa damage and can not be repaired in time, thus causes piglet loss in 7 ages in days serious.
Summary of the invention
The object of the present invention is to provide a kind of composition of prevention and therapy pig epidemic diarrhea, and be added with the mixed feed of said composition.
The technology used in the present invention solution is:
A composition for prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: probio 0.1-0.8 part, N-carbamylglutamic acid 0.02-0.04 part, protease preparation 0.04-0.05 part, tributyrin 0.2-0.3 part, acidulant 0.2-0.3 part, Yolk antibody 0.03-0.05 part.
Preferably, described probio comprises saccharomycete preparation and bacillus preparation, and the weight of saccharomycete preparation and bacillus preparation is 1: 0.5-2.
Preferably, described acidulant is that in compound acidulant, the content of acid calcium sulfate is 1% containing acid calcium sulfate compound acidulant.
A mixed feed for prevention and therapy pig epidemic diarrhea, it includes above-mentioned composition, and the content of composition in mixed feed is 0.3%-1.5%.
A breastfeeding sow compound feed for prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: corn 50-55 part, dregs of beans 20-25 part, wheat bran 10-15 part, fish meal 2-5 part, soya-bean oil 2-5 part, fatty powder 1-3 part, glucose 1-3 part, fibre and soya 1-3 part, salt 0.3-0.5 part, Choline Chloride 0.2-0.3 part, stone flour 1-3 part, calcium monohydrogen phosphate 1-2 part, potassium chloride 0.1-0.2 part, containing compound acidulant 0.2-0.3 part of acid calcium sulfate, mould inhibitor 0.1-0.3 part, 70% lysine sulphate 0.2-0.5 part, threonine 0.01-0.03 part, protease preparation 0.03-0.05 part, de-mould dose of 0.05-0.1 part, antioxidant 0.05-0.1 part, N-carbamylglutamic acid 0.01-0.03 part, Organic Chromium 0.01-0.03 part, saccharomycete preparation 0.3-0.5 part, bacillus preparation 0.3-0.5 part, Yolk antibody 0.01-0.03 part, tributyrin 0.1-0.3 part, yeast selenium 0.005-0.01 part, VE 0.01-0.02 part, biotin 0.01-0.03 part, many ore deposits 0.1-0.3 part, multidimensional 0.03-0.05 part.
Preferably, the weight of each raw material is: corn 54.5 parts, dregs of beans 21 parts, 12.5 parts, wheat bran, fish meal 2 parts, 2 parts, soya-bean oil, fatty powder 1 part, glucose 1 part, fibre and soya 3 parts, salt 0.42 part, Choline Chloride 0.25 part, stone flour 1 part, calcium monohydrogen phosphate 1.3 parts, 0.15 part, potassium chloride, containing the compound acidulant 0.2 part of acid calcium sulfate, mould inhibitor 0.1 part, 70% lysine sulphate 0.25 part, threonine 0.01 part, protease preparation 0.04 part, de-mould dose 0.05 part, antioxidant 0.05 part, N-carbamylglutamic acid 0.02 part, Organic Chromium 0.02 part, 0.4 part, saccharomycete preparation, bacillus preparation 0.4 part, Yolk antibody 0.03 part, tributyrin 0.2 part, yeast selenium 0.005-0.01 part, VE 0.01-0.02 part, biotin 0.01-0.03 part, many ore deposits 0.1-0.3 part, multidimensional 0.03-0.05 part.
Preferably, described many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.044 part, ferrous sulfate, manganese sulfate 0.024 part, 0.086 part, zinc sulfate, sodium selenite 0.016 part, KI 0.02 part.
Preferably, described multidimensional is grouped into by the one-tenth of following weight: VA 0.01 part, VD30.006 part, VK30.003 part, VB10.003 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, 0.001 part, pantothenic acid, biotin 0.001 part.
A kind of creep mixed feed for piglets of prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: corn 9.6 parts, normal meal 6.8 parts, 18 parts, flour, popcorn 23 parts, crack rice 10 parts, expanded soybean 4 parts, low albumen whey powder 6 parts, fish meal 3 parts, fermented bean dregs 9 parts, 1 part, soya-bean oil, Choline Chloride 0.16 part, glucose 4 parts, white sugar 3 parts, methionine 0.15 part, lysine 0.35 part, tryptophan 0.05 part, 0.15 part, zinc oxide, sweetener 0.03 part, flavouring agent 0.08 part, 0.2 part, many ore deposits, antioxidant 0.1 part, multidimensional 0.04 part, containing the compound acidulant 0.2 part of acid calcium sulfate, protease preparation 0.05 part, N-carbamylglutamic acid 0.04 part, 0.05 part, saccharomycete preparation, bacillus preparation 0.05 part, Yolk antibody 0.03 part, tributyrin 0.3 part.
Preferably, described many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.045 part, ferrous sulfate, manganese sulfate 0.02 part, 0.08 part, zinc sulfate, sodium selenite 0.015 part, KI 0.03 part; Described multidimensional is grouped into by the one-tenth of following weight: VA 0.02 part, VD30.004 part, VE 0.02 part, VK 30.004 parts, VB10.002 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, powdered rice hulls 0.339 part.
