CN108029854A - A kind of compound formulation of alternative feeding antibiotic - Google Patents
A kind of compound formulation of alternative feeding antibiotic Download PDFInfo
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- CN108029854A CN108029854A CN201711300997.2A CN201711300997A CN108029854A CN 108029854 A CN108029854 A CN 108029854A CN 201711300997 A CN201711300997 A CN 201711300997A CN 108029854 A CN108029854 A CN 108029854A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
Abstract
The present invention relates to enzyme preparation technical field, more particularly to a kind of compound formulation of alternative feeding antibiotic.The compound formulation of the alternative feeding antibiotic is made of glucose oxidase, Tiny ecosystem composition, Chinese herbal medicine extract and functional oligosaccharide.The compound formulation of the alternative feeding antibiotic has no toxic side effect animal, is not easy to be absorbed in animal intestinal tract, less residue or in a short time easily elimination in vivo, drug-fast bacteria generation is not induced, stability is strong in feed, is resistant to the degradation of animal intestines and stomach, and easily decomposing does not influence environment, feed palatability is not influenced, animal normal the gut flora is not destroyed, can be killed or be suppressed growth of pathogenic bacteria, can strengthen Abwehrkraft des Koepers, efficiency of feed utilization can be improved, promotes growth of animal, compatibility good.
Description
Technical field：
The present invention relates to enzyme preparation technical field, more particularly to a kind of compound formulation of alternative feeding antibiotic.
Background technology：
With the raising of aquaculture intensive degree and breeding performonce fo animals, the stress level of animal is continuously increased, to each
The resistivity of kind pathogenic microorganism declines, and often in clinical or subclinical pathological state, dives so as to influence animal productiong
The performance of energy and the economic benefit of aquaculture, for prevention disease and increase economic efficiency, widespread practice is added into feed
Added with antibiotic and chemical synthesis class medicine.
However, the effect of antibiotic is prevention and treatment disease, it is not to promote growth of animal, improve production performance.And more
Show come more evidences, the propagation of appearance and drug resistant gene of the livestock breeding industry abuse of antibiotics to bacterial drug resistance rises emphatically
Act on.Medicament residue serious threat in the generation and animal product of antibody-resistant bacterium human health.So European Union has prohibited
The only use of medicated premix, the U.S. also eliminates medicated premix and promotes the function of growth of animal, and is changed to prevent and controls
Corresponding disease.
The modem animal production model in domestic " high density, high production, short cycle ", breeding environment is poor, disease incident
High, majority of case is the running that this production model is supported by antibiotic, and the ban one by one of antibiotic is given
Aquaculture brings no small impact, is badly in need of finding a kind of substitute of antibiotic in industry, to maintain existing aquaculture model.
In addition, feed safety is the basis of animal food safety, with the improvement of living standards, people increasingly pay close attention to
Meat product safety and human body health, the requirement to feed safety is higher and higher, therefore, exploitation and use " green " feed
Additive will be China's feedstuff industry and the severe problem that is faced of safe animal product production.Research and development antibiotic replaces
Become disabling antibiotic premise for thing, be to maintain the key of Animal husbandry production sustainable development.
The content of the invention：
The present invention provides a kind of compound formulation of alternative feeding antibiotic, the compound formulation secondary work nontoxic to animal
With, be not easy to be absorbed in animal intestinal tract, in vivo less residue or in a short time easily eliminate, do not induce drug-fast bacteria generation, raising
Stability is strong in material, is resistant to the degradation of animal intestines and stomach, and easily decomposing does not influence environment, does not influence feed palatability, does not break
Bad animal normal the gut flora, can kill or suppress growth of pathogenic bacteria, can strengthen Abwehrkraft des Koepers, can improve efficiency of feed utilization,
Promote growth of animal, compatibility is good, solves problems of the prior art.
