CN1051674A

CN1051674A - The prescription of spur-subsiding pill and manufacture method

Info

Publication number: CN1051674A
Application number: CN 90103503
Authority: CN
Inventors: 左建平
Original assignee: Individual
Current assignee: Individual
Priority date: 1990-05-10
Filing date: 1990-05-10
Publication date: 1991-05-29

Abstract

The present invention is the Chinese medicine preparation and the manufacture method of a kind of treatment, prevention of osteoporosis hypertrophy disease.The innerwear Chinese medicine preparation that is used for the treatment of hyperosteogeny at present, the ubiquity short term effect is not good enough, imprecise, the problem of unstable of late result, and cure rate is lower.The present invention's prescription is: Carapax Et Plastrum Testudinis, Zaocys, Cortex Phellodendri, Rhizoma Atractylodis, Radix Cyathulae, the Radix Paeoniae Alba, Semen Persicae, Rhizoma Zingiberis Preparatum, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Olibanum, Radix Rehmanniae Preparata, Semen Strychni (processed), fresh pig spinal cord.Facture of the present invention is: except that Medulla Sus domestica, surplus medicine carries out crushing screening respectively, adds Medulla Sus domestica then in the prescription, through oven drying at low temperature sieving to obtain fine powder again, adds refined honey and water in fine powder, and general ball is after sterilization, dry getting final product.The present invention is used for the treatment of hyperosteogeny.

Description

The prescription of spur-subsiding pill and manufacture method

The present invention relates to be used for the treatment of, the Chinese medicine preparation and the manufacture method of prevention of osteoporosis hypertrophy disease.

Hyperosteogeny (having another name called bony spur) is commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people, this disease be with caused by liver and kidney deficiency, marrow deficiency, the old and feeble regression of osteoporosis, bone, tissue degeneratiaon are the presenium and the geratic period pathological changes of pathologic basis.The Chinese medicine of currently used treatment hyperosteogeny (innerwear Chinese medicine preparation), nearly this curative effect of ubiquity is not good enough, imprecise, the problem of unstable of late result, and cure rate is lower." hyperosteogeny treatment realization: attached 88 routine clinical observations " literary composition that " Hunan Journal of Traditional Chinese Medicine " the 5th periodical in 1988 is stepped on, with Herba Epimedii, Herba Pyrolae, each 30 gram of Caulis Spatholobi, Rhizoma Drynariae, each 15 gram of Fructus Chaenomelis, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Carapax Trionycis, Carapax et Plastrum Testudinis, each 10 gram of Radix Glycyrrhizae, Ramulus Cinnamomi, each 5 gram of Herba Asari are for square substantially; Disease adds Radix Puerariae 10 grams the cervical vertebra person; Add Radix Aconiti Lateralis Preparata 5 grams at lumbar vertebra; Add knee joint 10 grams in the bosom in knee joint.Application result: produce effects (pain disappears, and it is normal that limb function recovers fully) 53 examples account for 60.2%; Effective (pain disappear, it is normal that limb function recovers substantially) 35 examples." osteoarthritis 34 examples are treated in the ruling by law of the kidney invigorating collateral dredging " literary composition that " the Jiangsu traditional Chinese medical science " 2 periodicals in 1989 are stepped on is with medicinal Radix Rehmanniae Preparata, the Cortex Eucommiae, Rhizoma Drynariae, the Radix Paeoniae Alba, Rhizoma Cibotii, Cortex Periplocae, Fructus Chaenomelis, Radix Gentianae Macrophyllae, Radix Achyranthis Bidentatae, each 10 gram of Rhizoma Curcumae Longae, Radix Glycyrrhizae 6 grams.Deficiency of YIN person is with the easy Radix Rehmanniae Preparata of the Radix Rehmanniae, and meal with wine adds the Rhizoma Anemarrhenae, Cortex Phellodendri, Flos Chrysanthemi; Sick position last with the easy Radix Achyranthis Bidentatae of Ramulus Mori; Arthroncus and pain person drink and add Radix Aconiti Preparata, Pheretima, Eupolyphaga Seu Steleophaga for filling a prescription, and through treatment on the 5th～35, produce effects 20 examples accounted for 59%; Effective 12 examples account for 35.3%, and invalid 2 examples account for 5.7%, total effective rate 94.3%." spur and pain relieving liquid " that Beijing Tongrentang tincture distillery is produced, its prescription is: Radix Aconiti, Fructus Chaenomelis, Radix Clematidis, Fructus Mume, Radix Achyranthis Bidentatae, Ramulus Cinnamomi etc.