Advantageous Effects of the present invention is:
The invention provides a kind of composition for prevention and therapy pig epidemic diarrhea, said composition effectively reduces the use amount of antibiotics in pig industry, antibiotic dosage reduces more than 80%, can effectively prevent and treat the pig epidemic diarrhea caused by Porcine epidemic diarrhea virus, and safety non-toxic.Secondly the addition of said composition in feed is less, steady quality, and pig epidemic diarrhea rate can be made to reduce 60-80%, and the immunity of animal itself have also been obtained and greatly promotes.In addition the present composition is applied to conceived 95 days of sow in the milking sow material of again oestrusing and porket creep complete feed etc.; for prevention pig epidemic diarrhea, protection gastrointestinal mucosa; promote that gastrointestinal peristalsis tool is very helpful; can effectively avoid the dehydrating phenomena caused of suffering from diarrhoea, and can the overall immunity improving pig body.
The composition of prevention and therapy pig epidemic diarrhea of the present invention and be added with the mixed feed of said composition, by the organic assembling of anti diar rhea function, quick antidiarrheal, kills or suppresses harmful bacteria, recovers body to the resistance of virus.
More specific detail is carried out to primary raw material of the present invention below:
1, intestinal microflora plays an important role in enteron aisle metabolism, intestinal epithelial cell function, immune system and inflammatory reaction signal path etc., normally intestinal microflora composition relative constancy in animal body, and when body be in external environment change, accept antibiotic therapy or by pathogenic microorganism infection time, in animal body, intestinal microflora composition can change, cause the decline of Disorder of Digestion and A orption and immunity, diarrhoea is one of common symptom.The oxygen in enteron aisle can be consumed by the probio such as bacillus and saccharomycete fast, recover the anaerobic environment of enteron aisle, namely take oxygen mechanism by force by biology and suppress harmful bacteria growth, promote beneficial bacterium breeding, recover microecological balance; After bacillus enters animal intestinal simultaneously, sprout at front intestinal segment gemma, secrete multiple digestive ferment, assist feed to decompose, promote digesting and assimilating of nutriment, reduce the diarrhoea because indigestion causes; In addition, probio can resist the pathogenic microorganism of invasion by the binding site sticking intestinal epithelial cell with pathogenic microorganism competitiveness, reduce sticking site thus stoping the invasion as pathogenic microorganisms such as epec, enteropathogenic e.colis of cell surface; Wherein, yeast cell wall skin contains abundant manna oligosacchride, the aggegation harmful bacteria flagellum of contestable, and excretes thereupon; Abundant active metabolite can be produced through the bacillus of directive breeding and saccharomycete etc. simultaneously, especially produce antibacterial peptide and alexinic ability is greatly enhanced, can directly suppress or pathogenic microbe killing.
Pathogenic bacteria causes diarrhoea to occur, first require that pathogen attaches to the epithelial surface of small intestinal mucosa by adhesin, it a kind ofly can carry out the protein of specific binding with containing glycan molecule, this is the prerequisite causing diarrhoea to occur, utilize from the GI specific protease of saprophagous animal except having very strong proteopepsis ability, also by its proteolytic activity effect, to destroy on small intestinal mucosa epithelial cell can to the corresponding acceptor of pathogenic microorganism effect, break the interaction between pathogenic microorganism adhesin and small intestinal mucosa epithelial receptor, so just make cause of disease not microorganism can not invade in small intestine cells, the infringement to biological cells and tissues would not be caused, and then play the effect of control diarrhoea, in addition, it makes the agglutinant protein on pili and cell membrane destructurized by proteolysis, the combination of further prevention pathogen and intestinal cell.
Saccharomycete can alleviate by following three kinds of modes the diarrhoea that pathogenic bacteria toxin causes: 1) block pathogen toxin and its receptors bind; 2) mutagenesis is the acceptor of nosotoxin; 3) directly nosotoxin is destroyed.For example its a kind of serine protease produced, can directly eliminate Clestridium difficile toxin A and B, a kind of phosphatase of generation, can destroy the endotoxin of enteropathogenic E. Coli, can also produce the protein of a kind of 120ku, degraded cholera toxin.
Symptom of diarrhea can be improved fast by above-mentioned comprehensive function mechanism, elimination stress, the overall immune disease-resistance power of body is promoted to some extent, contribute to recover body to the resistance of virus.
2. saccharomycete, bacillus regulate organism immune response in the following manner: 1) in the slime layer of gut barrier, and S-IgA (sIgA) protects intestinal epithelial cell not attack by pathogenic microorganism by being combined with the surface antigen of pathogenic microorganism.Glucan in yeast cell wall strengthens the Effects on local immunological functions of animal by activating complement system, especially stimulates intestinal mucosa synthesis secretion type immunoglobulin (Ig) (sIgA).SIgA plays immune clearance effect, and does not cause immunization inflammatory reaction.SIgA, by being combined with microbial antigen, stops it to stick and invasion, is preventing from playing an important role in enteric infection.SIgA can also neutralize a toxin and stop virus to copy in intestinal epithelial cell, alleviates the infringement of virus to intestinal mucosa.2) Immunoglobulin in Serum G (IgG) level is improved; 3) suppress the signal transduction pathway of nuclear transcription factor-kappa B mediation, play antiinflammatory action.Research shows, probio wherein can suppress pathogenic bacteria transposition, protection liver, suppresses MAPK activation, reduces proinflammatory cytokines and also can significantly improve anti-inflammatory cytokines interleukin 10 (IL-10) content in serum; Stimulating expression of macrophage plays nospecific immunity simultaneously, sets up the first line of defence of body opposing virus infections.
