CN105998460A - Composition with efficacies of eliminating sleepiness as well as refreshing mind and preparation method of composition - Google Patents

Abstract

The invention relates to a composition with the efficacies of eliminating the sleepiness as well as refreshing the mind and a preparation method of the composition. The composition is characterized by being prepared from medicinal materials with the efficacy of inducing resuscitation and refreshing the mind, medicinal materials being fragrant and refreshing, medicinal materials being cool and refreshing, and medicinal materials being fragrant, being capable of invigorating the stomach, and being capable of inducing resuscitation, specifically, the composition is prepared from 0.2-20 weight parts of the medicinal materials with the efficacy of inducing resuscitation and refreshing the mind, 0.01-25 weight parts of the medicinal materials being fragrant and refreshing, 1-100 weight parts of the medicinal materials being cool and refreshing, and 0.01-40 weight parts of the medicinal materials being fragrant, being capable of invigorating the stomach, and being capable of inducing resuscitation. The composition is prepared into external preparations, wherein the external preparations comprise pigmentum, tinctures, liniments, gels, sprays, essential oil, plastics, lotions, cream, patches and plasters. The composition takes effect through the permeation of the skin, the meridians and collaterals and the acupuncture points, has the efficacies of eliminating sleepiness and refreshing the mind, is applied to fatigue and tiredness, brain swelling, sleepiness, dozing and the like caused by mental fatigue and physical fatigue, and enables a user to be invigorating, have concentrated attention, and have the enhanced physical ability. The composition is scientific and reasonable in formula and definite in effects, is safe and comfortable, is convenient to use, and has great economic value and social value.

Description

A kind of compositions driving away drowsiness, refreshment and preparation method thereof

Technical field

The invention belongs to practical technique field outside pharmaceutical preparation, be specifically related to a kind of group driving away drowsiness, refreshment Compound and preparation method thereof.

Background technology

Along with the continuous quickening of people's rhythm of life, the continuous increase of operating pressure, the deficiency of rest length of one's sleep, life Irregular, brain is chronically at high-pressure state, the situation felt sleepy, doze off often occurs, have influence on we work and Life；Or it is engaged in a certain operation, brain high-pressure for a long time, is easy for producing fatigue, enters drowsy, doze shape State, impact works on, and time serious, even injures life security, as dozed off in driving limit, limit, inevitable very dangerous.How Overcome this situation, maintenance brain sustained activity, maintain normal work, to this end, it is tired to it is desirable to research and develop effectively alleviation Labor, drive away sleepy, the medicine of refreshment, to help people to improve work efficiency, the most long-distance drive, student takes an examination, add Class stay up late wait personage need keep brain regain consciousness, attention concentration.The present invention be exactly for this purpose and researched and developed a kind of in advance Anti-fatigue, expeling drowsiness, the pharmaceutical composition of refreshment and preparation method.

Summary of the invention

It is an object of the invention to provide a kind of compositions driving away drowsiness, refreshment and preparation method thereof.The present invention is Grope the achievement obtained through long term test research by modern science and technology on the basis of traditional medicine.It by have strongly have one's ideas straightened out awake Brain, the Styrax of stimulating central nervous system system, Benzoinum, Camphora and there is causing resuscitation with aromatic drugs, the Lemon fruit haze wax of refreshment, indigo plant Oleum Eucalypti, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil etc. being furnished with have refrigerant ice feel well refresh oneself, Mentholum that clearance is had one's ideas straightened out, Herba Menthae Oil, Borneolum Syntheticum and being also aided with have a removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae with protection gastric qi of having one's ideas straightened out, facilitating digestion liquid point Secrete and prevent gastrointestinal abnormal fermentation, alleviate intestinal tube smooth muscle spasm, Oleum Caryophylli that stomach invigorating is refreshed oneself, Oleum Cinnamomi, Oleum Anisi Stellati, Folium Perillae The medicine compositions such as oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract；Thus constitute and have one's ideas straightened out when refreshing oneself, protect human righteousness, in making human righteousness Deposit, evil irrelevant, accomplish to refresh oneself and do not overtax one's nerves.

Principal agent of the present invention shows have stimulating central nervous system system for having strong inducing resuscitation, i.e. modern pharmacological research, Anti-hypoxia, protection brain, make brain keep the medicine of the effects such as excitatory state, and through experimental study, Soviet Union specifically selected by this group medicine Blending, Benzoinum and Camphora.

Styrax: the balsam oozed out for Hamamelidaceae Plants Styrax tree trunk, processed refining forms.Main product in The states such as the Turkey south of boundary, continent, Europe, Asia and Africa three and Syria, Egypt, Somalia.Styrax acrid in the mouth, warm in nature, GUIXIN, Spleen two warp, has refreshment of having one's ideas straightened out, and wards off dirty, effect of pain relieving, and modern pharmacological research shows, Styrax have penetrate blood brain barrier, The effects such as excited maincenter, anti-hypoxia, brain protection.

