CN114225003A - Traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold and preparation method and application thereof Download PDFInfo
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- CN114225003A CN114225003A CN202210088353.6A CN202210088353A CN114225003A CN 114225003 A CN114225003 A CN 114225003A CN 202210088353 A CN202210088353 A CN 202210088353A CN 114225003 A CN114225003 A CN 114225003A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention relates to a traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold, a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition are prepared from the following medicinal raw materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia serrulata leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of radix bupleuri, 1-15 parts of scutellaria baicalensis, 1-15 parts of rhizoma alismatis, 1-18 parts of red ginseng, 10-30 parts of cistanche and 10-30 parts of prepared rehmannia root. The traditional Chinese medicine composition and the massage cream prepared from the traditional Chinese medicine composition have the physiotherapy effects of tonifying fire, supporting yang, warming spleen and stomach and dispelling cold, and can remarkably relieve and treat uncomfortable symptoms such as dysmenorrheal and diarrhea caused by insufficient yang qi.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and a preparation method and application thereof.
Background
Substances and functions of promoting, warming and exciting the body belong to yang.
The function of the zang-fu organs will decline due to the decline of yang-qi. The body can have symptoms of qi deficiency, no speaking desire, anorexia, aversion to cold, cold limbs, spontaneous perspiration, pale complexion, diarrhea, abdominal psychroalgia, dreaminess, diarrhea before and during menstruation, and lower abdominal pain.
A series of products aiming at yang deficiency are mainly orally taken products in the market at present, and the products are convenient to take but have the defect of slow absorption. Meanwhile, people with poor spleen and stomach can cause uncomfortable symptoms such as stomachache, diarrhea and the like, which is another physical injury for patients.
Therefore, it is still necessary to develop an external product with the efficacies of tonifying fire, supporting yang, warming the middle-jiao and dispelling cold, which has the advantages of obvious effect, good absorption, no toxic or side effect and convenient use.
Disclosure of Invention
Based on the above, the invention aims to provide a traditional Chinese medicine composition for tonifying fire and supporting yang, warming middle-jiao and dispelling cold, which can effectively relieve symptoms of qi deficiency and disinclination to talk, anorexia, aversion to cold and cold limbs, spontaneous perspiration due to qi deficiency, pale complexion, diarrhea, abdominal cold pain, dreaminess, diarrhea before and during menstruation, lower abdominal pain and the like of a body due to insufficiency of yang qi.
The specific technical scheme is as follows:
the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following medicinal raw materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia serrulata leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of radix bupleuri, 1-15 parts of scutellaria baicalensis, 1-15 parts of rhizoma alismatis, 1-18 parts of red ginseng, 10-30 parts of cistanche and 10-30 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 5-17 parts of pilose antler, 15-25 parts of photinia leaf, 3-8 parts of ginger, 4-12 parts of gentian, 3-9 parts of radix bupleuri, 3-8 parts of scutellaria baicalensis, 3-8 parts of rhizoma alismatis, 5-15 parts of red ginseng, 13-20 parts of cistanche and 15-22 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 10-15 parts of pilose antler, 15-20 parts of photinia serrulata leaf, 4-8 parts of ginger, 7-12 parts of gentian, 4-8 parts of radix bupleuri, 4-8 parts of scutellaria baicalensis, 4-8 parts of rhizoma alismatis, 10-15 parts of red ginseng, 14-18 parts of cistanche and 15-20 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 11-13 parts of pilose antler, 17-19 parts of photinia serrulata leaf, 5-7 parts of ginger, 8-10 parts of gentian, 5-7 parts of radix bupleuri, 5-7 parts of scutellaria baicalensis, 5-7 parts of rhizoma alismatis, 11-13 parts of red ginseng, 15-17 parts of cistanche and 17-19 parts of prepared rehmannia root.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of radix bupleuri, 6 parts of scutellaria baicalensis, 6 parts of rhizoma alismatis, 12 parts of red ginseng, 16 parts of cistanche and 18 parts of prepared rehmannia root.
The traditional Chinese medicine composition disclosed by the invention is prepared from the following selected medicinal materials in part by pharmacological and medicinal properties:
pilose antler: sweet, salty and warm. It enters kidney and liver meridians. Strengthen kidney yang, replenish essence and blood, strengthen tendons and bones, and regulate thoroughfare and conception vessels. To relieve sore and remove toxic materials.
Leaf of Photinia serrulata: mild in nature, pungent and bitter in flavor. Dispelling pathogenic wind and invigorating kidney.
Ginger: pungent and warm. Relieve exterior syndrome, dispel cold, warm middle energizer, arrest vomiting, resolve phlegm and arrest vomiting.
Gentian: bitter and cold entering liver and gallbladder meridians. Clear heat and dry dampness, purge liver and arrest convulsion.
Bupleurum root: bitter and slightly cold entering liver and gallbladder meridians. Harmonize exterior and interior, soothe liver and raise yang.
Scutellaria baicalensis: bitter and cold. It enters lung, gallbladder, spleen and large and small intestines. Clear heat and dry dampness, purge fire and remove toxicity.
Rhizoma alismatis: sweet and cold in nature. Kidney, bladder channel. Induce diuresis, clear damp-heat.
Red ginseng: sweet, slightly bitter and warm. It enters spleen, lung and heart meridians. Tonify primordial qi, recover pulse to stop collapse, nourish qi and control blood. Cistanche deserticola: sweet, salty and warm. It enters kidney and large intestine meridians. Tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation
Prepared rehmannia root: sweet and warm, entering liver and kidney meridians. To nourish yin, enrich blood, replenish essence and replenish marrow.
The traditional Chinese medicine composition has the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold by synergistic cooperation of the medicinal materials, and can effectively relieve and treat diseases or uncomfortable symptoms such as dysmenorrheal and diarrhea caused by insufficient yang qi and decline of vital gate fire.
