CN101690770A - Preparation capable of reducing blood pressure and blood lipid and improving human immunity, and preparation method thereof - Google Patents
Preparation capable of reducing blood pressure and blood lipid and improving human immunity, and preparation method thereof Download PDFInfo
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- CN101690770A CN101690770A CN200910272404A CN200910272404A CN101690770A CN 101690770 A CN101690770 A CN 101690770A CN 200910272404 A CN200910272404 A CN 200910272404A CN 200910272404 A CN200910272404 A CN 200910272404A CN 101690770 A CN101690770 A CN 101690770A
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Abstract
The invention relates to a preparation capable of regulating blood pressure, reducing blood lipid, improving palpitation, chest stuffiness, breath shortness, insomnia and dreaminess and improving human immunity, and a preparation method thereof. The preparation is prepared from kudzuvine roots, lecithin oil, garter snakes, Chinese yams and mulberries. The preparation method comprises: heating and decocting kudzuvine roots, Chinese yams and mulberries twice; combining and standing the obtained product; filtering and removing residue; cooling and concentrating the obtained product to be thin paste; cooling the thin paste under vacuum and reduced pressure; obtaining dried extract A; drying and crushing garter snakes; adding ethanol; heating and hermetically decocting the obtained product twice; combining the obtained materials; recovering ethanol under reduced pressure; cooling the obtained product under vacuum and reduced pressure to obtain extract B; mixing the dried extract A, the extract B with lecithin oil; and obtaining the preparation. The clinical observation and trial of Liyuan Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology for the preparation show that the preparation obviously improves chest stuffiness, breath shortness, palpitation, asthma, somnolence, acratia, arrhythmia, hypertension, angina, myocardial infarction, lassitude, insomnia, dreaminess, low immunity and the like, and has the efficacy in regulating blood pressure, reducing blood lipid, improving human immunity, and the like.
Description
Technical field
The present invention relates to a kind ofly to transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve preparation of human immunologic function and preparation method thereof.
Background technology
Existing accent blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, the preparation that improves the human immunologic function has a lot, as " a kind of treatment cardiovascular and cerebrovascular vessel and hypertensive medicine " (Chinese patent application number 01113911.0), be to be the medicament that feedstock production forms by Pupa bombycis, Radix Puerariae, Borneolum Syntheticum." a kind of Chinese medicine composition that improves body immunity " (Chinese patent application number 200710014468.6), by Herba Saussureae Involueratae, Radix Codonopsis, Herba Ocimi (Herba Ocimi Pilosi), Radix Cynanchi Auriculati, Pheretima, Folium Ginkgo, Rhizoma Dioscoreae, Zaocys, Fructus Jujubae is formed." a kind of Chinese medicine for the treatment of palpitation and uneasiness, sensation of oppression over the chest with shortness of breath " (Chinese patent application number 200710133059), by Semen Ziziphi Spinosae (parched), Semen Platycladi, mountain cornel etc. is prepared from.
Summary of the invention
The objective of the invention is at above-mentioned present situation, aim to provide and a kind ofly can transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve preparation of human immunologic function and preparation method thereof.
The implementation of the object of the invention is, a kind ofly can transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve human immunologic function's preparation, be grouped into by the one-tenth of following weight: Radix Puerariae 10.5g-19.5g, lecithin oil 10.5g-19.5g, Zaocys 0.56g-1.04g, Rhizoma Dioscoreae 8.4g-15.6g, Fructus Mori 10.5g-19.5g.
A kind ofly can transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve the preparation method of human immunologic function's preparation, concrete steps are as follows:
1) will concoct qualified 10.5g-19.5g Radix Puerariae, 8.4g-15.6g Rhizoma Dioscoreae, 6.5g-11.5g Fructus Mori and put into the Chinese medicine extraction jar, and add its weight 6-8 water doubly, heating decocted 2 hours, filtered, and filtering residue adds 4-6 water doubly again, and heating decocted 2 hours, filter,
2) merge twice decoction liquor, left standstill 24 hours, filter and remove residue,
3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,
4) clear paste vacuum decompression drying gets dry extract A,
5) get the 0.56g-1.04g Zaocys, pulverize the oven dry back, adds the ethanol of 6 times of its weight, and heated sealant decocted 2 hours, filters, and filtering residue adds 5 times of amount ethanol, and sealing decocted 2 hours, filtered, and concentration of alcohol is 70%,
6) merge twice decoction liquor, decompression recycling ethanol, the dry extract B that gets of vacuum decompression,
7) dry extract A, extract B and 10.5g-19.5g lecithin oil mix homogeneously are promptly got preparation.
Liyuan Hospital Attached to Tongji Medical College, Huazhong Science and Technol shows the clinical observation test of this system, this preparation obviously improves item symptoms such as sensation of oppression over the chest with shortness of breath, nervous asthma, drowsiness weak, arrhythmia, hypertension, angina pectoris, heart infarction, lassitude, insomnia and dreamful sleep, hypoimmunities, illustrate this preparation have transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve human immunologic function's effect.The result shows that this preparation is evident in efficacy, proves effective and feasible.
