CN104844682A - Method for synergistically extracting and separating effective components of fructus swietenia macrophylla in cleaning manner - Google Patents
Method for synergistically extracting and separating effective components of fructus swietenia macrophylla in cleaning manner Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/06—Production of fats or fatty oils from raw materials by pressing
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B13/00—Recovery of fats, fatty oils or fatty acids from waste materials
- C11B13/02—Recovery of fats, fatty oils or fatty acids from waste materials from soap stock
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/74—Recovery of fats, fatty oils, fatty acids or other fatty substances, e.g. lanolin or waxes
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Abstract
The present invention relates to a method for synergistically extracting and separating effective components of fructus swietenia macrophylla in a cleaning manner. The method comprises the following steps: 1) squeezing fructus swietenia macrophylla; 2) extracting and concentrating the fructus swietenia macrophylla; 3) separating and purifying a fatty acid of the fructus swietenia macrophylla; 4) separating and purifying saponin of the fructus swietenia macrophylla; 5) separating and purifying flavone and isoflavone of the fructus swietenia macrophylla. Components of the fatty acid, the saponin, the flavone, the isoflavone and the like in the fructus swietenia macrophylla are synchronously extracted.
Description
Technical field
The present invention relates to former treasure and clean extraction and separation method to sky fruit the collaborative of effective constituent.
Background technology
Former treasure is the fruit (Swietenia Macrophylla) of Meliaceae plant swietenia macrophylla to sky fruit, come from and be described as " island the cleanest in the world " Solomon Islands, this island scenery is beautiful, pregnant with beauty and productive of talent, and virgin forest mystery is peaceful, blue sky clear water is azure deep and serene, exotic flowers and rare herbs are innumerable, and environment is clean, fertile soil, with heavy rainfall, be free of contamination pure land area, remain natural ecosystem, breed unique Saloman to sky fruit.Its activeconstituents of containing and precious pharmaceutical use far exceed other areas, and from different places, drug effect is completely different, this just to sky fruit as medicinal magical part, rare precious.The height of tree about 30 to 40 meters, through 15 years growth results, wide bottom fruit, top is sharp-pointed, and stand on end of the branch and gain the name to sky growth, fruit is beige, kernel bitter.The history that Saloman is recorded to sky fruit document just has more than 2000 year, it is the most authentic ancient population, as the magical plant of " after plant ", whole growth is in virgin forest depths, local original inhabitant carrys out the chronic diseases such as prevention and therapy diabetes, hypertension, hyperlipidemia, endocrine disturbance with to sky fruit always, has exceeded thousand.Record in " Malaysian herbal medicine catalogue " bitter, puckery, cool in nature, antipyretic to sky fruity, restrain, strong, the activeconstituents that it contains and precious pharmaceutical use, far exceed other areas, from different places, drug effect is also completely different, this just to sky fruit as medicinal magical part.The composition that Xiang Tianguo gives prominence to the most is containing the important component-Saponin/TSM in ginseng, and important component-chromocor compound in ginkgo, and Xiang Tianguo contains the large main component of lipid acid, saponin(e, flavones and isoflavones four.20 end of the centurys, medical college of Kai Er internation combination Malaya college professor Dr.Mustafa Ali Mohd and the system of medicament in Saudi Arabia doctor Dr.Ossama Arafat subtend sky fruit carry out going deep into scientific experiment research, result shows, three large activeconstituentss are rich in: Saponin/TSM to sky fruit, flavonoid, isoflavones.In addition, Xiang Tianguo is also containing the necessary nutrition of the human bodies such as multiple natural protein, vitamin A, B1, B3, B6, D, E and folic acid, iron, potassium
[1-4].To sky fruit Saponin/TSM function: 1. hypoglycemic, plasma cholesterol, falls in reducing blood-fat, improves lipid metabolism, prevention hyperlipidemia; 2. reduce platelet aggregation, avoid thrombosis, improve blood clotting and avoid myocardial infarction, increase heart and brain volume of blood flow, 3. improve body anti-anoxia ability, strengthen disease resistance and muscle power, increase the phagocytic activity of quantity of leucocyte thus improve immunologic function; 4. anticancer Tumor suppression.To sky fruit flavonoid function: 1. stimulate circulation, prevention cerebrovascular occlusion, prevention Alzheimer; 2. reduce the accumulation of fat on vessel wall, stop arteriosclerotic formation, reduce cholesterol level; 3. impel in body the antibody tormation preventing each tissue inflammation, remove too much free radical, prevent vivo oxidation.To sky fruit isoflavones function: 1. natural phant oestrogenic hormon, conditioning female pathology clock, menopausal symptoms of releiving; 2. skeleton bulking disease is prevented.In Xiang Tianguo, fats component content is more than 55%, and the absorption of activeconstituents in lipid component subtend sky fruit, transhipment, distribution in vivo and then activity level all may produce material impact.
