CN114225003B - Traditional Chinese medicine composition for tonifying fire and yang, warming middle-jiao and dispelling cold, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for tonifying fire and yang, warming middle-jiao and dispelling cold, and preparation method and application thereof Download PDFInfo
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- CN114225003B CN114225003B CN202210088353.6A CN202210088353A CN114225003B CN 114225003 B CN114225003 B CN 114225003B CN 202210088353 A CN202210088353 A CN 202210088353A CN 114225003 B CN114225003 B CN 114225003B
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Abstract
The invention relates to a traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold, a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition are prepared from the following medicinal raw materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of bupleurum, 1-15 parts of baikal skullcap root, 1-15 parts of alisma orientale, 1-18 parts of red ginseng, 10-30 parts of cistanche deserticola and 10-30 parts of prepared rehmannia root. The traditional Chinese medicine composition and the massage cream prepared from the traditional Chinese medicine composition have the physiotherapy effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and can remarkably relieve and treat uncomfortable symptoms such as dysmenorrhea, diarrhea and the like caused by deficiency of yang qi.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and a preparation method and application thereof.
Background
Has the functions of promoting, warming and exciting the human body, and belongs to yang.
The viscera function will be decreased with the deficiency of yang-qi. The organism can present symptoms such as less qi and lazy speaking, anorexia and eating less, aversion to cold and cold limbs, less qi and spontaneous perspiration, pale complexion, diarrhea, epigastric and abdominal cold pain, dreaminess, diarrhea before and during menstruation, lower abdominal pain and the like.
A series of products aiming at yang deficiency are mainly oral products in the market, and the products are easy to take, but have the defect of slow absorption. Meanwhile, for people with poor spleen and stomach, discomfort symptoms such as stomachache, diarrhea and the like can be caused, which is another physical injury for patients.
Therefore, it is still very necessary to develop an external product with obvious effect, good absorption, no toxic or side effect, convenient use and the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold.
Disclosure of Invention
Based on the above, the invention aims to provide a traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold, which can effectively relieve symptoms such as less qi, no speaking, anorexia, aversion to cold, cold limbs, spontaneous perspiration, pale complexion, diarrhea, epigastric and abdominal pain, dreaminess, diarrhea before menstruation, lower abdominal pain and the like caused by insufficient yang qi.
The specific technical scheme is as follows:
the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following medicinal materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of bupleurum, 1-15 parts of baikal skullcap root, 1-15 parts of alisma orientale, 1-18 parts of red ginseng, 10-30 parts of cistanche deserticola and 10-30 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 5-17 parts of pilose antler, 15-25 parts of photinia leaf, 3-8 parts of ginger, 4-12 parts of gentian, 3-9 parts of bupleurum, 3-8 parts of baikal skullcap root, 3-8 parts of alisma orientale, 5-15 parts of red ginseng, 13-20 parts of cistanche deserticola, and 15-22 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 10-15 parts of pilose antler, 15-20 parts of photinia leaf, 4-8 parts of ginger, 7-12 parts of gentian, 4-8 parts of bupleurum, 4-8 parts of baikal skullcap root, 4-8 parts of alisma orientale, 10-15 parts of red ginseng, 14-18 parts of cistanche deserticola, and 15-20 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 11-13 parts of pilose antler, 17-19 parts of photinia leaf, 5-7 parts of ginger, 8-10 parts of gentian, 5-7 parts of bupleurum, 5-7 parts of baikal skullcap root, 5-7 parts of alisma orientale, 11-13 parts of red ginseng, 15-17 parts of cistanche deserticola, and 17-19 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of bupleurum, 6 parts of baikal skullcap root, 6 parts of alisma orientale, 12 parts of red ginseng, 16 parts of cistanche deserticola and 18 parts of prepared rehmannia root.
The pharmacology and medicinal properties of the selected medicinal materials of the traditional Chinese medicine composition are as follows:
velvet antler: sweet, salty, warm. It enters kidney and liver meridians. Strengthen kidney yang, replenish essence and blood, strengthen tendons and bones, and regulate thoroughfare and conception vessels. To support sore.
Photinia fraseri leaf: neutral in nature, pungent and bitter in flavor. Dispelling wind and tonifying kidney.
Ginger: pungent and slightly warm. Relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomiting, resolving phlegm and arresting vomiting.
Gentian: bitter and cold, enter liver and gallbladder meridians. Clear heat and dry dampness, purge liver and arrest convulsion.
Bupleurum root: bitter and slightly cold, enter liver and gallbladder meridians. Relieving exterior and interior syndrome, soothing liver and raising yang.
Radix Scutellariae Baicalensis: bitter and cold. The Chinese medicinal composition is used for treating lung, gallbladder, spleen and large intestine. Clear heat and dry dampness, purge fire and detoxify.
Oriental Waterplantain rhizome: sweet and cold. Kidney, bladder meridian. Promoting urination, and clearing damp-heat.
Red ginseng: sweet, slightly bitter and warm. It enters spleen, lung and heart meridians. The primordial qi is greatly reinforced, the pulse is recovered, the qi is benefited, and the blood is taken. Cistanche deserticola: sweet, salty, warm. Enter kidney and large intestine meridians. Kidney-yang tonifying, essence and blood replenishing, bowel relaxing and constipation relieving
Prepared rehmannia root: sweet and slightly warm, enter liver and kidney meridians. Nourishing yin and replenishing blood, replenishing essence and replenishing marrow.
