CN104920787A - Probiotic traditional Chinese medicine compound preparation for promoting lactation of sows and improving milk quality - Google Patents
Probiotic traditional Chinese medicine compound preparation for promoting lactation of sows and improving milk quality Download PDFInfo
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Abstract
The invention discloses a probiotic traditional Chinese medicine compound preparation for promoting lactation of sows and improving milk quality. The preparation is compounded by a traditional Chinese medicine compound and probiotics. The traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of angel yeast, 5-15 parts of fructo-oligosaccharide, 1-4 parts of vitamin E, 5-15 parts of cowherb seeds, 1-3 parts of tetrapanax papyriferus, 4-6 parts of a complex enzyme preparation, 1-3 parts of soy isoflavone, 45-50 parts of medical stone powder and 17-25 parts of corn starch. The probiotics are mixed bacterial powder of bacillus subtilis and lactobacillus plantarum. In the probiotic traditional Chinese medicine compound preparation, the viable count of the bacillus subtilis is greater than or equal to 2x10<8>cfu/g and the viable count of the lactobacillus plantarum is greater than or equal to 3x10<8>cfu/g. According to the probiotic traditional Chinese medicine compound preparation, the probiotics and the traditional Chinese medicines are compounded, so that the expression level of prolactin can be improved, the lactation of sows is promoted, the ratio of feed to weight is reduced, and the feed utilization ratio is improved.
Description
Technical field
The present invention relates to a kind of probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality.
Background technology
Pig breast is the exclusive source obtaining route of nutrition after piglet birth, and the quality of milk composition quality directly affects the rear a series of growth and development state of piglet birth, has important function to the healthy development of piglet.Pig Ruzhong is except containing except the three large nutritional labelings such as lactose, lactoprotein and butterfat, and also containing some important biologically active growth factors, these growth factors play an important role in promotion piglet healthy development and raising immunity function.Because the seed selection of sow height makes its reproductive performance have large increase, but sow milk performance does not obtain corresponding improvement, thus affects the growth of suckling pig.Thus the Milk Production how improving lactating sow is most important for the production of pig industry.
In sow breeding process, normal because of the improper initiation hysteritis of feeding and management or mammitis after sows farrowing pig, cause sow hypogalactia.Now people often select to inject antibacterials, use antibiotics, diminish inflammation, but, use in a large number along with antibiotic and abuse the resistance and medicament residue harm humans health that cause, causing environmental pollution, the development of restriction sow.For the sow hypogalactia that non-inflammation causes, people often select Western medicine people with lactagogue spirit lactagogue or separately Chinese medicine lactagogue, but all can not reach desirable effect.The substitute of therefore seeking antibiotics becomes inexorable trend,
Summary of the invention
For above-mentioned prior art, the object of this invention is to provide a kind of probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality, by probio and Chinese medicine composite, prolactin expression can be improved, promote sow lactation, reduce feed-weight ratio, improve efficiency of feed utilization.
Another object of the present invention is to provide the preparation method of this probio compound Chinese medicinal preparation.
For achieving the above object, the present invention adopts following technical proposals:
Promote sow lactation and improve the probio compound Chinese medicinal preparation of milk water quality, by probio with Chinese medicine compound prescription is composite forms;
Described Chinese medicine compound prescription is made up of the raw material of following weight portion:
Angel Yeast 0.5-1.5 part, FOS 5-15 part, vitamin E 1-4 part, seed of cowherb 5-15 part, stem pith of the rice-paper plant 1-3 part, complex enzyme formulation 4-6 part, isoflavones 1-3 part, medical stone powder 45-50 part, cornstarch 17-25 part;
Described probio is the composite bacterium powder of bacillus subtilis and Lactobacillus plantarum;
In probio compound Chinese medicinal preparation, the viable count of bacillus subtilis is more than or equal to 2 × 10
8cfu/g, the viable count of Lactobacillus plantarum is more than or equal to 3 × 10
8cfu/g.
Preferably, described Chinese medicine compound prescription is made up of the raw material of following weight portion:
Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, complex enzyme formulation 5 parts, isoflavones 2 parts, medical stone powder 46 parts, cornstarch 21 parts.