The present invention is that technical solution is used by solving above-mentioned technical problem：
A kind of compound formulation of alternative feeding antibiotic, is made of the raw material of following parts by weight：Glucose oxidase
50-300 parts, 100-400 parts of Tiny ecosystem composition, 350-1600 parts of Chinese herbal medicine extract, 55-300 parts of functional oligosaccharide；
The Tiny ecosystem composition is made of the raw material of following parts by weight：25-100 parts of enterococcus faecalis, enterococcus faecium 25-
100 parts, 25-100 parts of bacillus coagulans, 25-100 parts of clostridium butyricum；
The Chinese herbal medicine extract is made of the raw material of following parts by weight：125-500 parts of radix scutellariae, fruit of glossy privet 125-500
Part, 50-200 parts of Herba Epimedii, 25-200 parts of Schisandra chinensis, 25-200 parts of astragalus polyose；
The functional oligosaccharide is made of the raw material of following parts by weight：25-100 parts of xylo-oligosaccharide, chitosan 15-100
Part, 15-100 parts of manna oligosacchride.
Preferably, the compound formulation of the alternative feeding antibiotic is made of the raw material of following parts by weight：Glucose
125 parts of oxidizing ferment, 150 parts of Tiny ecosystem composition, 625 parts of Chinese herbal medicine extract, 245 parts of functional oligosaccharide；
The Tiny ecosystem composition is made of the raw material of following parts by weight：55 parts of enterococcus faecalis, 55 parts of market coccus,
55 parts of bacillus coagulans, 55 parts of clostridium butyricum；
The Chinese herbal medicine extract is made of the raw material of following parts by weight：312 parts of radix scutellariae, 312 parts of the fruit of glossy privet, excessive sheep
125 parts of the leaves of pulse plants, 112 parts of Schisandra chinensis, 113 parts of astragalus polyose；
The functional oligosaccharide is made of the raw material of following parts by weight：65 parts of xylo-oligosaccharide, 58 parts of chitosan, sweet dew
58 parts of oligosaccharides.
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Beneficial effects of the present invention：
The compound formulation of the alternative feeding antibiotic with glucose oxidase and the Tiny ecosystem composition of particular combination, in
Herb extracts and functional oligosaccharide formulated in combination and obtain, glucose oxidase plays fungistatic effect at first wherein, glucose
The sour oxygen-consuming capacity of production of oxidizing ferment can create the living environment for being beneficial to beneficial bacterium in Tiny ecosystem composition rapidly.Tiny ecosystem group
Compound selects enterococcus faecalis, enterococcus faecium, bacillus coagulans and clostridium butyricum to be made with specific proportioning, is resistant to compound
The enzyme activity of additive amount in preparation, will not be killed, and the combination addition of several beneficial bacteriums can give animal and bird intestines environmental creation
The profitable strain of more advantage, squeezes harmful bacteria；Functional oligosaccharide selection xylo-oligosaccharide, chitosan and manna oligosacchride are with specific proportioning
It is made, as the reinforcing agent of beneficial bacterium, consolidates the useful effect of the adjusting enteron aisle of beneficial bacterium, and coordinate shell on the basis of oligosaccharide
Glycan and mannosan, compared to existing selection xylo-oligosaccharide, the overall sterilizing function of energy supplementary functionality oligosaccharides, and chitosan
Coordinate with manna oligosacchride, combine xylo-oligosaccharide, there is immunoactivator, the immune, disease resistance of enhancing livestock and poultry body.
Chinese herbal medicine extract selection radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and astragalus polyose, because each having different antimicrobial spectrums, phase
Mutually collaboration can expand antimicrobial spectrum and antibacterial species, and eliminate existing chemical classes Drug-resistant sex chromosome mosaicism, wherein, radix astragali is more
Sugar, the main resisting stress of Herba Epimedii, improve immunity, and radix scutellariae, the fruit of glossy privet, Schisandra chinensis are then led antibacterial, and five coordinate collaboration, do not lack one not
Can.