The above medicinal materials are cooperated, so that the traditional Chinese medicine composition has the effects of tonifying fire and yang, warming middle-jiao and dispelling cold, and can effectively relieve and treat diseases or uncomfortable symptoms such as dysmenorrhea, diarrhea and the like caused by deficiency of yang qi and decline of vital gate fire.
The invention also provides a preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold.
The specific technical scheme is as follows:
the preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
taking the raw materials, crushing or not crushing, then adding water or ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and supporting yang, warming middle-jiao and dispelling cold.
In some embodiments, the extracting with an aqueous ethanol solution comprises: ultrasonic extracting for 1-3 times; the conditions for each ultrasonic extraction included: the time is 35 minutes to 75 minutes, the ultrasonic power is 1100w to 1300w, and the extraction temperature is 30 ℃ to 45 ℃.
In some of these embodiments, the conditions for each ultrasound extraction include: the time is 45-65 minutes, the ultrasonic power is 1100w-1300w, and the extraction temperature is 30-40 ℃.
In some of these embodiments, the conditions for each ultrasound extraction include: the time is 58-63 minutes, the ultrasonic power is 1150-1250 w, and the extraction temperature is 32-38 ℃.
In some of these embodiments, the volume fraction of the aqueous ethanol solution is 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the raw materials.
In some of these embodiments, the adding water for extraction comprises: heating and extracting for 1-3 times, wherein the conditions of each extraction include: the extraction temperature is 80-100 ℃, the extraction time is 30-55 minutes, and the addition amount of water extracted each time is 4-10 times of the total weight of the raw materials of the medicinal materials.
In some embodiments, the concentration is reduced pressure concentration to a mass ratio of the concentrated solution to the total weight of the medicinal materials of 0.65-0.70:1.
In some of these embodiments, the conditions of reduced pressure concentration include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
The invention also provides application of the traditional Chinese medicine composition.
The specific technical scheme is as follows:
the application of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in preparing medicines for preventing and/or treating dysmenorrhea.
The application of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in preparing medicines for preventing and/or treating diarrhea.
The application of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in preparing cosmetics or skin care products for improving dysmenorrhea and/or diarrhea.
The invention also provides a massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold.
The specific technical scheme is as follows:
a massage cream with effects of invigorating fire and yang, warming middle-jiao and dispelling cold is prepared from functional components and acceptable carriers or auxiliary materials in the massage cream, wherein the functional components comprise the traditional Chinese medicine composition for invigorating fire and yang, warming middle-jiao and dispelling cold.
In some embodiments, the weight percentage of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in the massage cream is 35-45%.
In some embodiments, the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following raw materials in percentage by weight:
in some embodiments, the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following raw materials in percentage by weight:
the invention also provides a preparation method of the massage cream for warming channels and dredging collaterals.
The preparation method comprises the following steps:
a preparation method of a massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
(1) Adding water, the traditional Chinese medicine composition, 1, 3-propylene glycol, sodium stearoyl glutamate, xanthan gum, sodium alginate, allantoin and EDTA disodium into a water pot, heating to 80-90 ℃, and stirring for dissolution to obtain a water phase mixture;
(2) Adding isopropyl myristate, cetostearyl alcohol, stearyl alcohol polyether-21, polydimethylsiloxane, PEG-100 stearate, glycerol stearate, stearyl alcohol polyether-2 and bisabolol into an oil pan, heating to 80-90 ℃, stirring and dissolving to obtain an oil phase mixture;
(3) Mixing butanediol and titanium dioxide, and grinding uniformly;
(4) Adding the oil phase mixture obtained in the step (2) into a water pot in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring to uniformly mix;
(5) Cooling the mixture obtained in the step (4) to 50-60 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) And (3) cooling the mixture obtained in the step (5) to room temperature, adding phenoxyethanol and ethylhexyl glycerol, and stirring and mixing uniformly to obtain the massage cream for tonifying fire and supporting yang, warming middle-jiao and dispelling cold.
According to the traditional Chinese medicine composition disclosed by the invention, traditional Chinese medicine raw materials are selected, and pilose antler, prepared rehmannia root and cistanche are added according to the theory of 'monarch, minister, assistant and guide' of traditional Chinese medicine, so that the effects of invigorating kidney yang, replenishing essence and blood and strengthening tendons and bones are achieved; photinia leaf and red ginseng are added as ministers, and have the effects of strengthening heart and lung and tonifying kidney; adding Scutellariae radix, alismatis rhizoma, radix Gentianae and bupleuri radix as adjuvants, and has effects of promoting circulation, relieving exterior syndrome, clearing heat and detoxicating; ginger is added to reduce adverse-rising temperature. The traditional Chinese medicine composition has the physiotherapy effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, can effectively relieve symptoms such as less qi, no speaking, anorexia, aversion to cold, cold limbs, spontaneous perspiration, pale complexion, diarrhea, epigastric cold pain, dreaminess, diarrhea before menstruation, lower abdominal pain and the like caused by the deficiency of yang qi, and can remarkably improve, relieve and treat diseases and uncomfortable symptoms such as dysmenorrheal, diarrhea and the like caused by the deficiency of yang qi.
