CN104939089A - 具有改善骨密度功能的营养组合物及其制备方法与应用 - Google Patents
具有改善骨密度功能的营养组合物及其制备方法与应用 Download PDFInfo
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- CN104939089A CN104939089A CN201510358338.9A CN201510358338A CN104939089A CN 104939089 A CN104939089 A CN 104939089A CN 201510358338 A CN201510358338 A CN 201510358338A CN 104939089 A CN104939089 A CN 104939089A
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- alimentation composition
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- calcium carbonate
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- mixed powder
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- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 210000000988 bone and bone Anatomy 0.000 title abstract description 20
- 235000016709 nutrition Nutrition 0.000 title abstract description 8
- 230000035764 nutrition Effects 0.000 title abstract description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 title abstract description 7
- 239000011707 mineral Substances 0.000 title abstract description 7
- 239000002131 composite material Substances 0.000 title abstract 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 79
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 40
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 37
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
- 108010035532 Collagen Proteins 0.000 claims abstract description 22
- 229920001436 collagen Polymers 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 21
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 20
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 20
- 239000011812 mixed powder Substances 0.000 claims abstract description 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 20
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 79
- 230000037182 bone density Effects 0.000 claims description 24
- 230000007062 hydrolysis Effects 0.000 claims description 18
- 238000006460 hydrolysis reaction Methods 0.000 claims description 18
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- 239000002245 particle Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- -1 0.3 part Chemical compound 0.000 claims description 7
- 235000013376 functional food Nutrition 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 239000005018 casein Substances 0.000 abstract description 6
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract description 6
- 235000021240 caseins Nutrition 0.000 abstract description 6
- 210000003022 colostrum Anatomy 0.000 abstract description 4
- 235000021277 colostrum Nutrition 0.000 abstract description 4
- 108010001441 Phosphopeptides Proteins 0.000 abstract 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 22
- 239000011575 calcium Substances 0.000 description 22
- 229910052791 calcium Inorganic materials 0.000 description 22
- 241000700159 Rattus Species 0.000 description 17
- 241000209094 Oryza Species 0.000 description 15
- 235000007164 Oryza sativa Nutrition 0.000 description 15
- 235000009566 rice Nutrition 0.000 description 15
- 208000001132 Osteoporosis Diseases 0.000 description 10
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- 230000000694 effects Effects 0.000 description 9
- 239000011777 magnesium Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- 229910052749 magnesium Inorganic materials 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 5
- 238000011160 research Methods 0.000 description 5
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- 238000004458 analytical method Methods 0.000 description 4
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- 210000002997 osteoclast Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000006386 Bone Resorption Diseases 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
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- 210000002808 connective tissue Anatomy 0.000 description 3
