CN106943464A - A kind of biological nutrition compound composition of adjusting hypertension - Google Patents
A kind of biological nutrition compound composition of adjusting hypertension Download PDFInfo
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- CN106943464A CN106943464A CN201710135911.9A CN201710135911A CN106943464A CN 106943464 A CN106943464 A CN 106943464A CN 201710135911 A CN201710135911 A CN 201710135911A CN 106943464 A CN106943464 A CN 106943464A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Abstract
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black 50 70 parts of fruit Sorbus alnifloria extract；15 25 parts of Herba Saussureae Involueratae culture；5 15 parts of cassia seed extract；Sun-dried 5 15 parts of conopsea extraction.The suitable hypertension auxiliary treatment of the present invention, also is adapted for the prevention of high blood pressure and complication.
Description
Technical field
The present invention relates to food technology field, and in particular to a kind of biological nutrition compound composition of adjusting hypertension.
Background technology
Hypertension is China's illness rate highest chronic disease, and current hyperpietic's number is up to 2.7 hundred million, average every three
Just there is a people to suffer from hypertension in name adult.In recent years, diabetes occur rejuvenation trend, particularly children and youth hypertension,
Secondary hypertension etc. " special population ".
Blood is flowed through to vascular wall generation pressure when blood vessel reaches whole body everywhere from heart, and some human bloods can not be easy to
Ground is by whole body, and lesion makes blood vessel become narrow, and the pressure of blood flow will raise to ensure that blood flow passes through.So, artery
Blood pressure is formed hypertension more than normal value.
Hypertension is also the topmost hazards of cardiovascular and cerebrovascular diseases, its cerebral apoplexy, myocardial infarction, heart failure and chronic
The major complications such as kidney trouble, not only disable, fatal rate it is high, and medical treatment and social resources are seriously consumed, although hypertension people
Group is so huge, but still suffer from do not know high pressure, do not know how to be depressured, do not know how the present situation such as medication pressure control, cause blood pressure control
System is not fully up to expectations.China's hypertension control rate is only 6.1%, in patient receiving treatment, the people's blood pressure for also having 3/4
Do not control within 140/90mmHg.
The traditional therapy of hypertension is first set about from diuretics (such as hydrodiuril) row's sodium and attenuating blood volume, is lowered
Myocardial contractive power, reducing heart rate, attenuating cardiac output；If it is invalid, plus beta-blocker, such as reserpine or ethyldopa；
Such as still invalid, then simultaneously using 3 kinds of medicines, such as diuretics adds beta-blocker plus vasodilator (such as trap benzene pyridazine)；If
It is invalid again, while using 4 kinds of medicines, diuretics adds beta-blocker, plus vasodilator, then adds other depressor to be pressed as long
It is fixed.
Because Most patients go back complication with diabetes chronic diseases in addition to hypertension, it is therefore desirable to eat a variety of medicines, leakiness
Clothes, it is difficult to strict medication, this is very unfavorable to being depressured.
Meanwhile, many patients pursue reduction of blood pressure in high-speed effect simply, and ignore the steady of blood pressure, easily cause the heart, brain, kidney
Blood supply insufficiency and produce serious consequence.
The content of the invention
For defect of the prior art, the present invention provides a kind of biological nutrition compound composition of adjusting hypertension.
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：
Black 50-70 parts of fruit Sorbus alnifloria extract；
15-25 parts of Herba Saussureae Involueratae culture；
5-15 parts of cassia seed extract；
Sun-dried conopsea extraction 5-15 parts.
In the present invention, as a kind of perferred technical scheme, a kind of biological nutrition compound composition of adjusting hypertension, by
The raw material of following parts by weight is prepared from：
Black 60 parts of fruit Sorbus alnifloria extract；
20 parts of Herba Saussureae Involueratae culture；
10 parts of cassia seed extract；
Sun-dried 10 parts of conopsea extraction.
In the present invention, as a kind of perferred technical scheme, the biological nutrition compound composition uses following methods system
It is standby：
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Such as during compressing tablet, those skilled in the art can also can as needed add necessary auxiliary material with direct tablet compressing, micro-
Crystalline cellulose etc..