The invention also provides a preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold.
The specific technical scheme is as follows:
the preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
and (3) taking the medicinal raw materials, crushing or not crushing, then adding water or ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and supporting yang, and warming middle-jiao and dispelling cold.
In some of these embodiments, the adding an aqueous ethanol solution to perform the extraction comprises: ultrasonic extracting for 1-3 times; the conditions for each ultrasound extraction included: the time is 35-75 minutes, the ultrasonic power is 1100-1300 w, and the extraction temperature is 30-45 ℃.
In some of these embodiments, the conditions for each ultrasound extraction include: the time is 45-65 minutes, the ultrasonic power is 1100w-1300w, and the extraction temperature is 30-40 ℃.
In some of these embodiments, the conditions for each ultrasound extraction include: the time is 58 to 63 minutes, the ultrasonic power is 1150w to 1250w, and the extraction temperature is 32 ℃ to 38 ℃.
In some of these embodiments, the volume fraction of the aqueous ethanol solution is 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the medicinal materials.
In some of these embodiments, the adding water to extract comprises: heating and extracting for 1-3 times, wherein the conditions of each extraction comprise: the extraction temperature is 80-100 ℃, the extraction time is 30-55 minutes, and the addition amount of the extracted water is 4-10 times of the total weight of the medicinal materials.
In some embodiments, the concentration is performed under reduced pressure until the mass ratio of the concentrated solution to the total weight of the medicinal raw materials is 0.65-0.70: 1.
In some of these embodiments, the conditions of the reduced pressure concentration include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
The invention also provides application of the traditional Chinese medicine composition.
The specific technical scheme is as follows:
the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is applied to preparation of medicines for preventing and/or treating dysmenorrhea.
The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is applied to preparation of medicines for preventing and/or treating diarrhea.
The application of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in preparing cosmetics or skin care products for improving dysmenorrhea and/or diarrhea is provided.
The invention also provides a massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold.
The specific technical scheme is as follows:
a massage cream for tonifying fire and supporting yang and warming middle-jiao to dispel cold is prepared from functional components and a carrier or auxiliary materials acceptable in the massage cream, wherein the functional components comprise the traditional Chinese medicine composition for tonifying fire and supporting yang and warming middle-jiao to dispel cold.
In some embodiments, the weight percentage of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in the massage cream is 35-45%.
In some embodiments, the massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold is prepared from the following raw materials in percentage by weight:
in some embodiments, the massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold is prepared from the following raw materials in percentage by weight:
the invention also provides a preparation method of the massage cream for warming and activating the channels and collaterals.
The preparation method comprises the following steps:
a preparation method of the massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold comprises the following steps:
(1) adding water, the traditional Chinese medicine composition, 1, 3-propylene glycol, sodium stearyl glutamate, xanthan gum, sodium alginate, allantoin and EDTA disodium into a water kettle, heating to 80-90 ℃, and stirring for dissolving to obtain a water phase mixture;
(2) adding isopropyl myristate, cetostearyl alcohol, steareth-21, polydimethylsiloxane, PEG-100 stearate, glyceryl stearate, steareth-2 and bisabolol into an oil pan, heating to 80-90 deg.C, stirring for dissolving to obtain an oil phase mixture;
(3) mixing butanediol and titanium dioxide, and uniformly grinding;
(4) adding the oil phase mixture obtained in the step (2) into the water kettle obtained in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring and uniformly mixing;
(5) cooling the mixture obtained in the step (4) to 50-60 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) and (3) cooling the mixture obtained in the step (5) to room temperature, adding phenoxyethanol and ethylhexylglycerin, and uniformly stirring and mixing to obtain the massage cream for tonifying fire and supporting yang and warming middle-jiao to dispel cold.
According to the traditional Chinese medicine composition, the traditional Chinese medicine raw materials are selected, according to the theory of 'monarch, minister, assistant and guide' of the traditional Chinese medicine, the pilose antler, the prepared rehmannia root and the cistanche are added as monarch drugs, and the traditional Chinese medicine composition has the effects of tonifying kidney yang, benefiting essence and blood and strengthening bones and muscles; the photinia serrulata leaves and the red ginseng are added as ministers to achieve the effects of strengthening heart and lung and tonifying kidney; the radix scutellariae, the rhizoma alismatis, the radix gentianae and the radix bupleuri are added as assistants to achieve the effects of harmonizing exterior and interior and clearing away heat and toxic materials; ginger is added to lower the adverse-rising energy and warm the middle-jiao. The traditional Chinese medicine composition has the physical therapy effects of tonifying fire and supporting yang, warming the middle-jiao and dispelling cold, can effectively relieve symptoms of qi deficiency and disinclination to talk, anorexia, aversion to cold and cold limbs, spontaneous perspiration, pale complexion, diarrhea, abdominal psychroalgia, dreaminess, diarrhea before and during menstruation, lower abdominal pain and the like caused by insufficient yang qi, and can obviously improve, relieve and treat diseases and uncomfortable symptoms such as dysmenorrheal, diarrhea and the like caused by insufficient yang qi.
The massage cream prepared by combining the traditional Chinese medicine composition for supplementing fire and supporting yang, warming middle-jiao and dispelling cold and a common carrier or matrix of cosmetics has the physiotherapy effects of supplementing fire and supporting yang, warming and activating meridians, and can effectively relieve diseases and uncomfortable symptoms such as dysmenorrheal and diarrhea caused by insufficient yang qi. The massage cream is mild and non-irritant to skin, safe, free of toxic and side effects, convenient to use and convenient to clean.
Detailed Description
In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention provides a traditional Chinese medicine composition for warming and activating meridian, which is prepared from the following raw materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia serrulata leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of radix bupleuri, 1-15 parts of scutellaria baicalensis, 1-15 parts of rhizoma alismatis, 1-18 parts of red ginseng, 10-30 parts of cistanche and 10-30 parts of prepared rehmannia root.