Preferably, the bacillus subtilis B7348 of described bacillus subtilis to be deposit number be CCTCC M 2010260; The Lactobacillus plantarum LP of described Lactobacillus plantarum to be deposit number be CCTCC M 2010150.
Enzyme activity >=the 10000u/g of described complex enzyme formulation, purchased from Cangzhou Zhongxin Biological Technology Co., Ltd..
The total viable count of described Angel Yeast is 100 × 10
8-200 × 10
8cfu/g.
The preparation method of this probio compound Chinese medicinal preparation, step is as follows:
(1) after the seed of cowherb and the stem pith of the rice-paper plant being pulverized respectively, sieve, soak, boiling three times, by the filtrate after boiling and dregs of a decoction mixing, freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with probiotics bacterial powder, Angel Yeast, FOS, vitamin E, complex enzyme formulation, isoflavones, medical stone powder, cornstarch, obtain probio compound Chinese medicinal preparation.
In step (1), the amount of water soaked is 15-25 times of medicinal material weight, and soak time is 0.5-1.5h;
Preferably, amount of water is 20 times of medicinal material weight, and soak time is 1h.
In step (1), the amount of water of each boiling is 20 times of medicinal material weight, and each digestion time is 0.5h.
In this probio compound Chinese medicinal preparation, probio is nontoxic, have no side effect, and can promote growth of animal, improving efficiency of feed utilization, is a kind of feed addictive of green.Its mode of action becomes dominant microflora by a large amount of beneficial bacterium in the field planting of intestines and stomach propagation, harmful bacteria breeding is suppressed from aspects such as field planting, competition, nutrition, secretion and Immune-enhancing effect, strengthen body non-specific immune function, improve immunity, improve food conversion ratio and indirectly play the effect promoting growth of animal.
Seed of cowherb another name Wang Buliu, cow-fat, containing multiple saponin, having activating blood to promote menstruation, swelling and pain relieving, expedite the emergence of the function of lactogenesis, is the Chinese medicine of clinical conventional lactogenesis.
The stem pith of the rice-paper plant is the stem marrow of Araliaceae rice-paper plant, the effects such as taste is sweet, light, and cold nature has clearing away heat and promoting diuresis, and lactogenesis is sensible.
Isoflavones, as the extract of pure natural, safety, has anti-oxidant, oestrogen-like hormone effect and promotes multiple biologically active and the function such as cell proliferation and lactoprotein synthesis.
Vitamin E is a kind of liposoluble vitamin, and its hydrolysate is tocopherol, is one of topmost antioxidant.Tocopherol can promote that sex hormone is secreted, and improves female hormone concentration, improves fecundity.
FOS is a kind of water-soluble dietary fiber; to the proliferation function as selective in Bacillus acidi lactici, Bifidobacterium etc. of profitable strain in animal intestinal; profitable strain is taken advantage in enteron aisle; suppress the growth of harmful bacteria; reduce the formation of noxious material (as endotoxin, Ammonia etc.); to intestinal mucosa cells and liver, there is protective effect, strengthen immunity of organisms.
Complex enzyme formulation is the novel activated feed additive of a class, be the mix preparation of multiple digestive ferment, its major function factor is endogenous digestive ferment (amylase, protease and lipase etc.) and exogenous digestive ferment (cellulase, hemicellulase, plant enzyme enzyme, pectase etc.).In feed, add the digestive utilization ratio that complex enzyme formulation can improve feed, promote absorbing of nutriment.
Medical stone powder is that one has bioactive complex mineral or medicinal rock, main chemical compositions is inorganic silicon-aluminum hydrochlorate, there is the performances such as adsorptivity, dissolubility, modulability, biologically active and mineralising, noxious material in enteron aisle can be eliminated, there are certain absorption and releasability to bacterium, thus reduce the degree of germ infringement body.