In the present invention, as a kind of perferred technical scheme, the black fruit Sorbus alnifloria extract is prepared using following methods：Take
The fruit of black fruit Sorbus alnifloria is crushed, and is 1 according to solid-liquid ratio：5-10 adds distilled water, is warming up to 50-65 DEG C, is kept for 3-5 minutes, so
It is 1 to add solid-liquid ratio afterwards：3-5 ethanol solution, adjustment pH is 3.5-4.5, and in the case where temperature is 32-35 DEG C, heating water bath extracts 2-
3 hours, extract solution is then centrifuged into 30-45min under 2000-2800 revs/min of speed, and be warming up to 45-48 DEG C of decompression
Concentration, is then spray-dried, obtains black fruit Sorbus alnifloria extract.
In the present invention, as a kind of perferred technical scheme, the volume ratio of ethanol and water is 1 in ethanol solution：1.
In the present invention, as a kind of perferred technical scheme, the preparation method of Herba Saussureae Involueratae culture is as follows：
Using the method for culture plant cell, the callus work that Herba Saussureae Involueratae in vitro tissue is formed by dedifferentiation is chosen
For subculture seed, give certain condition and carry out squamous subculture, obtain plant tissue body；
Then obtained plant tissue body is dried 8-10 hours using oven in 70-80 DEG C of cryogenic dewatering, obtained
In solid-liquid ratio it is 1 using 70-80wt% ethanol by crushing material to 80 mesh to below water content 8wt% material：100 bar
Low temperature is extracted under part, by extract solution in 65-70 DEG C of ultrafiltration membrance filter, removes residue, filtrate cryogenic vacuum is concentrated, and in 65-
70 DEG C of spray drying, obtain Herba Saussureae Involueratae culture.
In the present invention, as a kind of perferred technical scheme, low temperature, which is extracted, to be referred to extract at 25-35 DEG C.
In the present invention, as a kind of perferred technical scheme, the preparation method of cassia seed extract is as follows：
Cassia seed is ground to form to the powder of 100-150 mesh, the 60wt% of 1-7 times of weight ethanol solution is added, 45- is soaked
After 60 minutes, 65-85 DEG C of backflow is heated to, ethanol is recovered under reduced pressure at 60-65 DEG C in vacuum rotary evaporator in filtrate by filtering
And concentrate, and be spray-dried at 60~80 DEG C of temperature, obtain cassia seed extract.
In the present invention, as a kind of perferred technical scheme, concentrate as the 1/7 of original volume.
In the present invention, as a kind of perferred technical scheme, the preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 90-100 mesh：15th, temperature be 25-35 DEG C at carry
Take, by extract solution in 70 DEG C of ultrafiltration membrance filters, remove residue, filtrate cryogenic vacuum is concentrated, and in 65 DEG C of spray drying, obtain
Sun-dried conopsea extraction.
In the present invention, black fruit Sorbus alnifloria (i.e. Black Box Tracing) belongs to perennial machaka, is a kind of emerging small berries.Really
It is real to be rich in flavonoids and liposoluble ingredient, with stronger antioxidation activity and remove the ability of free radical, anticancer, anti-inflammatory,
There is good pharmacological action in terms of hypotensive, hypoglycemic, anti-mutation, prevention and cure of cardiovascular disease.Eaten according to China Agricultural University
Product science is tested with key lab of functional food Beijing of nutrition engineering college to be shown：Content of mineral substances in fresh fruit reaches
580mg/100g, wherein potassium content are particularly pertinent, and sodium is micro.B group micro-elements are complete abundant, carotenoid (beta carotene, jade
Cream-coloured matter etc.) content is higher.Polyphenols is main functional activity material in black fruit Sorbus alnifloria, and Determination of Polyphenols is 3440-
7849mg/100g (dry weight).In the fruit of black fruit Sorbus alnifloria, containing abundant anthocyanidin, flavones, (fresh fruit content is up to 0.25%-
0.35%), polyphenol, also containing the material such as multivitamin and mineral element.Polyphenol is to improve the structure of capillary and blood vessel
With the very important material of function, additionally aid stimulation and improve the circulatory system.Anthocyanidin and flavones are able to maintain that the heart of people
The health of dirty and body.