The massage cream prepared by combining the traditional Chinese medicine composition for tonifying fire and yang and warming middle-jiao and dispelling cold with the common carrier or matrix of cosmetics has the physiotherapy effects of tonifying fire and yang, warming channels and dredging collaterals, and can effectively relieve diseases and uncomfortable symptoms such as dysmenorrheal, diarrhea and the like caused by insufficient yang qi. The massage cream has the advantages of mild and no stimulation to skin, safety, no toxic or side effect, convenient use and convenient cleaning.
Detailed Description
In order that the invention may be understood more fully, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended claims. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
The invention provides a traditional Chinese medicine composition for warming channels and dredging collaterals, which is prepared from the following active ingredients in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of bupleurum, 1-15 parts of baikal skullcap root, 1-15 parts of alisma orientale, 1-18 parts of red ginseng, 10-30 parts of cistanche deserticola and 10-30 parts of prepared rehmannia root.
Further preferably, the active ingredients of the traditional Chinese medicine composition for warming channels and dredging collaterals are prepared from the following raw materials in parts by weight: 5-17 parts of pilose antler, 15-25 parts of photinia leaf, 3-8 parts of ginger, 4-12 parts of gentian, 3-9 parts of bupleurum, 3-8 parts of baikal skullcap root, 3-8 parts of alisma orientale, 5-15 parts of red ginseng, 13-20 parts of cistanche deserticola, and 15-22 parts of prepared rehmannia root.
Further preferably, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal materials in parts by weight: 10-15 parts of pilose antler, 15-20 parts of photinia leaf, 4-8 parts of ginger, 7-12 parts of gentian, 4-8 parts of bupleurum, 4-8 parts of baikal skullcap root, 4-8 parts of alisma orientale, 10-15 parts of red ginseng, 14-18 parts of cistanche deserticola, and 15-20 parts of prepared rehmannia root.
More preferably, the active ingredients of the traditional Chinese medicine composition for warming channels and dredging collaterals are prepared from the following raw materials in parts by weight: 11-13 parts of pilose antler, 17-19 parts of photinia leaf, 5-7 parts of ginger, 8-10 parts of gentian, 5-7 parts of bupleurum, 5-7 parts of baikal skullcap root, 5-7 parts of alisma orientale, 11-13 parts of red ginseng, 15-17 parts of cistanche deserticola, and 17-19 parts of prepared rehmannia root.
Most preferably, the active ingredients of the traditional Chinese medicine composition for warming channels and dredging collaterals are prepared from the following raw materials in parts by weight: 12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of bupleurum, 6 parts of baikal skullcap root, 6 parts of alisma orientale, 12 parts of red ginseng, 16 parts of cistanche deserticola and 18 parts of prepared rehmannia root.
The traditional Chinese medicine composition provided by the invention is prepared by carefully selecting traditional Chinese medicine raw materials, and each medicine has a synergistic effect, so that the traditional Chinese medicine composition has the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and can effectively relieve and treat diseases or uncomfortable symptoms such as dysmenorrheal, diarrhea and the like caused by deficiency of yang qi.
The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold can be prepared according to a conventional method in the field of traditional Chinese medicines.
Preferably, the preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
taking the raw materials, crushing or not crushing, then adding water or ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and supporting yang, warming middle-jiao and dispelling cold.
In some embodiments, the adding water for extraction comprises: heating and extracting for 1-3 times, wherein the conditions of each extraction include: the extraction temperature is 80-100 ℃, the extraction time is 30-55 minutes, and the addition amount of water extracted each time is 4-10 times of the total weight of the raw materials of the medicinal materials.
In some embodiments, the adding an aqueous ethanol solution for extraction comprises: ultrasonic extracting for 1-3 times; the conditions for each ultrasonic extraction included: the time is 35 minutes to 75 minutes, the ultrasonic power is 1100w to 1300w, and the extraction temperature is 30 ℃ to 45 ℃. Further preferably, the conditions of each ultrasonic extraction include: the time is 45 minutes to 65 minutes, the ultrasonic power is 1100w to 1300w, and the extraction temperature is 30 ℃ to 40 ℃; further preferably, the conditions of each ultrasonic extraction include: the time is 58-63 minutes, the ultrasonic power is 1150-1250 w, and the extraction temperature is 32-38 ℃. The volume fraction of the ethanol aqueous solution is preferably 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the raw materials.
In some embodiments, the concentration is reduced pressure concentration to a mass ratio of the concentrated solution to the total weight of the medicinal materials of 0.65-0.70:1.
in some embodiments, the conditions of reduced pressure concentration include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines, health products or cosmetics for tonifying fire, supporting yang, warming middle-jiao and dispelling cold.
The traditional Chinese medicine composition provided by the invention can be prepared into massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold with a carrier or a matrix commonly used in cosmetics. The weight percentage of the traditional Chinese medicine composition in the massage cream is preferably 35-45%. The massage cream has physiotherapy effects of invigorating fire, supporting yang, warming spleen and stomach, and dispelling cold, and can effectively relieve dysmenorrhea, diarrhea, etc. and discomfort symptoms caused by yang qi deficiency. The massage cream has the advantages of mild and no stimulation to skin, safety, no toxic or side effect, convenient use and convenient cleaning.
The massage cream can be prepared by a conventional preparation method in the cosmetic field.
The present invention will be described in further detail with reference to specific examples.
