CN106417919B - Intestinal balance regulator special for livestock and poultry and preparation method and application thereof - Google Patents
Intestinal balance regulator special for livestock and poultry and preparation method and application thereof Download PDFInfo
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- CN106417919B CN106417919B CN201610896851.8A CN201610896851A CN106417919B CN 106417919 B CN106417919 B CN 106417919B CN 201610896851 A CN201610896851 A CN 201610896851A CN 106417919 B CN106417919 B CN 106417919B
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Classifications
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- C—CHEMISTRY; METALLURGY
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- Feed For Specific Animals (AREA)
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Abstract
The invention relates to a special intestinal tract balance regulator for livestock and poultry, which comprises the following components: tributyrin, glucose oxidase, composite probiotics, catalase, xylooligosaccharide, gamma-aminobutyric acid, hawthorn powder and nano montmorillonite. According to the invention, the tributyrin, the biological enzymes, the composite probiotics and the proper carrier are optimally combined, and the fluidized bed preparation technology is adopted to prepare the composite additive, so that the requirement on livestock intestinal tract balance can be met, the digestion and absorption capacity of the livestock can be improved, the health condition of the livestock can be obviously improved, the production performance can be improved, and the composite additive is suitable for popularization and application of large-scale farms.
Description
Technical Field
The invention relates to the field of feed additives, in particular to a livestock and poultry special intestinal balance regulator, and also relates to a preparation method and application of the livestock and poultry special intestinal balance regulator.
Background
The food safety law of the people's republic of China has been formally implemented in 2015 at 10-1 month, higher requirements are put forward on safety evaluation standards of veterinary drug residues and feed additives related to the animal husbandry industry, and the call for antibiotic-free breeding is higher and higher. In the past decades, the animal husbandry of China has been rapidly developed, and the diseases are continuously aggravated, the use varieties and the number of antibiotics, antibacterial drugs and drug feed additives are increased year by year, the drug resistance is aggravated year by year, and the safety risk of animal products is continuously increased. According to statistics of feed drug additive use specifications of 168 bulletin of Ministry of agriculture of the people's republic of China, 114 feed drug additive varieties are counted, wherein except oregano oil (natural plant essential oil), the feed drug additive varieties belong to chemical drugs and antibiotics. In recent years, along with banning and restriction of antibiotics in European Union and America, research and application of antibiotic substitutes and antibiotic breeding are in endlessly in China, and related products such as probiotics (directly fed microorganisms), feed oligosaccharides, plant natural extracts, bioactive oligopeptides, biological drug feed additives, acidifiers and the like for regulating intestinal balance are common in various scientific research institutes, universities and enterprises, the theoretical level is very high, and test data are very ideal. However, the effect feedback is different due to various factors such as different culture scales, common culture environment control level, different culture management levels, huge culture habit differences, different nutrition levels in various places and the like in China. Therefore, the compound feed additive specially used for conditioning the intestinal balance of the livestock and poultry, resisting stress and having no residue is actually developed by combining the physiological, biochemical and pharmacological aspects of the livestock and poultry with the culture production, and has very wide application and industrialization prospect in the large-scale livestock and poultry culture.
Disclosure of Invention
In order to solve the risks brought to food safety by the existing feed pharmaceutical additives and the defects of single type and inconsistent feedback effect of the intestinal tract conditioning balanced product, the intestinal tract balance regulator special for the livestock and poultry, which can comprehensively condition intestinal tract balance, is anti-stress and has no residue, all the raw materials are raw materials allowed to be used in feed catalogues, and no risk is caused to livestock products. The livestock and poultry special intestinal tract balance regulator can provide energy for the growth of livestock and poultry intestinal tracts, provide nutrition for the propagation of beneficial bacteria in the intestinal tracts, regulate the pH of the intestinal tracts, resist various stresses, enable the intestinal tracts to achieve relative balance, and has the effects of improving the digestion and absorption capacity, improving the feed conversion rate, enhancing the disease resistance, reducing diarrhea and the like, thereby obviously improving the health condition of the livestock and poultry.
The invention also provides a preparation method of the intestinal balance regulator special for livestock and poultry.
The invention also provides application of the livestock and poultry special intestinal tract balance regulator.
