CN101366453A - Non-antibiotic medicament for preventing and controlling pig lax - Google Patents
Non-antibiotic medicament for preventing and controlling pig lax Download PDFInfo
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- CN101366453A CN101366453A CNA2008100795272A CN200810079527A CN101366453A CN 101366453 A CN101366453 A CN 101366453A CN A2008100795272 A CNA2008100795272 A CN A2008100795272A CN 200810079527 A CN200810079527 A CN 200810079527A CN 101366453 A CN101366453 A CN 101366453A
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Abstract
The invention discloses a non-antibiotic drug for preventing and curing pig diarrhea. The drug comprises the following materials in weight percentage: 10 to 90 percent of nano montmorillonite and 10 to 90 percent of xylo-oligosaccharide. The materials are preliminarily mixed by a progressive mixing method and can be used when evenly mixed. The drug can be used by mixing with feed, and can also be used independently by pouring. The drug can not only have curative effects for pathological diarrhea infection, physiological diarrhea infection or mixed infection of pathological diarrhea and physiological diarrhea of pigs, but also fundamentally resolve the diarrhea problem; moreover, the drug can also treat other gstrointestinal tract diseases. The non-antibiotic drug has no residue and is a safe green drug.
Description
One, technical field:
The present invention relates to a kind of medicine that is used to prevent and treat diarrhea of pigs.
Two, background technology:
In principal disease aspect the pig enterogastric diseases is diarrhoeal diseases, grice diarrhoea particularly, basically can be divided into two big classes, the first is infective, is mainly caused by infectious enteritis virus, popular diarrhea virus, enterotoxigenic E, clostridium, salmonella, coccidia etc.These bacteriums or the pathogenic of virus can be communicable, also can be opportunistic, that is to say that irrational feeding environment or irrational nutritional condition are the essential condition of illness spread.Its two right and wrong are infective, because malnutritive, dyspepsia causes grice diarrhoea.The frequent reciprocal causation of infectious diarrhea and noninfectious diarrhea makes the symptom of grice diarrhoea ever-changing, causes and fails to respond to any medical treatment, and the piglet death rate raises.The method of control grice diarrhoea commonly used is with vaccinate, throws something and feeds or the intramuscular injection antibiotics is main.These class methods are effective for control pathology diarrhoea, but it is just not ideal enough for the effect of preventing and treating physiological diarrhoea, when pathologic diarrhoea and physiological are suffered from diarrhoea reciprocal causation, rely on antibiotics or vaccine to prevent and treat grice diarrhoea merely and just more can not obtain desirable effect.And,, the people become a matter of great account feelings for providing pollution-free food along with food-safety problem more and more is subjected to public attention.Forbid in clinical, using at existing most antibiotic of European Union, Japanese also residual and formulated " positive list system " to the chicken meat product detection of antibiotics of Chinese exports.So, use non-antibiotic medicament to treat the important topic that diarrhea of pigs has become research.
Three, summary of the invention:
Purpose of the present invention solves the above-mentioned problems in the prior art exactly, provides a kind of control diarrhea of pigs effective, and is the non-antibiotic medicament that is used to prevent and treat diarrhea of pigs of non-antibiotic medicament.
For finishing purpose of the present invention, technical solution of the present invention is: a kind of non-antibiotic medicament that is used to prevent and treat diarrhea of pigs, it is made by following raw material: count by weight percentage 10-90% nano montmorillonite and 10-90% wood oligose.With mixing method is slightly mixed with above-mentioned raw materials step by step, mix then and can use.Can with the food mixed edible, perhaps gavage separately.
Because the present invention adopted such scheme, montmorillonite for " bulk drug that Chinese pharmacopoeia is recorded, preparation montmorillonite are dispersed in people's prescription face also this product, as " dioctahedral smectite ", " must very "; Wood oligose is approved the feed addictive that also can use in animal for the Ministry of Agriculture.Nano montmorillonite is a kind of novel mineral medicament, be used for the treatment of fowl domestic animals diarrhoea, drug residue frees such as dysentery, generation has no drug resistance, curative effect is stable, have no side effect, and have characteristics of " traditional Chinese medicine ingredients; western medicine result ", a large amount of clinical pharmacologies studies show that, montmorillonite does not have antibacterial or bactericidal action, but montmorillonite is to Escherichia coli, comma bacillus, campylobacter jejuni, bacterium such as staphylococcus aureus and rotavirus and cholate, virus and bacteriotoxin etc. all have suction-operated preferably, the montmorillonite gelling of " carriage-type " structure these can be cured the disease, and unique suction type that the factor is fixed in " compartment " is the pharmacological basis that treatment is suffered from diarrhoea.(Xylo-ol igosaccharide XOS) claims xylo-oligosaccharide again to wood oligose, is a kind of novel functional oligosaccharide, uses as food additives the earliest, and the improvement deep and production technology along with research afterwards begins to be applied in the feed industry gradually.The nutrition physiology function of wood oligose: (1) improves intestinal environment, reduce environment PH in the animal intestinal, to the selective cultivation effect of animal intestinal beneficial bacterium especially Bifidobacterium, when beneficial bacteriums such as wherein Bifidobacterium, lactic acid bacteria are preponderated, can suppress harmful bacterium such as Escherichia coli adhering to and breed in enteron aisle, thereby reduce the generation of disease of digestive tract; (2) change the intestinal tissue form, the intestinal mucosa that watches for animals prevents the effect of its damage.The two combination is not only effective to the infection of pathologic diarrhoea, the infection of physiological diarrhoea or the two mixed infection, and can fundamentally solve the diarrhoea problem, and it also can treat other enterogastric diseases of pig.Montmorillonite, wooden poly oligosaccharide do not absorb at enteron aisle, can not enter blood circulation system in use, so this product noresidue, are a kind of safe green medicines.