Further preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 5-17 parts of pilose antler, 15-25 parts of photinia leaf, 3-8 parts of ginger, 4-12 parts of gentian, 3-9 parts of radix bupleuri, 3-8 parts of scutellaria baicalensis, 3-8 parts of rhizoma alismatis, 5-15 parts of red ginseng, 13-20 parts of cistanche and 15-22 parts of prepared rehmannia root.
Preferably, the active ingredients of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold are prepared from the following medicinal raw materials in parts by weight: 10-15 parts of pilose antler, 15-20 parts of photinia serrulata leaf, 4-8 parts of ginger, 7-12 parts of gentian, 4-8 parts of radix bupleuri, 4-8 parts of scutellaria baicalensis, 4-8 parts of rhizoma alismatis, 10-15 parts of red ginseng, 14-18 parts of cistanche and 15-20 parts of prepared rehmannia root.
More preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 11-13 parts of pilose antler, 17-19 parts of photinia serrulata leaf, 5-7 parts of ginger, 8-10 parts of gentian, 5-7 parts of radix bupleuri, 5-7 parts of scutellaria baicalensis, 5-7 parts of rhizoma alismatis, 11-13 parts of red ginseng, 15-17 parts of cistanche and 17-19 parts of prepared rehmannia root.
Most preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of radix bupleuri, 6 parts of scutellaria baicalensis, 6 parts of rhizoma alismatis, 12 parts of red ginseng, 16 parts of cistanche and 18 parts of prepared rehmannia root.
According to the traditional Chinese medicine composition provided by the invention, the traditional Chinese medicine raw materials are selected, and each traditional Chinese medicine material has a synergistic interaction effect, so that the obtained traditional Chinese medicine composition has the effects of tonifying fire, supporting yang, warming middle-jiao and dispelling cold, and can effectively relieve and treat diseases or discomfort symptoms such as dysmenorrheal and diarrhea caused by insufficient yang qi.
The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold can be prepared according to a conventional method in the field of traditional Chinese medicines.
Preferably, the preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold comprises the following steps:
and (3) taking the medicinal raw materials, crushing or not crushing, then adding water or ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and supporting yang, and warming middle-jiao and dispelling cold.
In some embodiments, the adding water to perform the extraction comprises: heating and extracting for 1-3 times, wherein the conditions of each extraction comprise: the extraction temperature is 80-100 ℃, the extraction time is 30-55 minutes, and the addition amount of the extracted water is 4-10 times of the total weight of the medicinal materials.
In some embodiments, the adding an aqueous ethanol solution to perform the extraction comprises: ultrasonic extracting for 1-3 times; the conditions for each ultrasound extraction included: the time is 35-75 minutes, the ultrasonic power is 1100-1300 w, and the extraction temperature is 30-45 ℃. Further preferably, the conditions of each ultrasonic extraction include: the time is 45-65 minutes, the ultrasonic power is 1100-1300 w, and the extraction temperature is 30-40 ℃; further preferably, the conditions of each ultrasonic extraction include: the time is 58 minutes to 63 minutes, the ultrasonic power is 1150w to 1250w, and the extraction temperature is 32 ℃ to 38 ℃. The volume fraction of the ethanol water solution is preferably 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the medicinal materials.
In some embodiments, the concentration is reduced pressure concentration until the mass ratio of the concentrated solution to the total weight of the medicinal raw materials is 0.65-0.70: 1.
in some of these embodiments, the conditions of the reduced pressure concentration comprise: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines, health-care products or cosmetics for tonifying fire and supporting yang, and warming middle-jiao to dispel cold.
The traditional Chinese medicine composition provided by the invention can be prepared into a massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold with a common carrier or matrix in cosmetics. The weight percentage of the traditional Chinese medicine composition in the massage cream is preferably 35-45%. The massage cream has the physiotherapy effects of invigorating fire, tonifying yang, warming spleen and stomach, dispelling cold, and can effectively relieve diseases and discomfort symptoms such as dysmenorrhea, diarrhea, etc. caused by yang qi deficiency. The massage cream is mild and non-irritant to skin, safe, free of toxic and side effects, convenient to use and convenient to clean.
The massage cream can be prepared by a conventional preparation method in the field of cosmetics.
The present invention will be described in further detail with reference to specific examples.
Example 1
The traditional Chinese medicine composition with the effects of supplementing fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following medicinal raw materials in parts by weight:
12 parts of pilose antler, 18 parts of photinia leaf, 6 parts of ginger, 9 parts of gentian, 6 parts of radix bupleuri, 6 parts of scutellaria baicalensis, 6 parts of rhizoma alismatis, 12 parts of red ginseng, 16 parts of cistanche and 18 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing the raw materials according to the weight parts, drying the prepared rehmannia root and the cistanche under reduced pressure (60-70 ℃ and-0.08 MPa-0.1 MPa), then crushing the dried prepared rehmannia root and the cistanche together with the rest medicinal materials, and crushing the crushed medicinal materials into coarse powder to obtain the Chinese medicinal powder.
(2) Adding an ethanol water solution with the weight 8 times of the total weight of the medicinal materials and the volume fraction of 60% into the traditional Chinese medicine powder obtained in the step (1), and carrying out ultrasonic extraction for 1 time, wherein the extraction conditions are as follows: the time is 60 minutes, the ultrasonic power is 1200w and the temperature is 35 ℃.
(3) And (3) carrying out low-speed centrifugation on the extracted product obtained in the step (2) (the rotating speed of a centrifugal machine is 2000rpm, the mesh number of filter cloth is 400 meshes), and taking the supernatant and then carrying out high-speed centrifugation (the rotating speed of the centrifugal machine is 20000rpm, the rotating speed of a peristaltic pump is 20rpm, and the pipe diameter is 6 mm). Collecting the supernatant to obtain the first extractive solution.