Antibacterial complexing agent is made in above-mentioned each components matching, for feeding antibiotic can be substituted in animal and fowl fodder completely, on
State glucose oxidase and produced with the Chinese herbal medicine extract that radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and astragalus polyose form
Raw sterilization and oxygen consumption efficiency can play effect of taking stopgap measures, and be matched somebody with somebody by enterococcus faecalis, enterococcus faecium, bacillus coagulans and clostridium butyricum
Production acid is closed, foster intestines can be played and effect of effecting a permanent cure；Above-mentioned each beneficial bacterium of screening can be cooperateed with glucose oxidase, in grape glycosyloxy
Change tachyauxesis under the good sour environment that enzyme is created, avoid it is existing beneficial bacterium is added in feed merely, and beneficial bacterium is difficult
To survive, the defects of reconciling the effect of enteron aisle purpose can not be reached, and the required substrate of the tachyauxesis of beneficial bacterium is even more by this
Particular functionality oligosaccharides combination in scheme of the invention is supported, and above-mentioned all the components coordinate functional oligosaccharide, are eaten in livestock and poultry
Afterwards, mutually collaboration in vivo, plays effect that is antibacterial, improving the immune adjusting enteric microorganism ecological balance, can lift livestock and poultry and resist altogether
Irritability, substantially reduces illness rate.
Embodiment：
In order to clarify the technical characteristics of the invention, below by embodiment, the present invention is explained in detail
State.
Embodiment 1
The compound formulation of the alternative feeding antibiotic, is made of the raw material of following weight：
Glucose oxidase 125Kg, Tiny ecosystem composition 150Kg, Chinese herbal medicine extract 625Kg, functional oligosaccharide
245Kg；
The Tiny ecosystem composition is made of the raw material of following weight：Enterococcus faecalis 55Kg, enterococcus faecium 55Kg, condense bud
Spore bacillus 55Kg, clostridium butyricum 55Kg；
The Chinese herbal medicine extract is made of the raw material of following weight：Radix scutellariae 312Kg, fruit of glossy privet 312Kg, Herba Epimedii
125Kg, Schisandra chinensis 112Kg, astragalus polyose 113Kg；
The functional oligosaccharide is made of the raw material of following weight：Xylo-oligosaccharide 65Kg, chitosan 58Kg, manna oligosacchride
58Kg。
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Preparation method：By above-mentioned weight, Tiny ecosystem composition, Chinese herbal medicine extract and functional oligosaccharide are first prepared respectively,
Then together mix, stir evenly, to obtain the final product.Tiny ecosystem composition, Chinese herbal medicine extract and functional oligosaccharide are also each by its
Mix, stir evenly by weight ratio from constituent.
Embodiment 2
The compound formulation of the alternative feeding antibiotic, is made of the raw material of following weight：
Glucose oxidase 50Kg, Tiny ecosystem composition 100Kg, Chinese herbal medicine extract 350Kg, functional oligosaccharide 55Kg；
The Tiny ecosystem composition is made of the raw material of following weight：Enterococcus faecalis 25Kg, enterococcus faecium 25Kg, condense bud
Spore bacillus 25Kg, clostridium butyricum 25Kg；
The Chinese herbal medicine extract is made of the raw material of following weight：Radix scutellariae 125Kg, fruit of glossy privet 125Kg, Herba Epimedii
50Kg, Schisandra chinensis 25Kg, astragalus polyose 25Kg；
The functional oligosaccharide is made of the raw material of following weight：Xylo-oligosaccharide 25Kg, chitosan 15Kg, manna oligosacchride
15Kg。
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Preparation method is the same as embodiment 1.
