CN105941870A - Nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry - Google Patents
Nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry Download PDFInfo
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- CN105941870A CN105941870A CN201610367881.XA CN201610367881A CN105941870A CN 105941870 A CN105941870 A CN 105941870A CN 201610367881 A CN201610367881 A CN 201610367881A CN 105941870 A CN105941870 A CN 105941870A
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Abstract
The invention discloses a nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry, and belongs to the field of animal feed additives. The nanometer montmorillonite feed additive compound is prepared from the following components in percentage by mass: 54.0-82.8 percent of nanometer montmorillonite, 10-20 percent of organic zinc, 2-10 percent of xylooligosaccharide, 0.2-1.0 percent of glucose oxidase and 5-15 percent glucose. The nanometer montmorillonite feed additive compound has the advantages that the diarrhea of piglets and chicks can be effectively prevented and treated, the growth property of livestock and poultry is improved, the survival rate of livestock and poultry, especially small livestock and poultry, is obviously improved, and the culture benefit is increased.
Description
Technical field
The invention belongs to animal feed additive field.
Background technology
All containing the multiple mycotoxin based on aflatoxin in animal and fowl fodder, be used mostly at present is anti-
The additive of mould detoxification is mainly common smectites.Montmorillonite relies on its huge specific surface area and unstable state
Current potential fixed effect, can the various mycotoxin of superpower absorption, make toxin inactivate in vivo, then get rid of external,
Never remain；This product does not absorb the healthy trace elements with household in feedstuff Middle nutrition composition and animal body, the most right
Animal alimentary canal, respiratory tract, nerve and skin do not produce any toxic side effects and harmful effect.Livestock and poultry cultivation
In industry, the big disease of modal digestion is exactly the diarrhoea caused by Pathogenic enteric antibacterial.After animal morbidity, raw
Long speed is slow, and the price of deed reduces, simultaneously because diarrhoea, the decline of animal body constitution, immunocyte decline,
Weakening the resistance of epidemic disease, other infectious disease of easy secondary, treatment will cause large quantities of death not in time,
Serious economic loss is caused to aquaculture.Owing to the cause of disease complicates and the continuous enhancing of bacterial drug resistance,
Currently used antibiotic is the most notable for the prevention effect of bacterial diarrhea.Therefore, seek efficiently, low toxicity,
Safe drugs increasingly become the focus of concern for the intestinal diarrhea disease preventing and treating poultry such as pig, chicken.
After the pathogenesis of the diarrhoea that poultry either antibacterial or virus infect is mainly bacterium invasion intestinal,
Invasion and attack small intestinal mucosa, and replicate on intestinal villi apical epithelial cells, destroy its Absorption and disaccharidase
Enzymatic structure, makes cell generation vacuolar degeneration, necrosis.And malabsorption and disaccharidase are not enough, cause intestinal
Mucosal epithelial cells comes off, absorbs water, causes electrolyte dysfunction, ultimately result in food digests the most complete
Saccharide and unabsorbed intestinal juice are trapped in enteric cavity, cause watery stool and diarrhoea.Conventional use antibiosis clinically
Usually correct electrolyte disturbance, but it easily remains, poultry, ecological environment and human health are caused potential
Threaten.
Summary of the invention
Because the drawbacks described above of prior art, the technical problem to be solved be to provide a kind of for
The nanometer Montmorillonitum feed additive complex rushed down is prevented in poultry detoxification.
For achieving the above object, the invention provides a kind of nanometer Montmorillonitum feedstuff prevented for poultry detoxification and rushing down
Additive complex, by nanometer Montmorillonitum, organic zinc, glucoseoxidase, oligomeric xylose and glucose group
Become；Described nanometer Montmorillonitum, organic zinc, glucoseoxidase, oligomeric xylose and glucose quality percentage ratio
For: nanometer Montmorillonitum 54.0-82.8%, zinc glycinate 10-20%, oligomeric xylose 2-10%, glucose aoxidize
Enzyme 0.2-1.0%, glucose 5-15%.
Use above technical scheme, in ablactational baby pig daily ration use can substitute zinc oxide, reduce preventative
Antibiotic, reduce the use of acidulant etc., avoid the problem of the drug resistance that abuse of antibiotics causes, anti-especially
Raw element inhibitory action developable to animal body immunization machine, releasing high dose height zinc, high consumption antibiotic make
By the inhibitory action to late growing stage, reduce the problem of environmental pollution that high zinc brings.