Herba Saussureae Involueratae culture is the method for appliable plant cell culture, chooses Herba Saussureae Involueratae in vitro tissue and passes through dedifferentiation
The callus of formation gives certain condition and carries out squamous subculture, therefrom extract the active ingredient of high concentration as subculture seed
Biological flavone isoreactivity material.Containing abundant biological flavone in Herba Saussureae Involueratae culture, biological flavone main function is exactly molten
Blood cake thrombus is solved, quick effectively cracking separation patch quickly removes thrombus, patch, cleans the toxin and lipid rubbish of blood kind,
By recovering the pliability of capillary, the capillary of hardening is set to recover elasticity.Saussurea involucrata culture not only contains and natural snow
The close active component of lotus, and also there is many pharmacological activity suitable therewith.Its main pharmacological analgesia, anti-inflammatory,
Antirheumatic；Suppress platelet aggregation, hypoglycemic, reducing blood lipid, improve blood circulation；There is adjustment effect to immune system.
Cassia seed is the seed of " Cassia ", is conventional Chinese medicine, bitter, sweet, salty, cold nature, enter liver, kidney, large intestine channel；Cure mainly
The diseases such as hypertension, headache, dizziness, acute conjunctivitis, ulcer of the cornea, glaucoma.There is blood fat-reducing blood pressure-decreasing, clearly in cassia seed extract
Liver improving eyesight, sharp water defecating feces excretion.Active ingredient is that blunt leaf Cassia seed contains anthraquinone analog compound, and main is rheum emodin, rheum emodin first
Ether, Chrysophanol and Rhein, Cassia glucoside and protein, sitosterol, amino acid and fat oil etc..These compositions can suit the medicine to the illness hypertension
Patient often has the symptoms such as dizzy, tinnitus, distending pain in the head, irritable, flushed face, insomnia and dreamful sleep, bitter taste dry, from the traditional Chinese medical science
For angle, equivalent to syndrome of upper hyperactivity of liver yang.
Sun-dried ginseng (be it is fresh ginseng clean up after, with drying plant, the ginseng of drying) it is warm-natured and dry have reinforce vital energy,
Reinforce the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind effect is intended to take off, weakness of the spleen and the stomach, lassitude hypodynamia, poor appetite, prolapse of the anus, nerve suitable for saving the deficiency of vital energy
It is weak to wait disease, it is also commonly used for treatment and quenches one's thirst or syndrome of consumption of fluid due to intense heat.Modern medicine study is proved, is not only contained in sun-dried conopsea extraction
Panaxoside, but also containing the nutriment such as fat, carbohydrate, several amino acids and multivitamin, with strengthening by means of tonics,
Muscle power and mental labour ability are improved, reduction fatigue improves the content of ferroheme in blood, adjusts the work of central nervous system
With for treatment angiocardiopathy, stomach and liver diseases, diabetes and neurasthenia have preferable curative effect.
The biological nutrition compound composition that the present invention is provided is the basic principle composition constituted according to traditional Chinese medical prescription compatibility
's.The medicine of composition prescription can be divided into monarch drug in a prescription, ministerial drug by its effect played in prescription, adjutant, make medicine, referred to as monarch, minister,
Help, make.Monarch drug in a prescription is black fruit Sorbus alnifloria extract, and pin high blood pressure plays anti-oxidant toxin expelling；Ministerial drug is Herba Saussureae Involueratae culture, auxiliary
Principal drug assistance treats main symptom, main softening and dredging blood vessel function；Adjutant is cassia seed extract, coordinates monarch-minister drug treatment accompanying symptoms, makees
With regulation liver and the function of kidney；It is sun-dried conopsea extraction to make medicine, guides the through diseased region of all medicines, reinforces vital energy, promote body
The synthesis of metabolism and protein and RNA, DNA.Four kinds of compositions of the above, which are mutually cooperateed with, to play a role, and plays adjustment hypertension
Effect.Moreover, inventor is by a large amount of experiments repeatedly, specific extraction, fermentation process are drawn, can be by the effective of each component
Composition is fully extracted and played a role, it is ensured that the effect of this several component synergy.The composition that the present invention is provided, it is pregnant
Woman, infant, children and fungi polysaccharide allergy sufferers, deficiency-cold in spleen and stomach and hypotensive's inedibility.