Embodiment 3
The compound formulation of the alternative feeding antibiotic, is made of the raw material of following weight：
Glucose oxidase 300Kg, Tiny ecosystem composition 400Kg, Chinese herbal medicine extract 1600Kg, functional oligosaccharide
300Kg；
The Tiny ecosystem composition is made of the raw material of following weight：Enterococcus faecalis 100Kg, enterococcus faecium 100Kg, condense
Bacillus 100Kg, clostridium butyricum 100Kg；
The Chinese herbal medicine extract is made of the raw material of following weight：Radix scutellariae 500Kg, fruit of glossy privet 500Kg, Herba Epimedii
200Kg, Schisandra chinensis 200Kg, astragalus polyose 200Kg；
The functional oligosaccharide is made of the raw material of following weight：Xylo-oligosaccharide 100Kg, chitosan 100Kg, manna oligosacchride
100Kg。
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Preparation method is the same as embodiment 1.
Embodiment 4
The compound formulation of the alternative feeding antibiotic, is made of the raw material of following weight：
Glucose oxidase 88Kg, Tiny ecosystem composition 126Kg, Chinese herbal medicine extract 486Kg, functional oligosaccharide 150Kg；
The Tiny ecosystem composition is made of the raw material of following weight：Enterococcus faecalis 40Kg, enterococcus faecium 40Kg, condense bud
Spore bacillus 40Kg, clostridium butyricum 40Kg；
The Chinese herbal medicine extract is made of the raw material of following weight：Radix scutellariae 200Kg, fruit of glossy privet 270Kg, Herba Epimedii
86Kg, Schisandra chinensis 75Kg, astragalus polyose 75Kg；
The functional oligosaccharide is made of the raw material of following weight：Xylo-oligosaccharide 45Kg, chitosan 35Kg, manna oligosacchride
35Kg。
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Preparation method is the same as embodiment 1.
Embodiment 5
The compound formulation of the alternative feeding antibiotic, is made of the raw material of following weight：
Glucose oxidase 212Kg, Tiny ecosystem composition 275Kg, Chinese herbal medicine extract 1112Kg, functional oligosaccharide
273Kg；
The Tiny ecosystem composition is made of the raw material of following weight：Enterococcus faecalis 75Kg, enterococcus faecium 75Kg, condense bud
Spore bacillus 75Kg, clostridium butyricum 75Kg；
The Chinese herbal medicine extract is made of the raw material of following weight：Radix scutellariae 450Kg, fruit of glossy privet 350Kg, Herba Epimedii
162Kg, Schisandra chinensis 165Kg, astragalus polyose 153Kg；
The functional oligosaccharide is made of the raw material of following weight：Xylo-oligosaccharide 80Kg, chitosan 78Kg, manna oligosacchride
76Kg。
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of the Tiny ecosystem composition are city
Sell bacterium powder product；Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of the Chinese herbal medicine extract are commercially available
Powder extracts.
Preparation method is the same as embodiment 1.
First, bacteriostatic experiment：
Antibacterial tests use fask oscillating method, by the compound formulation of the alternative feeding antibiotic of the present invention and reference substance and sulfuric acid
Colistin respectively contrasts the fungistatic effect of Escherichia coli and salmonella, as a result such as table 1 below.
Above-mentioned " control " group is test organisms；
" sulphur glues " group is to recommend colistine sulfate+test organisms of dosage；
Each embodiment group is each embodiment product+test organisms of dosage identical with " sulphur glues " group.
The above-mentioned dosage that recommends is：Test organisms bacterium solution is diluted to 105Under concentration levels, every liter of test bacteria liquid+0.6g sulphur
It is viscous.
Conclusion：The compound formulation of the alternative feeding antibiotic of 1-5 of the embodiment of the present invention, compared to recommending concentration
Sulphur glues, and 20.2%, 20.1%, 20.2%, 20%, 19.9% is higher by respectively to the inhibition of Escherichia coli；To salmonella
Inhibition be higher by 18.6%, 18.5%, 18.6%, 18.4%, 18.4% respectively.