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- 210000003205 muscle Anatomy 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 108010048734 sclerotin Proteins 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 239000004470 DL Methionine Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 238000004380 ashing Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 235000006109 methionine Nutrition 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 238000013001 point bending Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 101710089042 Demethyl-4-deoxygadusol synthase Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- HBYOLNPZXLHVQA-UHFFFAOYSA-J dicalcium dicarbonate Chemical compound [Ca+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HBYOLNPZXLHVQA-UHFFFAOYSA-J 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000019601 food appearance Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000031787 nutrient reservoir activity Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
钙(mg/g) | 镁(mg/g) | 磷(mg/g) | |
对照组 | 113.05±7.11 | 4.13±0.22 | 55.02±3.84 |
低剂量组 | 115.31±8.07 | 4.17±0.24 | 56.64±4.39 |
中剂量组 | 117.06±7.62* | 4.20±0.18* | 58.87±3.69 |
高剂量组 | 118.41±8.02* | 4.21±0.29* | 59.22±3.21* |
Claims (8)
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CN201510358338.9A CN104939089B (zh) | 2015-06-24 | 2015-06-24 | 具有改善骨密度功能的营养组合物及其制备方法与应用 |
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CN201510358338.9A CN104939089B (zh) | 2015-06-24 | 2015-06-24 | 具有改善骨密度功能的营养组合物及其制备方法与应用 |
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CN104939089A true CN104939089A (zh) | 2015-09-30 |
CN104939089B CN104939089B (zh) | 2017-09-15 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107460037A (zh) * | 2017-09-30 | 2017-12-12 | 陈芹芳 | 高钙山茶油及其生产工艺 |
CN108144047A (zh) * | 2017-12-30 | 2018-06-12 | 广州润虹医药科技股份有限公司 | 一种增加骨密度的含壳聚糖的保健组合物及其用途 |
CN109170916A (zh) * | 2018-11-02 | 2019-01-11 | 丽睿客信息科技(北京)有限公司 | 一种强身健体食品组合物及其制备方法 |
CN109805417A (zh) * | 2019-03-01 | 2019-05-28 | 河南九九一生物科技有限公司 | 一种能够增加骨密度的保健食品及其加工方法 |
Citations (5)
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JPH08242773A (ja) * | 1995-03-10 | 1996-09-24 | Meiji Milk Prod Co Ltd | カルシウム−カゼインホスホペプチド調製物の製造方法、骨塩減少抑制食品及び骨塩減少抑制剤 |
CN101049157A (zh) * | 2007-05-21 | 2007-10-10 | 北京东方兴企食品工业技术有限公司 | 一种具有预防骨质疏松作用的保健食品 |
CN101314031A (zh) * | 2008-07-14 | 2008-12-03 | 王冰 | 一种改善骨营养的制剂 |
CN102356877A (zh) * | 2011-10-14 | 2012-02-22 | 李泼 | Cbp养钙冲剂 |
CN104705658A (zh) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | 一种具有增加骨密度功能的保健食品 |
-
2015
- 2015-06-24 CN CN201510358338.9A patent/CN104939089B/zh active Active
Patent Citations (5)
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JPH08242773A (ja) * | 1995-03-10 | 1996-09-24 | Meiji Milk Prod Co Ltd | カルシウム−カゼインホスホペプチド調製物の製造方法、骨塩減少抑制食品及び骨塩減少抑制剤 |
CN101049157A (zh) * | 2007-05-21 | 2007-10-10 | 北京东方兴企食品工业技术有限公司 | 一种具有预防骨质疏松作用的保健食品 |
CN101314031A (zh) * | 2008-07-14 | 2008-12-03 | 王冰 | 一种改善骨营养的制剂 |
CN102356877A (zh) * | 2011-10-14 | 2012-02-22 | 李泼 | Cbp养钙冲剂 |
CN104705658A (zh) * | 2015-04-09 | 2015-06-17 | 四川健之源科技有限公司 | 一种具有增加骨密度功能的保健食品 |
Non-Patent Citations (2)
Title |
---|
吴益群,郁正刚: "各类营养物质与骨骼健康", 《中国骨质疏松杂志》 * |
渡部和哉,宋美玉,佐内勇亮,等: "蛋黄来源的骨代谢改善物质 -水解蛋黄粉的开发", 《中国食品添加剂》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107460037A (zh) * | 2017-09-30 | 2017-12-12 | 陈芹芳 | 高钙山茶油及其生产工艺 |
CN108144047A (zh) * | 2017-12-30 | 2018-06-12 | 广州润虹医药科技股份有限公司 | 一种增加骨密度的含壳聚糖的保健组合物及其用途 |
CN109170916A (zh) * | 2018-11-02 | 2019-01-11 | 丽睿客信息科技(北京)有限公司 | 一种强身健体食品组合物及其制备方法 |
CN109805417A (zh) * | 2019-03-01 | 2019-05-28 | 河南九九一生物科技有限公司 | 一种能够增加骨密度的保健食品及其加工方法 |
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Denomination of invention: Nutritional composition with function of improving bone mineral density and its preparation method and Application Effective date of registration: 20210910 Granted publication date: 20170915 Pledgee: Tianhe sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: Guangzhou Jin Tong special medicals Food Co.,Ltd. Registration number: Y2021980009192 |
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Inventor after: Zhang Hongrun Inventor after: Li Feng Inventor after: Wang Tao Inventor before: Zhang Hongrun Inventor before: Li Feng |
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Date of cancellation: 20221230 Granted publication date: 20170915 Pledgee: Tianhe sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: Guangzhou Jin Tong special medicals Food Co.,Ltd. Registration number: Y2021980009192 |
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