Four, the specific embodiment: the present invention is described in detail below in conjunction with specific embodiment.
Embodiment 1: present embodiment is made up of the wood oligose of 60% nano montmorillonite and 40%.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is to gavage, below the piglet body weight 10kg, and the 8g/ head; Body weight 10kg～50kg, the 15g/ head; More than the middle pig 50kg, the 20g/ head; Sow, 30g/ head, 2～3 times on the one, logotype 2～5 days.
Embodiment 2: present embodiment is made up of 90% nano montmorillonite and 10% wood oligose.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is mixed feeding, adds the every 1000kg feed of this product 1～10kg, logotype 2～5 days in feed.
Embodiment 3: present embodiment is made up of 80% nano montmorillonite and 20% wood oligose.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is to gavage, below the piglet body weight 10kg, and the 8g/ head; Body weight 10kg～50kg, the 15g/ head; More than the middle pig 50kg, the 20g/ head; Sow, 30g/ head, 2～3 times on the one, logotype 2～5 days.
Embodiment 4: present embodiment is made up of 10% nano montmorillonite and 90% wood oligose.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is mixed feeding, adds the every 1000kg feed of this product 1～10kg, logotype 2～5 days in feed.
Embodiment 5: present embodiment is made up of 30% nano montmorillonite and 70% wood oligose.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is to gavage, below the piglet body weight 10kg, and the 8g/ head; Body weight 10kg～50kg, the 15g/ head; More than the middle pig 50kg, the 20g/ head; Sow, 30g/ head, 2～3 times on the one, logotype 2～5 days.
Embodiment 6: present embodiment is made up of 50% nano montmorillonite and 50% wood oligose.The two with mixing method is slightly mixed step by step, is mixed packing then.Giving the using method of pig is mixed feeding, adds the every 1000kg feed of this product 1～10kg, logotype 2～5 days in feed.
The present invention did following efficacy test:
(1) prevention grice diarrhoea
Stress of baby pigs caused ablaction mainly shows as growth retardation, low, the serious diarrhoea of feed intake.This mainly is that piglet digestive enzyme system and physiological environment are difficult to adapt to and the stress reaction that causes because feed type by based on breast milk, changes into suddenly based on vegetality feedstuff.The traditional method of control diarrhoea is to use and adds high zinc, Organic Chromium etc. in antibiotic, the feed.Use antibiotic can destroy the gut flora balance, cause suprainfection, the nutritional labeling of using high zinc, high chromium can influence feed absorbs, and zinc, the chromium got rid of with ight soil can pollute environment.Do following test for the curative effect of verifying non-antibiotic medicament of the present invention is special.
1 materials and methods
1.1 medicine: non-antibiotic medicament of the present invention and colistin sulfate pre-mixing agent.
1.2 experimental animal grouping and processing
Choose wean in 28 days, body weight is close, well-developed to greatly enhance 84 of the assorted weanling pigs of binary, raise 3 days in advance after, be divided into three processed group at random, be respectively test group, medicine control group, blank group.5PPM colistin sulfate batch mixing is used in the not administration of blank group, medicine control group, and the drug test group is used non-antibiotic medicament 2.0kg/1000kg feed of the present invention.
1.3 the raising of experimental animal and management
Feeding experiment is carried out in fenestrate closed child care pig house, and the high bed of iron railings is raised, and 7 feeding piglets of each repetition are in same hurdle, and free choice feeding and drinking-water are then given and treatment if any grice diarrhoea or other disease in the process of the test.The full phase of test pig carries out according to production management rules in the pig farm, and suitable growing environment condition is provided, and carries out immunity inoculation according to the routine immunization program, keeps the uniformity of each test group management and environmental condition.Experimental period is 28 days.