Benzoinum: for Styracaceae plant styrax tonkinensis Craib ex Hart trunk through naturally damage or in the summer, isolate in season in autumn two trunk flow out After the resin that dries in the shade.Benzoinum main product is in Indonesian Sumatera and Vietnam, Laos, Thailand etc..Its acrid in the mouth, hardship, property Temperature, enters heart spleen lung stomach warp, has effect of refreshment of having one's ideas straightened out, blood-activating and qi-promoting, pain relieving.Modern pharmacological research shows, Benzoinum has emerging Put forth energy central action, effect protected to cerebral hypoxia ischemia；Blood brain barrier is had certain open effect, azovan blue can be promoted (EB) cerebral tissue, significant potentiation are entered；There is certain anti-endotoxin effect；Antioxidant activity.

Camphora: for root, dry, branch, the leaf of canella Camphor tree, through the crystalline particulate that refinement is made.To higher nervous center There is obvious excitation, in vivo through metabolic conversion, have obvious heart tonifying, boosting and excited Repiration.Camphora is applied to skin Skin has stimulation and the antisepsis of gentleness.Firmly embrocate and sent out effect red；Dab then has refrigerant sense, and this is owing to stimulating sense of cold sense The effect of receiver.

The use of these inducing resuscitation class medicines is a quantum jump of the present invention.Mainly collect at existing refreshment series products In refresh oneself at fragrance, by smearing or champignon, nose hear enfleurage material joyful spirit, stabilizing the emotions, or cool refreshing, i.e. local are refrigerant Stimulation, or both combinations.And champignon therapy only by nose hear inhale limited to central excitation, refrigerant stimulation only surface and effect is short Temporarily, thus, these product efficacy are extremely limited, the most excited maincenter, improve spirit, allaying tiredness, and the present invention The medicine fundamentally choosing excited maincenter is principal agent, from source, fundamentally sets about solving the problem, and carries in conjunction with using fragrance God and cool refreshing medicine, be also equipped with removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, refreshment nootropic drug, and penetrating agent promotes Transdermal absorption.From And effect of comprehensive performance refreshment, the speed that reaches to refresh oneself is fast, and effect is notable, the purpose of persistent.

Using fragrance medicine of refreshing oneself in the present invention is to close the medicine of thinking, obnubilation, or abnormal mind with one group for the treatment of heresy Thing, they are Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil.

Lemon fruit haze wax: obtained through squeezing by the fresh peel of Fructus Citri Limoniae.Having strong Fructus Citri Limoniae special aroma, abnormal smells from the patient is fresh, Pleasant, can prevent and allaying tiredness, antidepressant, contributes to refreshment, stabilizing the emotions, also has effect of beauty treatment.

Eucalyptus Globulus oil: the branch and leaf distillation for Myrtaceae eucalyptus plant Eucalyptus globulus Labill is produced, for colourless or slightly yellow supernatant liquid, gas There is special fragrance, refrigerant pleasant, can inspire enthusiasm, make the spirit of people keep excitatory state, attention is concentrated, clearheaded, Relatively it is suitable for the crowd of driving at night.

Oleum Santali albi: for Santalaceae plant Lignum Santali Albi heartwood through distill gained volatile oil, colourless or even faint yellow the most viscous The fluid of property, has the fragrance that Lignum Santali Albi is intrinsic, can alleviate nervous and anxiety, and relaxation effect is excellent.Health is also had spasmolytic With the function of reinforcement, can bring and loosen and the sensation of happiness.

Lignum Dalbergiae Odoriferae oil: for trunk or the distillation of root heartwood, light yellow to the amber viscous solution of leguminous plant Lignum Dalbergiae Odoriferae wingceltis Body, has the special Radix Aucklandiae and burnt odor, fragrance circulation of qi promoting, analgesic therapy of invigorating blood circulation.Lignum Dalbergiae Odoriferae, the clear strong person in perfume (or spice) also, therefore can ward off all and dislike Gas.Fragrance is refreshed oneself, promoting flow of QI and blood, pain relieving.

Herba Rosmarini Officinalis leaf oil: by Labiatae perennial shrub Herba Rosmarini Officinalis fresh sprout and the annual plumelet bloomed and Flower obtains through vapor distillation.Colourless or faint yellow volatile essential oil, have grass specific to Herba Rosmarini Officinalis like cool smell and Sweet Camphora breath.Energy blood circulation promoting, refreshment, activating brain cell, brain is also had good stimulation, makes brains Clear, memory reinforcing is also focused on, can ease off the pressure, relax battle-weary；Antioxidation, to brain and central nervous system System has significant effect, it is also possible to removes distracting thoughts and inspires intelligence；Can effectively alleviate gastric fullness, the gas caused by dyspepsia Swollen, promote intestinal peristalsis promoting, appetite strengthening, alleviate small intestinal and biliary spasm, enhancing muscle contraction, promote bile secretion.