Cultivate and observe through concrete practice, the compound formulation of the alternative feeding antibiotic of the present invention, to Escherichia coli, Salmonella
Main pathogenic bacteria have good inhibiting effect in the breeding environments such as bacterium.Use in livestock and poultry diet, add by per kilogram daily ration
Add the amount of application of the green compound formulation product of the 10g present invention, 100% can substitute the use that antibiotic in daily ration is fed in pig, chicken.
2nd, livestock and poultry cultivation antibiotic substitutes experiment (1)
1. experiment purpose
Compare the guarantor of the compound formulation and addition fodder antibiotics sulfate colistin of alternative feeding antibiotic of the invention
Pannage is educated, the influence to child care pig.
2. experimental animal and experimental design
Same breed, identical parity, weanling pig similar in date of parturition are selected, tests and being set by the packet of completely random method
Meter, is divided into 7 treatment groups, two control groups (blank control, antibiotic control group) and 5 experimental groups, each 3 weights for the treatment of group
It is multiple, it is each to repeat 8.
3. test daily ration and feeding management
Test pig uses identical feeding management and environmental condition.During experiment, immunity inoculation, disinfection and cleaning are defended
The work such as raw routinely carries out.Blank control group be not added with anything, antibiotic control group addition sulfate colistin, experimental group
1-5 adds the compound formulation of 1-5 of the embodiment of the present invention respectively, other medications are normally added, free using Manual material feeding, piglet
Feeding and drinking-water.
1 basal diet of table forms and trophic level
Note：Premix provides for every kilogram of daily ration：Iron 25mg, copper 25mg, manganese 7.5mg, zinc 25mg, iodine 0.1mg, selenium
0.05mg, calcium 0.13%, total phosphorus 0.04%, lysine 0.05%, VA 2 560 IU, VD3 500 IU, VE 5.5 IU, VK3
1.5mg, VB1 0.11mg, VB2 0.15mg, VB6 0.21mg, VB12 0.006mg, nicotinic acid 7.7mg, pantothenic acid 4.2mg, folic acid
0.069mg, biotin 12mg, choline 95mg.
2 antibiotic of table and additive addition situation
4. test index and assay method
Experimental period starts, each group piglet average weight (kg/) is calculated at the end of experimental period, while calculates during experiment respectively
Piglet daily gain；Feed consumption rate of each group piglet per the stage, and calculating piglet average daily gain [g/ (head d)], while calculate son
Pig feedstuff-meat ratio；Diarrhea and morbidity：Record each group diarrhea and incidence daily, when off-test, counts diarrhea rate, disease occurs
Situation and survival rate.
5. test results and analysis
3 XX animal farm child care pig production performance situations of table
As shown in Table 3, the initial age in days of 7 groups of test pigs is identical, than two control group weights of original body mass experimental group, terminates body
It is still that experimental group distinguishes high 38g, 41g, 32g, 27g, 30g than control group weight, daily gain experimental group than antibiotic control group again,
Distinguish high 70g, 73g, 64g, 59g, 62g than blank control group, and feedstuff-meat ratio experimental group it is lower than antibiotic control group 0.16,
0.12、0.14、0.08、0.10.Diarrhea head time and diarrhea rate blank control group highest, are secondly antibiotic control group, experiment 2
Group, 4 groups of experiment, 5 groups of experiment, 1 group of experiment, 1,3 group of experiment.In general, compound formulation group test effect is much better than antibiotic
Group and blank control group.The compound formulation of the alternative feeding antibiotic of the present invention, which substitutes above-mentioned feeding antibiotic, has pig cultivation
The effect of good diseases prevention antibacterial, growth promotion, lifting immunity.
6. test site：China's reputation feed pig farm.
7. test period：August in 2017 1 was to August 19 totally 19 days.