1.4 essential record index
Write down inventory every day in experimental period, and it is only healthy to observe pig, and a record diarrhoea number and fate and the pig death state of only falling ill.
1.5 testing index and method
During respectively at on-test, 14 ages in days and 28 age in days 9:00 in morning, will be on an empty stomach 12 hours examination pigs take by weighing weight, by a day statistics feed intake (so that to repeat be unit), and situations such as observed and recorded piglet morbidity every day, diarrhoea and death.Calculate average daily gain (ADG, Average daily gain), average daily ingestion amount (ADFI, Average dailyfeed intake), material anharmonic ratio (F/G, Feed/Gain), diarrhoea index, diarrhea frequency.Wherein, diarrhoea index=stools scored sum/total number of confession examination pig; Diarrhea frequency=∑ (a diarrhoea piglet number * grice diarrhoea fate)/(a test piglet number * test fate) * 100%.
1.6 data are handled and statistical method
Test all data and carry out variance analysis, carry out multiple ratio with Deng Kenshi (Duncan) duncan's new multiple range method with SPSS (13.0) statistical software.Result of the test adopts average ± standard error (M ± SE) expression
2 results
2.1 influence to diarrhea of weaned piglets.
Test early stage, the diarrhea frequency of medicine control group and drug test group is respectively 1.37% and 2.20%, far below 10.4% of blank group; The diarrhea frequency of test later stage drug test group, medicine control group is 0, all is better than the blank group.Test early stage, the diarrhoea index of medicine control group and drug test group is respectively 0.43 and 0.53, than 2.61 of blank group, and low 5 times and 4 times respectively; The diarrhoea index of test later stage drug test group, medicine control group is 0, with 0.31 of blank group.Above data declaration, trial drug and colistin sulfate all can be controlled grice diarrhoea well, do not have notable difference between the two.
2.2 influence to the weanling pig average daily gain
Test early stage, the ADG of drug study group improves 9.4% and 8.8% respectively (P〉0.05) than blank group and medicine control group, and the medicine control group is with basic identical to blank group ADG.The ADG of test later stage medicine control group and blank group is the 496g/d. head, and both all improve 6% than medicine control group, but statistical check difference not significantly (P〉0.05).Test the full phase, the ADG of test later stage drug test group and blank group improves 3.4% and 7% (P〉0.05) than medicine control group group respectively.See the following form
3 interpretations of result
3.1 influence to diarrhoea
Diarrhoea is early-weaned piglets growth retardation and the high main cause of the death rate, the reason that causes diarrhoea is many-sided, the change of feed type causes the small intestine structure to change, the intestinal villus height reduces, and crypts is deepened, and small intestine is absorbed reduce, secretion increasing, be not absorbed after entering gastral feed indigestion or digestion, cause osmotic pressure rising in the enteric cavity, cause osmotic diarrhea.Antigenic substance in the plant feed causes the intestinal mucosa allergic reaction, causes intestinal tract injury and suffers from diarrhoea; Piglet digestive system development imperfection, to the feed protein digestion power a little less than, thereby very responsive to the diet protein source, allergic reaction and diarrhoea degree that dregs of beans causes are the strongest, and be relevant with β-poly-globulin with the antigenic protein glycinin in the big dregs of beans of daily ration.This test confirms that this drug regimen has prevention effect preferably to weaned piglet diarrhoea, and its drug effect and colistin sulfate do not have difference, can replace colistin sulfate to use fully.
3.2 influence to the weanling pig average daily gain.
The average daily feed intake of test group piglet during whole test of colistin sulfate of adding the present invention and adding 5PPM in the weanling pig basal diet is all than blank group height, particularly the early stage of test drug test group and medicine control group ADFI all be significantly higher than control group (P＜0.05).This may be because control group is being tested early stage because the diarrhoea that ablactation stress causes is serious, cause the feed intake of piglet to descend, and add non-antibiotic medicament of the present invention and colistin sulfate can both be controlled diarrhoea to a certain extent, reduce ablactation stress, thereby improved feed intake.No matter the drug test group is that early stage, later stage or the ADG that tests the full phase all are higher than the blank group, but the medicine control group is only being tested early stage a little more than the blank group, and the ADG in test later stage is lower than the blank group on the contrary.
4 conclusions
Add non-antibiotic medicament of the present invention and can prevent grice diarrhoea in the weanling pig daily ration, its effect is suitable with the antibiotic colistin sulfate.