3. during animal suffering from disease, in body, SCFA (short-chain fatty acid, SCFA) content obviously declines, and SCFA is the important metabolite that in colon, anaerobe fermentation produces.Secrete a large amount of acetic acid, lactic acid etc. by beneficial bacterium, increase the level of SCFA (SCFAs) in enteron aisle.SCFAs can destroy gram-negative bacteria substance as the okioplast film of EHEC, Pseudomonas aeruginosa and salmonella etc. and kill pathogen, and the penetration capacity of SCFAs can be assisted other antimicrobial factorses to enter more easily in pathogen cells and be played antibacterial action.SCFAs or the important nutrient of intestinal mucosa, have important function to the metabolism of enteron aisle and function, SCFAs plays an important role to the heavily absorption of water and eletrolytes in enteron aisle, thus can the generation of alleviating diarrhoea symptom.
4. the nutritional effect of pair body intestinal mucosa: test proves, utilize saccharomycete can increase the expression of enteron aisle disaccharidase and alkaline phosphatase, to promote in intestines that the brush border enzymatic activitys such as isomaltase, invertase, lactase, alpha-Glucosidase and alkaline phosphatase significantly improve, thus promote the absorption and digestion of nutriment, and this function is lack in many acute and chronic diseases usually.By promoting digesting and assimilating carbohydrate, osmotic pressure in enteron aisle can be reduced, alleviating diarrhoea.
5. repair damaged intestine mucous membrane: intestinal epithelial cell (IECs) is considered to the immunity " sentry " in intestines and stomach, play an important role in the congenital and adaptability Intestinal Mucosal Immunity system of maintenance host, destroying this confluent monolayer cells barrier can cause body to decline to the immune tolerance ability of microorganism species, produces abnormal immune response.The saccharomycete adopted can activate the activity of zinc in conjunction with metalloproteinases, significantly improves the content of polyamines in enteron aisle (spermine, spermidine).The DNA replication dna that exists for of polyamines creates favourable condition, the translational speed of replication fork is accelerated, promote the growth of intestinal cell, propagation, division and differentiation, thus can promote that intestinal villus is reached maturity, also the intestinal villus breakage because virus causes can be repaired fast, intestinal villus is made to recover normal to the absorbability of water and eletrolytes, alleviating diarrhoea.
6, NCG effectively can improve the endogenous material such as alkene element (interleukin-1) in immunity, Promote immunity system secretion natural killer cell, phagocyte, white blood cell, is conducive to pre-preventing virus infection.
NCG can save arginic consumption in body in vivo; equal to add arginic intake; arginine immunoregulation effect in vivo realizes mainly through the adjustment of Arg/NO approach and Endocrine hormone; because arginine is the precursor forming NO; at adjustment immunity of organism, the aspects such as intestinal mucosa function and protecting and tumor-specific immunity play an important role.Because N0 can synthesize relaxation factor at endothelial cell, therefore it can promote the perimucosal microcirculation of wound, and wound is healed early.
In immune system, except lymphocyte, cytophagous vigor is also relevant with arginine.Arginine also comes activated macrophage, neutrophil cell by forming nitric oxide (NO), can activate its enzyme system, make it to kill the target cell such as tumour cell or bacterium.
Arginine effectively can strengthen humoral immunity, and Promote immunity globulin produces.Arginine, by improving T lymphocyte to the reactivity of mitogen, stimulates T lymphopoiesis, and can increase the secretion of spleen monocyte proleulzin (IL-2) and the activity of IL-2 acceptor, strengthens the IV type hypersensitivity of T cell mediation.Arginine also can strengthen the phagocytic activity of macrophage, plays immunoregulation effect by the direct or indirect reaction improving T cell mediated.In addition, arginine plays an important role in the maturation of pre B cell.Arginine is also the starting material of polyamines synthesis.Polyamines is important biology regulation and control substance, and the biological metabolism of DNA, RNA and protein is relevant, plays a crucial role in cell growth cycle process.
Arginine also by promoting the release of multiple endocrine hormone, comprising insulin, growth hormone, prolactin, antidiuretic hormone and catecholamine etc., reaching the effect of immunity moderation.Insulin can not only carry out remote-effects immune system by Auto-regulator metabolism with on the impact of other endocrine hormones, can also directly act on lymphocyte and Monocytes/Macrophages surface receptor.All growth hormone receptor is there is in immune monocyte and lymphocyte, growth hormone can improve the activity of macrophage, neutrophil cell and NK, strengthens the ability of the vigor of T lymphocytes in vitro, source, inside and outside agglutinin inducing T cell proliferation and interleukin 2 synthesis.Prolactin has a direct impact cell and humoral immunity, and its immunity receptor is present in thymoma, monocyte, normal B lymphocytes and T lymphocyte, and when carrying out immune response with prolactin, lymphocyte can the regulation of secretion factor.