This probio compound Chinese medicinal preparation regulates the probio of animal intestinal health and propagation beneficial bacterium, FOS and expedites the emergence of the Chinese medicine associating of lactogenesis effect by having, extra interpolation improves the complex enzyme formulation of efficiency of feed utilization, the isoflavones improving estrogen level and vitamin E, last with there is suction-operated, reduce the medical stone powder organic assembling of endotoxin level, act synergistically between each component, finally reach the effect promoting sow lactation and improve milk water quality.
Beneficial effect of the present invention:
(1) in probio compound Chinese medicinal preparation of the present invention, microecological balance in animal intestinal effectively can be supplemented, regulates or be maintained to probio, improves animal daily gain and improve efficiency of feed utilization, improving sow feed intake; Simultaneously probio can also secrete anti-microbial type material, can the effective inflammation such as prevention and therapy sow mammitis.Herbal component has promoting circulation of blood and stimulates the menstrual flow, and expedites the emergence of lactogenesis, and detumescence such as to hold back at the effect, also has natural sex, without advantages such as the resistance to the action of a drug, toxic and side effect are little simultaneously.Probio and Chinese herbal medicine are carried out compositely can realize cooperative effect, promote sow lactation and improve milk water quality;
(2) add 1 ‰ probio compound Chinese medicinal preparation of the present invention in lactating sow daily ration and can significantly improve Prolactin content, improve capacity of milk secretion of sow, reduce feed-weight ratio, improve efficiency of feed utilization;
(3) probio compound Chinese medicinal preparation of the present invention is owing to the addition of probio, can activate the immunocyte in systemic blood, promotes that body produces immunoglobulin (Ig).Improve immunoglobulin G and M level in sow milk, strengthen the immunity of piglet;
(4) probio compound Chinese medicinal preparation of the present invention can improve pig milk-quality, especially the content of butterfat;
(5) probio compound Chinese medicinal preparation of the present invention significantly reduces serum alkaline phosphatase and total bilirubin content, and the cell that watches for animals, tissue and organ are from damage; Improve total serum protein and globulin content, strengthen sow digesting and assimilating nutriment, improve pig body antibody horizontal.Finally reach and improve piglet incubation rate, promote the object of Piglet Development.
Detailed description of the invention
The present invention is further illustrated in conjunction with the embodiments, should be noted that following explanation is only to explain the present invention, not limiting its content.
Embodiment 1 promotes the preparation of the probio compound Chinese medicinal preparation of sow lactation and raising milk water quality
1. fill a prescription: Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, complex enzyme formulation 5 parts, isoflavones 2 parts, medical stone powder 46 parts, cornstarch 21 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Wherein, Lactobacillus plantarum LP (Lactobacillus plantarum), be preserved in China typical culture collection center on 06 21st, 2010, its deposit number is CCTCC M 2010150, is documented in another patent " strain can be used for lactic acid bacteria and the application thereof of biological preservation " (CN 101914475 B) of applicant; Bacillus subtilis B7348 (Bacillussubtilis B7348), be preserved in China typical culture collection center on October 12nd, 2010, its deposit number is CCTCC M 2010260, is documented in another patent " strain has bacillus subtilis and the application thereof of stronger bacteriostasis " (CN 102120975 B) of applicant; Angel Yeast is purchased from Angel Yeast Co., Ltd, and total viable count is 200 × 10
8cfu/g; The seed of cowherb and the stem pith of the rice-paper plant are purchased from Yongchun hall pharmacy of Yongchun, Tai'an hall pharmaceutcal corporation, Ltd; FOS (content 99%) is purchased from Shandong Long Xing bioengineering Co., Ltd; Vitamin E (content 99%) is purchased from Guangzhou profit derived food additive Co., Ltd; Complex enzyme formulation enzyme activity>=10000u/g, purchased from Cangzhou Zhongxin Biological Technology Co., Ltd.; Isoflavones (content 10%) is purchased from Hao Yuan bio tech ltd, Shouyang County, Shanxi Province; Medical stone powder and cornstarch are commercially available prod.