(2) to the treatment of grice diarrhoea
The diarrhoea piglet of 10-28 age in days diarrhoea sucking pig and 30-50 age in days is chosen in this experiment, and cardinal symptom breast piglet occurs that row is faint yellow, white, celadon starchiness or water sample stench duck excrement sample loose stool, with vomiting, is mixed with blood or bile in the vomitus.To 50 of 10-28 age in days sucking pigs, 42 of 30-50 age in days piglets, with non-antibiotic medicament treatment of the present invention, the treatment consumption: gavage, below the piglet body weight 10kg, the 8g/ head; Body weight 10kg～50kg, the 15g/ head; 2～3 times on the one, logotype 2 days.Earlier medicine is made suspension, fully shake up administration.10-28 age in days piglet is efficient as a result is 89.3%; The piglet of 30-50 age in days is efficient to be 91.4%.
Claims (6)
1. non-antibiotic medicament that is used to prevent and treat diarrhea of pigs, it is characterized in that: it is made by following raw material: count by weight percentage 10-90% nano montmorillonite and 10-90% wood oligose.
2. the non-antibiotic medicament that is used to prevent and treat diarrhea of pigs according to claim 1 is characterized in that: it is made by following raw material: count by weight percentage 60% nano montmorillonite and 40% wood oligose.
3. the non-antibiotic medicament that is used to prevent and treat diarrhea of pigs according to claim 1 is characterized in that: it is made by following raw material: count by weight percentage, 90% nano montmorillonite and 10% wood oligose are formed.
4. the non-antibiotic medicament that is used to prevent and treat diarrhea of pigs according to claim 1 is characterized in that: it is made by following raw material: count by weight percentage, 30% nano montmorillonite and 70% wood oligose are formed.
5. the non-antibiotic medicament that is used to prevent and treat diarrhea of pigs according to claim 1 is characterized in that: it is made by following raw material: count by weight percentage, nano montmorillonite by 50% and 50% wood oligose are formed.
6. preparation method that is used to prevent and treat the non-antibiotic medicament of diarrhea of pigs is characterized in that: nano montmorillonite and wood oligose according to each described proportioning in the claim 1 to 5, are slightly mixed with mixing method step by step, mix then.
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| CNA2008100795272A CN101366453A (en) | 2008-10-07 | 2008-10-07 | Non-antibiotic medicament for preventing and controlling pig lax |
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| CNA2008100795272A CN101366453A (en) | 2008-10-07 | 2008-10-07 | Non-antibiotic medicament for preventing and controlling pig lax |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228154A (en) * | 2011-06-30 | 2011-11-02 | 北京九州大地生物技术集团股份有限公司 | Efficient and green diarrhea-preventing feed additive composite for weaned pigs |
| CN103355498A (en) * | 2013-07-26 | 2013-10-23 | 河南碧云天饲料有限公司 | Biological feed composite, compound premix and milk replacer without antibiotic or plasma protein for suckling pigs |
| CN107712353A (en) * | 2017-11-10 | 2018-02-23 | 王芳 | A kind of feed addictive for preventing diarrhea of pigs and preparation method and application |
| CN109329566A (en) * | 2018-12-05 | 2019-02-15 | 湖南赛福资源饲料科技有限公司 | For improving the premixed feed and preparation method of piglet gastrointestinal health |
| CN112167451A (en) * | 2020-10-17 | 2021-01-05 | 北京华阜康生物科技股份有限公司 | Tree shrew feed and preparation method thereof |
-
2008
- 2008-10-07 CN CNA2008100795272A patent/CN101366453A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228154A (en) * | 2011-06-30 | 2011-11-02 | 北京九州大地生物技术集团股份有限公司 | Efficient and green diarrhea-preventing feed additive composite for weaned pigs |
| CN102228154B (en) * | 2011-06-30 | 2012-11-28 | 北京九州大地生物技术集团股份有限公司 | Efficient and green diarrhea-preventing feed additive composite for weaned pigs |
| CN103355498A (en) * | 2013-07-26 | 2013-10-23 | 河南碧云天饲料有限公司 | Biological feed composite, compound premix and milk replacer without antibiotic or plasma protein for suckling pigs |
| CN103355498B (en) * | 2013-07-26 | 2014-10-22 | 河南碧云天饲料有限公司 | Biological feed composite, compound premix and milk replacer without antibiotic or plasma protein for suckling pigs |
| CN107712353A (en) * | 2017-11-10 | 2018-02-23 | 王芳 | A kind of feed addictive for preventing diarrhea of pigs and preparation method and application |
| CN109329566A (en) * | 2018-12-05 | 2019-02-15 | 湖南赛福资源饲料科技有限公司 | For improving the premixed feed and preparation method of piglet gastrointestinal health |
| CN112167451A (en) * | 2020-10-17 | 2021-01-05 | 北京华阜康生物科技股份有限公司 | Tree shrew feed and preparation method thereof |
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