8. conclusion (of pressure testing)
Result of the test shows that the compound formulation of the alternative feeding antibiotic of the present invention substitutes feeding antibiotic sulfuric acid Bacillus adhaerens
After element, piglet growth performance obtains different degrees of improvement, and the death rate reduces, and efficiency of feed utilization improves, and particularly diarrhea rate has
Reduced, increase economic efficiency obvious, realize the green cultivation of complete substitute antibiotics.
3rd, livestock and poultry cultivation antibiotic substitutes experiment (2)
1st, experiment purpose：To determine the practical application effect of the compound formulation of the alternative feeding antibiotic of the present invention, to meat
Chicken carries out feeding experiment, and recruitment evaluation is carried out from the growth performance such as daily gain, death rate index, designs following experiment.
1.1 test material
1.1.1 experimental animal
1 Day-old Broiler Chickens similar in 700 plumage healthy weights.
1.1.2 diet is tested
Ration ingredient and nutritive water are average with reference to the preparation of NRC broiler chicken trophic level.Anticoccidial drug is only added in basal diet
Salinomycin (60ug/mL), does not add other antibiotic.The antibiotic of antibiotic group addition is Florfenicol, and additive amount is
0.1%.Compound prescription admixes basal diet and mixes feeding, additive amount 0.1%.
1.2 test method
1.2.1 experimental design
700 plumage of chick, is randomly divided into 7 groups, every group of 5 repetitions, often repeatedly 20 plumage, is respectively the sky for only feeding basal diet
White control group, adds the positive controls of antibiotic, and adds the experiment process group of 1-5 of the embodiment of the present invention respectively：Experiment
Group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5.Cycle is 42d, conventinal breeding.Cage stage by stage, each repeats list
Solely feed, free choice feeding drinking-water, daily management are routinely carried out with immune programme.
1.2.2 testing index
Per day entry feed intake, the death rate, weigh on an empty stomach respectively at testing the 42nd day morning, calculate the day for raising the full stage
Weightening, feed-weight ratio and the death rate.
1.3 data processing
Test data carries out variance analysis after Excel (2003) preliminary treatment, using ANOVA in SPSS (13.0),
Multiple range test is carried out using LSD methods, data are represented with average value scholar's standard deviation.
2 results and analysis
Influence of the compound formulation of 2.1 feeding embodiment of the present invention 1-5 to the full growth phase growth performance of broiler chicken
Influence (1-41 age in days) of the table 1 to meat chicken production performance
Note：Same column shoulder side lowercase difference person represents significant difference (P<0.05)；Letter is identical or does not mark alphabet
Show difference not significantly (P>0.05).
Known by table 1,1-41 age in days stages, the experimental group daily gain of various embodiments of the present invention is above blank control group and sun
Property control group, feedstuff-meat ratio are substantially less than blank control group and positive controls (P<0.05) it is, poor between the experimental group of each embodiment
Different not significantly (P>0.05), the experimental group feedstuff-meat ratio of each embodiment have dropped 0.08 than positive controls, 0.08,0.04,0.05,
0.06；The experimental group death rate of each embodiment is all low compared with blank control, positive control, and the wherein blank control death rate is up to
4.01%, secondly it is the 3.2% of positive controls, and the death rate of the experimental group of each embodiment is below 3%.
Result of the test shows that the compound formulation of the alternative feeding antibiotic of the present invention is applied to use in poultry daily ration of broiler,
Daily gain can be improved, feedstuff-meat ratio is reduced, reduces the death rate, there is active influence to the production performance of broiler chicken, effect can be with
Reach horizontal using the cultivation of antibiotic, be that nonreactive production of the substitute antibiotics on broiler chicken is possibly realized.
Above-mentioned embodiment cannot function as limiting the scope of the invention, for the technology people of the art
For member, any alternate modification or conversion made to embodiment of the present invention are all fallen within protection scope of the present invention.
Part is not described in detail by the present invention, is the known technology of those skilled in the art of the present technique.