The present invention is aided with and has cool refreshing, i.e. local skin is produced refrigerant stimulation and plays stimulating effect Medicine Mentholum, Oleum menthae, Borneolum Syntheticum, Camphora etc..

Mentholum: merit is apt to wind-dispelling heat-dissipating, refresh oneself, has the pungent fragrance taste of strong Herba Menthae speciality.Can optionally stimulate people Body skin or the Cold receptor of mucosa, produce sense of cold reflection and creeping chill, and (actually skin is protected to cause skin mucosa vasoconstriction Hold normal), ice is felt well pleasant, can pacify indignation, hysteria and frightened state, spirit can be made to improve, make attention concentrate, and Can allaying tiredness；The skin penetration enhancer being also commonly used as in medicine.

Oleum menthae: colourless or flaxen supernatant liquid.There is strong Herba Menthae fragrance, pungent and refrigerant, skin god can be stimulated Produce cool feeling, refreshment through tip, have strong altering property.

Borneolum Syntheticum: arduous, is slightly cold.GUIXIN, spleen, lung meridian.Effect inducing resuscitation, clearing away heat to improve acuity of vision.Nervus centralis is had excited and Suppression dual regulation effect, can improve ischemic tissue of brain energy metabolism, alleviate brain injury.Coordinate with Mentholum and can suitably increase clearly Cool feeling；The pungent perfume (or spice) of this product walks to alter power by force, and the rush being good oozes penetration enhancer, and through blood brain barrier, medicine is had preferable transdermal enhancing effect.

The present invention is also aided with fragrance stomach invigorating, inducing resuscitation medicine.Selection has removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, refreshment benefit Intelligence, with protection gastric qi of having one's ideas straightened out, the secretion of facilitating digestion liquid and prevention gastrointestinal abnormal fermentation, alleviates the Flos Caryophylli of intestinal tube smooth muscle spasm Oil, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract.They removing dampness by means of aromatics, circulation of qi promoting stomach invigorating, eliminating phlegm of having one's ideas straightened out is enough Become and have one's ideas straightened out when refreshing oneself, to protect gastric qi, the secretion of facilitating digestion liquid, and protect human righteousness, make human righteousness's internal memory, heresy not phase Dry, accomplish to refresh oneself and do not overtax one's nerves.

Oleum Caryophylli: Myrtaceae Eugenia plant of clove alabastrum, stem, leaf steam distillation prepares.For yellowish or Colourless clear and bright oily liquid, has the special aroma of Flos Caryophylli.Warming the stomach, sending down the abnormal ascending QI, the kidney warming, pain relieving.Bring positive influences for soul, swash The effect encouraged can enforce one's memory, and rouses oneself dejected emotion, contributes to rousing oneself drowsiness and dispirited spirit.Contribute to digestive system, Relieving flatulence, because Flos Caryophylli can reduce enteral and stay the effect of gas, can effectively suppress vomiting, diarrhoea yet, shying of intestinal, digestion is not Good.

Oleum Cinnamomi；For the bark of canella Cortex Cinnamomi, branch, leaf through distilling the volatile oil of gained.For yellow or yellowish-brown Supernatant liquid；Having the special fragrance of Cortex Cinnamomi, taste is sweet, pungent, fragrance stomach invigorating, wind dispelling.

Oleum Anisi Stellati: colourless or weak yellow liquid or crystallization.Having the special odor of Fructus Foeniculi, taste is sweet.There are the appetizing therapeutic method to keep the adverse QI flowing downwards, warming the kidney The effects such as cold expelling, also make excitement, dispel the wind, anti-tussive agents.

Perilla oil: the edible oil extracted for raw material with Folium Perillae, has relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach, relieving cough and asthma, profit diaphragm width Intestinal, solve the effect of all poison.There are increase brain nutrition, nourishing the brain and improving intelligence, raising ability of thinking, regulation cranial nerve and optic nerve function； Strengthen immune function of human body, regulate organism metabolism, delay body aging；Also have effect for reducing blood fat, anti-allergic effects.

Oil of Herba Pogostemonis: the volatile oil extracted with the stalk way of distillation from the leaf of Herba Pogostemonis.For yellow or green thick slime body.There is virtue Sweetening treatment is turbid, stomach function regulating preventing or arresting vomiting, delivers effect of expelling summer-heat.