(4) Adding ethanol water solution with weight 6 times of the total weight of the medicinal materials and volume fraction of 35% into the residue obtained after low-speed centrifugation, and performing ultrasonic extraction for 1 time under the following extraction conditions: the time is 60 minutes, the ultrasonic power is 1200w and the temperature is 35 ℃.
(5) And (4) carrying out low-speed centrifugation (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 meshes) on the extraction product obtained in the step (4), taking the supernatant, carrying out high-speed centrifugation (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, and the pipe diameter is 6mm), and taking the supernatant to obtain a second extracting solution.
(6) Combining the first extract and the second extract, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa-0.1 MPa), recovering ethanol, and concentrating until the mass ratio of the concentrated solution to the total weight of the medicinal materials is 0.67: 1.0 hr (i.e. concentrating to 670g per kg of medicinal materials).
Example 2
The traditional Chinese medicine composition with the effects of supplementing fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following medicinal raw materials in parts by weight:
20 parts of pilose antler, 10 parts of photinia leaf, 1 part of ginger, 1 part of gentian, 15 parts of radix bupleuri, 15 parts of scutellaria baicalensis, 1 part of rhizoma alismatis, 5 parts of red ginseng, 10 parts of cistanche and 10 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the medicinal materials according to the weight parts, placing the medicinal materials into an extraction tank, adding water (the weight of the added water is 8 times of the total weight of the medicinal materials), soaking for 30 minutes, and then starting heating extraction at the temperature of 100 ℃ for 55 minutes. Filtering after extraction to obtain filtrate 1. Adding water (the weight of the water is 6 times of the total weight of the medicinal materials) into the obtained medicinal residues, heating and extracting at 100 deg.C for 30 min, filtering after extraction to obtain filtrate 2, and discarding the medicinal residues. And combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (namely, concentrating each kilogram of medicinal materials to 670 g).
Example 3
The traditional Chinese medicine composition with the effects of supplementing fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following traditional Chinese medicinal materials in parts by weight:
5 parts of pilose antler, 15 parts of photinia leaf, 3 parts of ginger, 4 parts of gentian, 9 parts of radix bupleuri, 3 parts of scutellaria baicalensis, 8 parts of rhizoma alismatis, 18 parts of red ginseng, 13 parts of cistanche and 15 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
weighing the medicinal materials according to the weight parts, placing the medicinal materials into an extraction tank, adding water (the weight of the added water is 6 times of the total weight of the medicinal materials), soaking for 30 minutes, and then starting heating extraction at 100 ℃ for 45 minutes. Filtering after extraction to obtain filtrate 1. Adding water (the weight of the water is 4 times of the total weight of the medicinal materials) into the obtained medicinal residues, heating and extracting at 100 deg.C for 30 min, filtering after extraction to obtain filtrate 2, and discarding the medicinal residues. And combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (namely, concentrating each kilogram of medicinal materials to 670 g).
Example 4
The traditional Chinese medicine composition with the effects of supplementing fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following traditional Chinese medicinal materials in parts by weight:
1 part of pilose antler, 30 parts of photinia leaf, 10 parts of ginger, 15 parts of gentian, 3 parts of radix bupleuri, 1 part of scutellaria baicalensis, 3 parts of rhizoma alismatis, 15 parts of red ginseng, 20 parts of cistanche and 30 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing the raw materials according to the weight parts, drying the cistanche and the prepared rehmannia root under reduced pressure (60-70 ℃ and-0.08 MPa-0.1 MPa), crushing the dried cistanche and the prepared rehmannia root together with the rest raw materials, and crushing the mixture into coarse powder. Obtaining the traditional Chinese medicine powder.
(2) Adding ethanol aqueous solution with the weight 10 times of the total weight of the medicinal materials and the volume fraction of 45% into the traditional Chinese medicine powder obtained in the step (1), and carrying out ultrasonic extraction for 1 time, wherein the extraction conditions are as follows: the time is 45 minutes, the ultrasonic power is 1200w and the temperature is 35 ℃.
(3) And (3) carrying out low-speed centrifugation (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 meshes) on the extraction product obtained in the step (2), taking the supernatant, carrying out high-speed centrifugation (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, and the pipe diameter is 6mm), and taking the supernatant to obtain a first extracting solution.
(4) Adding ethanol water solution with the weight 10 times of the total weight of the medicinal materials and the volume fraction of 35% into the medicine residue obtained in the step (3), and ultrasonically extracting for 1 time, wherein the extraction conditions are as follows: the time is 45 minutes, the ultrasonic power is 1200w and the temperature is 35 ℃.
(5) And (3) performing low-speed centrifugation (the rotation speed of a centrifugal machine is 2000RPM, the mesh number of filter cloth is 400 meshes) on the extract obtained in the step (4), taking the supernatant, performing high-speed centrifugation (the rotation speed of the centrifugal machine is 20000RPM, the rotation speed of a peristaltic pump is 20RPM, and the pipe diameter is 6mm), and taking the supernatant to obtain a second extracting solution.
(6) Mixing the first extract and the second extract, concentrating under reduced pressure (70-75 deg.C, 0.08 MPa-0.1 MPa), recovering ethanol, and concentrating until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (i.e. concentrating to 670g per kg of medicinal materials).
Example 5
The traditional Chinese medicine composition with the effects of supplementing fire, supporting yang, warming middle-jiao and dispelling cold is prepared from the following traditional Chinese medicinal materials in parts by weight:
17 parts of pilose antler, 25 parts of photinia leaf, 8 parts of ginger, 12 parts of gentian, 1 part of radix bupleuri, 8 parts of scutellaria baicalensis, 15 parts of rhizoma alismatis, 1 part of red ginseng, 30 parts of cistanche and 22 parts of prepared rehmannia root.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing the raw materials of the medicinal materials according to the parts by weight.