Due to using above technical scheme, the invention has the advantages that：
1st, ecological safety, is formulated the raw materials used new resource food for ratifying production all from health ministry, does not have
Any potential health hazard；
2nd, formulation product sense organ and mouthfeel come from the true qualities of plant, and no chemistry addition allows people to be willing to accept；
3rd, the active constituent content of product is high, and effect is obvious, can reach the steady effect persistently taken effect；
4th, the present invention is both adapted to hypertension auxiliary treatment, and the prevention of high blood pressure and complication is adapted to again；
5th, during the formulation product is eaten, without any side effect.
Embodiment
Technical solution of the present invention is described in detail below in conjunction with specific embodiment.Following examples are only used for more
Plus technical scheme is clearly demonstrated, therefore example is only used as, and can not be limited the scope of the invention with this.
Embodiment 1
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black fruit flower
50 parts of Chinese catalpa extract；15 parts of Herba Saussureae Involueratae culture；5 parts of cassia seed extract；Sun-dried 5 parts of conopsea extraction.
The biological nutrition compound composition is prepared using following methods：
The black fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be according to solid-liquid ratio
1：5 add distilled water, are warming up to 50 DEG C, are kept for 3 minutes, it is 1 then to add solid-liquid ratio：Second in 3 ethanol solution, ethanol solution
The volume ratio of alcohol and water is 1：1, adjustment pH is 3.5, and in the case where temperature is 32 DEG C, heating water bath is extracted 2 hours, then by extract solution
30min is centrifuged under 2000 revs/min of speed, and is warming up to 45 DEG C and is concentrated under reduced pressure, is then spray-dried, obtains black fruit Sorbus alnifloria
Extract；
The preparation method of Herba Saussureae Involueratae culture is as follows：Using the method for culture plant cell, Herba Saussureae Involueratae is chosen in vitro
Organize to be used as subculture seed by the callus that dedifferentiation is formed, give certain condition and carry out squamous subculture, obtain plant group
Knit body；Then obtained plant tissue body is dried 8 hours using oven in 70 DEG C of cryogenic dewaterings, obtains water content
Below 8wt% material, in solid-liquid ratio is 1 using 70wt% ethanol by crushing material to 80 mesh：Under conditions of 100 at 25 DEG C
Low temperature is extracted, by extract solution in 25 DEG C of ultrafiltration membrance filters, removes residue, filtrate cryogenic vacuum is concentrated, and dry in 65 DEG C of sprayings
It is dry, obtain Herba Saussureae Involueratae culture；
The preparation method of cassia seed extract is as follows：Cassia seed is ground to form to the powder of 100 mesh, 1 times of weight is added
60wt% ethanol solution, immersion 45 minutes after, be heated to 65 DEG C backflow, filtering, by filtrate in vacuum rotary evaporator
It is the 1/7 of original volume that 60 DEG C, which are recovered under reduced pressure ethanol and concentrate, and is spray-dried under temperature 60 C, obtains cassia seed extraction
Thing；
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 90 mesh：15th, temperature is extraction at 65 DEG C, will be extracted
Liquid removes residue, filtrate cryogenic vacuum is concentrated in 70 DEG C of ultrafiltration membrance filters, and in 65 DEG C of spray drying, obtains sun-dried ginseng and carry
Take thing；
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Embodiment 2
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black fruit flower
70 parts of Chinese catalpa extract；25 parts of Herba Saussureae Involueratae culture；15 parts of cassia seed extract；Sun-dried 15 parts of conopsea extraction.