Rhizoma Acori Graminei extract: the rhizome for acorus gramineus araceae plant is processed and obtained, and this product fragrance is walked to alter, and not only has out The merit of key refreshment, and have removing dampness concurrently, eliminating phlegm, ward off dirty effect therefore be good at and control the foul heresy of phlegm-damp and blind the mind dusk that clear key is caused Disorderly.The secretion of energy facilitating digestion liquid and prevention gastrointestinal abnormal fermentation, and have the effect alleviating intestinal tube smooth muscle spasm.

In the present invention, Mentholum, Oleum menthae, Borneolum Syntheticum, Mice in camphor group cooperation are penetrating agent, can promote that various medicine and oils are saturating Skin absorbs.Owing to each volatile oil is the volatile little molecular chaperones of tool, skin can absorb sub-fraction, for having fully absorbed Effect, adds penetrating agent, plant volatile oil can be made to pass through skin and enter the amount increase several times of body circulation, and improve curative effect.

Above-mentioned mainly by inducing resuscitation, i.e. excited central nervous system and refresh oneself.In order to reach effect of preferably refreshing oneself Really, above-mentioned inducing resuscitation and fragrance are creatively refreshed oneself by the present invention, refreshing, fragrance stomach invigorating medicine of having one's ideas straightened out combine, By add Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil, Mentholum, Oleum menthae, Borneolum Syntheticum, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract so that the nucleus of stimulating central nervous system and refreshment Component is mutually promoted, effect is refreshed oneself in collaborative performance, plays the function of allaying tiredness, refreshment altogether.

The present composition can be wiped, it is also possible to hears, if feeling tried out tired in work on ordinary days, studying or living, incite somebody to action this Renzhong acupoint, temple, forehead are smeared in invention, and cervical region etc. after ear, by epidermal absorption refrigerant stimulation local skin, fast wake-up Brain centres, disappearance at once sleepy, tired；Meanwhile, hear and inhale its aromatic odor, i.e. can feel that the whole body is light, relaxed and joyful, brains Clearly, tiredness is paused and is disappeared, from head to foot up and down and all can have delicate fragrant and strong comfort to nose mesh.Circulated by meridians, freely Venting QI-blood, full activation human body, make to feel dizzy, the spirit various fatigues such as unable not well, tired disappear, to refreshment, Lax neural, eliminate fidgety, stabilizing the emotions, enhancing physical ability and have fabulous effect.

One of technical scheme:

A kind of compositions for driving away drowsiness, refreshment, including the medicine of following weight ratio, inducing resuscitation class medicine 0.2 20, fragrance is refreshed oneself class medicine 0.01 25, the medicine 1 100 of refreshing class, and fragrance stomach invigorating is had one's ideas straightened out class medicine 0.01 10, and it is made into external preparation, external preparation includes varnish, tincture, liniment, gel, spray, quintessence oil, painting Membrane, ointment, patch and emplastrum.

It is that inducing resuscitation class pharmaceutical pack is containing Styrax, Benzoinum and Camphora, its weight ratio: Storax extract 0.5 20, benzoin resin extract 0.2 10, Camphora 0.5 15；

Fragrance class pharmaceutical pack of refreshing oneself containing Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil and Herba Rosmarini Officinalis leaf oil etc., its weight ratio: Lemon fruit haze wax 1 25, Eucalyptus Globulus oil 0.1 15, Oleum Santali albi 0.5 20, Lignum Dalbergiae Odoriferae oil 0.01 5, Herba Rosmarini Officinalis leaf oil 0.01 5；

Refreshing class pharmaceutical pack containing Mentholum, Oleum menthae and Borneolum Syntheticum, its weight ratio: Mentholum 1 100, Oleum menthae 1 50, Borneolum Syntheticum 1 50；

Fragrance stomach invigorating class pharmaceutical pack of having one's ideas straightened out containing Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis and Rhizoma Acori Graminei extract, its Weight ratio: Oleum Caryophylli 0.5 40, Oleum Cinnamomi 0.05 15, Oleum Anisi Stellati 0.05 5, perilla oil 0.05 15, oil of Herba Pogostemonis 0.5 15, Rhizoma Acori Graminei extract 0.01 3.

And it being made into external preparation, external preparation includes varnish, tincture, liniment, gel, spray, quintessence oil, film Agent, ointment, patch and emplastrum.

Further, it is inducing resuscitation class drug weight ratio, preferably: Storax extract 0.1 3, benzoin resin carry Take thing 1 18, Camphora 0.5 8；

Fragrance is refreshed oneself class drug weight ratio, preferably: Lemon fruit haze wax 3 25, Eucalyptus Globulus oil 0.25 14, Oleum Santali albi 1 18, Lignum Dalbergiae Odoriferae Oil 0.05 4, Herba Rosmarini Officinalis leaf oil 0.05 4；

The refreshing class drug weight ratio of refreshing oneself of refrigerant ice, preferably: Mentholum 5 100, Oleum menthae 2 40, Borneolum Syntheticum 2 40；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, preferably: Oleum Caryophylli 1 840, Oleum Cinnamomi 0.1 15, Oleum Anisi Stellati 0.1 4, purple Soviet Union's oil 0.1 14, oil of Herba Pogostemonis 1 10, Rhizoma Acori Graminei extract 0.02 2.5.