Example 1
The traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold provided by the embodiment is prepared from the following medicinal materials in parts by weight:
12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of bupleurum, 6 parts of baikal skullcap root, 6 parts of alisma orientale, 12 parts of red ginseng, 16 parts of cistanche deserticola and 18 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) The preparation method comprises the steps of weighing the raw materials according to the parts by weight, firstly drying prepared rehmannia root and cistanche deserticola under reduced pressure (60-70 ℃ and minus 0.08MPa to minus 0.1 MPa), then crushing the dried prepared rehmannia root and cistanche deserticola together with the rest raw materials, and crushing the crushed dried prepared rehmannia root and cistanche deserticola into coarse powder to obtain traditional Chinese medicine powder.
(2) Adding ethanol water solution with the weight being 8 times of the total weight of the medicinal materials and the volume fraction being 60% into the traditional Chinese medicine powder obtained in the step (1), and carrying out ultrasonic extraction for 1 time under the following extraction conditions: the time was 60 minutes, the ultrasonic power was 1200w and the temperature was 35 ℃.
(3) And (3) carrying out low-speed centrifugation (the rotation speed of a centrifugal machine is 2000rpm, the mesh number of filter cloth is 400 meshes), taking supernatant, and carrying out high-speed centrifugation (the rotation speed of the centrifugal machine is 20000rpm, the rotation speed of a peristaltic pump is 20rpm, and the pipe diameter is 6 mm). Taking the supernatant to obtain a first extract.
(4) Adding ethanol water solution with the weight being 6 times of the total weight of the medicinal materials and the volume fraction being 35% into the residues obtained after low-speed centrifugation, and carrying out ultrasonic extraction for 1 time under the following extraction conditions: the time was 60 minutes, the ultrasonic power was 1200w and the temperature was 35 ℃.
(5) And (3) centrifuging the extracted product obtained in the step (4) at a low speed (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 mesh), centrifuging the supernatant at a high speed (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, and the pipe diameter is 6 mm), and collecting the supernatant to obtain a second extracting solution.
(6) Combining the first extract and the second extract, concentrating under reduced pressure (70-75 ℃ C., -0.08MPa to-0.1 MPa), recovering ethanol, and concentrating until the mass ratio of the concentrated solution to the total weight of the medicinal materials is 0.67:1.0 (i.e. 670g of concentrated solution per kg of medicinal materials).
Example 2
The traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold provided by the embodiment is prepared from the following medicinal materials in parts by weight:
20 parts of pilose antler, 10 parts of photinia leaf, 1 part of ginger, 1 part of gentian, 15 parts of bupleurum, 15 parts of baikal skullcap root, 1 part of alisma orientale, 5 parts of red ginseng, 10 parts of cistanche deserticola and 10 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
the raw materials of the medicines are weighed according to the weight parts, placed in an extraction tank, added with water (the weight of the added water is 8 times of the total weight of the medicines), soaked for 30 minutes, and then heated and extracted, wherein the temperature is 100 ℃ and the time is 55 minutes. Filtering after extraction to obtain filtrate 1. Adding water (the weight of the added water is 6 times of the total weight of the medicinal materials), heating and extracting at 100deg.C for 30 min, filtering to obtain filtrate 2, and discarding the medicinal residues. Combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa to-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (i.e. 670g per kilogram of medicinal materials).
Example 3
The traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold provided by the embodiment is prepared from the following traditional Chinese medicinal materials in parts by weight:
5 parts of pilose antler, 15 parts of photinia leaf, 3 parts of ginger, 4 parts of gentian, 9 parts of bupleurum, 3 parts of baikal skullcap root, 8 parts of alisma orientale, 18 parts of red ginseng, 13 parts of cistanche deserticola and 15 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
the raw materials of the medicines are weighed according to the weight parts, placed in an extraction tank, added with water (the weight of the added water is 6 times of the total weight of the medicines), soaked for 30 minutes, and then heated and extracted, wherein the temperature is 100 ℃ and the time is 45 minutes. Filtering after extraction to obtain filtrate 1. Adding water (4 times of the total weight of the medicinal materials) into the obtained residues, heating and extracting at 100deg.C for 30 min, filtering to obtain filtrate 2, and discarding residues. Combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa to-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (i.e. 670g per kilogram of medicinal materials).
Example 4
The traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold provided by the embodiment is prepared from the following traditional Chinese medicinal materials in parts by weight:
1 part of pilose antler, 30 parts of photinia leaf, 10 parts of ginger, 15 parts of gentian, 3 parts of bupleurum, 1 part of baikal skullcap root, 3 parts of alisma orientale, 15 parts of red ginseng, 20 parts of cistanche deserticola and 30 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the parts by weight, firstly drying cistanche deserticola and radix rehmanniae preparata under reduced pressure (60-70 ℃ and minus 0.08MPa to minus 0.1 MPa), and then crushing the cistanche deserticola and the radix rehmanniae preparata together with the rest raw materials into coarse powder. Chinese medicinal powder.
(2) Adding an ethanol water solution with the weight being 10 times of the total weight of the medicinal materials and the volume fraction being 45% into the traditional Chinese medicine powder obtained in the step (1), and carrying out ultrasonic extraction for 1 time under the following extraction conditions: the time was 45 minutes, the ultrasonic power was 1200w and the temperature was 35 ℃.