(2) Putting the traditional Chinese medicine powder obtained in the step (1) into an extraction tank, adding water (the weight of the added water is 10 times of the total weight of the medicinal materials), soaking for 30 minutes, and then starting heating extraction at the temperature of 100 ℃ for 35 minutes. Filtering after extraction to obtain filtrate 1. Adding water (the weight of the water is 8 times of the total weight of the medicinal materials) into the obtained medicinal residues, heating and extracting at 100 deg.C for 35 min, filtering after extraction to obtain filtrate 2, and discarding the medicinal residues. And combining the filtrate 1 and the filtrate 2, concentrating under reduced pressure (70-75 ℃ and-0.08 MPa-0.1 MPa) until the mass ratio of the medicinal materials to the concentrated solution is 1:0.67 (namely, concentrating each kilogram of medicinal materials to 670 g).
Example 6
The embodiment provides a massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold, which comprises the traditional Chinese medicine composition (main functional ingredients) prepared in the embodiment 1 and a cosmetic carrier, wherein the cosmetic carrier comprises a solvent, a skin conditioner, a humectant, an emollient, a thickener, an emulsifier, a chelating agent and the like; wherein the contents of all components are shown in
TABLE 1 (weight percent of the components in the table%)
The preparation method of the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold in the embodiment is as follows:
(1) adding the components 1, 2, 12, 13, 14, 15 and 17 into a water kettle, heating to 85 ℃, and stirring to fully dissolve;
(2) adding the components 4, 5, 6, 7, 8, 9 and 16 into an oil pan, heating to 85 ℃, and stirring to completely dissolve;
(3) pre-mixing the component 3 and the component 11, and uniformly grinding;
(4) adding the mixture obtained in the step (2) into the water kettle obtained in the step (1), homogenizing, stirring and mixing uniformly, adding the mixture obtained in the step (3) into the water kettle, homogenizing, stirring and mixing uniformly;
(5) cooling the mixture obtained in the step (4) to 55 ℃, adding the component 18, and uniformly stirring;
(6) and (3) cooling the mixture obtained in the step (5) to room temperature, adding the residual material component 10, and uniformly stirring and mixing to obtain a finished product, namely the massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold prepared in the embodiments 6-1, 6-2 and 6-3 respectively.
EXAMPLE 7 storage stability test of the massage cream for tonifying fire and supporting Yang, warming the middle-jiao and dispelling cold prepared in example 6-1, 6-2 and 6-3
High temperature resistance test: adjusting a constant temperature incubator to 45 +/-1 ℃ in advance, weighing about 10g of massage cream for supplementing fire and supporting yang and warming the middle and dissipating cold (example 6-1, example 6-2 and example 6-3) in weighed culture dishes respectively, strickling, precisely weighing, obliquely placing on a 15-degree frame in the constant temperature incubator for 24 hours, sampling, placing in a dryer for cooling, weighing again, if oil seeps out, carefully wiping off the oil to leave a paste part, weighing the culture dishes and the rest paste part, and calculating the oil seepage rate of a sample according to the following formula (numerical values are expressed in percent):
oil permeability (%) - (m)1-m2) 100% m (m-mass of sample, unit in g; m is1-the mass of the sample plus the mass of the culture dish after 24 hours, in g; m is2The mass of the sample after the oil-bleed portion was wiped off plus the mass of the petri dish in g) and the results are given in table 2 below: in a high-temperature resistance experiment, the oil permeability of the massage creams for tonifying fire and strengthening yang and warming the middle-jiao and dispelling cold prepared in the examples 6-2 and 6-3 is more than 0.1%, and the massage creams for tonifying fire and strengthening yang and warming the middle-jiao and dispelling cold prepared in the examples 6-1 are more stable in property.
Low temperature resistance test: the massage creams for tonifying fire and strengthening yang and warming the middle-jiao and dispelling cold prepared in the embodiments 6-1, 6-2 and 6-3 are placed at the temperature of-5 to 10 ℃ for 24 hours and then returned to the room temperature, and the massage creams for tonifying fire and strengthening yang and warming the middle-jiao and dispelling cold prepared in the embodiments 6-2 and 6-3 have the phenomenon of coarseness; the massage cream prepared in example 6-1 has no obvious change in effects of nourishing fire, supporting yang, warming the middle-jiao and dispelling cold.
TABLE 2
Example 8 skin irritation test of massage cream for tonifying fire, supporting yang, warming the middle-jiao, and dispelling cold
Single and multiple skin irritation tests were performed using the fire-tonifying yang-supporting, middle-warming and cold-dispelling massage cream of example 6-1.
1. Test drugs
Example 6-1 massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold
2. Test animal
20 healthy white rabbits (single skin irritation test) were used for both males and females, weighing (2.0+0.2) kg; 50 Kunming mice (multiple skin irritation tests) are used for both male and female, and the weight is 18-22 g. The experimental animals are provided by southern medical university laboratory center (license number: SCXK (Yue) 2011-. The animals are all bred in a single cage, fed freely and drunk freely, and are adapted to the environment of an animal house by feeding the animals regularly for 5 days before experiments.
3. Test methods and results
3.1 methods
The skin irritation test method and procedure of single administration and multiple administration were performed according to the skin irritation test method and procedure of "cosmetic safety specification 2015", wherein the test group was applied with the massage cream for tonifying fire and supporting yang, warming middle-jiao and dispelling cold of example 6-1 of the present invention, and the control group was not applied with any substance.
3.2 results
3.2.1 Single-dose skin irritation test, in which all rabbits were coated with 0.2g/kg of the test substance on the depilated skin area on one side and the skin on the other side was used as a control. The skin irritation intensity of the massage cream of example 6-1 was judged by applying the skin irritation cream for 2 hours in a closed test, removing the test substance, observing the skin reaction at the applied part for 1, 24, 48 and 72 hours, respectively, and observing the skin irritation intensity of the massage cream of example 6-1 according to the observation for 1, 24, 48 and 72 hours. The results are shown in Table 3.