Further, inducing resuscitation class drug weight ratio, more preferably: Storax extract 2 15, benzoin resin extract Thing 17, Camphora 2 13；

Fragrance is refreshed oneself class drug weight ratio, more preferably: Lemon fruit haze wax 5 25, Eucalyptus Globulus oil 0.8 12, Oleum Santali albi 2 17, fall Oleum sesami 0.1 3.5, Herba Rosmarini Officinalis leaf oil 0.1 3.5；

The refreshing class drug weight ratio of refreshing oneself of refrigerant ice, more preferably: Mentholum 8 90, Oleum menthae 2 35, Borneolum Syntheticum 2 35；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, more preferably: Oleum Caryophylli 2 35, Oleum Cinnamomi 0.2 13, Oleum Anisi Stellati 0.5 3.5, Perilla oil 0.2 13, oil of Herba Pogostemonis 1.5 8, Rhizoma Acori Graminei extract 0.05 2；

Further, inducing resuscitation class drug weight ratio, most preferably: Storax extract 4 12, benzoin resin extract 26, Camphora 4 12；

Fragrance is refreshed oneself class drug weight ratio, most preferably: Lemon fruit haze wax 8 22, Eucalyptus Globulus oil 1 12, Oleum Santali albi 4 15, Lignum Dalbergiae Odoriferae Oil 0.5 2, Herba Rosmarini Officinalis leaf oil 0.5 2；

The refreshing class drug weight ratio of refreshing oneself of refrigerant ice, most preferably: Mentholum 10 85, Oleum menthae 5 25, Borneolum Syntheticum 5 25；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, most preferably: Oleum Caryophylli 4 30, Oleum Cinnamomi 0.3 10, Oleum Anisi Stellati 13, Folium Perillae Oil 0.5 10, oil of Herba Pogostemonis 36, Rhizoma Acori Graminei extract 0.5 1.5.

The two of technical scheme:

A kind of expeling drowsiness, preparation method of composition of refreshment of being applied to:

1, weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refreshed oneself medicine, be uniformly mixed, (1) liquid；

2, weigh respectively in Mentholum, Borneolum Syntheticum, Camphora addition (1) liquid, be stirred to dissolve and obtain (2) liquid completely；

3, (2) liquid constitutes expeling drowsiness, the square foundation of refreshment, adds different adjuvants, make not in square foundation Same external preparation, external preparation includes varnish, tincture, liniment, gel, spray, quintessence oil, liniment, emulsion, cream Agent, patch and emplastrum.

One of them:

Make quintessence oil, its preparation method:

A, make adjuvant used by quintessence oil and weight ratio is:

(1) solvent: Oleum Vitis viniferae 2 600, liquid paraffin 5 500；

(2) skin conditioning agent: octyl dodecanol 1 60,1,2-pentanediol 0.2 10, butanediol 0.1 5；

(3) antioxidant: butylated hydroxyarisol (BHA) 0.01 1,2,6-di-t-butyl hydroxy-methylbenzene (BHT) 0.01 0.5, vitamin E 0.1 5 etc..

B, preparation method:

(1) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refresh oneself medicine, added in Oleum Vitis viniferae, be uniformly mixed；

(2) weigh respectively in Mentholum, Borneolum Syntheticum, the Camphora above-mentioned solution of addition, be stirred to dissolve completely；

(3) weigh skin conditioning agent under agitation to add in above-mentioned solution, be uniformly mixed；

(4) in above-mentioned solution, add antioxidant, be uniformly mixed；

(5) add liquid paraffin to full dose, stir evenly, filter, fill, to obtain final product.

Two wherein:

Make ointment or emulsion agent, its preparation method:

Adjuvant used by A, ointment and weight ratio thereof be:

(1) emulsifying agent: poloxamer 1 50, Cremophor RH40 0.2 8, tween 80 0.2 10, Olivem 1000 0.2—6；

(2) thickening agent: carbomer 0.01 2, hypromellose 0.05 0.5, hyaluronate sodium 0.01 1, carboxymethyl shell Polysaccharide 0.1 1；

(3) skin conditioning agent: glycerol 1 20, propylene glycol 1 10, octyl dodecanol 0.5 20,1,2-pentanediol 0.2 10, Butanediol 0.1 20；

(4) antioxidant: sodium sulfite 0.01 1, sodium sulfite 0.01 1, sodium pyrosulfite 0.01 1, sodium thiosulfate 0.01 0.5, ascorbic acid 0.1 3 etc.；

(5) pH adjusting agent: triethanolamine is appropriate；

(6) antibacterial: Methylisothiazolinone 0.01 1, ethyl hydroxybenzoate 0.001 0.2, methyl hydroxybenzoate 0.001 0.2, hydroxyl Phenylpropyl alcohol ester 0.001 0.2.