2. preparation method:
(1) after the seed of cowherb and the stem pith of the rice-paper plant being pulverized respectively, cross 60 mesh sieves, add the water soaking 1h of 20 times of medicinal material weight, boiling 3 times, the amount of water of each boiling is 20 times of medicinal material weight, big fire is boiled, slow fire boils 30min, finally by the filtrate of three boilings and dregs of a decoction mixing, and whole freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with Angel Yeast, FOS, vitamin E, complex enzyme formulation, isoflavones, medical stone powder, cornstarch, obtain probio compound Chinese medicinal preparation.
In the probio compound Chinese medicinal preparation of preparation, the viable count of bacillus subtilis B7348 is 2 × 10
8the viable count of cfu/g, Lactobacillus plantarum LP is 3 × 10
8cfu/g.
Embodiment 2 promotes the preparation of the probio compound Chinese medicinal preparation of sow lactation and raising milk water quality
Formula: Angel Yeast 0.5 part, FOS 15 parts, vitamin E 1 part, the seed of cowherb 15 parts, the stem pith of the rice-paper plant 1 part, complex enzyme formulation 6 parts, isoflavones 1 part, medical stone powder 50 parts, cornstarch 17 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Raw material sources in formula and preparation method are with embodiment 1.
In the probio compound Chinese medicinal preparation of preparation, the viable count of bacillus subtilis B7348 equals 3 × 10
8cfu/g, the viable count of Lactobacillus plantarum LP equals 4 × 10
8cfu/g.
Embodiment 3 promotes the preparation of the probio compound Chinese medicinal preparation of sow lactation and raising milk water quality
Formula: Angel Yeast 1.5 parts, FOS 5 parts, vitamin E 4 parts, the seed of cowherb 5 parts, the stem pith of the rice-paper plant 3 parts, complex enzyme formulation 4 parts, isoflavones 3 parts, medical stone powder 45 parts, cornstarch 25 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Raw material sources in formula and preparation method are with embodiment 1.
In the probio compound Chinese medicinal preparation of preparation, the viable count of bacillus subtilis B7348 equals 2 × 10
8cfu/g, the viable count of Lactobacillus plantarum LP equals 4 × 10
8cfu/g.
Comparative example 1:
Formula: Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, complex enzyme formulation 5 parts, medical stone powder 48 parts, cornstarch 21 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Preparation method:
(1) after the seed of cowherb and the stem pith of the rice-paper plant being pulverized respectively, cross 60 mesh sieves, add the water soaking 1h of 20 times of medicinal material weight, boiling 3 times, the amount of water of each boiling is 20 times of medicinal material weight, big fire is boiled, slow fire boils 30min, finally by the filtrate of three boilings and dregs of a decoction mixing, and whole freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with Angel Yeast, FOS, vitamin E, complex enzyme formulation, medical stone powder, cornstarch, obtain compound preparation.
In the compound preparation of preparation, the viable count of bacillus subtilis B7348 is 2 × 10
8the viable count of cfu/g, Lactobacillus plantarum LP is 3 × 10
8cfu/g.
Comparative example 2:
Formula: Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, medical stone powder 52 parts, cornstarch 22 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Preparation method:
(1) after the seed of cowherb and the stem pith of the rice-paper plant being pulverized respectively, cross 60 mesh sieves, add the water soaking 1h of 20 times of medicinal material weight, boiling 3 times, the amount of water of each boiling is 20 times of medicinal material weight, big fire is boiled, slow fire boils 30min, finally by the filtrate of three boilings and dregs of a decoction mixing, and whole freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with Angel Yeast, FOS, vitamin E, medical stone powder, cornstarch, obtain compound preparation.
In the compound preparation of preparation, the viable count of bacillus subtilis B7348 is 2 × 10
8the viable count of cfu/g, Lactobacillus plantarum LP is 3 × 10
8cfu/g.
Comparative example 3:
Formula: Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 20 parts, complex enzyme formulation 5 parts, medical stone powder 42 parts, cornstarch 19 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Preparation method:
(1) after the seed of cowherb being pulverized, cross 60 mesh sieves, add the water soaking 1h of 20 times of medicinal material weight, boiling 3 times, the amount of water of each boiling is 20 times of medicinal material weight, big fire is boiled, slow fire boils 30min, finally by the filtrate of three boilings and dregs of a decoction mixing, and whole freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with Angel Yeast, FOS, vitamin E, complex enzyme formulation, medical stone powder, cornstarch, obtain compound preparation.
