CN106417919A - Special intestinal balance regulator for livestock as well as preparation method and application thereof - Google Patents

Special intestinal balance regulator for livestock as well as preparation method and application thereof Download PDF

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Publication number
CN106417919A
CN106417919A CN201610896851.8A CN201610896851A CN106417919A CN 106417919 A CN106417919 A CN 106417919A CN 201610896851 A CN201610896851 A CN 201610896851A CN 106417919 A CN106417919 A CN 106417919A
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parts
powder
poultry
tributyrin
special
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CN106417919B (en
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肖建森
郭丽华
刘亚群
刘在青
曾勇庆
陈宝江
沈广戈
白耀国
李鑫燕
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SHANDONG DEZHOU SHENNIU ANIMAL HEALTH PRODUCTS CO Ltd
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SHANDONG DEZHOU SHENNIU ANIMAL HEALTH PRODUCTS CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01006—Catalase (1.11.1.6)

Abstract

The invention relates to a special intestinal balance regulator for livestock. The special intestinal balance regulator is prepared from tributyrin, glucose oxidase, complex probiotics, catalase, xylooligosaccharides, gamma-aminobutyric acid, hawthorn fruit powder and nano-montmorillonite. The compound additive prepared from the tributyrin, biological enzymes, the complex probiotics and a proper carrier through optimized combination with a fluidized bed preparation technology not only can meet the intestinal balance requirements of the livestock, but also can improve the digestion and absorption capabilities of the livestock, improve the health condition of the livestock obviously and improve the production performance, thereby being suitable for promotion and application to large-scale farms.

Description

Special intestinal equilibrium modifier of a kind of poultry and its preparation method and application
Technical field
The present invention relates to the special intestinal equilibrium modifier of feed additive field, more particularly to a kind of poultry, further relates to poultry special Preparation method and application with intestinal equilibrium modifier.
Background technology
《People's Republic of China's the law of food safety》Formal execution in 1 day October in 2015, to being related to the beast of livestock The security evaluation criteria of medicine residual and feed additive is put forward higher requirement, the cry more and more higher of nonreactive cultivation.? In the decades in past, the animal husbandry of China is developed rapidly, and the thing followed is exactly constantly increasing for epidemic disease, antibiosis Element, antimicrobial drug, being increased using kind and quantity year by year of medicated feed additive, drug resistance increases year by year, livestock product safety wind Danger continues to increase.No. 168 feedstuff medicated premix operating specification statistics is announced according to The Ministry of Agriculture of the People's Republic of China, MOA, altogether 114 feedstuff medicated premix kinds of meter, wherein remove Herba Origani oil（Natural plant essential oils）Outward, chemical drugss and antibiotic are all belonged to. In recent years, as European Union and the U.S. to the disabling of antibiotic and limit the use of, China is cultivated with regard to nonreactive, the research of Substitutes For Antibiotic Emerge in an endless stream with application, conditioning intestinal balance such as probiotics（Direct-Fed Microbials）, feedstuff oligosaccharide, natural plant carry The correlation door product such as thing, bioactive oligopeptides, bio-pharmaceutical feed additive, acidulant is taken in Ge great scientific research institutions, university Common with enterprise, theoretical level is very high, and test data is ideal.But, as China's cultivation scale differs, cultivates ring Border manipulation level is general, aquaculture management level is uneven, cultivation custom difference is huge, trophic level various places not on an equal basis many because Element, staining effect differs.So being exclusively used in from poultry physiology, biochemistry, each angle of pharmacology with reference to breeding production actual development one kind Conditioning animal and bird intestines balance, anti-stress, the composite feed additive of noresidue, in the application of poultry large-scale cultivation and industrialization Prospect will be very wide.
Content of the invention
In order to solve risk and the above-mentioned intestinal canal regulating balance product that above existing feedstuff medicated premix brings to food safety Class is single, the shortcoming that feedback effectss differ, provide a kind of can nurse one's health comprehensively intestinal balance, anti-stress, noresidue poultry special Use intestinal equilibrium modifier, raw materials used be in feedstuff catalogue the raw material for allowing to use, any risk is not caused to livestock products. The special intestinal equilibrium modifier of poultry of the present invention can grow for animal and bird intestines energy is provided, for intestinal beneficial bacterium breeding offer battalion Support, regulating intestinal canal PH, resist various stress, enable to intestinal and reach relative equilibrium, show as abilities of digestive and absorption lifting, raise Material conversion ratio is improved, premunition strengthens, minimizing and other effects of suffering from diarrhoea, hence it is evident that improve livestock birds health situation.