The biological nutrition compound composition is prepared using following methods：
The black fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be according to solid-liquid ratio
1：10 add distilled water, are warming up to 65 DEG C, are kept for 5 minutes, it is 1 then to add solid-liquid ratio：In 5 ethanol solution, ethanol solution
The volume ratio of ethanol and water is 1：1, adjustment pH is 4.5, and in the case where temperature is 35 DEG C, heating water bath is extracted 3 hours, then will be extracted
Liquid centrifuges 45min under 2800 revs/min of speed, and is warming up to 48 DEG C and is concentrated under reduced pressure, and is then spray-dried, and obtains black fruit flower
Chinese catalpa extract；
The preparation method of Herba Saussureae Involueratae culture is as follows：Using the method for culture plant cell, Herba Saussureae Involueratae is chosen in vitro
Organize to be used as subculture seed by the callus that dedifferentiation is formed, give certain condition and carry out squamous subculture, obtain plant group
Knit body；Then obtained plant tissue body is dried 10 hours using oven in 80 DEG C of cryogenic dewaterings, obtains water content
Below 8wt% material, in solid-liquid ratio is 1 using 80wt% ethanol by crushing material to 80 mesh：Under conditions of 100 at 35 DEG C
Low temperature is extracted, by extract solution in 70 DEG C of ultrafiltration membrance filters, removes residue, filtrate cryogenic vacuum is concentrated, and dry in 70 DEG C of sprayings
It is dry, obtain Herba Saussureae Involueratae culture；
The preparation method of cassia seed extract is as follows：Cassia seed is ground to form to the powder of 150 mesh, 7 times of weight are added
60wt% ethanol solution, immersion 60 minutes after, be heated to 85 DEG C backflow, filtering, by filtrate in vacuum rotary evaporator
65 DEG C are recovered under reduced pressure ethanol and concentrate as the 1/7 of original volume, and are spray-dried at 80 DEG C of temperature, obtain cassia seed extraction
Thing；
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 100 mesh：15th, temperature is extraction at 35 DEG C, will be carried
Take liquid in 70 DEG C of ultrafiltration membrance filters, remove residue, filtrate cryogenic vacuum is concentrated, and in 65 DEG C of spray drying, obtain sun-dried ginseng
Extract；
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Embodiment 3
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black fruit flower
60 parts of Chinese catalpa extract；20 parts of Herba Saussureae Involueratae culture；10 parts of cassia seed extract；Sun-dried 10 parts of conopsea extraction.
The biological nutrition compound composition is prepared using following methods：
The black fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be according to solid-liquid ratio
1：8 add distilled water, are warming up to 60 DEG C, are kept for 4 minutes, it is 1 then to add solid-liquid ratio：Second in 4 ethanol solution, ethanol solution
The volume ratio of alcohol and water is 1：1, adjustment pH is 4, and in the case where temperature is 33 DEG C, heating water bath is extracted 3 hours, and then extract solution exists
40min is centrifuged under 2500 revs/min of speed, and is warming up to 46 DEG C and is concentrated under reduced pressure, is then spray-dried, black fruit Sorbus alnifloria is obtained and carries
Take thing；
The preparation method of Herba Saussureae Involueratae culture is as follows：Using the method for culture plant cell, Herba Saussureae Involueratae is chosen in vitro
Organize to be used as subculture seed by the callus that dedifferentiation is formed, give certain condition and carry out squamous subculture, obtain plant group
Knit body；Then obtained plant tissue body is dried 9 hours using oven in 75 DEG C of cryogenic dewaterings, obtains water content
Below 8wt% material, in solid-liquid ratio is 1 using 75wt% ethanol by crushing material to 80 mesh：Under conditions of 100 at 30 DEG C
Low temperature is extracted, by extract solution in 70 DEG C of ultrafiltration membrance filters, removes residue, filtrate cryogenic vacuum is concentrated, and dry in 70 DEG C of sprayings
It is dry, obtain Herba Saussureae Involueratae culture；
The preparation method of cassia seed extract is as follows：Cassia seed is ground to form to the powder of 130 mesh, 1-7 times of weight is added
60wt% ethanol solution, immersion 50 minutes after, be heated to 70 DEG C backflow, filtering, by filtrate in vacuum rotary evaporator
It is the 1/7 of original volume that 65 DEG C, which are recovered under reduced pressure ethanol and concentrate, and is spray-dried under temperature 60 C, obtains cassia seed extraction
Thing；
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 90 mesh：15th, temperature is extraction at 30 DEG C, will be extracted
Liquid removes residue, filtrate cryogenic vacuum is concentrated in 70 DEG C of ultrafiltration membrance filters, and in 65 DEG C of spray drying, obtains sun-dried ginseng and carry
Take thing；
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Embodiment 4
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black fruit flower
50 parts of Chinese catalpa extract；25 parts of Herba Saussureae Involueratae culture；5 parts of cassia seed extract；Sun-dried 15 parts of conopsea extraction.