In the compound preparation of preparation, the viable count of bacillus subtilis B7348 is 2 × 10
8the viable count of cfu/g, Lactobacillus plantarum LP is 3 × 10
8cfu/g.
Comparative example 4:
Formula: Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, complex enzyme formulation 5 parts, 10 parts, compound soybean lecithin powder, medical stone powder 41 parts, cornstarch 18 parts, bacillus subtilis B7348 bacterium powder, Lactobacillus plantarum LP bacterium powder.
Compound soybean lecithin powder (content 50%) is purchased from Fu Hong bio tech ltd, Zhengzhou.
Preparation method:
(1) after respectively the seed of cowherb, the stem pith of the rice-paper plant being pulverized, cross 60 mesh sieves, add the water soaking 1h of 20 times of medicinal material weight, boiling 3 times, the amount of water of each boiling is 20 times of medicinal material weight, big fire is boiled, slow fire boils 30min, finally by the filtrate of three boilings and dregs of a decoction mixing, and whole freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with Angel Yeast, FOS, vitamin E, complex enzyme formulation, compound soybean lecithin powder, medical stone powder, cornstarch, obtain compound preparation.
In the compound preparation of preparation, the viable count of bacillus subtilis B7348 is 2 × 10
8the viable count of cfu/g, Lactobacillus plantarum LP is 3 × 10
8cfu/g.
Embodiment 4: compliance test result
1 test material and method
1.1 experimental design
Choose the growth of livestock, parity, body weight close, be in a good state of health, the normal PIC in-pig of nipple 60, be divided into 6 groups at random, often organize 10 repetitions, each repetition 1 sow.I group is blank group, basal diet of feeding; II, III, IV, V group is contrast groups, adds compound preparation prepared by the comparative example 1 of 1 ‰ (percentage by weights), comparative example 2, comparative example 3 and comparative example 4 respectively in basal diet; VI group is test group, probio compound Chinese medicinal preparation prepared by the embodiment of the present invention 1 of adding 1 ‰ in basal diet; Feed every day twice (8:00 and 16:00), and freely drink water, every day cleans colony house, control temperature.The positioning rail that to be driven in by sow for first 5 days of giving a birth is raised, and within antenatal 3 days, reduce scale of feeding, childbirth sow on the same day can feed 1-1.5kg daily ration, and the scale of feeding in 2-3 days postpartum is the 1/3-1/2 of normal scale of feeding, is progressively transitioned into free choice feeding afterwards.From Farrowing test, to 28 days wean terminate, period piglet do not carry out feed supplement.
1.2 basal diet
The sow diets of lactation is prepared according to Chinese milking sow feeding standard (2004), and basal diet composition and trophic level are in table 1.Daily ration is powdery.
Table 1 sow basal diet composition and trophic level (basis of feeding)
1premix provides for every kilogram of feed: zinc 100.00mg, violent 30.00mg, iron 90.00mg, copper 5.40mg, selenium 0.30mg, iodine 0.25mg; VA 10000IU, VD 2000IU, VE 44IU, nicotinic acid 14.50mg, pantothenic acid 13.00mg, riboflavin 6.00mg, VK 2.50mg, VB
120.025mg, VB
61.80mg, folic acid 1.70mg, thiamine 1.00mg, biotin 0.20mg.
1.3 sample collections and detection method
1.3.1 28 days lactation periods of mensuration sow of total lactation amount, took a sample test 1 day every 4 days in lactation period, front and back measure 7 days altogether.Whenever taking a sample test day, 24 hours round the clock on duty, observes and record lactation number of times.Approximately every actual measurement in a 4 hours lactation amount, full-time actual measurement 6 times.The assay method of each lactation amount claims to survey the litter weight before and after piglet lactation, and the difference of the litter weight before and after piglet lactation is this lactation amount.6 times lactation amount sum is average each lactation amount divided by 6, and each lactation amount is multiplied by full-time lactation number of times, is full-time lactation amount.7 day, the average of lactation amount was multiplied by 28, was total lactation amount of 28 days lactations.