Present invention also offers the preparation method of the special intestinal equilibrium modifier of above-mentioned poultry.
Present invention also offers the application of the special intestinal equilibrium modifier of above-mentioned poultry.
The technical solution used in the present invention is：
A kind of special intestinal equilibrium modifier of poultry, raw material weight proportioning of soup processed is as follows：
Tributyrin 100-140 part, glucoseoxidase 15-25 part, compound probiotic 8-20 part, catalase 6-14 Part, oligomeric xylose 20-40 part, γ-aminobutyric acid 5-12 part, 80～130 parts of Fructus Crataegi powder, nanometer Montmorillonitum 40-70 part.
The special intestinal equilibrium modifier of described poultry, preferred feedstock weight proportion is as follows：
Tributyrin 105-135 part, glucoseoxidase 18-22 part, compound probiotic 18-19 part, catalase 8- 13 parts, oligomeric xylose 25-28 part, γ-aminobutyric acid 8-9 part, 95～120 parts of Fructus Crataegi powder, nanometer Montmorillonitum 45-58 part.
The special intestinal equilibrium modifier of described poultry, preferred feedstock weight proportion is as follows：
120 parts of tributyrin, 18 parts of glucoseoxidase, 19 parts of compound probiotic, 8 parts of catalase, oligomeric xylose 25 parts, 8 parts of γ-aminobutyric acid, 95 parts of Fructus Crataegi powder, 48 parts of nanometer Montmorillonitum.
The special intestinal equilibrium modifier of described poultry, the preferably compound probiotic are Bacillus licheniformis, hay bud One or more of spore bacillus, streptococcus thermophiluss, bacillus bifiduss, Lactobacillus buchneri and Clostridium butyricum.
The special intestinal equilibrium modifier of described poultry, preferably in the compound probiotic, raw material weight proportioning of soup processed is：Lichens Bacillus cereuss 3-7 part, bacillus subtilises 2-5 part, streptococcus thermophiluss 4-8 part, Clostridium butyricum 3-8 part.It is preferred that lichens spore bar Bacterium 4-5 part, bacillus subtilises 3-4 part, streptococcus thermophiluss 4-5 part, 6 parts of Clostridium butyricum.
The special intestinal equilibrium modifier of described poultry, preferably in the compound probiotic, raw material weight proportioning of soup processed is：Lichens 5 parts of spore bar, 4 parts of bacillus subtilises, 4 parts of streptococcus thermophiluss, 6 parts of Clostridium butyricum.
The preparation method of the special intestinal equilibrium modifier of described poultry：
（1）Tributyrin and nanometer Montmorillonitum, compare 3 according to weight:1, from fluid bed, liquid tributyrin is entered After row atomization is dusted so as to become the tributyrin powder of mix homogeneously, standby；
（2）Catalase and nanometer Montmorillonitum, compare 1 according to weight:1, from fluid bed, liquid hydroperoxide enzyme is carried out mist Change after dusting so as to become the hydrogen peroxide enzyme powder of mix homogeneously, standby；
（3）By Fructus Crataegi powder fluidized bed, dry 20-50 minute at 60-80 DEG C, internal control moisture, less than 35 DEG C are let cool, obtains standby mountain Short, bristly hair or beard powder；
（4）Oligomeric xylose, compound probiotic, glucoseoxidase, γ-aminobutyric acid sequentially add the standby Fructus Crataegi powder after letting cool Interior, tributyrin powder and hydrogen peroxide enzyme powder is added, mix homogeneously is obtained final product.
Described preparation method, preferred steps（1）、（2）Middle selection fluidization, prepares tributyrin powder and mistake During hydrogen oxide enzyme powder, from 35 degree of inlet temperature, air inducing frequency 35Hz, spray gun pressure 0.15MPa, 200 revs/min of wriggling pump speed Clock.