The technical scheme adopted by the invention is as follows:
the intestinal tract balance regulator for livestock and poultry comprises the following raw materials in parts by weight:
140 parts of tributyrin 100, 15-25 parts of glucose oxidase, 8-20 parts of composite probiotics, 6-14 parts of catalase, 20-40 parts of xylo-oligosaccharide, 5-12 parts of gamma-aminobutyric acid, 80-130 parts of hawthorn powder and 40-70 parts of nano montmorillonite.
The intestinal balance regulator special for livestock and poultry preferably comprises the following raw materials in parts by weight:
135 parts of tributyrin 105, 18-22 parts of glucose oxidase, 18-19 parts of composite probiotics, 8-13 parts of catalase, 25-28 parts of xylo-oligosaccharide, 8-9 parts of gamma-aminobutyric acid, 95-120 parts of hawthorn powder and 45-58 parts of nano montmorillonite.
The intestinal balance regulator special for livestock and poultry preferably comprises the following raw materials in parts by weight:
120 parts of tributyrin, 18 parts of glucose oxidase, 19 parts of composite probiotics, 8 parts of catalase, 25 parts of xylooligosaccharide, 8 parts of gamma-aminobutyric acid, 95 parts of hawthorn powder and 48 parts of nano montmorillonite.
Preferably, the composite probiotics is more than one of bacillus licheniformis, bacillus subtilis, streptococcus thermophilus, bifidobacterium, lactobacillus buchneri and clostridium butyricum.
The intestinal balance regulator special for livestock and poultry preferably comprises the following raw materials in parts by weight: 3-7 parts of bacillus licheniformis, 2-5 parts of bacillus subtilis, 4-8 parts of streptococcus thermophilus and 3-8 parts of clostridium butyricum. Preferably 4-5 parts of bacillus licheniformis, 3-4 parts of bacillus subtilis, 4-5 parts of streptococcus thermophilus and 6 parts of clostridium butyricum.
The intestinal balance regulator special for livestock and poultry preferably comprises the following raw materials in parts by weight: 5 parts of bacillus licheniformis, 4 parts of bacillus subtilis, 4 parts of streptococcus thermophilus and 6 parts of clostridium butyricum.
The preparation method of the intestinal balance regulator special for livestock and poultry comprises the following steps:
(1) selecting a fluidized bed to atomize and spray liquid tributyrin into tributyrin powder for later use after the tributyrin and the nano montmorillonite are mixed uniformly according to the weight ratio of 3: 1;
(2) spraying and atomizing catalase and nano montmorillonite by using a fluidized bed according to the weight ratio of 1:1 to obtain uniformly mixed catalase powder for later use;
(3) feeding fructus crataegi powder into fluidized bed, oven drying at 60-80 deg.C for 20-50 min, controlling water content, cooling to below 35 deg.C to obtain fructus crataegi powder;
(4) sequentially adding xylo-oligosaccharide, composite probiotics, glucose oxidase and gamma-aminobutyric acid into the cooled standby hawthorn powder, adding tributyrin powder and hydrogen peroxide enzyme powder, and uniformly mixing to obtain the product.
In the preparation method, the fluidized bed technology is preferably selected in the steps (1) and (2), and when the tributyrin powder and the hydrogen peroxide enzyme powder are prepared, the air inlet temperature is 35 ℃, the air induction frequency is 35Hz, the pressure of a spray gun is 0.15MPa, and the speed of a peristaltic pump is 200 r/min.
The application of the livestock and poultry special intestinal tract balance regulator in preparing the livestock and poultry intestinal tract balance regulating medicine.
The application preferably selects the medicine for regulating the intestinal balance of the livestock and poultry, improves the digestive absorption capacity of the livestock and poultry, reduces diarrhea, reduces the feed conversion ratio, improves the health condition of the livestock and poultry, and improves the production performance.
A large number of experiments show that the compound additive prepared by the raw materials according to a proper proportion can generate obvious synergistic effect, has the effects of improving digestion and absorption capacity (reducing overfeeding phenomenon), improving feed conversion rate (reducing feed conversion ratio), enhancing disease resistance (reducing drug cost), reducing diarrhea and the like, and obviously improves the health condition of livestock and poultry.