TABLE 3
The results show that: 1. the skin reaction of the smearing part is observed for 24, 48 and 72 hours, and no erythema or edema, pimple, congestion and ulcer are observed. The total evaluation score and the average score of the skin irritation response are both 0, and the average response irritation intensity is less than 0.5, which indicates no irritation.
3.2.2 skin irritation test with multiple administrations, in the test process, 0.5g of the test substance is smeared on the unhaired skin area of one side of all Kunming mice, and the skin of the other side is used as a control. Applied 1 time per day for 14 days. From the next day, the hair should be cut and the residual test substance removed with water or a non-irritating solvent before each application. The results were observed for one hour. The results of judging the skin irritation intensity of the massage cream of example 6-1 by a plurality of times are shown in Table 4.
TABLE 4
The results show that 50 tested Kunming mice, 1 of which showed erythema and 1 of which showed papules, were scored on average less than 0.5 per animal per day on the first day; the next day 50 test Kunming mice, one of which developed pimples with an average score per animal of less than 0.5 per day; on days 3-14, all of the Kunming mice tested did not develop papules, erythema, congestion, ulcers. Multiple skin irritation levels were non-irritating according to standard evaluation criteria.
Example 9 antidiarrheal Effect test
In this example, the antidiarrheal effect of the Chinese medicinal composition of the present invention was tested by examining the effect of the massage cream prepared from the Chinese medicinal composition of the present invention on the number of defecation granules of mice with senna leaf-induced diarrhea.
Experimental animals: healthy Kunming mice, five weeks old, 18-22g in weight, clean grade, 105 mice, randomly divided into 7 groups: normal control group, model control group, experimental group 1-experimental group 5, 15 of each group. The experimental animals are provided by southern medical university laboratory center (license number: SCXK (Yue) 2011-. The indoor temperature is 24 +/-1 ℃, and the test is carried out after 5 days of adaptive feeding.
Establishing a mouse diarrhea model by using senna leaf decoction, wherein the preparation method of the senna leaf decoction comprises the following steps: soaking 15g folium sennae in 100ml water for 15 min, boiling with middle fire for 15 min, stopping fire, and filtering to obtain folium sennae decoction).
The tested drugs are: the test drug of experimental group 1 was the massage cream prepared in example 6-1 (the Chinese medicinal composition prepared in example 1 was added); the tested drugs of experimental groups 2-5 were: the massage creams prepared by the method of the embodiment 6-1 are added with the Chinese medicinal composition of the embodiment 2-5 respectively; namely, the massage creams of the experimental groups 1 to 5 are different in the added Chinese medicinal composition, and the other components and the preparation method are the same as those of the massage cream of the example 6-1.
The normal control group mice were not treated at all; taking model control group and experimental group 1-5, fasting for 24 hr, and performing intragastric administration with a 12 # 55mm small-head bent intragastric administration device according to 0.15mL/10g folium sennae decoction; then, the mice of the model control group are not treated, and the experimental groups 1-5 coat corresponding massage creams on the Guanyuan acupoint, the Zusanli acupoint and the nearby area of the mice, wherein the coating amount is 0.1mg, the coating is carried out for 1 minute each time, the administration is carried out for 2 times, and the interval time is 2 hours; after the administration, each group of mice was normally rested and fed with a diet, the mice were observed and the total number of wet feces excreted for 24 hours from each group of mice was calculated. The test results are shown in table 5.
TABLE 5
| Group of | Number of animals | Number of wet manure particles |
| Normal control group | 15 | 15.23±1.79 |
| Model control group | 15 | 25.87±1.68 |
| Experimental group 1 | 15 | 16.47±1.57 |
| Experimental group 2 | 15 | 20.67±1.49 |
| Experimental group 3 | 15 | 20.28±1.69 |
| Experimental group 4 | 15 | 21.79±1.59 |
| Experimental group 5 | 15 | 22.78±1.64 |
From the above results it can be seen that: the number of wet feces discharged by the mice in the model control group in 24 hours is obviously higher than that of the mice in the normal group, which indicates that the diarrhea model of the mice is successfully established. The number of wet feces grains discharged by the mice in the experimental groups 1-5 in 24 hours is reduced to a certain extent compared with that of a model control group, which shows that the massage cream prepared by the traditional Chinese medicine composition can reduce the number of the feces grains of the mice with senna leaf-induced diarrhea and has a good antidiarrheal effect, wherein the massage cream prepared by the traditional Chinese medicine composition in the embodiment 1 has the best antidiarrheal effect.
Example 10 clinical efficacy test of massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold
Subject selection: 400 female dysmenorrhea patients who met the criteria for inclusion were selected as subjects, aged 18-40 years.
Subject inclusion criteria: dysmenorrhea is manifested by abdominal discomfort and radioactive pain in lumbosacral regions before and during menstruation, accompanied by any of the following symptoms (aversion to cold, cold limbs, abdominal pain, cold pain in waist and knees, frequent nocturia, dysuria, edema of limbs, dark red menstruation with blood clot, and diarrhea during or before menstruation).
The tested drugs are: treatment groups: the massage cream prepared in example 6-1; control group: the massage cream prepared according to the method of example 6-1, to which the Chinese medicinal composition of the present invention was not added, i.e., the massage cream of the control group was different from the massage cream prepared according to example 6-1 in that the Chinese medicinal composition of the present invention was not added, and the other components and the preparation method were the same as those of example 6-1.