The special intestinal equilibrium modifier of described poultry is preparing the application for adjusting in animal and bird intestines Balance Pharmaceuticals.
Described application, preferably adjusts animal and bird intestines Balance Pharmaceuticals lifting poultry abilities of digestive and absorption, reduces diarrhoea, reduces Feedstuff-meat ratio, improves livestock birds health situation, improves production performance.
The present invention is had found by lot of experiments, will comprising above-mentioned each raw material, the compound additive for preparing in the proper ratio, Obvious synergy can be produced, shows as abilities of digestive and absorption lifting（Punishment in advance phenomenon is reduced）, feed conversion rate improve（Material meat Than reducing）, premunition strengthen（Expenses for medicine reduces）, diarrhoea reduce and other effects, hence it is evident that improve livestock birds health situation.
In the special intestinal balance additive of poultry of the present invention：
Tributyrin：Villous vessels hypertrophy can be promoted as signaling molecule, promote intestinal growth；Directly absorbed by intestinal, Quick energy supply；
Glucoseoxidase：Breakdown of glucose is gluconic acid and hydrogen peroxide, liver protection suppression harmful microorganism breeding；
Compound probiotic：Regulating intestinal canal Micro Ecosystem is balanced, and prevents diarrhoea；
Catalase：As the scavenger of oxygen active substance, can make hydrogen peroxide that water and oxygen is decomposed into, reduce in intestinal mucosa The quantity of oxygen active substance, the second message,second messenger's effect for weakening oxygen active substance, so as to play a part of to protect intestinal mucosa；
Oligomeric xylose：Prebioticses, are that intestinal beneficial microbes provide abundant nutrition；
Food spice γ-aminobutyric acid：Modulation of appetite maincenter, anti-stress；Fructus Crataegi powder：Appetite-stimulating indigestion-relieving, suppresses antibacterial, strengthens machine The immunity of body；
Nanometer Montmorillonitum：Specific surface area is huge, covers digestive tract surface, and adsorbable fixation suppresses multiple viruses, pathogenic bacterias and its institute The toxin of generation, strengthens Mucosa Barrier, balances normal flora, improves gastral immunologic function.
Tributyrin, biological enzyme, compound probiotic and proper auxiliary materials are optimized combination by the present invention, using stream Change the compound additive that bed is made, be natural component, green safety, food safety composition is affected without hormone, antibiotic etc., because This is very wide in the popularization and application of scale livestock farming and industrialization prospect.
Beneficial effect：
（1）The optimum organization in the proper ratio of biological enzyme, compound probiotic and proper auxiliary materials is prepared into compound adding by the present invention Plus agent, with obvious synergy, poultry abilities of digestive and absorption can be effectively lifted, reduce diarrhoea, improve food conversion ratio（Material Meat is than reducing）, hence it is evident that improve livestock birds health situation, production performance is improved, be particularly suitable for scale livestock farming prevention and health care；
（2）From fluid bed preparation technology, under whole sealing status, liquid glycerol monobutyralte and catalase are passed through high pressure Spray gun is allowed to be atomized, and is uniformly sprayed in the nanometer Montmorillonitum of fluidized state, and the technique integrates spraying, mixing, dries, Simple to operate, time saving and energy saving, efficiency can be improved, while production cost is reduced, improve production environment；
（4）Natural component is using raw material, green, environmental protection, safety, without becoming for the impact food safety such as hormone, antibiotic Point, the rebound phenomena being both avoided that during hormone therapy, the drug resistance in antibiotic usage can be overcome again to strengthen problem, especially The popularization and application of suitable scale livestock farming and industrialization.
Specific embodiment
In order to be better understood from the present invention, further illustrate with reference to specific embodiment.