The nanometer Montmorillonitum used in the present invention has powerful adsorption function, can adsorb in harmful bacteria and feedstuff
Mycotoxin.Nanometer Montmorillonitum also has the effect of slow-released carrier, so that oligomeric xylose in complex,
The gastrointestinal tract of the poultry such as glucoseoxidase slowly discharges such that it is able to make oligosaccharide and enzyme preparation whole
Intestinal can work, especially play a role in rear intestinal persistence, poultry are greatly improved the youngest
The survival rate of little poultry, increases culture benefit.
It is also preferred that the left described organic zinc is zinc citrate, zinc gluconate, zinc methionine, zinc glycyrrhizate or sweet ammonia
One in acid zinc.
It is also preferred that the left described nanometer Montmorillonitum particle diameter≤30 nanometer, described nanometer Montmorillonitum aperture are that 5-100 receives
Rice, specific surface area >=300m2/ g, unit weight are 0.3-0.6 (kg/m3)。
The invention has the beneficial effects as follows: the present invention can effectively prevent and treat piglet, chickling diarrhoea, improves growth of animals or poultry
Performance, can significantly improve the survival rate of the most immature poultry of poultry, increases culture benefit.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment one, a kind of nanometer Montmorillonitum feed additive complex preventing for poultry detoxification rushing down, by receiving
Rice montmorillonite, organic zinc, glucoseoxidase, oligomeric xylose and glucose composition；Described nanometer Montmorillonitum,
Organic zinc, glucoseoxidase, oligomeric xylose and glucose quality percentage ratio is: nanometer Montmorillonitum 54.0%,
Zinc glycinate 20%, oligomeric xylose 10%, glucoseoxidase 1.0%, glucose 15%.
In the present embodiment, described nanometer Montmorillonitum particle diameter≤200 nanometer, described nanometer Montmorillonitum aperture are 5-100
Nanometer, specific surface area >=300m2/ g, unit weight are 0.3-0.6 (kg/m3)。
Certain organic zinc of the present invention can also be zinc citrate, zinc gluconate, zinc methionine or Radix Glycyrrhizae
One in zinc.
Embodiment two, the present embodiment is essentially identical with embodiment one, except that: described nanometer Montmorillonitum,
Organic zinc, glucoseoxidase, oligomeric xylose and glucose quality percentage ratio is: nanometer Montmorillonitum 82.8%,
Zinc glycinate 10%, oligomeric xylose 2%, glucoseoxidase 0.2%, glucose 5%.
The glucose that glucoseoxidase can be catalyzed in intestinal produces gluconic acid and hydrogen peroxide, works as peroxidating
When hydrogen runs up to finite concentration, directly suppress escherichia coli, Salmonella, pasteurellosis bacillus, staphylococcus,
The growth and breeding of vibrio.Its mechanism of action is totally different from antibiotic, will not produce thalline Drug resistance or medicine
Residual.Glucoseoxidase can be catalyzed glucose and remove oxygen in intestinal, for anaerobism probiotics bacillus bifidus
Propagation manufactures anaerobic environment.The gluconic acid generated can reduce stomach intestinal pH, manufactures acid for lactobacter growth
Property environment.Formation Tiny ecosystem competitive advantage is bred in probiotics in a large number, is unfavorable for escherichia coli, Salmonella etc.
The survival of harmful bacteria, controls to infect, gets rid of corrupt substance, improve macrophage activity, thus improve body
Immunity.Glucoseoxidase is the succedaneum that antibiotic is ideal.Glucoseoxidase is a kind of green
Additive, be environmental protection to human non-toxic, side effect.
Oligomeric xylose is not decomposed absorption by animal intestinal, and it can be as " the false receptor " of pathogen with sick
The phytohemagglutinin part of former bacterium cell surface combines, and reduces what pathogenic bacteria was combined with Intestinal epithelial cells receptor
Chance so that it is dead because of hungry, reaches to suppress the purpose of pathogen growth.The barrier action of oligomeric xylose makes
Pathogenic bacterium cannot on host cell field planting and in free state exist, be allowed to the toleration of antibiotic is dropped significantly
Low, thus improve antibiotic and pathogen is killed and inhibitory action.Oligomeric xylose can induce animal immune system
Cytokine profiles in system, promotes the generation of interferon, activating macrophage and T, bone-marrow-derived lymphocyte, carries
The lethality of high natural killer cell (NK), promotes that antibody produces, thus strengthens the immunologic function of animal.Low
After xylan enters animal large intestine, there is the fundamental characteristics of soluble fiber, reduce toxic metabolite, can promote
Enter intestinal peristalsis promoting, strengthen digestion mechanism, improve hormonal readiness in blood, promote the anabolism of body, thorn
Exciting thing immune function, by immunization route enhancing body premunition.Oligomeric xylose relatively other oligosaccharide have
The features such as acid-resisting is strong, good stability, consumption are extremely low, coordinate the nanometer Montmorillonitum with same absorbability
Have and preferably adsorb bacterium, the effect of preventing and treating diarrhoea.