7, the effect of Yolk antibody
The formation of Yolk antibody, the immune system of bird comprises cellular immunity and humoral immunity, is subject to the control of thymus gland and the bursa of farbricius respectively.After body is subject to exotic antigen stimulation, B cell differentiation in the bursa of farbricius becomes thick liquid cell, and secreting specificity antibody enters blood circulation, when blood flows through ovary, specific antibody (mainly IgG) is accumulated gradually in egg cell, forms Yolk antibody; When egg cell secretion enters fallopian tubal, flow through the specific antibody (mainly IgA and IgM) contained in oviducal blood and enter in egg white, form egg white antibody.IgG divides a word with a hyphen at the end of a line and enters the result that egg cell is receptor acting, and thus IgG can accumulate in a large number in egg cell, and concentration is higher than the IgG in blood.Compared with Yolk antibody, the time that egg cell is divided a word with a hyphen at the end of a line in fallopian tubal is shorter, and thus egg white antibody content is atomic.Yolk antibody progresses into fowl embryo blood in fowl embryo hatching process, for firm hatch chick provides passive immune protection.
The character of yolk antibody IgY.The character of IgY is similar to mammiferous IgG.The molecular weight of normal chicken IgY is about 180KDa, and be made up of two light chains (2L) and two heavy chains (2H), molecular weight is respectively 60-70KDa and 22-30KDa.Its isoelectric point is about 5.2.IgY is compared with general mammal IgG, and IgY has stronger heat-resisting, acidproof, anti-ionic strength and certain resistance to enzymic degradation ability.
Lower than under 75 DEG C of conditions, IgY has good heat endurance.IgY preparation 4 DEG C of storages 5 years or in room temperature storage 6 months its activity still without significant change or decline, can keep more than 24h when 65 DEG C, heat its activity just obviously decline 60 DEG C after 90min when 70 DEG C, under 30min condition, pasteurization does not affect IgY; Higher than 80 DEG C, most of IgY loses activity.IgY is more stable when pH4.0-11.0, and active decline rapidly during pH3.0-3.5, during pH12, activity also declines to some extent.IgY has higher resistance to pepsin, but very responsive to trypsase.By pepsin and IgY after pH2.0 incubation 1h, nearly all loss of activity, but the activity that can keep 91% when pH4.0 after 1h, even still have 63% active after incubation 10h.IgY respectively with trypsase and pancreas renin incubation 8h, activity keeps 39% and 41% respectively.Illustrating can to the digestion of opposing two kinds of enzymes in IgY certain hour.
The mechanism of action of IgY.The Yolk antibody of specific pathogen bacterium can directly attach on the cell membrane of pathogen, changes the integrality of pathogenic cell, directly suppresses the growth of pathogen; Yolk antibody can attach on the pili of bacterium, makes it to attach to intestinal mucosa epithelial cell; Part Yolk antibody is under the effect of enteron aisle digestive ferment, being degraded to can binding fragment, these fragments contain diminished peptide (Fab) part of antibody, these little peptides are easy to by intestinal absorption, can be combined with specific pathogen adhesion factor after entering blood, make pathogen not stick permissive cell and to lose pathogenic, and the stable region of IgY (Fe part) is stayed in intestines.
The application of IgY in disease prevention and cure anti-human diarrhoeal diseases Escherichia coli IgY can make Escherichia coli assemble, thus the Growth and Reproduction of anti-bacteria, and promote that Escherichia coli are from the eliminating of enteron aisle.HRV (HRV) is the main pathogens causing immunoenzyme technics intestines problem, and in food, add anti-human rotavirus IgY can prevent food pollution, plays passive immune protection effect to human body.Anti-HRV-IgY is added at food.Effective passive immune protection may be provided completely for baby.But for older people, must protect IgY, avoid it destroyed in alimentary canal.Effectively can resist pepsic digestion in sour environment with liposome embedded lgY, make the oral disease preventing and treating of IgY become possibility.
Research shows, IgY can resist the digestion of trypsase and chymotrypsin in young animal enteron aisle.Therefore add a certain amount of IgY for some specified disease in be everlasting cub feed or additive, obtain effective passive immunity to make it.
8, with the acidulant that acid calcium sulfate (ACS) is composite
ACS has the inorganic acid compared with low-corrosiveness, can reduce PH in enteron aisle fast with the acidulant that ACS is composite, helps to maintain the colony balance in body.
9, tributyrin
Glycerol monobutyralte can provide protection of intestinal mucosal barrier cells energy source, promotes epithelial cell proliferation and differentiation, increases villi height, promotes Nutrient Absorption; By promoting the expression of tight junction protein, promote gut barrier function; Promote intestinal beneficial microbes (as lactic acid bacteria) propagation; In enteron aisle release slowly, through hindgut, compared with sodium butyrate, speed can increase butyric acid validity in 3 times; Raising animal body is disease-resistant, anti-stress ability, alleviates various stress loss.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A composition for prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: probio 0.1 part, N-carbamylglutamic acid 0.04 part, protease preparation 0.05 part, tributyrin 0.2 part, acidulant 0.2 part, Yolk antibody 0.05 part.