The special intestinal tract balance additive for livestock and poultry comprises the following components in parts by weight:
glycerol tributyrate: as a signal molecule, the polypeptide can promote the proliferation of villus vessels and promote the development of intestinal tracts; can be directly absorbed by intestinal tract to supply energy rapidly;
glucose oxidase: glucose is decomposed into gluconic acid and hydrogen peroxide, so that the liver is protected and harmful microorganism propagation is inhibited;
compounding probiotics: regulating intestinal microecological system balance, and preventing diarrhea;
catalase: as a scavenger of oxygen active substances, hydrogen peroxide can be decomposed into water and oxygen, the amount of oxygen active substances in intestinal mucosa is reduced, and the second messenger effect of the oxygen active substances is weakened, so that the intestinal mucosa is protected;
and (3) xylo-oligosaccharide: prebiotics, which provide abundant nutrition for beneficial microorganisms in the intestinal tract;
flavor for food γ -aminobutyric acid: regulating appetite center, and resisting stress; hawthorn powder: promoting appetite and digestion, inhibiting bacteria, and enhancing immunity;
nano montmorillonite: the specific surface area is huge, the coating covers the surface of the digestive tract, can adsorb, fix and inhibit various viruses, germs and toxins generated by the viruses and the germs, strengthen mucosal barriers, balance normal flora and improve the immunologic function of the digestive tract.
According to the invention, the tributyrin, the biological enzymes, the composite probiotics and the appropriate auxiliary materials are optimally combined, and the composite additive prepared by the fluidized bed is natural, green and safe, does not contain components which affect food safety, such as hormones, antibiotics and the like, and has very wide popularization and application and industrialization prospects in large-scale farms.
Has the advantages that:
(1) according to the invention, biological enzymes, compound probiotics and appropriate auxiliary materials are optimally combined in a proper proportion to prepare the compound additive, so that the compound additive has an obvious synergistic effect, can effectively improve the digestive absorption capacity of livestock and poultry, reduce diarrhea, improve the feed conversion rate (feed conversion ratio is reduced), obviously improve the health condition of the livestock and poultry, improve the production performance, and is particularly suitable for prevention and health care of large-scale farms;
(2) the preparation method has the advantages that a fluidized bed preparation process is selected, the liquid glyceryl butyrate and the catalase are atomized through a high-pressure spray gun and uniformly sprayed in the boiling nano-montmorillonite in a fully sealed state, the process integrates spraying, mixing and drying, the operation is simple, time and labor are saved, the efficiency can be improved, the production cost is reduced, and the production environment is improved;
(4) the raw materials are all natural components, are green, environment-friendly and safe, do not contain components which influence food safety, such as hormone, antibiotics and the like, can avoid rebound phenomenon in the hormone treatment process, can overcome the problem of drug resistance enhancement in the use of antibiotics, and are particularly suitable for popularization and application and industrialization of large-scale farms.
Detailed Description
For a better understanding of the present invention, reference is made to the following examples.
Example 1
The intestinal tract balance additive special for livestock and poultry is characterized by being obtained through the following steps:
(1) 105 parts of tributyrin and 35 parts of nano montmorillonite, and atomizing and spraying liquid tributyrin into powder of the evenly mixed tributyrin by using a fluidized bed according to the proportion of 3:1 for later use;
(2) spraying 10 parts of catalase and 10 parts of nano montmorillonite in a ratio of 1:1 by using a fluidized bed to atomize and spray liquid catalase to obtain uniformly mixed catalase powder for later use;
(3) feeding 120 parts of hawthorn powder into a fluidized bed, drying at 75 ℃ for 25 minutes, controlling the water content to be 2%, and cooling to 30 ℃ for later use;
(4) 25 parts of xylo-oligosaccharide, 4 parts of bacillus licheniformis, 3 parts of bacillus subtilis, 5 parts of streptococcus thermophilus, 6 parts of clostridium butyricum, 20 parts of glucose oxidase and 9 parts of gamma-aminobutyric acid, sequentially feeding in vacuum, adding into hawthorn powder, adding into tributyrin powder and hydrogen peroxide enzyme powder, and uniformly mixing to obtain the product.