Embodiment 1
A kind of special intestinal of poultry balances additive, it is characterized in that obtaining by following steps：
（1）105 parts of tributyrin and 35 parts of nanometer Montmorillonitum, according to 3:1 ratio, will be sweet for three butanoic acid of liquid from fluid bed Grease is carried out after atomization dusts so as to become the tributyrin powder of mix homogeneously, standby；
（2）10 parts of catalase and 10 parts of nanometer Montmorillonitum, according to 1:1 ratio, from fluid bed by liquid hydroperoxide enzyme Carry out after atomization dusts so as to become the hydrogen peroxide enzyme powder of mix homogeneously, standby；
（3）By 120 parts of Fructus Crataegi powder, fluidized bed, 75 degree, dry 25 minutes, internal control moisture 2%, let cool to 30 degree, standby；
（4）25 parts of oligomeric xylose, 4 parts of lichens spore bar, 3 parts of bacillus subtilises, 5 parts of streptococcus thermophiluss, 6 parts of Clostridium butyricum, 20 parts of glucoseoxidase, 9 parts of γ-aminobutyric acid, pass sequentially through vacuum feeding, add in Fructus Crataegi powder, add three butanoic acid sweet Grease powder and hydrogen peroxide enzyme powder, mix homogeneously is obtained final product.
Embodiment 2
A kind of special intestinal of poultry balances additive, it is characterized in that obtaining by following steps：
（1）120 parts of tributyrin and 40 parts of nanometer Montmorillonitum, according to 3:1 ratio, will be sweet for three butanoic acid of liquid from fluid bed Grease is carried out after atomization dusts so as to become the tributyrin powder of mix homogeneously, standby；
（2）8 parts of catalase and 8 parts of nanometer Montmorillonitum, according to 1:Liquid hydroperoxide enzyme is entered by 1 ratio from fluid bed After row atomization is dusted so as to become the hydrogen peroxide enzyme powder of mix homogeneously, standby；
（3）By 95 parts of Fructus Crataegi powder, fluidized bed, 65 degree, dry 20 minutes, internal control moisture 2.5%, let cool to 25 degree, standby；
（4）25 parts of oligomeric xylose, 5 parts of lichens spore bar, 4 parts of bacillus subtilises, 4 parts of streptococcus thermophiluss, 6 parts of Clostridium butyricum, 18 parts of glucoseoxidase, 8 parts of γ-aminobutyric acid, pass sequentially through vacuum feeding, add in Fructus Crataegi powder, add three butanoic acid sweet Grease powder and hydrogen peroxide enzyme powder, mix homogeneously is obtained final product.
Embodiment 3
A kind of special intestinal of poultry balances additive, it is characterized in that obtaining by following steps：
（1）135 parts of tributyrin and 45 parts of nanometer Montmorillonitum, according to 3:1 ratio, will be sweet for three butanoic acid of liquid from fluid bed Grease is carried out after atomization dusts so as to become the tributyrin powder of mix homogeneously, standby；
（2）13 parts of catalase and 13 parts of nanometer Montmorillonitum, according to 1:1 ratio, from fluid bed by liquid hydroperoxide enzyme Carry out after atomization dusts so as to become the hydrogen peroxide enzyme powder of mix homogeneously, standby；
（3）By 100 parts of Fructus Crataegi powder, fluidized bed, 70 degree, dry 30 minutes, internal control moisture 2%, let cool to 33 degree, standby；
（4）28 parts of oligomeric xylose, 4 parts of lichens spore bar, 3 parts of bacillus subtilises, 5 parts of streptococcus thermophiluss, 6 parts of Clostridium butyricum, 22 parts of glucoseoxidase, 9 parts of γ-aminobutyric acid, pass sequentially through vacuum feeding, add in Fructus Crataegi powder, add three butanoic acid sweet Grease powder and hydrogen peroxide enzyme powder, mix homogeneously is obtained final product.
Effect test
First, the impact to Growth Performance of Weaning Piglets and health
1st, materials and methods
（1）Test packet：Select later lactation 40 nest of DABAI piglet, totally 402（The body weight body condition of piglet, birth and wean Date is close）, by random district's groups, 40 nest piglets are divided into 4 treatment groups, i.e. matched group, test group A, experiment group B, test group C, 10 nests are per group（It is that each process has 10 repetitions）, each test group piglet is in first 5 days, i.e. 23 ages in days that wean（28 ages in days break Milk）Start, the additive that test group A is obtained using embodiment 1, the additive that experiment group B is obtained using embodiment 2, test group C The additive for being obtained using embodiment 3, matched group is not used.By per the uniform spice 50kg of 100g, 15 days are used in conjunction, each group presses pig farm Routine carries out same feeding and management, tests and terminates to 76 age in days child care phases, 53 days experimental periods.All-the-way tracking record piglet growth Performance and dead naughty and onset state.