1.3.2 the mensuration accurate recording litter size of piglet average daily gain, strong young number, weak young number (that piglet litter weight at birth≤900g is weak son), detailed record every sow litter born weight, respectively at 14d and 28d in postpartum, piglet is weighed, calculate average daily gain.
1.3.3 the mensuration of milk-quality often organizes random selecting 6 sows at the 14th day lactation period and 28 days, respectively from before, during and after 3 nipples gather milk samples after mix, every gathers 20mL ,-20 DEG C of preservations after sample collection.Butterfat, lactoprotein, lactose, non-fat solid content and total solids content adopt quick milk composition automatic analyzer to measure; ELISA kit is adopted to measure milk immunoglobulin G and M level.
1.3.4 the mensuration of Serum Indexes: each processed group random selecting 6 sows are respectively at Farrowing 14d, 28d Baoding blood sampling on an empty stomach.Every sow auricular vein or basal part of the ear portion venous blood collection 10mL, leave standstill 15min, and adopt centrifuge to carry out (3000r/min) centrifugal 15min, serum is sub-packed in EP pipe, in-20 DEG C of freezen protective.ELISA kit is adopted to measure Prolactin and estradiol content.
2 results
2.1 probio compound Chinese medicinal preparation are on the impact of milk yield of sow
Table 2 probio compound Chinese medicinal preparation is on the impact of milk yield of sow
Colleague's data are takeed on mark and are represented difference not significantly (P>0.05) without letter or same letter, and different lowercase alphabet shows significant difference (P<0.05), and following table is same.
As shown in Table 2, the day lactation amount of II group, V group and VI group is significantly higher than I group of (CK) (P<0.05), exceeds 32.53%, 28.94% and 36.10% respectively; 28 days total lactation amounts II group and VI group are significantly higher than all the other each group (P<0.05), exceed 32.54% and 34.80% respectively than I group (CK); Total feed consumption rate aspect, each group difference is not all significantly (P>0.05).In raising day lactation amount and 28 days total lactation amounts, VI group of effect is best.
2.2 probio compound Chinese medicinal preparation are on the impact of piglet average daily gain
Table 3 probio compound Chinese medicinal preparation is on the impact of piglet average daily gain
As shown in Table 3, in number born alive, VI group at most, significantly exceeds IV group 19.96% (P<0.05), compares difference all not significantly (P>0.05) with all the other each group; In piglet average daily gain, during 0-14d, VI group the highest, with I group (CK), III group, IV group to compare respectively significantly (P<0.05) with V group and exceed 45.39%, 37.58%, 54.14% and 31.41%, compare difference with II group significantly (P>0.05); During 14-28d, VI group the highest, and with I (CK), significantly (P<0.05) exceeds 49.08%, 15.17%, 29.95%, 64.19% and 27.23% respectively compared with II, III, IV, V group.Illustrate that VI group of effect is best in the average daily gain of raising piglet.
2.3 probio compound Chinese medicinal preparation are on the impact of pig milk-quality
Table 4 probio compound Chinese medicinal preparation is on the impact (%) of pig milk-quality
As shown in Table 4, during 14d, milk fat content is respectively organized all higher than I group (CK), and VI group the highest, is secondly V group, and each group difference is not significantly (P>0.05).Non-fat and protein content are all VI group the highest, are secondly I-CK groups, but each group difference is not significantly (P>0.05).Lactose content VI group is the highest, and exceeding I-CK group 2.09%, is secondly II group, but each group difference is not all significantly (P>0.05); During 28d, milk fat content VI group is the highest, and a little higher than I-CK organizes 3.85% (P>0.05).Non-fat, albumen and lactose content are all that I-CK group is the highest, but compare difference with all the other each group all not significantly (P>0.05).In a word, VI group in raising 14d milk fat, non-fat, albumen and lactose content effect better, simultaneously the highest in conjunction with total lactation amount index VI group, during total lactation amount height, each index content of milk quality can reduce, illustrate VI group in improving milk quality effect better.