B, preparation method:

(1) weighing hypromellose, be the most slowly sprinkled into, temperature keeps more than 80 DEG C, suitable quantity of water, under being stirred continuously It is cooled to room temperature, obtains (1) liquid；

(2) weigh emulsifying agent and/or thickening agent, under be sprinkled into lentamente in (1) liquid, continue to be slowly stirred 0.5 hour, room temperature is put Put, swelling more than 2.5 hours, then be separately added into skin conditioning agent, antioxidant, antibacterial, be uniformly mixed, filter, obtain (2) Liquid；

(3) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refreshed oneself medicine, mix homogeneously, add skin conditioning agent, stir evenly, add emulsifying agent, stir evenly, (3) liquid；

(4) weigh Mentholum, Borneolum Syntheticum, Camphora respectively, add in (3) liquid, be stirred to dissolve, obtain (4) liquid；

(5) respectively (2) liquid and (4) liquid are heated to 70 DEG C, under vigorous stirring, (4) liquid are slowly added in (2) liquid, add Rear continuation stirs 10 minutes, adds water to full dose, continues to stir evenly, is cooled to about 35 DEG C, adjusts pH value to 6.0 with 10% triethanolamine ±0.5；

(6) homogenizer homogenizing is used 10 minutes, froth breaking, filters, fill, to obtain final product.

Three wherein:

Make liniment, its preparation method:

Adjuvant used by A, liniment and weight ratio thereof be:

(1) polyvinyl alcohol 1 60, polyvinylpyrrolidone one K30 0.1 30；

(2) emulsifying agent: poloxamer 1 50, Cremophor RH40 0.2 8, tween 80 1 20, Olivem 1000 0.2—6；

(3) thickening agent: hypromellose 0.05 0.5, hyaluronate sodium 0.01 1, carboxymethyl chitosan 0.1 1；

(4) skin conditioning agent: glycerol 1 20, propylene glycol 1 20, octyl dodecanol 0.5 20,1,2-pentanediol 0.2 10, Butanediol 0.1 20；

(5) antioxidant: sodium sulfite 0.01 1, sodium sulfite 0.01 1, sodium pyrosulfite 0.01 1, sodium thiosulfate 0.01 0.5, ascorbic acid 0.1 3 etc.；

(6) pH adjusting agent: triethanolamine is appropriate；

(7) antibacterial: Methylisothiazolinone 0.01 1, ethyl hydroxybenzoate 0.001 0.2, methyl hydroxybenzoate 0.001 0.2, hydroxyl Phenylpropyl alcohol ester 0.001 0.2.

B, preparation method:

(1) weighing polyvinyl alcohol, adds water in right amount, soaks swelling, be placed in water-bath and be heated to 95 DEG C so that it is be completely dissolved, then Adding polyvinylpyrrolidone one K30, stirring makes it dissolve completely, adds appropriate glycerol, shake up, standby, obtains (1) liquid；

(2) weigh emulsifying agent and/or thickening agent, be sprinkled into the most lentamente in water, continue to be slowly stirred 0.5 hour, room temperature Place, swelling more than 2.5 hours, then be separately added into skin conditioning agent, antioxidant, antibacterial, be uniformly mixed, filter, (2) liquid；

(3) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refreshed oneself medicine, mix homogeneously, add skin conditioning agent, stir evenly, add emulsifying agent, stir evenly, (3) liquid；

(4) weigh Mentholum, Borneolum Syntheticum, Camphora respectively, add in (3) liquid, be stirred to dissolve, obtain (4) liquid；

(5) under agitation, (1) liquid is added in (2) liquid, continue stirring, mix homogeneously, obtain (5) liquid；

(6) respectively (4) liquid and (5) liquid are heated to 70 75 DEG C, under vigorous stirring, (4) liquid are slowly added in (5) liquid, Continue stirring 10 minutes after adding, add water to full dose, stir evenly, be cooled to about 35 DEG C, adjust pH value extremely with 10% triethanolamine 6.0—7.5；

(7) homogenizer homogenizing is used 10 minutes, froth breaking, filters, fill, to obtain final product.