The specific embodiment
Preparation of the present invention is made up of Radix Puerariae, lecithin oil, Zaocys, Rhizoma Dioscoreae, Fructus Mori.
This pharmaceutical formulation is scientific and reasonable, and wherein Radix Puerariae energy decreased heart rate reduces the heart total peripheral resistance, reduces myocardial oxygen consumption; Improving myocardium work efficiency. puerarin can also obviously reduce the generation of the myocardium lactic acid that ischemia causes, improves the metabolism of infarcted myocardium.
Lecithin can make cerebral nerve in time obtain nutritional supplementation, and the duty of keeping fit is beneficial to allaying tiredness, intensifies brain cell, improves because of diseases such as the nervous irritability that causes, irritability, insomnias.The effect that lecithin also has emulsifying, cuts grease, can promote blood circulation, improve serum lipids, remove peroxide, make cholesterol and the reduction of neutral fat content in the blood, reduce fat in the holdup time of blood vessel, promote the dissipation of atherosis speckle, prevent the tunica intima damage that causes by cholesterol.
Zaocys can obviously play the antifatigue effect.Rhizoma Dioscoreae has reinforcing spleen and kidney, supports the effect of lung, antidiarrheal, arresting sweating, is " the food medicine " of well nourishing.Fructus Mori have the YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, effect such as intestine moistening is dry, cure mainly deficiency of YIN-blood and cause have a dizzy spell tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the xerostomia of quenching one's thirst, diseases such as constipation with dry stool.
Preparation method is that Radix Puerariae, Rhizoma Dioscoreae, Fructus Mori heating decoct twice, merging is left standstill, filter and remove residue, and cooling concentration becomes clear paste, clear paste vacuum decompression drying, get dry extract A, the Zaocys oven dry is pulverized, and adds ethanol, heated sealant decocts twice merging, decompression recycling ethanol, vacuum decompression dry extract B, dry extract A, extract B and lecithin mix preparation.
Liyuan Hospital Attached to Tongji Medical College, Huazhong Science and Technol has done the clinical observation test to this preparation, and test situation is as follows:
40 example ages are in the old people between 40-70 year, oral preparation, every day 2 times, each 1, one-period in January.
Formulate efficacy assessment standard with reference to " new Chinese medicine clinical research guideline " that health ministry was issued in 2002, its symptom efficacy result sees the following form:
As can be seen from the table, this preparation obviously improves item symptoms such as sensation of oppression over the chest with shortness of breath, nervous asthma, drowsiness weak, arrhythmia, hypertension, angina pectoris, heart infarction, lassitude, insomnia and dreamful sleep, hypoimmunities, illustrate this preparation have transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve human immunologic function's effect.Experimental result shows that this preparation is evident in efficacy, proves effective and feasible.
Enumerate specific embodiments of the invention below:
Example 1, qualified 10.5g Radix Puerariae will be concocted, 8.4g Rhizoma Dioscoreae, boiled 2 hours 10.5g Fructus Mori add the 177g decocting, filter, filtering residue adds the 118g decocting again and boiled 2 hours, merge decoction liquor twice, left standstill filter and remove residue 24 hours, filtrate is cooled to 4 ℃, being concentrated into relative density is 1.25, and the medicine juice amount is 1/3 a clear paste of former amount of filtrate, clear paste vacuum decompression drying, get dry extract A, get the 0.56g Zaocys, pulverize the oven dry back, adds 3.36g ethanol, heated sealant decocted 2 hours, filter, filtering residue adds 2.80g ethanol, and sealing decocted 2 hours, filter, concentration of alcohol is 70%, merges decoction liquor twice, decompression recycling ethanol, the dry extract B that gets of vacuum decompression, then with dry extract A, extract B and 10.5g lecithin oil mix homogeneously close top, make soft capsule 500mg/ grain.
Example 2, with example 1, different is, gets to concoct qualified 16.5g Radix Puerariae, 12.4g Rhizoma Dioscoreae, 8.5g Fructus Mori and add 261.8g water, heating decocted 2 hours, filtered, and filtering residue adds 187g water again, being concentrated into relative density is 1.20, and the medicine juice amount is 1/4 a clear paste of former amount of filtrate, makes extract A; 0.56g Zaocys adds 3.36g ethanol, filters, filtering residue adds 2.80g ethanol.
Example 3, with example 1, different is, gets to concoct qualified 11.5g Radix Puerariae, 9.4g Rhizoma Dioscoreae, 11.5g Fructus Mori and add 259.2g water, heating decocted 2 hours, filtered, and filtering residue adds 794.4g water again, being concentrated into relative density is 1.25, and the medicine juice amount is 1/3 a clear paste of former amount of filtrate, makes extract A; 0.66g Zaocys adds 3.96g ethanol, filters, filtering residue adds 3.30g ethanol and 14.5g lecithin oil mix homogeneously.