Claims (3)
1. a kind of compound formulation of alternative feeding antibiotic, it is characterized in that：It is made of the raw material of following parts by weight：Glucose
50-300 parts of oxidizing ferment, 100-400 parts of Tiny ecosystem composition, 350-1600 parts of Chinese herbal medicine extract, functional oligosaccharide 55-300
Part；
The Tiny ecosystem composition is made of the raw material of following parts by weight：25-100 parts of enterococcus faecalis, enterococcus faecium 25-100
Part, 25-100 parts of bacillus coagulans, 25-100 parts of clostridium butyricum；
The Chinese herbal medicine extract is made of the raw material of following parts by weight：It is 125-500 parts of radix scutellariae, 125-500 parts of the fruit of glossy privet, excessive
50-200 parts of the sheep leaves of pulse plants, 25-200 parts of Schisandra chinensis, 25-200 parts of astragalus polyose；
The functional oligosaccharide is made of the raw material of following parts by weight：It is 25-100 parts of xylo-oligosaccharide, 15-100 parts of chitosan, sweet
Reveal 15-100 parts of oligosaccharides.
2. a kind of compound formulation of alternative feeding antibiotic according to claim 1, it is characterized in that：By following parts by weight
Several raw materials are made：125 parts of glucose oxidase, 150 parts of Tiny ecosystem composition, 625 parts of Chinese herbal medicine extract, functional oligosaccharide
245 parts；
The Tiny ecosystem composition is made of the raw material of following parts by weight：55 parts of enterococcus faecalis, 55 parts of market coccus, condense bud
55 parts of spore bacillus, 55 parts of clostridium butyricum；
The Chinese herbal medicine extract is made of the raw material of following parts by weight：312 parts of radix scutellariae, 312 parts of the fruit of glossy privet, Herba Epimedii 125
Part, 112 parts of Schisandra chinensis, 113 parts of astragalus polyose；
The functional oligosaccharide is made of the raw material of following parts by weight：65 parts of xylo-oligosaccharide, 58 parts of chitosan, manna oligosacchride 58
Part.
3. a kind of compound formulation of alternative feeding antibiotic according to claim 1 or 2, it is characterized in that：Micro- life
Raw material enterococcus faecalis, enterococcus faecium, bacillus coagulans and the clostridium butyricum of state composition are commercially available bacterium powder product；In described
Raw material radix scutellariae, the fruit of glossy privet, Herba Epimedii, Schisandra chinensis and the astragalus polyose of herb extracts are commercial powder extract.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108935970A (en) * | 2018-09-06 | 2018-12-07 | 青岛康尔生物工程有限公司 | A kind of nonreactive feed functional product, preparation method and application containing chitosan oligosaccharide |
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| WO2019095935A1 (en) * | 2017-11-20 | 2019-05-23 | 济南百斯杰生物工程有限公司 | Microecological formulation compatible with glucose oxidase, preparation method therefor and use thereof |
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| CN110024905A (en) * | 2019-05-22 | 2019-07-19 | 河南聚推牧业有限公司 | A kind of enterococcus faecalis feed addictive |
| CN110074279A (en) * | 2019-05-24 | 2019-08-02 | 四川品信饲料有限公司 | A kind of child care compound feed prescription for promoting intestine of young pigs health reduction diarrhea rate |
| CN111557389A (en) * | 2020-03-06 | 2020-08-21 | 广东溢多利生物科技股份有限公司 | Anti-bacterial Chinese herbal medicine enzyme composition and application thereof |
| CN111557389B (en) * | 2020-03-06 | 2023-02-17 | 广东溢多利生物科技股份有限公司 | Anti-bacterial Chinese herbal medicine enzyme composition and application thereof |
| CN114129588A (en) * | 2021-10-28 | 2022-03-04 | 湖南农业大学 | Antibacterial composition containing astragalus extract and application thereof |
| CN114129588B (en) * | 2021-10-28 | 2024-01-23 | 湖南农业大学 | Antibacterial composition containing astragalus extract and application thereof |
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