To sky fruit, there is following clinical application: 1) treat diabetes, adjustment body metabolism function, the Regular Insulin of self is made to be able to " resurrection " and to play a role, make blood sugar absorb by body tissue cell and utilize, reduce blood sugar, Xiang Tianguo is not only directly hypoglycemic, and can replace ofhypoglycemic medicine, can prevent or reduce complication.2) treat hypertension, the headache syndromes of hyperpietic can be alleviated, the apoplexy that blood circulation prevention cerebrovascular occlusion causes can be promoted, prevention Alzheimer, improve the arteriosclerosis of blood vessel, strengthening heart function, reduce the use of other antihypertensive drugs.3) regulate the hemolytic system of body, anticoagulant, improves blood clotting, reduces thrombosis, increase heart and brain volume of blood flow, 4) treatment hyperlipidemia, hypercholesterolemia, suppress cholesterol in the absorption of enteron aisle, improve metabolism of fat, prevention hyperlipidemia, reduces blood fat and cholesterol.5) homeostasis between each organ of human body is regulated; ensure the normal activity of cell; there is health care function, Yang strengthening and life essence tonifying, Ginseng Extract, physical strength reinforcing, toxin expelling, repair tissue, raising conceptual quotient, strengthening healthy qi, active cells, pretty and dazzling beauty treatment, pre-anti-aging, strong stomach are good for lung, Antialcoholic liver-protecting, beneficial blood supplements, strong Pi antidiarrheal, detoxicating toxin expelling, are regulated the effect such as blood sugar, tranquilizing by nourishing the heart
[5-9].
Reference:
[1]Ekimoto H，Irie Y，Araki Y，et ai.Platelet aggregation inhibitors from seeds of Swietenia mahagoni：inhabition ofin vitro and in vivo platelet-activating factor induced effects of tetranortriterpenoids related to swietenine andswietenolide[J].Planta Med，1991，57(1)：56-58
[2]Dewanjee S，Maiti A，Das AK，et al.Swietenine：Apotential oral hypoglycemic from Swietenia macrophyllaseed[J].Fitoterapia，2009，80(4)：249-251
[3]Mona MGS，Tetsuo I，Matsumi D，ET AL，Swietenialides，novel ring dopened phragmalin limonoid orthoestersfrom Swietenia mahogany JACQ[J].Tetrahedronlett，2003，59(10)：8027-8033
[4]Mulholland DA，Parel B，Coombes PH.The Chemistry of the Meliaceae and Ptaeroxylaceae of southern andeastern Africa and Madagascar[J].Curr Org Chem，2000，4(10)：1011-1054
[5]Nagalakshmi MA，Thangadurai D，Rao DM，et al，Phytochemical and antimicrobial study of Chukrasia tabularisleaves[J].Fitoterapia，2001，72(1)；62-64
[6]Marisi GS.lnterespecific variation in the composition of volatile oils from the leaves of Swietenia macrophyllaking(Meliaceae)[J].Quim Nova，2010，33(5)：1141-1144
[7]Marisi GS，Luciane G，Batista Pereira.Electrophysiological responses of female and male Hypsipyla grand ellato Swietenia macrophylla essential oils[J].J Chem Ecol，2003，29(9)：2143-2151
[8]Lin BD，Zhang CR，Yang SP，et al.D-ring-opened phragmalin type limonoid orthoesters from the twigs ofSwietenia macrophylla[J].J Nat Prod Prod，2009，72(7)：1305-1313
[9]Maiti A，Dewanjee S，Sahu R.lsolation of hypoglycemic phytoconstituent from Swietenia macrophyllaSeeds[J].Phytother Res，2009，23(12)：1731-1733
Summary of the invention
For overcoming the deficiency in background technology, the present invention aims to provide former treasure and cleans extraction and separation method to sky fruit the collaborative of effective constituent.
Technical solution of the present invention is:
Former treasure cleans extraction and separation method to sky fruit the collaborative of effective constituent, comprises the steps:
(1) squeezing of Xiang Tianguo.
(2) extraction of Xiang Tianguo, concentrated.
(3) to the separation and purification of sky fruit lipid acid.
(4) to the separation and purification of sky fruit saponin(e.
(5) to sky fruit flavones and the separation and purification of isoflavones.
