CN104926722A - 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 - Google Patents

羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 Download PDF

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Publication number
CN104926722A
CN104926722A CN201510258095.1A CN201510258095A CN104926722A CN 104926722 A CN104926722 A CN 104926722A CN 201510258095 A CN201510258095 A CN 201510258095A CN 104926722 A CN104926722 A CN 104926722A
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CN
China
Prior art keywords
compound
cell
mixture
leukemia
deuterium
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Pending
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CN201510258095.1A
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English (en)
Chinese (zh)
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弗兰克·默丘里奥
凯尔·W·H·陈
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BioTheryX Inc
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BioTheryX Inc
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Publication of CN104926722A publication Critical patent/CN104926722A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201510258095.1A 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途 Pending CN104926722A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35043110P 2010-06-01 2010-06-01
US61/350,431 2010-06-01
CN2011800377765A CN103038216A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途

Related Parent Applications (1)

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CN2011800377765A Division CN103038216A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途

Publications (1)

Publication Number Publication Date
CN104926722A true CN104926722A (zh) 2015-09-23

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CN201510258095.1A Pending CN104926722A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途
CN201510258042.XA Pending CN104945318A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途
CN2011800377765A Pending CN103038216A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途

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CN201510258042.XA Pending CN104945318A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途
CN2011800377765A Pending CN103038216A (zh) 2010-06-01 2011-06-01 羟基吡啶酮衍生物、其药物组合物及其用于治疗增生性疾病的治疗用途

Country Status (8)

Country Link
US (2) US8334307B2 (https=)
EP (1) EP2576513A1 (https=)
JP (1) JP5844354B2 (https=)
CN (3) CN104926722A (https=)
AU (1) AU2011261499B2 (https=)
CA (1) CA2801001A1 (https=)
MX (1) MX2012013879A (https=)
WO (1) WO2011153197A1 (https=)

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CN116687941A (zh) * 2014-11-11 2023-09-05 堪萨斯大学 用环吡酮、环吡酮胺或环吡酮前药治疗膀胱癌的方法
GB201420348D0 (en) * 2014-11-17 2014-12-31 Univ Northumbria Newcastle Compounds for treating neurodegenerative diseases
MA55556A (fr) 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
CN110354121B (zh) * 2019-07-08 2023-05-02 温州医科大学 环吡酮胺在制备治疗肿瘤药物中的应用和包含环吡酮胺的组合药物及用途
CN113603640A (zh) * 2021-08-06 2021-11-05 成都化润药业有限公司 一种羟吡酮乙胺盐的合成方法
CN113588852A (zh) * 2021-08-16 2021-11-02 浙江鼎泰药业股份有限公司 一种高活性透皮贴膏中挥发性成分含量的测定方法
KR102800868B1 (ko) * 2021-12-31 2025-04-29 주식회사 삼양케이씨아이 치환된 1-하이드록시-2-피리돈 화합물의 신규한 제조 방법
WO2025214612A1 (en) 2023-04-14 2025-10-16 Syngenta Crop Protection Ag Pesticidally-active 2,2-dihalocyclopropyl compounds
WO2025261608A1 (en) 2023-06-29 2025-12-26 Syngenta Crop Protection Ag Pesticidally-active 2,2-dihalocyclopropyl compounds

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Also Published As

Publication number Publication date
CA2801001A1 (en) 2011-12-08
US20130072526A1 (en) 2013-03-21
JP5844354B2 (ja) 2016-01-13
US8334307B2 (en) 2012-12-18
MX2012013879A (es) 2013-04-03
US20120022115A1 (en) 2012-01-26
JP2013528619A (ja) 2013-07-11
WO2011153197A1 (en) 2011-12-08
CN104945318A (zh) 2015-09-30
US9273005B2 (en) 2016-03-01
EP2576513A1 (en) 2013-04-10
AU2011261499A1 (en) 2013-01-10
AU2011261499B2 (en) 2015-07-16
CN103038216A (zh) 2013-04-10

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Application publication date: 20150923