Above-mentioned probio comprises saccharomycete preparation and bacillus preparation, and the weight of saccharomycete preparation and bacillus preparation is 1: 1.Above-mentioned acidulant is that in compound acidulant, the mass content of acid calcium sulfate is 1% containing acid calcium sulfate compound acidulant.
Embodiment 2
A composition for prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: probio 0.8 part, N-carbamylglutamic acid 0.02 part, protease preparation 0.04 part, tributyrin 0.3 part, acidulant 0.3 part, Yolk antibody 0.03 part.
Above-mentioned probio comprises saccharomycete preparation and bacillus preparation, and the weight of saccharomycete preparation and bacillus preparation is 1: 2.Above-mentioned acidulant is that in compound acidulant, the mass content of acid calcium sulfate is 1% containing acid calcium sulfate compound acidulant.
Embodiment 3
A composition for prevention and therapy pig epidemic diarrhea, it is made up of the raw material of following weight parts proportioning: probio 0.5 part, N-carbamylglutamic acid 0.03 part, protease preparation 0.05 part, tributyrin 0.2 part, acidulant 0.3 part, Yolk antibody 0.04 part.
Above-mentioned probio comprises saccharomycete preparation and bacillus preparation, and the weight of saccharomycete preparation and bacillus preparation is 1: 1.Above-mentioned acidulant is that in compound acidulant, the mass content of acid calcium sulfate is 1% containing acid calcium sulfate compound acidulant.
Embodiment 4
Each raw material is taken by following weight:
Corn 54.5 parts, dregs of beans 21 parts, 12.5 parts, wheat bran, fish meal 2 parts, 2 parts, soya-bean oil, fatty powder 1 part, glucose 1 part, fibre and soya 3 parts, salt 0.42 part, Choline Chloride 0.25 part, stone flour 1 part, calcium monohydrogen phosphate 1.3 parts, 0.15 part, potassium chloride, containing the compound acidulant 0.2 part of acid calcium sulfate, mould inhibitor 0.1 part, 70% lysine sulphate 0.25 part, threonine 0.01 part, protease preparation 0.04 part, de-mould dose 0.05 part, antioxidant 0.05 part, N-carbamylglutamic acid 0.02 part, Organic Chromium 0.02 part, 0.4 part, saccharomycete preparation, bacillus preparation 0.4 part, Yolk antibody 0.03 part, tributyrin 0.2 part, yeast selenium 0.005 part, VE 0.02 part, biotin 0.03 part, 0.1 part, many ore deposits, multidimensional 0.03 part.
Many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.044 part, ferrous sulfate, manganese sulfate 0.024 part, 0.086 part, zinc sulfate, sodium selenite 0.016 part, KI 0.02 part.
Multidimensional is grouped into by the one-tenth of following weight: VA 0.01 part, VD30.006 part, VK30.003 part, VB10.003 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, 0.001 part, pantothenic acid, biotin 0.001 part.
Preparation method is as follows:
By corn, dregs of beans, wheat bran, soya-bean oil, fish meal, fatty powder, glucose, fibre and soya, salt, Choline Chloride, stone flour, calcium monohydrogen phosphate, potassium chloride, mould inhibitor, 70% lysine sulphate, threonine, de-mould dose, antioxidant, Organic Chromium, yeast selenium, VE, biotin, many ore deposits, multidimensional, mixer mixing 120-150s is put into after 2.0 particle diameters are pulverized, by mixed material vapour pressure the steam of 6-8Kg expanded through 3.0-4.0mm aperture ring die pelleter temperature 85-95 DEG C pulverize extrude pellet, feed granules is obtained through cooler cooling.By containing the compound acidulant of acid calcium sulfate, protease preparation, N-carbamylglutamic acid, saccharomycete preparation, bacillus preparation, Yolk antibody, tributyrin mixing, obtain composition additive.Above-mentioned feed granules of once granulating is sent into mixer in the lump with described composition additive after 0.5-0.8mm or 2.0mm pulverizes mix; incorporation time 120-150s; again mixture is put into 2.0-2.5mm aperture ring die pelleter and extrude pellet temperature 50-60 DEG C of scope; through cooler cooling obtained complete diet pellet particle, the i.e. breastfeeding sow compound feed of prevention and therapy pig epidemic diarrhea.
Embodiment 5
Each raw material is taken by following weight:
Corn 50 parts, dregs of beans 25 parts, 10 parts, wheat bran, fish meal 2 parts, 2 parts, soya-bean oil, fatty powder 1 part, glucose 1 part, fibre and soya 3 parts, salt 0.5 part, Choline Chloride 0.2 part, stone flour 1 part, calcium monohydrogen phosphate 2 parts, 0.1 part, potassium chloride, containing the compound acidulant 0.2 part of acid calcium sulfate, mould inhibitor 0.1 part, 70% lysine sulphate 0.5 part, threonine 0.01 part, protease preparation 0.05 part, de-mould dose 0.05 part, antioxidant 0.05 part, N-carbamylglutamic acid 0.03 part, Organic Chromium 0.01 part, 0.5 part, saccharomycete preparation, bacillus preparation 0.5 part, Yolk antibody 0.03 part, tributyrin 0.3 part, yeast selenium 0.005 part, VE 0.01 part, biotin 0.03 part, 0.1 part, many ore deposits, multidimensional 0.05 part.