Example 2
The intestinal tract balance additive special for livestock and poultry is characterized by being obtained through the following steps:
(1) 120 parts of tributyrin and 40 parts of nano montmorillonite, and atomizing and spraying liquid tributyrin into powder of the evenly mixed tributyrin by using a fluidized bed according to the proportion of 3:1 for later use;
(2) 8 parts of catalase and 8 parts of nano montmorillonite, and atomizing and spraying the liquid catalase by using a fluidized bed according to the proportion of 1:1 to obtain uniformly mixed catalase powder for later use;
(3) feeding 95 parts of hawthorn powder into a fluidized bed, drying at 65 ℃ for 20 minutes, controlling the water content to be 2.5%, and cooling to 25 ℃ for later use;
(4) 25 parts of xylo-oligosaccharide, 5 parts of bacillus licheniformis, 4 parts of bacillus subtilis, 4 parts of streptococcus thermophilus, 6 parts of clostridium butyricum, 18 parts of glucose oxidase and 8 parts of gamma-aminobutyric acid, sequentially feeding in vacuum, adding into hawthorn powder, adding into tributyrin powder and hydrogen peroxide enzyme powder, and uniformly mixing to obtain the product.
Example 3
The intestinal tract balance additive special for livestock and poultry is characterized by being obtained through the following steps:
(1) 135 parts of tributyrin and 45 parts of nano montmorillonite, according to the proportion of 3:1, atomizing and spraying liquid tributyrin by using a fluidized bed to obtain evenly mixed tributyrin powder for later use;
(2) 13 parts of catalase and 13 parts of nano montmorillonite, and atomizing and spraying the liquid catalase by using a fluidized bed according to the proportion of 1:1 to obtain uniformly mixed catalase powder for later use;
(3) 100 parts of hawthorn powder is put into a fluidized bed, dried for 30 minutes at 70 ℃, internally controlled in moisture content of 2 percent, and cooled to 33 ℃ for standby;
(4) 28 parts of xylo-oligosaccharide, 4 parts of bacillus licheniformis, 3 parts of bacillus subtilis, 5 parts of streptococcus thermophilus, 6 parts of clostridium butyricum, 22 parts of glucose oxidase and 9 parts of gamma-aminobutyric acid, sequentially feeding in vacuum, adding into hawthorn powder, adding into tributyrin powder and hydrogen peroxide enzyme powder, and uniformly mixing to obtain the product.
Effect test
Influence on growth performance and health of weaned piglets
1. Materials and methods
(1) Grouping tests: selecting 40 litters and 402 litters of the white piglets at the later stage of lactation (the weight body condition and birth date and weaning date of the piglets are similar), dividing the 40 litters into 4 treatment groups according to a random block group, namely a control group, a test group A, a test group B and a test group C, wherein each group is 10 litters (namely 10 times of each treatment), the piglets of each test group start 5 days before weaning, namely 23 days old (28 days old weaning), the additive obtained in the example 1 is used in the test group A, the additive obtained in the example 2 is used in the test group B, the additive obtained in the example 3 is used in the test group C, and the additive obtained in the example 3 is not used in the control group. 50kg of the feed is evenly mixed every 100g for 15 days, the same feeding management is carried out on each group according to the routine of a pig farm, the test is finished till the conservation period of 76 days, and the test period is 53 days. The growth performance, death and elutriation and morbidity of the piglets are tracked and recorded in the whole process.
2. Measurement index
(1) Determination of the production Properties
The feeding management measures of the piglets of each test group and the piglets of the control group are completely consistent. The weight of weaning, the weight of finishing nursing (weight of breeding), the death and wash rate of piglets and the development condition of fur are measured during the test period (weaning to finishing nursing), and the difference of the weight gain speed and the breeding rate of the piglets of each test group and the piglets of the control group during the test period is respectively counted.
Determination of weight gain speed: the weight of weaning of each group of test pigs at 28 days of age was weighed on an empty stomach (W1), the test pigs were fed for 48 days of nursing, and the average daily gain was (W2-W1)/48 when the test pigs were similarly weighed on an empty stomach (W2) at the end of nursing (76 days of age).
As can be seen from Table 1, the weights of the 76-day-old nursery piglets in the test group A, B, C are higher than those in the control group, and are respectively increased by 11.81%, 11.41% and 5.07% compared with those in the control group. Compared with a control group, the average daily gain test group A, B, C in the nursery period is improved by 11.62%, 15.39% and 7.19%, wherein the improvement range of the test group B is the largest, and the difference of the test group A is obvious compared with the control group (P is less than 0.05).