The biological nutrition compound composition is prepared using following methods：
The black fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be according to solid-liquid ratio
1：5 add distilled water, are warming up to 65 DEG C, are kept for 3 minutes, it is 1 then to add solid-liquid ratio：Second in 5 ethanol solution, ethanol solution
The volume ratio of alcohol and water is 1：1, adjustment pH is 3.5, and in the case where temperature is 35 DEG C, heating water bath is extracted 2 hours, then by extract solution
30min is centrifuged under 2800 revs/min of speed, and is warming up to 48 DEG C and is concentrated under reduced pressure, is then spray-dried, obtains black fruit Sorbus alnifloria
Extract；
The preparation method of Herba Saussureae Involueratae culture is as follows：Using the method for culture plant cell, Herba Saussureae Involueratae is chosen in vitro
Organize to be used as subculture seed by the callus that dedifferentiation is formed, give certain condition and carry out squamous subculture, obtain plant group
Knit body；Then obtained plant tissue body is dried 10 hours using oven in 70 DEG C of cryogenic dewaterings, obtains water content
Below 8wt% material, in solid-liquid ratio is 1 using 70wt% ethanol by crushing material to 80 mesh：Under conditions of 100 at 35 DEG C
Low temperature is extracted, by extract solution in 65 DEG C of ultrafiltration membrance filters, removes residue, filtrate cryogenic vacuum is concentrated, and dry in 70 DEG C of sprayings
It is dry, obtain Herba Saussureae Involueratae culture；
The preparation method of cassia seed extract is as follows：Cassia seed is ground to form to the powder of 100 mesh, 7 times of weight are added
60wt% ethanol solution, immersion 45 minutes after, be heated to 85 DEG C backflow, filtering, by filtrate in vacuum rotary evaporator
60 DEG C are recovered under reduced pressure ethanol and concentrate as the 1/7 of original volume, and are spray-dried at 80 DEG C of temperature, obtain cassia seed extraction
Thing；
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 90 mesh：15th, temperature is extraction at 35 DEG C, will be extracted
Liquid removes residue, filtrate cryogenic vacuum is concentrated in 70 DEG C of ultrafiltration membrance filters, and in 65 DEG C of spray drying, obtains sun-dried ginseng and carry
Take thing；
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Embodiment 5
A kind of biological nutrition compound composition of adjusting hypertension, is prepared from by the raw material of following parts by weight：Black fruit flower
65 parts of Chinese catalpa extract；17 parts of Herba Saussureae Involueratae culture；6 parts of cassia seed extract；Sun-dried 12 parts of conopsea extraction.