2nd, testing index
（1）The measure of production performance
The feeding and management measure of each test group and matched group piglet is completely the same.Piglet during determination test（Wean～child care is tied Bundle）Weaning weight, child care terminate weight（It is bred as weight）, the death rate of piglet and fur development condition, count each test group respectively The difference of speed of weight increment, incubation rate with matched group piglet during testing.
The measure of speed of weight increment：Each group test pig claims 28 age in days weaning weights on an empty stomach（W1）, raise through the child care phases of 48 days, At the end of test pig child care（76 ages in days）Equally weigh on an empty stomach（W2）, then average daily gain=（W2-W1）/ 48.
As can be seen from Table 1,76 age in days child care pig weight, test group A, B, C are above matched group, compared with matched group It is respectively increased 11.81%, 11.41%, 5.07%.Child care phase average daily gain test group A, B, C are all increased compared with matched group, point 11.62%, 15.39%, 7.19% is not improve, wherein, the amplitude maximum that experiment group B is improved, next to that test group A, with matched group Compare significant difference（P<0.05）.
The impact of 1 pair of wean child care piglet growth performance of table
Project Test group A Experiment group B Test group C Matched group
Head number（Nest number） 99（10 nests） 102（10 nests） 97（10 nests） 102（10 nests）
28 age in days weaning weights/kg 8.61±1.45 7.85±0.90 7.69±0.90 7.67±0.42
76 age in days child care weight/kg 28.03±4.38 27.93±3.00 26.34±1.03 25.07±0.62
Child care phase average daily gain/g 404.67±60.88a 418.33±41.63a 388.58±23.27ab 362.53±7.77b
（2）The test and appraisal of piglet health status
The evaluation of piglet diarrhea situation：Observe and record test during the daily diarrhoea situation of per test pig, by 4 grades score into Row test and appraisal, wherein, 0 is divided into and not suffering from diarrhoea（Feces are apparent normal）, 1 is divided into mild diarrhea（Feces are apparent softer）, 2 are divided into moderate abdomen Rush down（Feces are apparent diluter）, 3 are divided into severe diarrhea（Feces are apparent for liquid）；Scours index=observed and recorded fraction summation/sight Examine total natural law.
The evaluation of piglet fur development condition：The child care phase terminates first 1 day, respectively the fur development condition of test pig is carried out Evaluation.The grading system used by subjective scoring system is 1～5 point, i.e. 1=fur is very coarse；2=rough coat；3=fur More smooth；4=fur is smooth；5=fur unusual light is simultaneously glossy.
As can be seen from Table 2, compared with matched group, the death rate for testing A, B, C group wean child care piglet all becomes in decline Gesture, reduces 2.82,2.94,2.74 percentage points respectively, and wherein experiment group B death rate is minimum.Piglet diarrhea index is respectively tested Group is all on a declining curve, have dropped 21.82%, 23.57%, 19.03% respectively（P<0.05）, and test the diarrhoea of B group and A group Index is substantially less than matched group（P<0.05）.The each test group of piglet fur development condition scoring is respectively increased compared with matched group 20.71%、19.53%、28.70%（P<0.05）, wherein test A, B, C group and be significantly higher than matched group（P<0.05）.
The impact of 2 pairs of wean child care piglet health status of table
Project Test group A Experiment group B Test group C Matched group
Head number（Nest number） 99 102 97 102
Death rate/% 4.04（4/99） 3.92（4/102） 4.12（4/97） 6.86（7/102）
Survival rate/% 95.96（95/99） 96.08（98/102） 95.88（93/97） 93.14（95/102）
Piglet diarrhea index 0.534c 0.522c 0.553bc 0.683a
Fur development condition scores 4.08±0.35a 4.04±0.22a 4.35±0.41a 3.38±0.25b
（3）The measure of Serum Biochemical Index in Piglets
1 day before off-test, per group 4 piglets of random choose（Totally 20）10 mL of blood sampling, add containing the true of coagulant on an empty stomach In empty blood taking tube, coagulant pipe is put into after 20 min of water-bath, serum transfers are entered centrifuge tube, -20 DEG C save backup.Use Hitachi 7170A type automatic clinical chemistry analyzer determines Biochemical Indices In Serum.