The preparation method of compound additive of the present invention is as follows: by nanometer Montmorillonitum, organic zinc, Fructus Vitis viniferae
Carbohydrate oxidase, oligomeric xylose and glucose weigh raw material by above-mentioned mass percent and are sufficiently stirred for mixing, subpackage
Obtain.
Specific experiment checking is as follows:
Embodiment 1, the present invention is directed to ablactational baby pig effect test
1, experimental design: choose 25 ages in days, average weight is the ablactational baby pig 128 of 6.0 ± 0.2kg,
It is randomly divided into 4 groups: (1) control group fed basal diet (is added with 10% sulphuric acid of 0.02% in basal diet
Colistin)；(2) common zinc oxide group: add 0.3% common zinc oxide on the basis of basal diet；
(3) common montmorillonite group: add 0.3% common montmorillonite on the basis of basal diet；(4) nanometer is covered
De-stone complex group: add 0.3% special nanometer Montmorillonitum complex group on the basis of basal diet.Often group
Individual process 4 repetition, 8 pigs of each repetition.Feeding period is two weeks after of weaning, totally 14 days.
2, the feed intake of each pig group, drinking-water situation are observed during test, record feed consumption rate and piglets diarrhoea
Situation.Measuring the wean body weight of latter 21 days, calculate daily gain, feed-weight ratio, diarrhea rate, concrete outcome is shown in
Following table:
Result of the test shows, uses nanometer Montmorillonitum additive to be combined in the present invention in ablactational baby pig basal diet
Thing relative comparison group, common zinc oxide, common montmorillonite group improve ablactational baby pig daily gain, reduce material
Anharmonic ratio.In terms of preventing and treating piglet diarrhea, the anti-diarrhea effect of nanometer Montmorillonitum is more preferable, diarrhea rate comparison respectively
42.47%, 15.38%, 32.29% is reduced according to group, common zinc oxide, common montmorillonite group.Nanometer is covered de-
Stone additive complex significantly reduces the diarrhea rate of 12 weeks after ablactational baby pig is weaned, and shows that nanometer is covered simultaneously
It is de-that stone additive complex can substitute common zinc oxide, common montmorillonite effectively reduces diarrhea of weaned piglets rate,
The high dose zinc oxide growth inhibitory effect to ablactational baby pig can be reduced again simultaneously, thus improve ablactational baby pig
Growth performance.
Embodiment 2, the nanometer Montmorillonitum additive complex P suffered from diarrhoea for chickling preventing and treating and effect test thereof
1, experimental design: choose 1 age in days, average weight is the Sanhuang broiler 160 of 30.0 ± 2g, with
Machine is divided into 4 groups: (1) control group fed basal diet (basal diet is added with 0.02% 10% sulphuric acid glue
Bacillin pre-mixing agent and the 12% Salinomycin Sodium pre-mixing agent of 0.05%)；(2) common montmorillonite group: in basis day
0.3% common montmorillonite is added on the basis of grain；(3) nanometer Montmorillonitum group: add on the basis of basal diet
The special nanometer Montmorillonitum that adds 0.2%；(4) nanometer Montmorillonitum complex group: add on the basis of basal diet
0.3% special nanometer Montmorillonitum complex group.Each process 4 repetition, 10 chickens of each repetition.Raise
Phase be 1 age in days to 15 ages in days, totally 15 days.
2, the feed intake of each chickling group, drinking-water situation are observed during test, record feed consumption rate and chickling abdomen
Rush down the situations such as rate.Emphasis measures the body weight raised 15 days, calculates daily gain, feed-weight ratio, diarrhea rate, tool
Body result see table:
Result of the test shows, uses nanometer Montmorillonitum additive complex phase in the present invention in chickling basal diet
Matched group, common montmorillonite, nanometer Montmorillonitum group are improve Sanhuang chicken broiler chicks daily gain, reduces material
Anharmonic ratio.In terms of preventing and treating chickling diarrhoea, the diarrhea effect of nanometer Montmorillonitum and nanometer Montmorillonitum complex group thereof
Fruit the best, and the preventing and treating of nanometer Montmorillonitum diarrhoea better, respectively than matched group, common montmorillonite, receive
Rice montmorillonite group reduces 40.54%, 32.26%, 22.22%.Nanometer Montmorillonitum additive complex significantly drops
The low chickling early stage diarrhea rate of 2 weeks, shows that nanometer Montmorillonitum additive complex can substitute common illiteracy simultaneously
De-stone, nanometer Montmorillonitum effectively reduce chickling diarrhea rate, improve the daily gain of chickling simultaneously, reduce material
Anharmonic ratio.