The application method of the massage cream comprises the following steps: 1. the subject lies prostrate, takes a proper amount of massage cream to be evenly smeared on the lower waist and the back, massages the channels and collaterals of the lower waist and the back in sequence for 30 minutes, warms up for 20 minutes by using a far infrared lamp, and then scrubs by using a paper towel or warm water; 2. the testee lies on the back, a proper amount of massage cream is uniformly smeared on the lower abdomen, the channels and collaterals of the lower abdomen are sequentially massaged for 30 minutes, and then the testee is warmed for 20 minutes by using a far infrared lamp and then scrubbed by using a paper towel or warm water. It is applied before menstruation and stopped on the day of menstruation. The treatment is given once every 2 days, 4 times as a course of treatment.
Evaluation criteria for efficacy: all symptoms such as discomfort of lower abdomen and radioactive pain of lumbosacral parts during and before menstruation, chilly limbs, abdominal psychroalgia, psychroalgia of waist and knees, frequent nocturia, dysuresia, limb edema, dark red menstruation with blood clot, and diarrhea in menstrual period or before menstruation disappear to cure; the symptoms such as discomfort of lower abdomen and radioactive pain of lumbosacral parts during and before menstruation, chilly limbs, abdominal psychroalgia, psychroalgia of waist and knees, frequent nocturia, dysuresia, limb edema, dark red menstruation with blood clot, diarrhea in menstrual period or before menstruation are improved, and the like are effective; all symptoms such as discomfort of lower abdomen and radioactive pain of lumbosacral parts during and before menstruation, chilly limbs, abdominal psychroalgia, psychroalgia of waist and knees, frequent nocturia, dysuresia, edema of limbs, dark red menstruation with blood clot, and diarrhea in menstruation or before menstruation are unchanged and are ineffective.
The effect after one treatment course is shown in table 6.
TABLE 6
The results show that: 200 of the participants, wherein 178 participants completely disappear all symptoms such as discomfort of lower abdomen and radioactive pain of lumbosacral parts during and before menstruation, cold limbs, abdominal psychroalgia, psychroalgia of waist and knees, frequent nocturia, dysuresia, edema of limbs, dark red menstruation with blood clot, beginning diarrhea during or before menstruation, and the like; all symptoms of aversion to cold, cold limbs, abdominal cold pain, cold pain of waist and knees, frequent nocturia, dysuresia, edema of limbs, dark red menstruation with blood clot, and diarrhea during or before menstruation of 14 participants in the menstrual period and before the menstrual period, and radioactive pain of parts of lumbosacral and the like are improved; the symptoms of aversion to cold, cold limbs, abdominal cold pain, cold pain of waist and knees, frequent nocturia, difficult urination, edema of limbs, dark red menstruation with blood clots, menstrual diarrhea or diarrhea before menstruation and the like of 8 participants in the menstrual period and before the menstrual period are not improved, and the effective rate is 96.0%. In the control group, 200 test persons were enrolled, all the participants had no improvement in symptoms such as discomfort in the lower abdomen and radioactive pain in the lumbosacral region during and before menstruation, cold limbs and aversion to cold, abdominal cold pain, cold pain in the waist and knees, frequent nocturia, dysuria, edema of limbs, dark red menstruation with blood clots, and diarrhea in the menstruation or before menstruation, and the effective rate was 0.
Example 11 clinical efficacy test of massage cream for tonifying fire, supporting yang, warming middle-jiao and dispelling cold
Subject selection: 300 diarrhea patients meeting the inclusion criteria of the subjects are selected as the subjects, and the patients are 18-60 years old and are male and female.
Subject inclusion criteria: diarrhea is accompanied by any of the following symptoms (white complexion, aversion to cold, cold limbs, cold pain in the abdomen, soreness and weakness of the waist and knees, frequent nocturia, pale and swollen tongue with teeth marks).
The tested drugs are: treatment groups: the massage cream prepared in example 6-1; control group: the massage cream prepared according to the method of example 6-1, to which the Chinese medicinal composition of the present invention was not added, i.e., the massage cream of the control group was different from the massage cream prepared according to example 6-1 in that the Chinese medicinal composition of the present invention was not added, and the other components and the preparation method were the same as those of example 6-1.
The application method of the massage cream comprises the following steps: 1. the subject lies prostrate, takes a proper amount of massage cream to be evenly smeared on the lower waist and the back, massages the channels and collaterals of the lower waist and the back in sequence for 30 minutes, warms up for 20 minutes by using a far infrared lamp, and then scrubs by using a paper towel or warm water; 2. the testee lies on the back, a proper amount of massage cream is uniformly smeared on the lower abdomen, the channels and collaterals of the lower abdomen are sequentially massaged for 30 minutes, and then the testee is warmed for 20 minutes by using a far infrared lamp and then scrubbed by using a paper towel or warm water. The treatment is given once every 2 days, 4 times as a course of treatment.
Evaluation criteria for efficacy: diarrhea, all symptoms accompanied with white complexion, aversion to cold, cold limbs, psychroalgia in abdomen, soreness of waist and knees, frequent micturition at night, pale and swollen tongue with teeth mark disappear to cure; the composition can be used for improving diarrhea accompanied with white complexion, aversion to cold, cold limbs, psychroalgia in abdomen, soreness of waist and knees, frequent micturition at night, pale and swollen tongue, and teeth mark; diarrhea, marked by white complexion, aversion to cold, cold limbs, cold pain in the abdomen, soreness and weakness of the waist and knees, frequent urination at night, pale and swollen tongue with teeth marks, was not effective.
The effect after one treatment course is shown in table 7.