2.4 probio compound Chinese medicinal preparation are on the impact of 14 days normal newborn immunoglobulin contents of sow
Table 5 is on the impact (ng/mL) of 14 days normal newborn immunoglobulin contents of sow
As shown in Table 5,14 days sow normal Ruzhong immunoglobulin Ms and G content VI group all the highest, exceed 81.13% and 53.24% respectively compared with I-CK group, significant difference (P<0.05).Illustrate that the use of VI group of probio compound Chinese medicinal preparation can significantly improve the content of sow normal Ruzhong immunoglobulin (Ig), improve pigling immunity.
2.5 probio compound Chinese medicinal preparation are on the impact of sow Prolactin and estradiol content
Table 6 is on the impact (ng/mL) of sow Prolactin and estradiol content
As shown in Table 6, prolactin (PRL) is a kind of proteohormone secreted by anterior pituitary acidophil, and Main Function is for promoting mammogenesis growth, starting and maintaining lactation.In plasma prolactin content, in 14 days and 28 days sow milk, plasma prolactin content VI group is all the highest, exceeds 41.92% and 35.38% respectively, significant difference (P<0.05) compared with I-CK group; In estradiol content, in 14 days and 28 days sow milk, estradiol content VI group is all the highest, exceeds 57.77% and 23.03% respectively, significant difference (P<0.05) compared with I-CK group; Illustrate that VI group of effect is better in the lactation of promotion sow.
2.6 probio compound Chinese medicinal preparation are on the impact of sow Biochemical Indices In Serum
Table 7 probio compound Chinese medicinal preparation is on the impact of Biochemical Indices In Serum
Represent difference not significantly (P>0.05) with column data shoulder mark without letter or same letter, different lowercase alphabet shows significant difference (P<0.05).
The situation that the function of Biochemical Indices In Serum reflection pig soma organ, Nutrition and Metabolism and Nutrients Digestion utilize, when body is subject to the impact of external factor and physiology or pathological change occur, inherently reflects in physiochemical indice.The alkaline phosphatase from different tissues and bilirubin is had, wherein to be organized as master from liver and gall-bladder etc. in serum.When animal meet with stress, tissue and cellular damage or hepatic disease time, alkaline phosphatase and bilirubin will be discharged in a large number in blood and its concentration is raised.As shown in Table 7,28 days sow serum alkaline phosphatases and total bilirubin content VI group all minimum, remarkable in 34.34% (P<0.05) and 63.04% (P<0.05) respectively compared with I-CK group.Illustrate that VI group can make lactating sow serum alkaline phosphatase and obviously reduce with content of bilirubin, illustrate that VI group has the cell that watches for animals, tissue and the organ function from damage.
The content of total serum protein is relevant with metabolism status with the absorption of body protein.This result of study shows, VI group of the Total albumen content is significantly higher than I-CK and organizes 11.95% (P<0.05), illustrates that VI group can be improved sow to the digestion of protein, absorption and utilization.Serum globulins are produced by liver, derive from plasmacytic secretion, mainly comprise antibody molecule and complement component, so the rising of globulin content reflects the raising of body antibody horizontal to a certain extent in serum.This research shows, VI group of serum globulins content is significantly higher than I-CK and organizes 25.70% (P<0.05), illustrate that VI group can make the immunity of organisms of sow be largely increased, also can strengthen immunity and the resistance against diseases of suckling pig body simultaneously.
Conclusion:
1, add 1 ‰ probio compound Chinese medicinal preparation of the present invention in lactating sow daily ration and can significantly improve Prolactin content, improve capacity of milk secretion of sow, reduce feed-weight ratio, improve efficiency of feed utilization;
2, probio compound Chinese medicinal preparation of the present invention is owing to the addition of probio, can activate the immunocyte in systemic blood, promotes that body produces immunoglobulin (Ig), improves immunoglobulin G and M level in sow milk, strengthen the immunity of piglet;
3, probio compound Chinese medicinal preparation of the present invention can improve pig milk-quality, especially the content of butterfat;
4. probio compound Chinese medicinal preparation of the present invention significantly reduces serum alkaline phosphatase and total bilirubin content, and the cell that watches for animals, tissue and organ are from damage; Total serum protein and globulin content can be significantly improved, strengthen sow digesting and assimilating nutriment, improve pig body antibody horizontal.Finally reach and improve piglet incubation rate, promote the object of Piglet Development.