The present invention is to combine modern scientific research achievement with traditional medicine to be achieved, and opens with Styrax, Benzoinum, Camphora Key refreshment is principal agent, is aided with the causing resuscitation with aromatic drugs medicines such as Fructus Citri Limoniae oil, Eucalyptus globulus Labill leaf oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil, more auxiliary With cool refreshing medicines such as Mentholum, Oleum menthae, Borneolum Syntheticums, and add Oleum Caryophylli, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei, Cortex Cinnamomi Oil, Oleum Anisi Stellati etc. fragrance stomach invigorating have one's ideas straightened out class medicine composition, make varnish, tincture, liniment, gel, spray, quintessence oil, film The external preparation such as agent, emulsifiable paste (emulsion, cream) agent, ointment, patch, emplastrum, produce through skin, meridians, acupuncture point osmotic absorption Raw effect, has that expeling is sleepy, effect of refreshment, it is adaptable to mental fatigue, physical fatigue and the fatigue that causes is tired, dizzy Feeling of fullness in the head, drowsy, doze etc., it is allowed to improve spirit, improves attention, strengthen physical ability.Inventive formulation is scientific and reasonable, effect Fruit is definite, has good economic worth and social value.

Detailed description of the invention

The present invention by the following examples can the invention will be further described, but, the scope of the present invention is also It is not limited to following embodiment.

Embodiment 1

[prescription]

Storax extract 10g benzoin resin extract 4g Camphora 5 g Lemon fruit haze wax 20g Eucalyptus Globulus oil 10 g Oleum Santali albi 5g Lignum Dalbergiae Odoriferae oil 1g Herba Rosmarini Officinalis leaf oil 1g Mentholum 80g Oleum menthae 10g Borneolum Syntheticum 20g Oleum Caryophylli 30g meat Cassia oil 10g Oleum Anisi Stellati 2g perilla oil 10g oil of Herba Pogostemonis 5g Rhizoma Acori Graminei extract 1g Oleum Vitis viniferae 500ml octyl group ten Glycol 60g 1,2-pentanediol 10g butanediol 5g butylated hydroxyarisol 0.2g liquid paraffin adds to 1000ml

Preparation method:

1, weigh respectively Storax extract, benzoin resin extract, Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil, Oleum menthae, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract, add Semen Vitis viniferae In oil, it is uniformly mixed, obtains (1) liquid；

2, weigh respectively in Mentholum, Borneolum Syntheticum, Camphora addition (1) liquid, be stirred to dissolve and obtain (2) liquid completely；

3, by octyl dodecanol, 1,2-pentanediol, butanediol, be under agitation sequentially added in (2) liquid, be uniformly mixed, (3) liquid；

4, in (3) liquid, add butylated hydroxyarisol, be uniformly mixed；

5, add liquid paraffin to full dose, stir, filter, fill, to obtain final product.

Embodiment 2

[prescription]

Storax extract 6 g benzoin resin extract 4g Camphora 10 g Lemon fruit haze wax 10g

Eucalyptus Globulus oil 1 g Oleum Santali albi 13g Lignum Dalbergiae Odoriferae oil 1g Herba Rosmarini Officinalis leaf oil 2g Mentholum 10g Oleum menthae 20g Borneolum Syntheticum 5g Oleum Caryophylli 5g Oleum Cinnamomi 0.5g Oleum Anisi Stellati 2g perilla oil 1g oil of Herba Pogostemonis 5g Rhizoma Acori Graminei extract 1g PEG- 40 castor oil hydrogenated 2g tween 80 10g

Butanediol 20g propylene glycol 10g glycerol 12g poloxamer 50g carbomer 1.5g hyaluronate sodium 0.5g Sodium sulfite 0.1 g Methylisothiazolinone 1g water adds to 1000ml

Preparation method:

1, weigh poloxamer, carbomer, hyaluronate sodium, be sprinkled into the most lentamente in water, be slowly stirred 0.5 hour, Room temperature places (swelling) more than 2.5 hours, then be separately added into Cremophor RH40, tween 80, propylene glycol, sodium sulfite, Methylisothiazolinone, glycerol, be uniformly mixed, and obtains (1) liquid；

2, weigh respectively Storax extract, benzoin resin extract, Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil, Oleum menthae, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract, mix homogeneously, (2) liquid；

3, weigh butanediol under agitation to add in (2) liquid, stir evenly, obtain (3) liquid；

4, weigh Mentholum, Borneolum Syntheticum, Camphora respectively, add in (3) liquid, be stirred to dissolve, obtain (4) liquid；

5, (4) liquid is slowly added in (1) liquid, stirs, add water to full dose, continue stirring and evenly mixing, adjust with 10% triethanolamine PH value is to 6.0 ± 0.5；

6, use homogenizer homogeneous uniform, filter, fill, to obtain final product.