As can be seen from Table 3, total protein in each test group child care Serum Biochemical Index in Piglets（TP）, albumin（ALB）, ball Albumen（GLB）, glucose（GLU）, calcium（Ca）, phosphorus（IP）Equal difference is not notable compared with matched group（P>0.05）, wherein, each examination Test group serum T P, IP and matched group is above, and serum Ca is below matched group, but difference is not notable（P>0.05）.Test group A, The serum urea of B, C（UREA）Content is all low than matched group, respectively reduce by 3.92%, 21.57%, 4.71%, wherein experiment group B with Matched group compares significant difference（P<0.05）.
Impact of the table 3 to child care piglet serum biochemical parameters
Project Test group A Experiment group B Test group C Matched group
Total protein TP (mg/mL) 57.23±1.67 53.5±4.82 54.18±3.72 52.05±4.63
Albumin A LB (mg/mL) 28.58±2.45 25.38±2.00 27.8±1.65 25.65±1.15
Lysozyme LB (mg/mL) 28.65±1.24 28.13±4.60 26.38±4.80 26.40±4.42
Serum urea UREA (mg/mL) 2.45±0.94a 2.00±0.62b 2.43±0.32a 2.55±1.06a
Glucose GLU (mg/mL) 6.19±0.53 6.02±1.05 6.11±0.59 6.16±0.55
Calcium Ca (mg/mL) 2.69±0.25 2.64±0.11 2.66±0.12 2.73±0.30
Phosphorus IP (mg/mL) 2.99±0.56 3.01±0.24 3.12±0.16 2.84±0.42
（4）Impact to child care piglet activity of serum enzyme
As can be seen from Table 4, each test group and its matched group child care piglet serum glutamic pyruvic transminase（ALT）Activity difference is not notable （P>0.05）.Compared with matched group, test group A, B, the alkali phosphatase of C（ALP）Activity difference high by 27.53%, 25.32%, 18.05%（P<0.05）.
Impact of the table 4 to child care piglet activity of serum enzyme
Project Test group A Experiment group B Test group C Matched group
Glutamate pyruvate transaminase ALT (U/L) 51.00±4.08 43.75±4.03 46.50±8.35 49.75±16.46
Glutamic oxaloacetic transaminase, GOT AST (U/L) 56.75±14.45a 53.25±21.12ab 60.75±24.76a 58.50±8.06a
Alkaline phosphatase (U/L) 245.50±28.38a 241.25±66.05a 227.25±76.17a 192.50±21.46b
Conclusion：This experimental study is proved, feeds regulator of the present invention before and after weaned piglet, can effectively alleviate wean to piglet Stress, immunity and the metabolism of body is lifted, the speed of weight increment during piglet cradling is improved, improves its growth promoter and health Situation, reduces diarrhoea and death rate.Integrated comparative, in 3 kinds of prescription test specimens, the effect of embodiment 2 is more notable.
2nd, on meat chicken production performance impact test
1st, materials and methods
Select with a collection of baby chick（Large-scale AA broiler soon）, same plant, same management mode and raise competence totally 4 canopy, test A Group totally 17820, the additive for being obtained using embodiment 1；Test B group totally 17930, the additive for being obtained using embodiment 2； Test C group totally 17950, the additive for being obtained using embodiment 3；Each test group is respectively at 1-7 age in days, 15-21 age in days, 29- 35 ages in days, every night is calculated according to whole day consumption, is watered 2000kg by every 500g and is concentrated use in, and totally 17945 not for matched group Add, routinely same feeding and management is carried out, test to 41 ages in days and deliver end, 40 days experimental periods for sale.All-the-way tracking record is dead Naughty rate, survival rate, feedstuff-meat ratio.
2nd, result of the test：Concrete outcome is as follows
As can be seen from Table 5, test group A, B, C death rate reduce by 0.69,1.93,0.47 percentage point respectively than control group, examination Test group feedstuff-meat ratio and reduce by 0.07,0.13,0.06 respectively than control group.