(3) And (3) centrifuging the extracted product obtained in the step (2) at a low speed (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 mesh), centrifuging the supernatant at a high speed (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, and the pipe diameter is 6 mm), and collecting the supernatant to obtain the first extract.
(4) Adding ethanol water solution with the weight being 10 times of the total weight of the medicinal materials and the volume fraction being 35% into the medicinal residues obtained in the step (3), and carrying out ultrasonic extraction for 1 time under the following extraction conditions: the time was 45 minutes, the ultrasonic power was 1200w and the temperature was 35 ℃.
(5) And (3) centrifuging the extract obtained in the step (4) at a low speed (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 mesh), centrifuging the supernatant at a high speed (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, the pipe diameter is 6 mm), and collecting the supernatant to obtain a second extract.
(6) Combining the first extract and the second extract, concentrating under reduced pressure (70-75 ℃ C., -0.08MPa to-0.1 MPa), recovering ethanol, and concentrating until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (i.e. concentrating to 670g per kilogram of medicinal materials).
Example 5
The traditional Chinese medicine composition with the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold provided by the embodiment is prepared from the following traditional Chinese medicinal materials in parts by weight:
17 parts of pilose antler, 25 parts of photinia leaf, 8 parts of ginger, 12 parts of gentian, 1 part of bupleurum, 8 parts of baikal skullcap root, 15 parts of alisma orientale, 1 part of red ginseng, 30 parts of cistanche deserticola and 22 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) Weighing the raw materials according to the weight portions.
(2) Placing the traditional Chinese medicine powder obtained in the step (1) into an extraction tank, adding water (the weight of the added water is 10 times of the total weight of the medicinal materials), soaking for 30 minutes, and then heating and extracting at 100 ℃ for 35 minutes. Filtering after extraction to obtain filtrate 1. Adding water (the weight of the added water is 8 times of the total weight of the medicinal materials), heating and extracting at 100deg.C for 35 min, filtering to obtain filtrate 2, and discarding the medicinal residues. Combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa to-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (i.e. 670g per kilogram of medicinal materials).
Example 6
The embodiment provides a massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold, which comprises the traditional Chinese medicine composition (main functional components) prepared in the embodiment 1 and a cosmetic carrier, wherein the cosmetic carrier comprises a solvent, a skin conditioner, a humectant, an emollient, a thickener, an emulsifier, a chelating agent and the like; wherein the content of each component is shown in
TABLE 1 (the contents of the components in the tables are weight percent wt%)
The preparation method of the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in the embodiment comprises the following steps:
(1) Adding components 1, 2, 12, 13, 14, 15 and 17 into a water pot, heating to 85 ℃, and stirring to fully dissolve;
(2) Adding components 4, 5, 6, 7, 8, 9 and 16 into an oil pan, heating to 85 ℃, and stirring to completely dissolve;
(3) Pre-mixing the component 3 and the component 11, and grinding uniformly;
(4) Adding the mixture obtained in the step (2) into the water pot in the step (1), homogenizing, stirring and mixing uniformly, and adding the mixture obtained in the step (3) into the water pot, homogenizing, stirring and mixing uniformly;
(5) Cooling the mixture obtained in the step (4) to 55 ℃, adding the component 18, and uniformly stirring;
(6) And (3) cooling the mixture obtained in the step (5) to room temperature, adding the residual material component 10, and stirring and mixing uniformly to obtain a finished product, wherein the finished product is the massage cream prepared in the examples 6-1, 6-2 and 6-3 and used for tonifying fire and yang, warming middle-jiao and dispelling cold.
EXAMPLE 7 storage stability test of massage cream prepared in examples 6-1, 6-2 and 6-3 for tonifying fire and yang, warming middle-jiao and dispelling Cold
High temperature resistance experiment: the constant temperature incubator is adjusted to 45+/-1 ℃ in advance, about 10g of fire-supplementing yang-supporting, middle-warming and cold-dispelling massage cream (example 6-1, example 6-2 and example 6-3) is weighed in a weighed culture dish respectively, scraped, precisely weighed again, obliquely placed on a 15-degree frame in the constant temperature incubator, sampled after 24 hours, placed in a dryer for cooling, weighed again, if oil seeps out, carefully wiped off the oil, a cream part is left, the culture dish is weighed together with the rest of the cream part, and the oil seepage rate of a sample is calculated according to the following formula (numerical value is expressed in percent):
oil permeability (%) = (m) 1 -m 2 ) 100% (m-mass of sample in g); m is m 1 The mass of the sample after 24 hours plus the mass of the petri dish in g; m is m 2 The mass of the sample after wiping off the oil-impregnated portion, in g, plus the mass of the petri dish, results are shown in table 2 below: in the high temperature resistance experiment, the oil permeability of the heat-tonifying yang-invigorating, middle-warming and cold-dispelling massage cream prepared in the embodiment 6-2 and the embodiment 6-3 is more than 0.1%, and the heat-tonifying yang-invigorating, middle-warming and cold-dispelling massage cream prepared in the embodiment 6-1 has more stable properties.
Low temperature resistance experiment: the massage cream with the functions of tonifying fire, supporting yang, warming middle-jiao and dispelling cold prepared in the examples 6-1, 6-2 and 6-3 is placed for 24 hours at the temperature of-5-10 ℃ and then the room temperature is restored, and the phenomena of coarseness appear in the massage cream with the functions of tonifying fire, supporting yang, warming middle-jiao and dispelling cold prepared in the examples 6-2 and 6-3; the massage cream prepared in example 6-1 for tonifying the fire and yang, warming the middle-jiao and dispelling cold has no obvious change.