Embodiment
To steam in three layers of cooking pot to sky fruit and fry, the first layer adds water-wet and steams 30-40min, moisture 15-18%, material temperature 90-95 DEG C, second and third layer of heat drying 30-40min, moisture is 2-3%, enter to squeeze material temperature 110-115 DEG C, through screw extrusion press squeezing, oil yield 45-50%.Grouts are crushed to 40-60 order and drop in extractor, add the ethanol of 95% as extraction agent, use recycle pump that ethanol is circulated in material.First time extracts the 95% extraction using alcohol 3.0h adding 8 times amount of material quantity, release extracting solution, material slag second time extracts the 95% extraction using alcohol 2.0h adding 6 times amount, release extracting solution, material slag third time extracts the 95% extraction using alcohol 1.5h adding 4 times amount, and extracting solution is as the extracting solution of next raw material for the third time.The extracting solution of first twice merges, be evaporated to proportion 1.05-1.10 and will extract enriched material with petroleum ether extraction 3-5 time, using petroleum ether extraction liquid as extraction agent, extract the thick oil of squeezing, collect sherwood oil, add the atlapulgite of 3-5%, at about 90 DEG C, more than vacuum tightness 90Kpa, decolouring 30min, after having decoloured, oil temperature is down to less than 40 DEG C, with filter, oil is separated with carclazyte, obtain bleached oil, then precipitation, vacuumize in precipitation tower and steam sherwood oil, after sherwood oil has steamed, strengthen vacuum tightness, at-0.095Mpa, 80-100 DEG C removes residual solvent, obtain to sky fruit lipid acid.Resistates after petroleum ether extraction is with isopyknic n-butanol extraction 3-5 time, butanol extraction liquid is sent in thickener, reduction vaporization propyl carbinol, to the greatest extent, reclaims propyl carbinol and recycles, and obtains to sky fruit saponin(e concentrated solution, by concentrated solution polyamide chromatography, thin-layer chromatography detects, and chromatographic solution is collected in cutting, must containing the elutriant to sky fruit saponin(e, concentrating under reduced pressure, obtains to sky fruit saponin(e.Saturated limewater is added by the residual solution of extraction saponin(e, regulate more than pH12, abundant stirring, flavonoid compound and plurality of impurities is made to generate insoluble calcium salt and inner complex, separate out precipitation, suction filtration, washing, filter residue washes with water to colourless, discard filtrate, the ethanol of 95% is added in filter residue, fully stir into suspension, suspension pH4-6 is regulated again with the sulfuric acid of 30-40%, major part weak acid yellow ketone compounds dissolves, acid stronger organic acid can not dissolve, filter, collect filtrate, adding 20-30% sodium hydroxide in greenery adjusts pH to neutral, further removing calcium sulfate, the impurity such as sodium salt and tanning, filter, collect filtrate, leave standstill, filter, obtain flavonoid compound filtrate, filtrate is sent in thickener, concentrating under reduced pressure, enriched material.In above-mentioned enriched material, add the gac of feed liquid 3-5%, be heated to boil, suction filtration, collect filtrate, under vacuum, 50-60 DEG C of decline filtrate is concentrated into dry, dry, obtains to sky fruit flavones and isoflavone compounds.
Claims (7)
1. former treasure to sky fruit the collaborative of effective constituent clean extraction and separation method, with former treasure to sky fruit for raw material, the method includes the steps of:
(1) Xiang Tianguo's is softening, strip plate.
(2) squeezing of Xiang Tianguo.
(3) extraction of Xiang Tianguo, concentrated.
(4) to the separation and purification of sky fruit lipid acid.
(5) to the separation and purification of sky fruit saponin(e.
(6) to sky fruit flavones and the separation and purification of isoflavones.
2. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, softening temperature 60-65 DEG C in step (1), regulate moisture content 10-12%, softening time 15-20min, strip plate destroys cell walls, makes protein denaturation, rolls into the blank of thickness 0.4-0.5mm.
3. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, to steam in three layers of cooking pot to sky fruit in step (2) and fry, the first layer adds water-wet and steams 30-40min, moisture 15-18%, material temperature 90-95 DEG C, second and third layer of heat drying 30-40min, moisture is 2-3%, enters to squeeze material temperature 110-115 DEG C, through screw extrusion press squeezing, oil yield 45-50%.
4. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, in step (3), grouts are crushed in 40-60 order input extractor, add the ethanol of 95% as extraction agent, use recycle pump that ethanol is circulated in material.First time extracts the 95% extraction using alcohol 3.0h adding 8 times amount of material quantity, release extracting solution, material slag second time extracts the 95% extraction using alcohol 2.0h adding 6 times amount, release extracting solution, material slag third time extracts the 95% extraction using alcohol 1.5h adding 4 times amount, and extracting solution is as the extracting solution of next raw material for the third time.The extracting solution of first twice merges, and is evaporated to proportion 1.05-1.10.
5. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, enriched material will be extracted in step (4) with petroleum ether extraction 3-5 time, using petroleum ether extraction liquid as extraction agent, extract the thick oil of squeezing, collect sherwood oil, add the atlapulgite of 3-5%, at about 90 DEG C, more than vacuum tightness 90Kpa, decolouring 30min, after having decoloured, oil temperature is down to less than 40 DEG C, with filter, oil is separated with carclazyte, obtain bleached oil, then precipitation, vacuumize in precipitation tower and steam sherwood oil, after sherwood oil has steamed, strengthen vacuum tightness, at-0.095Mpa, 80-100 DEG C removes residual solvent, obtain to sky fruit lipid acid.
6. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, in step (5) will (3) PetroChina Company Limited. ether extract after resistates with isopyknic n-butanol extraction 3-5 time, butanol extraction liquid is sent in thickener, reduction vaporization propyl carbinol is to most, recovery propyl carbinol recycles, obtain to sky fruit saponin(e concentrated solution, by concentrated solution polyamide chromatography, thin-layer chromatography detects, and chromatographic solution is collected in cutting, must containing the elutriant to sky fruit saponin(e, concentrating under reduced pressure, obtains to sky fruit saponin(e.
7. former treasure as claimed in claim 1 cleans extraction and separation method to sky fruit the collaborative of effective constituent, it is characterized in that, saturated limewater is added by the residual solution in (4) in step (6), regulate more than pH12, abundant stirring, flavonoid compound and plurality of impurities is made to generate insoluble calcium salt and inner complex, separate out precipitation, suction filtration, washing, filter residue washes with water to colourless, discard filtrate, the ethanol of 95% is added in filter residue, fully stir into suspension, suspension pH4-6 is regulated again with the sulfuric acid of 30-40%, major part weak acid yellow ketone compounds dissolves, acid stronger organic acid can not dissolve, filter, collect filtrate, adding 20-30% sodium hydroxide in greenery adjusts pH to neutral, further removing calcium sulfate, the impurity such as sodium salt and tanning, filter, collect filtrate, leave standstill, filter, obtain flavonoid compound filtrate, filtrate is sent in thickener, concentrating under reduced pressure, enriched material.In above-mentioned enriched material, add the gac of feed liquid 3-5%, be heated to boil, suction filtration, collect filtrate, under vacuum, 50-60 DEG C of decline filtrate is concentrated into dry, dry, obtains to sky fruit chromocor compound.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685863A (en) * | 2015-12-31 | 2016-06-22 | 苗娥 | Fructus swietenia macrophylla nutrition powder capable of lowering blood glucose and preparation method thereof |
| CN105943840A (en) * | 2016-05-10 | 2016-09-21 | 上海天慈国际药业有限公司 | Health care product for reducing blood glucose and reducing fat |
| CN106176529A (en) * | 2016-08-16 | 2016-12-07 | 张�杰 | A kind of anti-ageing beautifying facial mask and preparation method thereof |
| CN108553559A (en) * | 2018-06-22 | 2018-09-21 | 南昌糖友安健康科技有限公司 | A kind of vegetables and fruits extraction composition formula and preparation method for preventing type II diabetes |
-
2015
- 2015-03-16 CN CN201510122331.7A patent/CN104844682A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 21CN财经网: "《21CN财经网》", 26 March 2014 * |
| 朱莉莉等: "向天果脂肪酸成分的气相色谱-质谱分析", 《安徽中医药大学学报》 * |
| 漆淑华等: "椿亚科和麻楝亚科植物化学成分和生物活性的研究进展", 《天然产物研究与开发》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105685863A (en) * | 2015-12-31 | 2016-06-22 | 苗娥 | Fructus swietenia macrophylla nutrition powder capable of lowering blood glucose and preparation method thereof |
| CN105943840A (en) * | 2016-05-10 | 2016-09-21 | 上海天慈国际药业有限公司 | Health care product for reducing blood glucose and reducing fat |
| CN106176529A (en) * | 2016-08-16 | 2016-12-07 | 张�杰 | A kind of anti-ageing beautifying facial mask and preparation method thereof |
| CN108553559A (en) * | 2018-06-22 | 2018-09-21 | 南昌糖友安健康科技有限公司 | A kind of vegetables and fruits extraction composition formula and preparation method for preventing type II diabetes |
| CN108553559B (en) * | 2018-06-22 | 2021-03-23 | 南昌糖友安健康科技有限公司 | Formula and preparation method of vegetable and fruit extract for preventing and treating type II diabetes |
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