TABLE 1 Effect on growth Performance of weaned piglets
| Item | Test group A | Test group B | Test group C | Control group |
| Number of head (nest number) | 99 (10 pits) | 102 (10 pits) | 97 (10 nest) | 102 (10 pits) |
| Weight/kg of 28-day-old weaning | 8.61±1.45 | 7.85±0.90 | 7.69±0.90 | 7.67±0.42 |
| Weight/kg for nursing 76 days old | 28.03±4.38 | 27.93±3.00 | 26.34±1.03 | 25.07±0.62 |
| Average daily gain/g in nursery period | 404.67±60.88a | 418.33±41.63a | 388.58±23.27ab | 362.53±7.77b |
(2) Evaluation of health status of piglets
Evaluation of piglet diarrhea status: observing and recording the daily diarrhea condition of each test pig during the test period, and carrying out evaluation according to 4 grades, wherein 0 grade is no diarrhea (feces apparent normal), 1 grade is mild diarrhea (feces apparent soft), 2 grade is moderate diarrhea (feces apparent thin), and 3 grade is severe diarrhea (feces apparent liquid); diarrhea index is the sum of the scores recorded per day of observation.
Evaluation of the piglet fur development condition: and (4) evaluating the fur development condition of the test pigs 1 day before the end of the nursing period. The subjective scoring system is 1-5 points, namely 1= fur is very rough; 2= rough fur; 3= the fur is smoother; 4= fur smoothness; 5= the fur was very smooth and glossy.
As can be seen from table 2, the mortality of the weaned piglets in the A, B, C test group was decreased by 2.82, 2.94 and 2.74 percentage points, respectively, compared with the control group, wherein the mortality of the test group B was the lowest. The diarrhea index of piglets is reduced by 21.82%, 23.57% and 19.03% respectively in each test group (P < 0.05), and the diarrhea index of the test group B and the test group A is obviously lower than that of the control group (P < 0.05). The piglet fur development status scores of the test groups are respectively improved by 20.71%, 19.53% and 28.70% (P < 0.05) compared with the control group, wherein the test A, B, C group is obviously higher than the control group (P < 0.05).
TABLE 2 Effect on weaned piglets health
| Item | Test group A | Test group B | Test group C | Control group |
| Number of head (nest number) | 99 | 102 | 97 | 102 |
| Mortality and mortality/The | 4.04（4/99） | 3.92（4/102） | 4.12（4/97） | 6.86（7/102） |
| Survival rate/% | 95.96（95/99） | 96.08（98/102） | 95.88（93/97） | 93.14（95/102） |
| Index of diarrhea in piglets | 0.534c | 0.522c | 0.553bc | 0.683a |
| Fur development status scoring | 4.08±0.35a | 4.04±0.22a | 4.35±0.41a | 3.38±0.25b |
(3) Determination of biochemical indexes of piglet serum
1 day before the test, 4 piglets (20 piglets in total) are randomly selected for each group, blood is collected on empty stomach by 10 mL, the blood is added into a vacuum blood collection tube containing a coagulant, the coagulant tube is placed into a water bath for 20 min, and then the serum is transferred into a centrifuge tube and stored at the temperature of minus 20 ℃ for standby. Serum biochemical indexes were measured with Hitachi 7170A full-automatic biochemical analyzer.
As can be seen from Table 3, the biochemical indexes of the serum of the nursery piglets in each test group are respectively and not significantly different (P > 0.05) compared with the control group in Total Protein (TP), Albumin (ALB), Globulin (GLB), Glucose (GLU), calcium (Ca) and phosphorus (IP), wherein the serum TP and IP of each test group are higher than the control group, the serum Ca is lower than the control group, but the difference is not significant (P > 0.05). The content of serum UREA (UREA) of the test group A, B, C is lower than that of the control group, and is respectively reduced by 3.92%, 21.57% and 4.71%, wherein the difference between the test group B and the control group is significant (P < 0.05).