Many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.044 part, ferrous sulfate, manganese sulfate 0.024 part, 0.086 part, zinc sulfate, sodium selenite 0.016 part, KI 0.02 part.
Multidimensional is grouped into by the one-tenth of following weight: VA 0.01 part, VD30.006 part, VK30.003 part, VB10.003 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, 0.001 part, pantothenic acid, biotin 0.001 part.
Preparation method is with embodiment 4.
Embodiment 6
Each raw material is taken by following weight:
Corn 55 parts, dregs of beans 20 parts, 15 parts, wheat bran, fish meal 5 parts, 5 parts, soya-bean oil, fatty powder 3 parts, glucose 3 parts, fibre and soya 1 part, salt 0.3 part, Choline Chloride 0.3 part, stone flour 3 parts, calcium monohydrogen phosphate 1 part, 0.2 part, potassium chloride, containing the compound acidulant 0.3 part of acid calcium sulfate, mould inhibitor 0.3 part, 70% lysine sulphate 0.2 part, threonine 0.03 part, protease preparation 0.03 part, de-mould dose 0.1 part, antioxidant 0.1 part, N-carbamylglutamic acid 0.01 part, Organic Chromium 0.03 part, 0.3 part, saccharomycete preparation, bacillus preparation 0.3 part, Yolk antibody 0.01 part, tributyrin 0.1 part, yeast selenium 0.01 part, VE 0.02 part, biotin 0.01 part, 0.3 part, many ore deposits, multidimensional 0.03 part.
Many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.044 part, ferrous sulfate, manganese sulfate 0.024 part, 0.086 part, zinc sulfate, sodium selenite 0.016 part, KI 0.02 part.
Multidimensional is grouped into by the one-tenth of following weight: VA 0.01 part, VD30.006 part, VK30.003 part, VB10.003 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, 0.001 part, pantothenic acid, biotin 0.001 part.
Preparation method is with embodiment 4.
Embodiment 7
Each raw material is taken by following weight:
Corn 9.6 parts, normal meal 6.8 parts, 18 parts, flour, popcorn 23 parts, crack rice 10 parts, expanded soybean 4 parts, low albumen whey powder 6 parts, fish meal 3 parts, fermented bean dregs 9 parts, 1 part, soya-bean oil, Choline Chloride 0.16 part, glucose 4 parts, white sugar 3 parts, methionine 0.15 part, lysine 0.35 part, tryptophan 0.05 part, 0.15 part, zinc oxide, sweetener 0.03 part, flavouring agent 0.08 part, 0.2 part, many ore deposits, antioxidant 0.1 part, multidimensional 0.04 part, containing the compound acidulant 0.2 part of acid calcium sulfate, protease preparation 0.05 part, N-carbamylglutamic acid 0.04 part, 0.05 part, saccharomycete preparation, bacillus preparation 0.05 part, Yolk antibody 0.03 part, tributyrin 0.3 part.
Above-mentioned many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.045 part, ferrous sulfate, manganese sulfate 0.02 part, 0.08 part, zinc sulfate, sodium selenite 0.015 part, KI 0.03 part.
Above-mentioned multidimensional is grouped into by the one-tenth of following weight: VA 0.02 part, VD30.004 part, VE 0.02 part, VK 30.004 parts, VB10.002 part, VB20.003 part, VB60.002 part, VB120.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, powdered rice hulls 0.339 part.
Preparation method is as follows:
By corn, normal meal, flour, popcorn, crack rice, expanded soybean, low albumen whey powder, fish meal, fermented bean dregs, soya-bean oil, Choline Chloride, glucose, white sugar, methionine, lysine, tryptophan, zinc oxide, sweetener, flavouring agent, Duo Kuang, antioxidant, multidimensional; mixer mixing 120-150s is put into after 2.0 particle diameters are pulverized; by mixed material vapour pressure the steam of 6-8Kg expanded through 3.0-4.0mm aperture ring die pelleter temperature 85-95 DEG C pulverize extrude pellet, through cooler cooling obtain feed granules.By containing the compound acidulant of acid calcium sulfate, protease preparation, N-carbamylglutamic acid, saccharomycete preparation, bacillus preparation, Yolk antibody, tributyrin mixing, obtain composition additive.Above-mentioned feed granules of once granulating is sent into mixer in the lump with described composition additive after 0.5-0.8mm or 2.0mm pulverizes mix; incorporation time 120-150s; again mixture is put into 2.0-2.5mm aperture ring die pelleter and extrude pellet temperature 50-60 DEG C of scope; through cooler cooling obtained complete diet pellet particle, the i.e. creep mixed feed for piglets of prevention and therapy pig epidemic diarrhea.