Claims (10)
1. promote sow lactation and improve the probio compound Chinese medicinal preparation of milk water quality, it is characterized in that, by Chinese medicine compound prescription with probio is composite forms;
Described Chinese medicine compound prescription is made up of the raw material of following weight portion:
Angel Yeast 0.5-1.5 part, FOS 5-15 part, vitamin E 1-4 part, seed of cowherb 5-15 part, stem pith of the rice-paper plant 1-3 part, complex enzyme formulation 4-6 part, isoflavones 1-3 part, medical stone powder 45-50 part, cornstarch 17-25 part;
Described probio is the Mixed Microbes powder of bacillus subtilis and Lactobacillus plantarum.
2. the probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality as claimed in claim 1, it is characterized in that, in probio compound Chinese medicinal preparation, the viable count of bacillus subtilis is more than or equal to 2 × 10
8cfu/g, the viable count of Lactobacillus plantarum is more than or equal to 3 × 10
8cfu/g.
3. the as claimed in claim 2 probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality, is characterized in that, the bacillus subtilis B7348 of described bacillus subtilis to be deposit number be CCTCC M 2010260; The Lactobacillus plantarum LP of described Lactobacillus plantarum to be deposit number be CCTCC M 2010150.
4. the probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality as claimed in claim 1, it is characterized in that, described Chinese medicine compound prescription is made up of the raw material of following weight portion:
Angel Yeast 1 part, FOS 10 parts, vitamin E 3 parts, the seed of cowherb 10 parts, the stem pith of the rice-paper plant 2 parts, complex enzyme formulation 5 parts, isoflavones 2 parts, medical stone powder 46 parts, cornstarch 21 parts.
5. the probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality as claimed in claim 1, is characterized in that, the enzyme activity >=10000u/g of described complex enzyme formulation.
6. the probio compound Chinese medicinal preparation promoting sow lactation and improve milk water quality as claimed in claim 1, it is characterized in that, the total viable count of described Angel Yeast is 100 × 10
8-200 × 10
8cfu/g.
7. the preparation method of the probio compound Chinese medicinal preparation of the promotion sow lactation described in any one of claim 1 to 6 and raising milk water quality, it is characterized in that, step is as follows:
(1) after the seed of cowherb and the stem pith of the rice-paper plant being pulverized respectively, sieve, soak, boiling three times, by the filtrate after boiling and dregs of a decoction mixing, freeze-drying, obtained Chinese medicine freeze-dried powder, for subsequent use;
(2) by Chinese medicine freeze-dried powder prepared by step (1), mix with probiotics bacterial powder, Angel Yeast, FOS, vitamin E, complex enzyme formulation, isoflavones, medical stone powder, cornstarch, obtain probio compound Chinese medicinal preparation.
8. preparation method as claimed in claim 7, is characterized in that, in step (1), the amount of water soaked is 15-25 times of medicinal material weight, and soak time is 0.5-1.5h.
9., as preparation method as claimed in claim 8, it is characterized in that, in step (1), the amount of water soaked is 20 times of medicinal material weight, and soak time is 1.0h.
10. preparation method as claimed in claim 7, it is characterized in that, in step (1), the amount of water of each boiling is 20 times of medicinal material weight, and each digestion time is 0.5h.
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Denomination of invention: Probiotic traditional Chinese medicine compound preparation for promoting lactation of sows and improving milk quality Effective date of registration: 20180413 Granted publication date: 20180109 Pledgee: Bank of Tai'an Limited by Share Ltd Pledgor: Shandong Baolai-leelai Bio-engineering Co., Ltd. Registration number: 2018370000070 |
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