TABLE 2
Example 8 skin irritation test of massage cream for tonifying fire and yang, warming middle warmer and dispelling Cold
Single and multiple skin irritation tests were performed using the fire-tonifying yang-supporting, middle-warming cold-dispelling massage cream of example 6-1.
1. Test drug
The massage cream prepared in example 6-1 for tonifying fire, supporting yang, warming middle-jiao and dispelling cold
2. Test animals
20 healthy white rabbits (single skin irritation test), both male and female, weight (2.0+0.2) kg; 50 mice (multiple skin irritation tests) were used in both male and female animals, and had a body weight of 18-22g. The above experimental animals were all supplied by the university of south medical science laboratory center (license number: SCXK (Guangdong) 2011-0015). The animals are kept in a male-female cage, are fed with free diet and free drinking water, and are fed for 5 days in advance before experiments so as to adapt to the environment of animal houses.
3. Test methods and results
3.1 methods
The skin irritation test method and step of single administration and the skin irritation test method and step of multiple administration are carried out according to the skin irritation test method and step in cosmetic safety technical Specification 2015, wherein the test group is coated with the fire-supplementing yang-invigorating, middle-warming and cold-dispelling massage cream of the embodiment 6-1, and the control group is not coated with any article.
3.2 results
3.2.1 skin irritation test with a single administration all rabbits were given a test of 0.2g/kg of test substance on one side and skin on the other side during the test. The skin irritation intensity of the massage cream of example 6-1 was determined by observing skin reactions at the application site at 1, 24, 48, and 72 hours, respectively, using a seal test, removing the test substance after application time of 2 hours, and observing 1, 24, 48, and 72 hours, respectively. The results are shown in Table 3.
TABLE 3 Table 3
The results show that: 1. skin reactions at the application sites were observed 24, 48 and 72 hours, and no macroscopic erythema or edema, pimple, congestion, ulcer appeared. The total score and the average score of the skin irritation response evaluation are both 0, and the average response irritation intensity is less than 0.5 score, which indicates no irritation.
3.2.2 multiple skin irritation test with one side of all Kunming mice, the dehaired skin area was coated with 0.5g of test substance and the other side was used as a control. The application was performed 1 time a day for 14 days. From the next day, the residual test substance is removed by shearing the hair before each application, with water or a non-irritating solvent. One hour observations were made. The results of the skin irritation intensities of the massage cream of example 6-1 were evaluated, and are shown in Table 4.
TABLE 4 Table 4
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The results showed that 50 test Kunming mice on the first day had 1 erythema and 1 pimple, with an average score of less than 0.5 per animal per day; the following day 50 test Kunming mice, one of which developed papules, each animal had an average score of less than 0.5 per day; all of the test Kunming mice did not develop pimples, erythema, congestion, ulcers on day 3-day 14. The multiple skin irritation intensity was non-irritating according to the standard evaluation criteria.
Example 9 antidiarrheal Effect experiment
The effect of the massage cream prepared by the traditional Chinese medicine composition on the number of grains of diarrhea-induced mice caused by senna leaves is examined, so that the antidiarrheal effect of the traditional Chinese medicine composition is tested.
Experimental animals: healthy Kunming mice, five weeks old, weighing 18-22g, clean grade, 105, randomized into 7 groups: normal control group, model control group, experimental group 1-experimental group 5, 15 per group. The above experimental animals were all supplied by the university of south medical science laboratory center (license number: SCXK (Guangdong) 2011-0015). The indoor temperature is 24+/-1 ℃, and the test is carried out after the adaptive feeding is carried out for 5 days.
The diarrhea model of the mice is established by using the senna leaf decoction, and the preparation method of the senna leaf decoction is as follows: soaking 15g of folium sennae in 100ml of water for 15 min, boiling with medium fire for 15 min, stopping fire, and filtering to obtain decoction.
Test drug: the test drug of experiment group 1 was the massage cream prepared in example 6-1 (the Chinese medicinal composition prepared in example 1 was added); the test drugs for experimental groups 2-5 were: the Chinese medicinal compositions of examples 2-5 were added respectively, and the massage cream prepared by the method of example 6-1 was used; namely, the massage cream of experimental group 1-5 was different in that the added Chinese medicinal composition was different, and the other components and the preparation method were the same as those of example 6-1.
Normal control mice were not treated at all; taking a model control group and an experimental group, and fasted for 24 hours, and pouring the senna leaf decoction into the stomach according to the ratio of 0.15mL/10g by using a 12-number 55mm small-head curved stomach-pouring device; then, mice in a model control group are not treated, corresponding massage cream is smeared on Guanyuan acupoint, zusanli acupoint and nearby areas of the mice in an experimental group 1-5, the smearing amount is 0.1mg, each time of smearing is 1 minute, the administration is carried out 2 times, and the interval time is 2 hours; after administration, each group of mice was allowed to rest and eat normally, the mice were observed and the total particle count of wet feces discharged from each group of mice was calculated for 24 hours. The test results are shown in Table 5.