The preferred embodiment of the present invention described in detail above.Should be appreciated that the ordinary skill of this area
Personnel just can make many modifications and variations according to the design of the present invention without creative work.Therefore, all
Technical staff passes through logical analysis the most on the basis of existing technology, pushes away in the art
Reason or the limited available technical scheme of experiment, all should be at the protection model being defined in the patent claims
In enclosing.
Claims (3)
1. the nanometer Montmorillonitum feed additive complex preventing rushing down for poultry detoxification, it is characterised in that:
It is made up of nanometer Montmorillonitum, organic zinc, glucoseoxidase, oligomeric xylose and glucose；Described nanometer is covered
Taking off stone, organic zinc, glucoseoxidase, oligomeric xylose and glucose quality percentage ratio is: nanometer Montmorillonitum
54.0-82.8%, organic zinc 10-20%, oligomeric xylose 2-10%, glucoseoxidase 0.2-1.0%, Fructus Vitis viniferae
Sugar 5-15%.
A kind of prevent that the nanometer Montmorillonitum feed additive that rushes down is multiple for poultry detoxification
Compound, is characterized in that: described organic zinc be zinc glycinate, zinc citrate, zinc gluconate, zinc methionine,
Or the one in zinc glycyrrhizate.
A kind of prevent that the nanometer Montmorillonitum feed additive that rushes down is multiple for poultry detoxification
Compound, is characterized in that: described nanometer Montmorillonitum particle diameter≤200 nanometer, described nanometer Montmorillonitum aperture are 5-100
Nanometer, specific surface area >=300m2/ g, unit weight are 0.3-0.6 (kg/m3)。
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| CN201610367881.XA CN105941870A (en) | 2016-05-27 | 2016-05-27 | Nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry |
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| CN201610367881.XA CN105941870A (en) | 2016-05-27 | 2016-05-27 | Nanometer montmorillonite feed additive compound for detoxifying and diarrhea prevention of livestock and poultry |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106417919A (en) * | 2016-10-14 | 2017-02-22 | 山东德州神牛药业有限公司 | Special intestinal balance regulator for livestock as well as preparation method and application thereof |
| CN107333995A (en) * | 2017-08-14 | 2017-11-10 | 深圳市金新农科技股份有限公司 | Feed addictive, the feed of non-oxidation zinc and its application |
| CN107811118A (en) * | 2017-10-31 | 2018-03-20 | 广东新和盈生物科技有限公司 | A kind of application of zinc glycyrrhizate as animal feed additive |
| CN107821794A (en) * | 2017-10-31 | 2018-03-23 | 广州骊加生物科技有限公司 | A kind of feed addictive for preventing animal diarrhea |
| CN112868934A (en) * | 2021-01-19 | 2021-06-01 | 山东省汇富农牧发展有限公司 | Nano montmorillonite meat rabbit feed additive compound for detoxification and diarrhea prevention |
-
2016
- 2016-05-27 CN CN201610367881.XA patent/CN105941870A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106417919A (en) * | 2016-10-14 | 2017-02-22 | 山东德州神牛药业有限公司 | Special intestinal balance regulator for livestock as well as preparation method and application thereof |
| CN106417919B (en) * | 2016-10-14 | 2020-02-07 | 山东德州神牛药业有限公司 | Intestinal balance regulator special for livestock and poultry and preparation method and application thereof |
| CN107333995A (en) * | 2017-08-14 | 2017-11-10 | 深圳市金新农科技股份有限公司 | Feed addictive, the feed of non-oxidation zinc and its application |
| CN107811118A (en) * | 2017-10-31 | 2018-03-20 | 广东新和盈生物科技有限公司 | A kind of application of zinc glycyrrhizate as animal feed additive |
| CN107821794A (en) * | 2017-10-31 | 2018-03-23 | 广州骊加生物科技有限公司 | A kind of feed addictive for preventing animal diarrhea |
| CN112868934A (en) * | 2021-01-19 | 2021-06-01 | 山东省汇富农牧发展有限公司 | Nano montmorillonite meat rabbit feed additive compound for detoxification and diarrhea prevention |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160921 |
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