TABLE 3 Effect on serum Biochemical parameters of nursing piglets
| Item | Test group A | Test group B | Test group C | Control group |
| Total protein TP (mg/mL) | 57.23±1.67 | 53.5±4.82 | 54.18±3.72 | 52.05±4.63 |
| Albumin ALB (mg/mL) | 28.58±2.45 | 25.38±2.00 | 27.8±1.65 | 25.65±1.15 |
| Globulin GLB (mg/mL) | 28.65±1.24 | 28.13±4.60 | 26.38±4.80 | 26.40±4.42 |
| Serum UREA UREA (mg/mL) | 2.45±0.94a | 2.00±0.62b | 2.43±0.32a | 2.55±1.06a |
| Glucose GLU (mg/mL) | 6.19±0.53 | 6.02±1.05 | 6.11±0.59 | 6.16±0.55 |
| Calcium Ca (mg/mL) | 2.69±0.25 | 2.64±0.11 | 2.66±0.12 | 2.73±0.30 |
| Phosphorus IP (mg/mL) | 2.99±0.56 | 3.01±0.24 | 3.12±0.16 | 2.84±0.42 |
(4) Influence on the activity of serum enzyme of nursery pig
As can be seen from Table 4, the difference of the serum glutamic pyruvic transaminase (ALT) activity of the nursery piglets of each test group and the control group is not significant (P > 0.05). The alkaline phosphatase (ALP) activity of the test group A, B, C was 27.53%, 25.32%, 18.05% higher (P < 0.05) than that of the control group, respectively.
TABLE 4 Effect on the serum enzyme Activity of nursing piglets
| Item | Test group A | Test group B | Test group C | Control group |
| Alanine aminotransferase ALT (U/L) | 51.00±4.08 | 43.75±4.03 | 46.50±8.35 | 49.75±16.46 |
| Glutamic-oxaloacetic transaminase AST (U/L) | 56.75±14.45a | 53.25±21.12ab | 60.75±24.76a | 58.50±8.06a |
| Alkaline phosphatase ALP (U/L) | 245.50±28.38a | 241.25±66.05a | 227.25±76.17a | 192.50±21.46b |
And (4) conclusion: the experimental study proves that the regulator provided by the invention is fed to piglets before and after weaning, so that the stress of weaning on piglets can be effectively relieved, the immunity and metabolic function of organisms are improved, the weight gain speed of piglets during nursing is increased, the growth, development and health conditions of the piglets are improved, and the diarrhea and death and culling rate are reduced. In comprehensive comparison, the effect of example 2 is more remarkable in 3 kinds of test samples.
Secondly, testing influence on broiler chicken production performance
1. Materials and methods
Selecting 4 barns with the same batch of young chickens (fast large AA broiler chickens), the same farm, the same management mode and the same feeding level, wherein 17820 chickens in the test group A are used, and the additive obtained in the example 1 is used; trial B group 17930 pieces in total, using the additive obtained in example 2; trial C group 17950 in total, using the additive obtained in example 3; the test groups are respectively 1-7 days old, 15-21 days old and 29-35 days old, the dosage of every day is calculated in the evening according to the whole day, every 500g of water is added for centralized use, 17945 control groups are not added, the same feeding management is carried out according to the routine, the test is finished when the test is out of the column at 41 days old, and the test period is 40 days. And tracking and recording the death and culling rate, the survival rate and the feed conversion ratio in the whole process.
2. And (3) test results: the concrete results are as follows
As can be seen from Table 5, the death and culling rate of the test group A, B, C was reduced by 0.69, 1.93 and 0.47 percentage points respectively, and the meat-to-feed ratio of the test group was reduced by 0.07, 0.13 and 0.06 percentage points respectively.
TABLE 5 influence on broiler productivity
| Item | Test group A | Test group B | Test group C | Control group |
| Number of chickens | 17820 | 17930 | 17950 | 17945 |
| Death and culling (only) | 695 | 477 | 739 | 823 |
| Death rate (%) | 3.90 | 2.66 | 4.12 | 4.59 |
| Survival rate (%) | 96.10 | 97.34 | 95.88 | 95.41 |
| Meat ratio of materials | 1.71:1 | 1.65:1 | 1.72:1 | 1.78:1 |
And (4) conclusion: the experimental research proves that the compound feed additive can effectively reduce the death and culling rate, improve the survival rate, reduce the feed conversion ratio and improve the economic benefit when the broiler chickens are fed in stages. In comprehensive comparison, the effect of example 2 is more remarkable in 3 kinds of test samples.