TABLE 5
| Group of | Number of animals | Wet manure grain number |
| Normal control group | 15 | 15.23±1.79 |
| Model control group | 15 | 25.87±1.68 |
| Experiment group 1 | 15 | 16.47±1.57 |
| Experiment group 2 | 15 | 20.67±1.49 |
| Experiment group 3 | 15 | 20.28±1.69 |
| Experiment group 4 | 15 | 21.79±1.59 |
| Experiment group 5 | 15 | 22.78±1.64 |
From the above results, it can be seen that: the number of wet manure particles discharged by the mice in the model control group for 24 hours is obviously higher than that of the mice in the normal group, which indicates that the diarrhea model of the mice is successfully established. The mice in experimental groups 1-5 have a certain reduction in the number of wet feces discharged in 24 hours compared with the model control group, which indicates that the massage cream prepared by the traditional Chinese medicine composition can reduce the number of feces discharged by mice with diarrhea induced by senna leaves, and has a better antidiarrheal effect, wherein the massage cream prepared by the traditional Chinese medicine composition of example 1 has the best antidiarrheal effect.
Example 10 clinical efficacy test of massage cream for tonifying fire and yang, warming middle-jiao and dispelling Cold
Subject selection: 400 female dysmenorrhea patients meeting the subject inclusion criteria were selected as subjects, aged 18-40 years.
Subject inclusion criteria: dysmenorrhoea is manifested by radioactive pain in the parts such as the abdomen discomfort and lumbosacral parts before menstruation and menstrual period, and accompanied by any symptoms (aversion to cold, cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period).
Test drug: treatment group: the massage cream prepared in example 6-1; control group: the massage cream prepared in the same manner as in example 6-1, without adding the Chinese medicinal composition of the present invention, i.e., the massage cream of the control group was different from the massage cream prepared in example 6-1 in that the Chinese medicinal composition of the present invention was not added, and other components and preparation methods were the same as in example 6-1.
The use method of the massage cream comprises the following steps: 1. the subject is prone to lie down, a proper amount of massage cream is evenly smeared on the lower waist and back, channels and collaterals of the lower waist and back are sequentially massaged for 30 minutes, and after the subject is warm-cultivated for 20 minutes by a far infrared lamp, the subject is scrubbed by paper towel or warm water; 2. the subject lies on the back, a proper amount of massage cream is evenly smeared on the lower abdomen, the channels and collaterals of the lower abdomen are sequentially massaged for 30 minutes, and after the massage is performed for 20 minutes by using a far infrared lamp, the subject is scrubbed by using paper towels or warm water. It is used before menstruation, and is stopped on the same day as menstruation. 1 time every 2 days, and 4 times is a treatment course.
Efficacy evaluation criteria: all symptoms such as radioactive pain in the menstrual period and the parts such as the abdomen discomfort before the menstrual period, cold intolerance and cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period come up are all disappeared, so that the medicine is cured; the traditional Chinese medicine composition is effective in improving symptoms such as radioactive pain in the menstrual period, discomfort of the lower abdomen before menstrual period, cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period; it is ineffective because all symptoms such as radioactive pain in the menstrual period and the parts such as the abdomen discomfort before the menstrual period, cold intolerance and cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before the menstrual period comes, etc. are not changed.
The effect after one course of treatment is shown in Table 6.
TABLE 6
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The results show that: 200 test persons, wherein 178 test persons have radioactive pain in the menstrual period, the abdomen discomfort before menstrual period, lumbo sacrum and other parts, and all symptoms such as aversion to cold, cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period comes out completely disappear; the radioactive pain in the parts of 14 test persons such as menstrual period, discomfort of the lower abdomen before menstrual period, lumbosacral and the like, and all symptoms such as aversion to cold, cold pain of limbs, cold pain of the abdomen, cold pain of the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period comes are improved; the symptoms of menstrual period and discomfort of the lower abdomen, lumbosacral and other parts of 8 test persons, such as aversion to cold, cold limbs, cold pain of the epigastrium and abdomen, cold pain of the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period comes, and the like are not improved, and the effective rate is 96.0%. In the control group, 200 test persons have no improvement on symptoms such as menstrual period and pain in the abdomen, lumbosacral and other parts before menstrual period, cold limbs, cold pain in the abdomen, cold pain in the waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstrual color with blood clots, menstrual period or diarrhea before menstrual period, and the effective rate is 0.
Example 11 clinical efficacy test of massage cream for tonifying fire and yang, warming middle-jiao and dispelling Cold
Subject selection: 300 diarrhea patients meeting the subject selection criteria are selected as subjects, and the ages of 18-60 years are not limited for men and women.
Subject inclusion criteria: diarrhea is accompanied by any one of the following symptoms (pale complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness of waist and knees, nocturia, pale and fat tongue with tooth marks).
Test drug: treatment group: the massage cream prepared in example 6-1; control group: the massage cream prepared in the same manner as in example 6-1, without adding the Chinese medicinal composition of the present invention, i.e., the massage cream of the control group was different from the massage cream prepared in example 6-1 in that the Chinese medicinal composition of the present invention was not added, and other components and preparation methods were the same as in example 6-1.
The use method of the massage cream comprises the following steps: 1. the subject is prone to lie down, a proper amount of massage cream is evenly smeared on the lower waist and back, channels and collaterals of the lower waist and back are sequentially massaged for 30 minutes, and after the subject is warm-cultivated for 20 minutes by a far infrared lamp, the subject is scrubbed by paper towel or warm water; 2. the subject lies on the back, a proper amount of massage cream is evenly smeared on the lower abdomen, the channels and collaterals of the lower abdomen are sequentially massaged for 30 minutes, and after the massage is performed for 20 minutes by using a far infrared lamp, the subject is scrubbed by using paper towels or warm water. 1 time every 2 days, and 4 times is a treatment course.