Example 4, with example 1, different is, gets to concoct qualified 12.5g Radix Puerariae, 10.4g Rhizoma Dioscoreae, 12.5g Fructus Mori and add 247.8g water, heating decocted 2 hours, filtered, and filtering residue adds 177g water again, being concentrated into relative density is 1.30, and the medicine juice amount is 1/4 a clear paste of former amount of filtrate, makes extract A; 0.76g Zaocys adds 4.56g ethanol, filters, filtering residue adds 3.80g ethanol and 12.5g lecithin oil mix homogeneously.
Example 5, with example 1, different is, gets to concoct qualified 15.5g Radix Puerariae, 13.4g Rhizoma Dioscoreae, 8.5g Fructus Mori and add 261.8g water, heating decocted 2 hours, filtered, and filtering residue adds 187g water again, being concentrated into relative density is 1.25, and the medicine juice amount is 1/4 a clear paste of former amount of filtrate, makes extract A; 0.96g Zaocys adds 5.76g ethanol, filters, filtering residue adds 4.80g ethanol and 16.5g lecithin oil mix homogeneously.
Example 6, with example 1, different is, gets and concocts qualified 19.5g Radix Puerariae, 15.4g Rhizoma Dioscoreae, 19.5g Fructus Mori, adds 436.8g water, heating decocted 2 hours, filtered, and filtering residue adds 327.6 water again, being concentrated into relative density is 1.30, and the medicine juice amount is 1/3 a clear paste of former amount of filtrate, makes extract A; 1.04g Zaocys adds 6.24g ethanol, filters, filtering residue adds 5.20g ethanol and 19.5g lecithin oil mix homogeneously.
Claims (2)
- One kind can transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve human immunologic function's preparation, it is characterized in that forming: Radix Puerariae 10.5g-19.5g, lecithin oil 10.5g-19.5g, Zaocys 0.56g-1.04g, Rhizoma Dioscoreae 8.4g-15.6g, Fructus Mori 10.5g-19.5g by following components by weight proportion.
- Claim 1 describedly a kind ofly can transfer that blood pressure, blood fat reducing, improvement are nervous, sensation of oppression over the chest with shortness of breath, insomnia and dreamful sleep, improve human immunologic function's preparation method, it is characterized in that concrete steps are as follows: 1) will concoct qualified 10.5g-19.5g Radix Puerariae, 8.4g-15.6g Rhizoma Dioscoreae, 6.5g-11.5g Fructus Mori and put into the Chinese medicine extraction jar, add its weight 6-8 water doubly, heating decocted 2 hours, filtered, filtering residue adds 4-6 water doubly again, heating decocted 2 hours, filtered2) merge twice decoction liquor, left standstill 24 hours, filter and remove residue,3) filtrate is cooled to 4 ℃, and being concentrated into relative density is 1.25 ± 0.05, and the medicine juice amount is the clear paste of the 1/3-1/4 of former amount of filtrate,4) clear paste vacuum decompression drying gets dry extract A,5) get the 0.56g-1.04g Zaocys, pulverize the oven dry back, adds the ethanol of 6 times of its weight, and heated sealant decocted 2 hours, filters, and filtering residue adds 5 times of amount ethanol, and sealing decocted 2 hours, filtered, and concentration of alcohol is 70%,6) merge twice decoction liquor, decompression recycling ethanol, the dry extract B that gets of vacuum decompression,7) dry extract A, extract B and 10.5g-19.5g lecithin oil mix homogeneously are promptly got preparation.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734718A (en) * | 2013-12-24 | 2014-04-23 | 广西博士海意信息科技有限公司 | Anti-fatigue composition |
| CN104531331A (en) * | 2015-02-03 | 2015-04-22 | 张家界仙踪林农业科技开发有限公司 | Method for extracting Zaocys dhumnades oil by enzymolysis |
| CN106754155A (en) * | 2017-02-17 | 2017-05-31 | 重庆葛根文化传播有限公司 | Pueraria root health care liquor and preparation method thereof |
| CN111919968A (en) * | 2020-07-02 | 2020-11-13 | 佛山科学技术学院 | Weever feed and preparation method thereof |
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| CN1051674A (en) * | 1990-05-10 | 1991-05-29 | 左建平 | The prescription of spur-subsiding pill and manufacture method |
| CN1140587A (en) * | 1995-07-19 | 1997-01-22 | 覃志忠 | Ant and snake compound capsule |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734718A (en) * | 2013-12-24 | 2014-04-23 | 广西博士海意信息科技有限公司 | Anti-fatigue composition |
| CN104531331A (en) * | 2015-02-03 | 2015-04-22 | 张家界仙踪林农业科技开发有限公司 | Method for extracting Zaocys dhumnades oil by enzymolysis |
| CN106754155A (en) * | 2017-02-17 | 2017-05-31 | 重庆葛根文化传播有限公司 | Pueraria root health care liquor and preparation method thereof |
| CN111919968A (en) * | 2020-07-02 | 2020-11-13 | 佛山科学技术学院 | Weever feed and preparation method thereof |
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Application publication date: 20100407 |