The synthesis of the following steps: the intestinal balance regulator special for livestock and poultry can effectively improve the digestive absorption capacity of the livestock and poultry, reduce diarrhea, improve the feed conversion rate (feed conversion ratio is reduced), obviously improve the health condition of the livestock and poultry and improve the production performance.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the embodiments, and any other changes, modifications, combinations, substitutions and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents and are included in the scope of the present invention.
Claims (8)
1. The intestinal tract balance regulator special for livestock and poultry is characterized by comprising the following raw materials in parts by weight:
140 parts of tributyrin 100, 15-25 parts of glucose oxidase, 8-20 parts of composite probiotics, 6-14 parts of catalase, 20-40 parts of xylo-oligosaccharide, 5-12 parts of gamma-aminobutyric acid, 80-130 parts of hawthorn powder and 40-70 parts of nano montmorillonite; the composite probiotics are more than one of bacillus licheniformis, bacillus subtilis, streptococcus thermophilus, bifidobacterium, lactobacillus buchneri and clostridium butyricum;
the preparation method of the intestinal balance regulator special for livestock and poultry comprises the following steps:
(1) the preparation method comprises the following steps of (1) atomizing liquid tributyrin by using a fluidized bed according to the weight ratio of 3:1, and uniformly spraying the liquid tributyrin into boiling nano montmorillonite to obtain uniformly mixed tributyrin powder for later use;
(2) atomizing catalase and nano-montmorillonite by using a fluidized bed according to the weight ratio of 1:1, and uniformly spraying the liquid catalase into the boiling nano-montmorillonite to obtain uniformly mixed catalase powder for later use;
(3) feeding fructus crataegi powder into fluidized bed, oven drying at 60-80 deg.C for 20-50 min, controlling water content, cooling to below 35 deg.C to obtain fructus crataegi powder;
(4) sequentially adding xylo-oligosaccharide, composite probiotics, glucose oxidase and gamma-aminobutyric acid into the cooled standby hawthorn powder, adding tributyrin powder and hydrogen peroxide enzyme powder, and uniformly mixing to obtain the product.
2. The livestock and poultry special intestinal balance regulator according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
135 parts of tributyrin 105, 18-22 parts of glucose oxidase, 18-19 parts of composite probiotics, 8-13 parts of catalase, 25-28 parts of xylo-oligosaccharide, 8-9 parts of gamma-aminobutyric acid, 95-120 parts of hawthorn powder and 45-58 parts of nano montmorillonite.
3. The livestock and poultry special intestinal balance regulator according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
120 parts of tributyrin, 18 parts of glucose oxidase, 19 parts of composite probiotics, 8 parts of catalase, 25 parts of xylooligosaccharide, 8 parts of gamma-aminobutyric acid, 95 parts of hawthorn powder and 48 parts of nano montmorillonite.
4. The livestock and poultry special intestinal balance regulator according to claim 1, characterized in that the weight ratio of the raw materials in the composite probiotics is as follows: 3-7 parts of bacillus licheniformis, 2-5 parts of bacillus subtilis, 4-8 parts of streptococcus thermophilus and 3-8 parts of clostridium butyricum.
5. The livestock and poultry special intestinal balance regulator according to claim 4, characterized in that the weight ratio of the raw materials in the composite probiotics is as follows: 5 parts of bacillus licheniformis, 4 parts of bacillus subtilis, 4 parts of streptococcus thermophilus and 6 parts of clostridium butyricum.
6. The livestock and poultry special intestinal tract balance regulator according to claim 1, which is characterized in that in the steps (1) and (2), when the fluidized bed technology is selected and used for preparing tributyrin powder and catalase powder, the air inlet temperature is 35 ℃, the air induction frequency is 35Hz, the pressure of a spray gun is 0.15MPa, and the speed of a peristaltic pump is 200 r/min.
7. The use of the livestock and poultry special intestinal balance regulator as defined in any one of claims 1-6 in the preparation of a medicament for regulating livestock and poultry intestinal balance.
8. The use of claim 7, wherein the medicament for regulating the intestinal balance of livestock and poultry improves the digestive absorption capacity of livestock and poultry, reduces diarrhea, reduces the feed conversion ratio, improves the health condition of livestock and poultry, and improves the productivity.
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