The objective of the invention is can treat hyperosteogeny efficiently and safely, and have the formation and development of prevention bony spur, delay the old and feeble degeneration of bone and the Chinese medicine preparation of preventing and treating the osteoporosis effect in order to provide a kind of, and the manufacture method of the Chinese medicine preparation of should filling a prescription.

The Chinese medicine preparation of spur-subsiding pill of the present invention and the percentage by weight of each component are: Carapax Et Plastrum Testudinis (it is general to go up Carapax et Plastrum Testudinis) 15-25%; Zaocys (removing the dry all of internal organs) 10-25%; Cortex Phellodendri 3-8%; Rhizoma Atractylodis 5-7%; Radix Cyathulae 5-7%; Radix Paeoniae Alba 5-10%; Semen Persicae (peeling) 4-6%; Rhizoma Zingiberis Preparatum 3-5%; Pericarpium Citri Reticulatae 3-5%; Fructus Chaenomelis 5-7%; Olibanum (system) 3-5%; The bright product ratio of Radix Rehmanniae Preparata dry product 16-25%(25-38%); Semen Strychni (processed) 4.5-9.7%; The bright product ratio of fresh pig spinal cord dry product 3-5%(20-35%), the manufacture method of the Chinese medicine preparation of the present invention's prescription is: with the Carapax Et Plastrum Testudinis of vinegar system, Zaocys and Radix Cyathulae through the wine stir-fry, Cortex Phellodendri through the salt stir-fry, the Rhizoma Atractylodis that the husband fries, the Radix Paeoniae Alba through the wine stir-fry, Semen Strychni (processed) through 250-275 ℃ of stir-baking in sand 1-3 minute, Semen Persicae, Rhizoma Zingiberis Preparatum, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Olibanum (system), Radix Rehmanniae Preparata is ground into coarse powder (Radix Rehmanniae Preparata is got dry powder rate about 65%), to remove the fresh pig spinal cord and the above-mentioned coarse powder of crust then mixes thoroughly, (fresh pig spinal cord is got dry powder about 15%), at oven drying at low temperature below 55 ℃, be ground into fine powder again, through 100 mesh sieves, mixing; Add refined honey (old honey) 20-35 gram and an amount of water (10-15 gram) in per 100 gram fine powders, general ball, after sterilize, drying promptly makes Chinese medicine preparation of the present invention.The character of said preparation is the small honey pill of dark brown black, bitter in the mouth.

The present invention has the different of matter based on the method treatment hyperosteogeny of " benefiting essence and marrow, nourishing the liver and kidney " with existing " analgesia, blood circulation promoting and blood stasis dispelling dispel the wind " and Therapeutic Method such as " the kidney invigorating collateral dredging "; The present invention selects " fresh pig spinal cord is given birth to and used " for use, and three flavor animals and plants medicines combinations such as " the stir-baking in sand Semen Strychni is for oral administration ", " Zaocys " produce good clinical effectiveness; Select product such as Carapax et Plastrum Testudinis, Radix Rehmanniae Preparata for use, with taste fill out kidney essense, moisten nourishing the liver wood, in order to do solid skeleton and pliable tendons, make bony spur spontaneous recovery.The present invention has with marrow benefit marrow, mends bone, supports meat with meat with bone, control that it is basic, stop the effect in the source of falling ill, the present invention can delay the aging and the degeneration of muscles and bones and body tissue effectively, the muscles and bones tissue of repairing damage, and dual regulation arranged to blood pressure is higher, on the low side.The present invention treats the cure rate height at a specified future date of hyperosteogeny, can reach more than 90% (tracing observation more than 3 years not recidivist).Medicine of the present invention is fixed, and the medicine source is sufficient and inexpensive, and production technology is easy, and production cost is low, helps pharmaceutical industries production.The present invention selects Semen Strychni (processed) for use, but as long as strict press formula proportion, concocted specification, usage and dosage production and use, and safe without toxic side effect not only, and also clinical effectiveness is remarkable.Use the present invention's (experimental group) and " spur and pain relieving liquid " (matched group) that uses Beijing Tongrentang tincture distillery to produce to compare observation, draw the result of table one, table two, have significant statistical significance (X ²=10.828, P＜0.001):