Efficacy evaluation criteria: diarrhea, with pale complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness of waist and knees, nocturia, pale and fat tongue with teeth marks, all symptoms disappear, and the disease is cured; diarrhea, with symptoms of pale complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness of waist and knees, nocturia, pale and fat tongue with teeth marks, is effective; diarrhea, with pale complexion, aversion to cold, cold limbs, cold pain in the abdomen, soreness of the waist and knees, frequent nocturia, pale and fat tongue with teeth marks, is ineffective.
The effect after one treatment course is shown in Table 7.
TABLE 7
The results show that: in the treatment group, 150 participants had diarrhea, and all symptoms of pale complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness of waist and knees, nocturia, pale and fat tongue with teeth marks had disappeared; 3 test persons have diarrhea, and all symptoms of white complexion, aversion to cold, cold pain in abdomen, soreness and weakness of waist and knees, nocturia, pale and fat tongue with tooth marks are improved; diarrhea of 2 test persons, with pale complexion, aversion to cold, cold pain in abdomen, soreness of waist and knees, nocturia, pale and fat tongue with tooth trace, all symptoms have no obvious change; the effective rate is 98.67%
In the control group, 150 test persons have diarrhea, and all symptoms of white complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness of waist and knees, frequent nocturia, pale and fat tongue with teeth marks have no obvious change.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is characterized by comprising the following active ingredients in parts by weight: 12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of bupleurum, 6 parts of baikal skullcap root, 6 parts of alisma orientale, 12 parts of red ginseng, 16 parts of cistanche deserticola and 18 parts of prepared rehmannia root;
the preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
pulverizing the raw materials, adding ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and yang, warming middle-jiao and dispelling cold;
the adding ethanol water solution for extraction comprises the following steps: ultrasonic extracting for 1-3 times; the conditions for each ultrasonic extraction included: the time is 58-63 minutes, the ultrasonic power is 1150-1250 w, and the extraction temperature is 32-38 ℃;
the volume fraction of the ethanol water solution is 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the raw materials;
concentrating under reduced pressure until the mass ratio of the concentrated solution to the total weight of the medicinal materials is 0.65-0.70:1;
the conditions of the reduced pressure concentration include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
2. A method for preparing a traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 1, which is characterized by comprising the following steps:
pulverizing the raw materials, adding ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and yang, warming middle-jiao and dispelling cold;
the adding ethanol water solution for extraction comprises the following steps: ultrasonic extracting for 1-3 times; the conditions for each ultrasonic extraction included: the time is 58-63 minutes, the ultrasonic power is 1150-1250 w, and the extraction temperature is 32-38 ℃;
the volume fraction of the ethanol water solution is 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the raw materials;
concentrating under reduced pressure until the mass ratio of the concentrated solution to the total weight of the medicinal materials is 0.65-0.70:1;
the conditions of the reduced pressure concentration include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
3. The method for preparing the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 2, wherein the condition of each ultrasonic extraction comprises the following steps: the time was 60 minutes, the ultrasonic power was 1200w and the extraction temperature was 35 ℃.
4. The method for preparing the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to any one of claims 2 to 3, wherein the concentration is reduced pressure concentration until the mass ratio of the concentrated solution to the total weight of the raw materials of the medicinal materials is 0.67:1.
5. the use of the Chinese medicinal composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold as claimed in claim 1 in the preparation of medicaments for improving, preventing and/or treating dysmenorrhea and diarrhea.
6. The massage cream is characterized by being prepared from functional components and acceptable auxiliary materials in the massage cream, wherein the functional components are the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 1.
7. The massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 6, wherein the weight percentage of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in the massage cream is 35-45%.
8. The massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 6, wherein the massage cream is prepared from the following raw materials in percentage by weight:
；
。
9. the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 8, wherein the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following raw materials in percentage by weight:
；
。
10. a method for preparing the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 8 or 9, which is characterized by comprising the following steps:
(1) Adding water, the traditional Chinese medicine composition, 1, 3-propylene glycol, sodium stearoyl glutamate, xanthan gum, sodium alginate, allantoin and EDTA disodium into a water pot, heating to 80-90 ℃, and stirring for dissolution to obtain a water phase mixture;
(2) Adding isopropyl myristate, cetostearyl alcohol, stearyl alcohol polyether-21, polydimethylsiloxane, PEG-100 stearate, glycerol stearate, stearyl alcohol polyether-2 and bisabolol into an oil pan, heating to 80-90 ℃, stirring and dissolving to obtain an oil phase mixture;
(3) Mixing butanediol and titanium dioxide, and grinding uniformly;
(4) Adding the oil phase mixture obtained in the step (2) into a water pot in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring to uniformly mix;
(5) Cooling the mixture obtained in the step (4) to 50-60 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) And (3) cooling the mixture obtained in the step (5) to room temperature, adding phenoxyethanol and ethylhexyl glycerol, and stirring and mixing uniformly to obtain the massage cream for tonifying fire and supporting yang, warming middle-jiao and dispelling cold.
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