Impact of the table 5 to meat chicken production performance
Project Test group A Experiment group B Test group C Matched group
Chicken number 17820 17930 17950 17945
Dead naughty（Only） 695 477 739 823
Death rate（%） 3.90 2.66 4.12 4.59
Survival rate（%） 96.10 97.34 95.88 95.41
Feedstuff-meat ratio 1.71:1 1.65:1 1.72:1 1.78:1
Conclusion：This experimental study is proved, the interim feeding of broiler composite feed additive of the present invention, can effectively reduce dead washing in a pan Rate, improves survival rate, reduces feedstuff-meat ratio, increases economic efficiency.Integrated comparative, in 3 kinds of prescription test specimens, the effect of embodiment 2 Fruit is more notable.
Summary：A kind of special intestinal equilibrium modifier of poultry of the present invention, can effectively lift poultry abilities of digestive and absorption, Reduce diarrhoea, improve food conversion ratio（Feedstuff-meat ratio reduces）, hence it is evident that improve livestock birds health situation, improve production performance.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not limited by embodiment System, other any spirit without departing from the present invention and the change that is made under principle, modification, combines, substitutes, simplifying and all should be Equivalence replacement mode, is included within protection scope of the present invention.

Claims (10)

1. the special intestinal equilibrium modifier of a kind of poultry, it is characterised in that raw material weight proportioning of soup processed is as follows：
Tributyrin 100-140 part, glucoseoxidase 15-25 part, compound probiotic 8-20 part, catalase 6-14 Part, oligomeric xylose 20-40 part, γ-aminobutyric acid 5-12 part, 80～130 parts of Fructus Crataegi powder, nanometer Montmorillonitum 40-70 part.
2. the special intestinal equilibrium modifier of poultry according to claim 1, it is characterised in that raw material weight proportioning of soup processed is as follows：
Tributyrin 105-135 part, glucoseoxidase 18-22 part, compound probiotic 18-19 part, catalase 8- 13 parts, oligomeric xylose 25-28 part, γ-aminobutyric acid 8-9 part, 95～120 parts of Fructus Crataegi powder, nanometer Montmorillonitum 45-58 part.
3. the special intestinal equilibrium modifier of poultry according to claim 1, it is characterised in that raw material weight proportioning of soup processed is as follows：
120 parts of tributyrin, 18 parts of glucoseoxidase, 19 parts of compound probiotic, 8 parts of catalase, oligomeric xylose 25 parts, 8 parts of γ-aminobutyric acid, 95 parts of Fructus Crataegi powder, 48 parts of nanometer Montmorillonitum.
4. the special intestinal equilibrium modifier of poultry according to claim 1, it is characterised in that the compound probiotic is ground One or more of clothing bacillus cereuss, bacillus subtilises, streptococcus thermophiluss, bacillus bifiduss, Lactobacillus buchneri and Clostridium butyricum.
5. the special intestinal equilibrium modifier of poultry according to claim 1, it is characterised in that the compound probiotic Central Plains Expect that weight proportion is：Bacillus licheniformis 3-7 part, bacillus subtilises 2-5 part, streptococcus thermophiluss 4-8 part, Clostridium butyricum 3-8 Part.
6. the special intestinal equilibrium modifier of poultry according to claim 3, it is characterised in that the compound probiotic Central Plains Expect that weight proportion is：5 parts of lichens spore bar, 4 parts of bacillus subtilises, 4 parts of streptococcus thermophiluss, 6 parts of Clostridium butyricum.
7. a kind of preparation method of the special intestinal equilibrium modifier of poultry any one of claim 1-6, its feature exists In
（1）Tributyrin and nanometer Montmorillonitum, compare 3 according to weight:1, from fluid bed, liquid tributyrin is entered After row atomization is dusted so as to become the tributyrin powder of mix homogeneously, standby；
（2）Catalase and nanometer Montmorillonitum, compare 1 according to weight:1, from fluid bed, liquid hydroperoxide enzyme is carried out mist Change after dusting so as to become the hydrogen peroxide enzyme powder of mix homogeneously, standby；
（3）By Fructus Crataegi powder fluidized bed, dry 20-50 minute at 60-80 DEG C, internal control moisture, less than 35 DEG C are let cool, obtains standby mountain Short, bristly hair or beard powder；
（4）Oligomeric xylose, compound probiotic, glucoseoxidase, γ-aminobutyric acid sequentially add the standby Fructus Crataegi powder after letting cool Interior, tributyrin powder and hydrogen peroxide enzyme powder is added, mix homogeneously is obtained final product.