Table one experimental group and matched group curative effect are relatively

Grouping	Recovery from illness	Produce effects	Take a turn for the better	Invalid	Add up to	Recovery from illness and obvious effective rate %
							Experimental group	44	5	1	0	50	98
Matched group	10	12	8	5	35	62.86
							Add up to	54	17	9	5	85

Table two experimental group and matched group pattern of syndrome are relatively

Embodiment:, be combined as the best in following ratio according to prescription provided by the invention and manufacture method:

Carapax Et Plastrum Testudinis 200g(20%), Zaocys 120g(12%), Cortex Phellodendri 60g(6%), Rhizoma Atractylodis 50g(5%), Radix Rehmanniae Preparata 200g(dry product 19%, bright product ratio 30%), Radix Cyathulae 50g(5%), Radix Paeoniae Alba 50g(5%), Semen Persicae 50g(5%), Rhizoma Zingiberis Preparatum 40g(4%), Pericarpium Citri Reticulatae 40g(4%), Fructus Chaenomelis 50g(5%), Olibanum (system) 40g(4%), Semen Strychni 48g(4.8%), Medulla Sus domestica 350g(dry product 5%, bright product get 35%).

Except that Medulla Sus domestica, earlier all the other each medicines are carried out crushing screening respectively, then fresh pig spinal cord and each powder medicine are mixed thoroughly, in oven dry below 55 ℃, be ground into fine powder again and cross 100 mesh sieves, Radix Rehmanniae Preparata is crossed 40 mesh sieves, its flour extraction rate (dry product) about 70%, so proportion compatibility should omit height, Medulla Sus domestica is by bright product percentage calculation.Add refined honey (old honey) 25 grams and suitable quantity of water 100-150 gram in the fine powders at per 100 grams, make small honey pill, every heavily about 0.2g contains Semen Strychni (processed) powder about 0.0084 and restrains, after sterilize, drying promptly makes spur-subsiding pill.Oral, a 24-36 grain (about 4.8-7.2 gram), 2 times on the one, serveing on 3 months is a course of treatment, can serve on 1-3 the course of treatment.

Claims

1, a kind of spur-subsiding pill Chinese medicine preparation that is used for the treatment of hyperosteogeny, it is characterized in that the prescription of each medicine and the percentage by weight of each component are: Carapax Et Plastrum Testudinis (it is general to go up Carapax et Plastrum Testudinis) 15-25%, Zaocys (removing the dry all of internal organs) 10-15%, Cortex Phellodendri 3-8%, Rhizoma Atractylodis 5-7%, Radix Cyathulae 5-7%, Radix Paeoniae Alba 5-10%, Semen Persicae (peeling) 4-6%, Rhizoma Zingiberis Preparatum 3-5%, Pericarpium Citri Reticulatae 3-5%, Fructus Chaenomelis 5-7%, Olibanum (system) 3-5%, Radix Rehmanniae Preparata dry product 16-25% (bright product ratio 25-38%), Semen Strychni (processed) 4.5-9.7%, fresh pig spinal cord dry product 3-5% (bright product ratio 20-35%).

2, a kind of manufacture method for the treatment of the spur-subsiding pill of hyperosteogeny is characterized in that:

A, with the Carapax Et Plastrum Testudinis of vinegar system, Zaocys, Radix Cyathulae and the Radix Paeoniae Alba through the wine stir-fry, the Cortex Phellodendri of frying through salt, the Rhizoma Atractylodis of frying through the husband, the Semen Strychni (processed) through 250-270 ℃ of stir-baking in sand 1-3 minute, and Semen Persicae, Rhizoma Zingiberis Preparatum, Pericarpium Citri Reticulatae, Fructus Chaenomelis, Olibanum (system), Radix Rehmanniae Preparata, be ground into coarse powder; Then

B, the fresh pig spinal cord that will remove crust and above-mentioned coarse powder are mixed thoroughly, and at oven drying at low temperature below 55 ℃, are ground into fine powder again, cross 100 mesh sieves, mixing; In

C, per 100 gram fine powders add refined honey (old honey) 20-35 gram and suitable quantity of water (10-15 gram), general ball, after sterilize, drying gets final product.