TABLE 7
The results show that: in the treatment group, 150 ginseng test persons, wherein 145 ginseng test persons have diarrhea and all symptoms accompanied with white complexion, intolerance of cold, cold limbs, abdominal psychroalgia, soreness and weakness of waist and knees, frequent micturition at night, pale and swollen tongue with teeth marks disappear; 3 ginseng testers have improved diarrhea accompanied with all symptoms of white complexion, intolerance of cold, cold limbs, cold pain in abdomen, soreness and weakness of waist and knees, frequent micturition at night, pale and swollen tongue with teeth marks; the diarrhea of 2 tested persons has no obvious change along with all symptoms of white complexion, intolerance of cold, cold limbs, cold pain in abdomen, soreness and weakness of waist and knees, frequent micturition at night, pale and swollen tongue and tooth marks; the effective rate is 98.67%
In the control group, 150 participants had diarrhea, and all the diarrhea symptoms accompanied with white complexion, aversion to cold, cold limbs, cold pain in abdomen, soreness and weakness of waist and knees, frequent micturition at night, pale and swollen tongue with teeth marks were not changed significantly.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold is characterized in that the active ingredients are prepared from the following medicinal raw materials in parts by weight: 1-20 parts of pilose antler, 10-30 parts of photinia serrulata leaf, 1-10 parts of ginger, 1-15 parts of gentian, 1-15 parts of radix bupleuri, 1-15 parts of scutellaria baicalensis, 1-15 parts of rhizoma alismatis, 1-18 parts of red ginseng, 10-30 parts of cistanche and 10-30 parts of prepared rehmannia root.
2. The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 1, characterized in that the active ingredients are prepared from the following medicinal raw materials in parts by weight: 10-15 parts of pilose antler, 15-20 parts of photinia serrulata leaf, 4-8 parts of ginger, 7-12 parts of gentian, 4-8 parts of radix bupleuri, 4-8 parts of scutellaria baicalensis, 4-8 parts of rhizoma alismatis, 10-15 parts of red ginseng, 14-18 parts of cistanche and 15-20 parts of prepared rehmannia root.
3. The traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 1, characterized in that the active ingredients are prepared from the following medicinal raw materials in parts by weight: 11-13 parts of pilose antler, 17-19 parts of photinia serrulata leaf, 5-7 parts of ginger, 8-10 parts of gentian, 5-7 parts of radix bupleuri, 5-7 parts of scutellaria baicalensis, 5-7 parts of rhizoma alismatis, 11-13 parts of red ginseng, 15-17 parts of cistanche and 17-19 parts of prepared rehmannia root.
4. A method for preparing the traditional Chinese medicine composition for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold according to any one of claims 1 to 3, which is characterized by comprising the following steps:
and (3) taking the medicinal raw materials, crushing or not crushing, then adding water or ethanol water solution for extraction, centrifuging or filtering, and concentrating to obtain the traditional Chinese medicine composition for tonifying fire and supporting yang, and warming middle-jiao and dispelling cold.
5. The preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 4, wherein the adding ethanol water solution for extraction comprises: ultrasonic extracting for 1-3 times; the conditions for each ultrasound extraction included: the time is 35 to 75 minutes, the ultrasonic power is 1100 to 1300w, and the extraction temperature is 30 to 45 ℃;
the adding water for extraction comprises: heating and extracting for 1-3 times, wherein the conditions of each extraction comprise: the extraction temperature is 80-100 ℃, the extraction time is 30-55 minutes, and the addition amount of the extracted water is 4-10 times of the total weight of the medicinal materials each time;
preferably, the conditions for each ultrasound extraction include: the time is 58 minutes to 63 minutes, the ultrasonic power is 1150w to 1250w, and the extraction temperature is 32 ℃ to 38 ℃;
preferably, the volume fraction of the ethanol aqueous solution is 35-65%; the addition amount of the ethanol water solution extracted each time is 6-10 times of the total weight of the medicinal materials.
6. The preparation method of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold according to claim 4 or 5, characterized in that the concentration is carried out under reduced pressure until the mass ratio of the concentrated solution to the total weight of the raw materials of the medicinal materials is 0.65-0.70: 1; preferably, the conditions for concentration under reduced pressure include: the temperature is 70-75 ℃, and the pressure is-0.08 MPa to-0.1 MPa.
7. Use of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold according to any one of claims 1 to 3 in the preparation of medicines, cosmetics or skin care products for improving, preventing and/or treating dysmenorrhea and/or diarrhea.
8. A massage cream for tonifying fire and supporting yang and warming the middle-jiao to dispel cold is characterized by being prepared from an effective component and a carrier or an auxiliary material acceptable in the massage cream, wherein the effective component comprises the traditional Chinese medicine composition for tonifying fire and supporting yang and warming the middle-jiao to dispel cold according to any one of claims 1 to 3;
preferably, the weight percentage of the traditional Chinese medicine composition for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold in the massage cream is 35-45%.
9. The massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold according to claim 8 is characterized by being prepared from the following raw materials in percentage by weight:
preferably, the massage cream for tonifying fire and yang and warming the middle-jiao to dispel cold is prepared from the following raw materials in percentage by weight:
10. a method for preparing the massage cream for tonifying fire, supporting yang, warming the middle-jiao and dispelling cold according to claim 9, which is characterized by comprising the following steps:
(1) adding water, the Chinese medicinal composition, 1, 3-propylene glycol, sodium stearyl glutamate, xanthan gum, sodium alginate, allantoin and disodium EDTA into a water kettle, heating to 80-90 deg.C, stirring for dissolving to obtain water phase mixture;
(2) adding isopropyl myristate, cetostearyl alcohol, steareth-21, polydimethylsiloxane, PEG-100 stearate, glyceryl stearate, steareth-2 and bisabolol into an oil pan, heating to 80-90 ℃, and stirring for dissolving to obtain an oil phase mixture;
(3) mixing butanediol and titanium dioxide, and uniformly grinding;
(4) adding the oil phase mixture obtained in the step (2) into the water kettle obtained in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring and uniformly mixing;
(5) cooling the mixture obtained in the step (4) to 50-60 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) and (3) cooling the mixture obtained in the step (5) to room temperature, adding phenoxyethanol and ethylhexylglycerin, and uniformly stirring and mixing to obtain the massage cream for tonifying fire and supporting yang and warming middle-jiao to dispel cold.
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