8. preparation method according to claim 7, it is characterised in that step（1）、（2）Middle selection fluidization, prepares When tributyrin powder and hydrogen peroxide enzyme powder, from 35 degree of inlet temperature, air inducing frequency 35Hz, spray gun pressure 0.15MPa, 200 revs/min of wriggling pump speed.
9. described in a kind of special intestinal equilibrium modifier of poultry any one of claim 1-6 and claim 7 or 8 The special intestinal equilibrium modifier of poultry that preparation method is prepared is preparing the application for adjusting in animal and bird intestines Balance Pharmaceuticals.
10. application according to claim 9, it is characterised in that adjust animal and bird intestines Balance Pharmaceuticals lifting poultry and digest and assimilate Ability, reduces diarrhoea, reduces feedstuff-meat ratio, improve livestock birds health situation, improve production performance.
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CN108029854A (en) * 2017-12-10 2018-05-15 济南诺能生物工程有限公司 A kind of compound formulation of alternative feeding antibiotic
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CN110179010A (en) * 2019-06-27 2019-08-30 南京农业大学 It is a kind of for improving the premixed feed and its preparation method and application of laying hen intestinal health
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CN111227126A (en) * 2019-12-31 2020-06-05 山西大禹生物工程股份有限公司 Anti-diarrhea growth-promoting piglet feed additive and preparation method thereof
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CN106900981A (en) * 2017-03-02 2017-06-30 江西派尼生物药业有限公司 It is a kind of to be applied to the immunopotentiating composition containing micro-powder of Chinese herbs, xylo-oligosaccharide, enzyme preparation and probiotics in livestock and poultry cultivation
CN107927328A (en) * 2017-04-26 2018-04-20 山东弘德农牧科技有限公司 A kind of preparation method and applications of feed composite microecologic agent
CN107927382A (en) * 2017-10-30 2018-04-20 山东弘德农牧科技有限公司 A kind of complex enzyme preparation for feeding and preparation method and application
WO2019095935A1 (en) * 2017-11-20 2019-05-23 济南百斯杰生物工程有限公司 Microecological formulation compatible with glucose oxidase, preparation method therefor and use thereof
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CN108029854A (en) * 2017-12-10 2018-05-15 济南诺能生物工程有限公司 A kind of compound formulation of alternative feeding antibiotic
CN108497212A (en) * 2018-04-27 2018-09-07 佛山科学技术学院 The microbial association fermented feed preparation method of one breeder
CN111802513A (en) * 2019-04-11 2020-10-23 河北维尔利动物药业集团有限公司 Preparation method of glucose oxidase probiotic additive for poultry livestock feed
CN110179010A (en) * 2019-06-27 2019-08-30 南京农业大学 It is a kind of for improving the premixed feed and its preparation method and application of laying hen intestinal health
CN110373396A (en) * 2019-07-15 2019-10-25 上海尤特尔生化有限公司 A kind of chaetomium thermophilum heatproof catalase and application
CN110839779A (en) * 2019-12-13 2020-02-28 济南百斯杰生物工程有限公司 Glucose oxidase composite product for reducing feed conversion ratio of broiler chickens and application thereof
CN111227126A (en) * 2019-12-31 2020-06-05 山西大禹生物工程股份有限公司 Anti-diarrhea growth-promoting piglet feed additive and preparation method thereof
CN111149919A (en) * 2020-01-14 2020-05-15 湖南泰丰动物药业有限公司 Glycerol butyrate compound for poultry as well as preparation method and application thereof
CN114027414A (en) * 2021-11-20 2022-02-11 广东溢多利生物科技股份有限公司 Traditional Chinese medicine esterase composition for laying hens and application thereof

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