In order to verify the beneficial effect of feed of the present invention, do following Animal experiment:
One, sow test
1, experimental design: experimental animal is selected to know the test that pig people animal husbandry is carried out 50 days under the Daxin Group of Shandong.Test adopts single factor test contrast test, and select second fetus, body weight is close, and the pregnancy length of 90 days be in a good state of health, large binary sow 30, be divided into two processed group (control group and test group), often organize 15.Test group to start to feed breastfeeding sow compound feed prepared by the embodiment of the present invention 4 in pregnancy for 90 days, feeds until rutting again.Control group fed lactation material is that Qingdao great Xin feed corporation,Ltd produces and commercially available high-quality milking sow complete diet pellet, the same experimental group of program of feeding.
2, test period: 2015.1.22-2015.3.12, test site: Qingdao Zhi Zhuren animal husbandry Co., Ltd
3, feeding and management: feeding manner is conveniently raised, observes the ight soil diarrhoea situation of piglet, test data sheet piglet Birth weight, diarrhea rate, weaning weight, the death rate after farrowing.
4, evaluation criterion:
Observe piglet ight soil situation, ight soil is divided into normally, jewelry, expensive clothing and other valuables, thickness, water sample and bloody stool 5 grades, and jewelry, expensive clothing and other valuables, thickness, water sample and bloody stool are all judged to be diarrhoea.
5, result of the test is as following table 1.
Table 1
| Project | Control group | Test group |
| Average number born alive (head number) | 11.1 | 10.7 |
| Birth counterpoise (Kg) | 1.45 | 1.49 |
| 25 age in days wean young number (head) alive | 9.2 | 10.3 |
| The death rate (%) | 17.1 | 3.7 |
| Wean counterpoise (Kg) in 25 days | 7.55 | 7.94 |
| Grice diarrhoea rate (%) | 21.3 | 4.6 |
Result of the test shown in table 1 shows, milking sow adequate diet prepared by the present invention that feeds, and birth weight, the weaning weight of piglet are all greatly improved; Grice diarrhoea rate reduces 16.7%.
Two, piglet therapeutic test
1, experimental design: experimental animal is selected to know the test that pig people animal husbandry is carried out 10 days under the Daxin Group of Shandong.Test adopts single factor test contrast test, chooses the piglet 100 of happening and prevelence diarrhoea, is divided into two processed group (control group and test group), test group 75, creep mixed feed for piglets prepared by the embodiment of the present invention of feeding 7.Control group 25.Control group fed creep feed is that Qingdao great Xin feed corporation,Ltd produces and commercially available high-quality creep feed.The test pig main clinic symptoms chosen is that defecation frequency increases, and not shaping, ight soil is water sample, and occur vomiting, lassitude, anorexia, by Qingdao, experimental animal knows that pig people animal husbandry provides.
2, test period: 2014.1.27-2015.2.10, test site: Qingdao Zhi Zhuren animal husbandry Co., Ltd
3, feeding and management: feeding manner is conveniently raised, and creep mixed feed for piglets of the present invention of feeding, scale of feeding 1.5-2Kg/ head, feeds 4 times/day, feeds continuously 7 days.The full price creep feed that the large letter of control group fed is normally commercially available, takes LIJUNJING to treat, and injection consumption 0.2ml/Kg body weight, intramuscular injection, is used in conjunction 7 by 1 times/day.
4, the standard of curative effect evaluation:
The death rate: the dead pig with autonomous diarrhoea classical symptom and pathology accounts for the percentage of this test group pig.
Efficient: during off-test, respectively to organize the percentage that survival pig accounts for this test group pig.
Cure rate: after treatment, the percentage accounting for this test group pig that sick pig clinical symptoms disappear completely.
5, test data is as following table 2.
Table 2
| Project | Control group | Test group |
| Sum (head) | 25 | 75 |
| Death toll (head) | 12 | 5 |
| The death rate (%) | 48 | 6.7 |
| Cure number (head) | 11 | 68 |
| Cure rate (%) | 44 | 90.6 |
| Efficient (%) | 52 | 93.3 |
Result of the test shown in table 2 shows, the test group of porket creep adequate diet prepared by the present invention that feeds is compared with control group, and the death rate reduces by 41.3%, and cure rate improves 46.6%, efficient raising 41.3%, Be very effective.
Claims (10)
1. a composition for prevention and therapy pig epidemic diarrhea, is characterized in that it is made up of the raw material of following weight parts proportioning: probio 0.1-0.8 part, N-carbamylglutamic acid 0.02-0.04 part, protease preparation 0.04-0.05 part, tributyrin 0.2-0.3 part, acidulant 0.2-0.3 part, Yolk antibody 0.03-0.05 part.
2. the composition of a kind of prevention and therapy pig epidemic diarrhea according to claim 1, is characterized in that: described probio comprises saccharomycete preparation and bacillus preparation, and the weight of saccharomycete preparation and bacillus preparation is 1: 0.5-2.
3. the composition of a kind of prevention and therapy pig epidemic diarrhea according to claim 1, is characterized in that: described acidulant is that in compound acidulant, the content of acid calcium sulfate is 1% containing acid calcium sulfate compound acidulant.
4. a mixed feed for prevention and therapy pig epidemic diarrhea, is characterized in that: this mixed feed includes above-mentioned composition, and the content of composition in mixed feed is 0.3%-1.5%.