The biological nutrition compound composition is prepared using following methods：
The black fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be according to solid-liquid ratio
1：9 add distilled water, are warming up to 55 DEG C, are kept for 5 minutes, it is 1 then to add solid-liquid ratio：In 3.5 ethanol solution, ethanol solution
The volume ratio of ethanol and water is 1：1, adjustment pH is 4.2, and in the case where temperature is 35 DEG C, heating water bath is extracted 2.3 hours, then will be carried
Take liquid to centrifuge 43min under 2200 revs/min of speed, and be warming up to 46 DEG C and be concentrated under reduced pressure, be then spray-dried, obtain black fruit
Sorbus alnifloria extract；
The preparation method of Herba Saussureae Involueratae culture is as follows：Using the method for culture plant cell, Herba Saussureae Involueratae is chosen in vitro
Organize to be used as subculture seed by the callus that dedifferentiation is formed, give certain condition and carry out squamous subculture, obtain plant group
Knit body；Then obtained plant tissue body is dried 9 hours using oven in 78 DEG C of cryogenic dewaterings, obtains water content
Below 8wt% material, in solid-liquid ratio is 1 using 72wt% ethanol by crushing material to 80 mesh：Under conditions of 100 at 33 DEG C
Low temperature is extracted, by extract solution in 67 DEG C of ultrafiltration membrance filters, removes residue, filtrate cryogenic vacuum is concentrated, and dry in 70 DEG C of sprayings
It is dry, obtain Herba Saussureae Involueratae culture；
The preparation method of cassia seed extract is as follows：Cassia seed is ground to form to the powder of 140 mesh, 2 times of weight are added
60wt% ethanol solution, immersion 55 minutes after, be heated to 67 DEG C backflow, filtering, by filtrate in vacuum rotary evaporator
60 DEG C are recovered under reduced pressure ethanol and concentrate as the 1/7 of original volume, and are spray-dried at 78 DEG C of temperature, obtain cassia seed extraction
Thing；
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 95 mesh：15th, temperature is extraction at 30 DEG C, will be extracted
Liquid removes residue, filtrate cryogenic vacuum is concentrated in 70 DEG C of ultrafiltration membrance filters, and in 65 DEG C of spray drying, obtains sun-dried ginseng and carry
Take thing；
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, bag
Dress.
Measure of merit embodiment
30 mild hypertensions are randomly divided into tri- groups of A, B, C, wherein, A groups take the biological battalion that the present invention is provided
Compound composition is supported, daily 6 (0.5g/) each three of morning and afternoon, chew or swallowed；It is that the most frequently used candy is husky that B groups, which are taken,
It is smooth；C groups do not take any medicament.
As a result it is as follows：
Note：+ refer to that blood pressure is raised ,-refer to blood pressure reduction.
As can be seen from the above results：
The biological nutrition compound composition that the present invention is provided has relatively more significant effect for adjusting hypertension, although clothes
It is not so good as Candesartan with the antihypertensive effect of period, but after being discontinued, blood pressure rise is relatively slow, also illustrates have more for blood pressure
Long-acting adjustment effect.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among the claim of the present invention and the scope of specification.
Claims (10)
1. the biological nutrition compound composition of a kind of adjusting hypertension, it is characterised in that by the raw material preparation of following parts by weight
Into：
Black 50-70 parts of fruit Sorbus alnifloria extract；
15-25 parts of Herba Saussureae Involueratae culture；
5-15 parts of cassia seed extract；
Sun-dried conopsea extraction 5-15 parts.
2. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 1, it is characterised in that by following
The raw material of parts by weight is prepared from：
Black 60 parts of fruit Sorbus alnifloria extract；
20 parts of Herba Saussureae Involueratae culture；
10 parts of cassia seed extract；
Sun-dried 10 parts of conopsea extraction.
3. a kind of biological nutrition compound composition of adjusting hypertension according to claim 1, it is characterised in that use with
It is prepared by lower section method：
Weigh black fruit Sorbus alnifloria extract, Herba Saussureae Involueratae culture, cassia seed extract and sun-dried conopsea extraction, compressing tablet, packaging.
4. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 1, it is characterised in that described black
Fruit Sorbus alnifloria extract is prepared using following methods：Take the fruit of black fruit Sorbus alnifloria to crush, be 1 according to solid-liquid ratio：5-10 adds distillation
Water, is warming up to 50-65 DEG C, is kept for 3-5 minutes, it is 1 then to add solid-liquid ratio：3-5 ethanol solution, adjustment pH is 3.5-4.5,
Temperature be 32-35 DEG C at heating water bath extract 2-3 hours, then by extract solution under 2000-2800 revs/min of speed from
Heart 30-45min, and be warming up to 45-48 DEG C and be concentrated under reduced pressure, then it is spray-dried, obtains black fruit Sorbus alnifloria extract.
5. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 4, it is characterised in that ethanol is molten
The volume ratio of ethanol and water is 1 in liquid：1.
6. a kind of biological nutrition compound composition of adjusting hypertension according to claim 1, it is characterised in that the day
The preparation method of mountain Saussurea involucrata culture is as follows：
Using the method for culture plant cell, choose the callus that Herba Saussureae Involueratae in vitro tissue formed by dedifferentiation be used as after
For seed, give certain condition and carry out squamous subculture, obtain plant tissue body；
Then obtained plant tissue body is dried 8-10 hours using oven in 70-80 DEG C of cryogenic dewatering, contained
Below water 8wt% material, in solid-liquid ratio is 1 using 70-80wt% ethanol by crushing material to 80 mesh：Under conditions of 100
Low temperature is extracted, by extract solution in 65-70 DEG C of ultrafiltration membrance filter, removes residue, filtrate cryogenic vacuum is concentrated, and at 65-70 DEG C
Spray drying, obtains Herba Saussureae Involueratae culture.
7. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 6, it is characterised in that low temperature is carried
Take and refer to extract at 25-35 DEG C.
8. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 1, it is characterised in that described to determine
The preparation method of pine torch extract is as follows：
Cassia seed is ground to form to the powder of 100-150 mesh, the 60wt% of 1-7 times of weight ethanol solution, 45-60 points of immersion is added
Zhong Hou, is heated to 65-85 DEG C of backflow, and in vacuum rotary evaporator at 60-65 DEG C ethanol is recovered under reduced pressure and dense in filtrate by filtering
Contracting, and be spray-dried at 60~80 DEG C of temperature, obtain cassia seed extract.
9. a kind of biological nutrition compound composition of adjusting hypertension according to claim 8, it is characterised in that concentrate and be
The 1/7 of original volume.
10. the biological nutrition compound composition of a kind of adjusting hypertension according to claim 1, it is characterised in that described
The preparation method of sun-dried conopsea extraction is as follows：
In solid-liquid ratio it is 1 using 75wt% ethanol by crushing material to 90-100 mesh：15th, temperature is extraction at 25-35 DEG C, will
Extract solution removes residue, filtrate cryogenic vacuum is concentrated in 70 DEG C of ultrafiltration membrance filters, and in 65 DEG C of spray drying, obtains sun-dried
Conopsea extraction.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107691960A (en) * | 2017-10-12 | 2018-02-16 | 吉林化工学院 | A kind of double fruit effervescence granulars and preparation method thereof |
| CN108464500A (en) * | 2018-03-13 | 2018-08-31 | 武春风 | A kind of dietary composition of auxiliary adjustment hypertension |
| CN111587973A (en) * | 2019-02-20 | 2020-08-28 | 吉林省绿色食品工程研究院 | Preparation process of black chokeberry and ginseng composite multifunctional solid beverage |
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| CN103540466A (en) * | 2013-09-11 | 2014-01-29 | 辽宁省干旱地区造林研究所 | Wine with aronia melenocarpa juice and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107691960A (en) * | 2017-10-12 | 2018-02-16 | 吉林化工学院 | A kind of double fruit effervescence granulars and preparation method thereof |
| CN108464500A (en) * | 2018-03-13 | 2018-08-31 | 武春风 | A kind of dietary composition of auxiliary adjustment hypertension |
| CN111587973A (en) * | 2019-02-20 | 2020-08-28 | 吉林省绿色食品工程研究院 | Preparation process of black chokeberry and ginseng composite multifunctional solid beverage |
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Application publication date: 20170714 |