5. a breastfeeding sow compound feed for prevention and therapy pig epidemic diarrhea, is characterized in that it is made up of the raw material of following weight parts proportioning: corn 50-55 part, dregs of beans 20-25 part, wheat bran 10-15 part, fish meal 2-5 part, soya-bean oil 2-5 part, fatty powder 1-3 part, glucose 1-3 part, fibre and soya 1-3 part, salt 0.3-0.5 part, Choline Chloride 0.2-0.3 part, stone flour 1-3 part, calcium monohydrogen phosphate 1-2 part, potassium chloride 0.1-0.2 part, containing compound acidulant 0.2-0.3 part of acid calcium sulfate, mould inhibitor 0.1-0.3 part, 70% lysine sulphate 0.2-0.5 part, threonine 0.01-0.03 part, protease preparation 0.03-0.05 part, de-mould dose of 0.05-0.1 part, antioxidant 0.05-0.1 part, N-carbamylglutamic acid 0.01-0.03 part, Organic Chromium 0.01-0.03 part, saccharomycete preparation 0.3-0.5 part, bacillus preparation 0.3-0.5 part, Yolk antibody 0.01-0.03 part, tributyrin 0.1-0.3 part, yeast selenium 0.005-0.01 part, VE 0.01-0.02 part, biotin 0.01-0.03 part, many ore deposits 0.1-0.3 part, multidimensional 0.03-0.05 part.
6. the breastfeeding sow compound feed of a kind of prevention and therapy pig epidemic diarrhea according to claim 5, it is characterized in that the weight of each raw material is: corn 54.5 parts, dregs of beans 21 parts, 12.5 parts, wheat bran, fish meal 2 parts, 2 parts, soya-bean oil, fatty powder 1 part, glucose 1 part, fibre and soya 3 parts, salt 0.42 part, Choline Chloride 0.25 part, stone flour 1 part, calcium monohydrogen phosphate 1.3 parts, 0.15 part, potassium chloride, containing the compound acidulant 0.2 part of acid calcium sulfate, mould inhibitor 0.1 part, 70% lysine sulphate 0.25 part, threonine 0.01 part, protease preparation 0.04 part, de-mould dose 0.05 part, antioxidant 0.05 part, N-carbamylglutamic acid 0.02 part, Organic Chromium 0.02 part, 0.4 part, saccharomycete preparation, bacillus preparation 0.4 part, Yolk antibody 0.03 part, tributyrin 0.2 part, yeast selenium 0.005-0.01 part, VE 0.01-0.02 part, biotin 0.01-0.03 part, many ore deposits 0.1-0.3 part, multidimensional 0.03-0.05 part.
7. the breastfeeding sow compound feed of a kind of prevention and therapy pig epidemic diarrhea according to claim 5 or 6, is characterized in that described many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.044 part, ferrous sulfate, manganese sulfate 0.024 part, 0.086 part, zinc sulfate, sodium selenite 0.016 part, KI 0.02 part.
8. the breastfeeding sow compound feed of a kind of prevention and therapy pig epidemic diarrhea according to claim 5 or 6, is characterized in that described multidimensional is grouped into by the one-tenth of following weight: VA 0.01 part, VD3 0.006 part, VK3 0.003 part, VB1 0.003 part, VB2 0.003 part, VB6 0.002 part, VB12 0.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, 0.001 part, pantothenic acid, biotin 0.001 part.
9. the creep mixed feed for piglets of a prevention and therapy pig epidemic diarrhea, it is characterized in that it is made up of the raw material of following weight parts proportioning: corn 9.6 parts, normal meal 6.8 parts, 18 parts, flour, popcorn 23 parts, crack rice 10 parts, expanded soybean 4 parts, low albumen whey powder 6 parts, fish meal 3 parts, fermented bean dregs 9 parts, 1 part, soya-bean oil, Choline Chloride 0.16 part, glucose 4 parts, white sugar 3 parts, methionine 0.15 part, lysine 0.35 part, tryptophan 0.05 part, 0.15 part, zinc oxide, sweetener 0.03 part, flavouring agent 0.08 part, 0.2 part, many ore deposits, antioxidant 0.1 part, multidimensional 0.04 part, containing the compound acidulant 0.2 part of acid calcium sulfate, protease preparation 0.05 part, N-carbamylglutamic acid 0.04 part, 0.05 part, saccharomycete preparation, bacillus preparation 0.05 part, Yolk antibody 0.03 part, tributyrin 0.3 part.
10. the creep mixed feed for piglets of a kind of prevention and therapy pig epidemic diarrhea according to claim 9, is characterized in that described many ore deposits are grouped into by the one-tenth of following weight: 0.01 part, copper sulphate, 0.045 part, ferrous sulfate, manganese sulfate 0.02 part, 0.08 part, zinc sulfate, sodium selenite 0.015 part, KI 0.03 part; Described multidimensional is grouped into by the one-tenth of following weight: VA 0.02 part, VD3 0.004 part, VE 0.02 part, VK 30.004 parts, VB1 0.002 part, VB2 0.003 part, VB6 0.002 part, VB12 0.001 part, 0.004 part, nicotinic acid, 0.001 part, folic acid, powdered rice hulls 0.339 part.
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Application publication date: 20151014 |