Embodiment 3

[prescription]

Storax extract 10 g benzoin resin extract 5g Camphora 8 g Lemon fruit haze wax 20g Eucalyptus Globulus oil 2 g wingceltis Fragrant 12 g Lignum Dalbergiae Odoriferae oil 1g Herba Rosmarini Officinalis leaf oil 2g Mentholum 50g Oleum menthae 20g Borneolum Syntheticum 10g Oleum Caryophylli 30g meat Cassia oil 0.5g Oleum Anisi Stellati 2g perilla oil 8g Herba Pogostemonis 5g Rhizoma Acori Graminei extract 1g Cremophor RH40 2g tells Temperature-80 20g butanediol 20g propylene glycol 10g glycerol 20g poloxamer 50g carbomer 0.5g hyaluronate sodiums 0.5g carboxymethyl chitosan 0.5 g polyvinylpyrrolidone one K30(PVP.K30) 30 g

Polyvinyl alcohol (PVA1788) 60 g sodium sulfite 0.1 g Methylisothiazolinone 1g water adds to 1000ml

Preparation method:

1, weighing polyvinyl alcohol (PVA1788), adds water in right amount, soaks swelling, be placed in water-bath and be heated to 95 DEG C so that it is completely Dissolving, add polyvinylpyrrolidone one K30 (PVP.K30), stirring makes it dissolve completely, adds appropriate glycerol, shake Even, standby, obtain (1) liquid；

2, weigh poloxamer, carbomer, hyaluronate sodium, carboxymethyl chitosan under agitation, be sprinkled into lentamente in water, continue Being slowly stirred 0.5 hour, room temperature places (swelling) more than 2.5 hours, then is separately added into propylene glycol, sodium sulfite, the different thiophene of methyl Oxazoline ketone, is uniformly mixed, and filters, and obtains (2) liquid；

3, weigh respectively Storax extract, benzoin resin extract, Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil, Herba Rosmarini Officinalis leaf oil, Oleum menthae, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis, Rhizoma Acori Graminei extract, mix homogeneously, add Enter butanediol, stir evenly, add Cremophor RH40, tween 80, stir evenly, obtain (3) liquid；

4, weigh Mentholum, Borneolum Syntheticum, Camphora respectively, add (3) liquid, be stirred to dissolve, obtain (4) liquid；

5, under agitation, (1) liquid is added (2) liquid, continue stirring, mix homogeneously, obtain (5) liquid；

6, respectively (4) liquid and (5) liquid are heated to 70 75 DEG C, under vigorous stirring, (4) liquid are slowly added in (5) liquid, add Continue stirring 10 minutes after complete, add water to full dose, stir evenly.It is cooled to about 35 DEG C, adjusts pH value to 6.0 with 10% triethanolamine 7.5；

7, homogenizer homogenizing is used 10 minutes, froth breaking, filters, fill, to obtain final product.

Embodiment 4

Skin irritation and sensitivity test are studied:

1, irritation test: take Cavia porcellus 16, male and female half and half, is divided into single-dose group and multiple dosing group, often organizes each 8 Only.Carefully cutting the most back part of animal left and right sides by hair before being administered, going to hair-fields is 3cm × 3 cm, 24 h after unhairing, checks unhairing Whether skin scratches because of unhairing, and such as skin damage, this Cavia porcellus need not.Matched group and administration group use consubstantiality left and right sides self right Ratio method, all right side are coated with the embodiment of the present invention 1 sample, and left side is coated with normal saline, application area 2.5 cm × 2.5 cm, uses Cover fixing with gauze and adhesive tape after medicine.Each treated animal all dismantles after 24 h, washes away residual tested material with clear water.Single Secondary administration treated animal is given only 1 time；Multiple dosing treated animal is administered once daily, continuous 7 d.Single-dose treated animal is in removal Tested material 1,24,48 and 72 h；Multiple dosing treated animal in every day be administered after 24 h, last be administered after 1,24,48 and 72 h, Removing tested material, perusal also records coating position with or without the reaction such as erythema, edema.By Ministry of Public Health " cosmetics health specification " Within 2007, version skin wound repair standards of grading are marked.

After irritation test test result indicate that single, multiple dosing, it is administered and the scoring of Vehicle controls group is " 0 ", shows that this product does not has zest to skin.Observed result is shown in Table 1,2.

Table 1 single-dose skin wound repair experiment appraisal result (n=8)

Table 2 multiple dosing skin wound repair experiment appraisal result (n=8)

2, skin allergy test: take Cavia porcellus 24, male and female half and half, carefully cut the most back part of animal left and right sides in being administered front 24 h By hair, going to hair-fields is 4 cm × 4 cm, and such as skin damage, this Cavia porcellus need not.3 groups it are randomly divided into, often group 8: solvent before test Matched group (normal saline), tested material group (embodiment of the present invention 1 sample), positive controls (1% 2,4-dinitro-chloro-benzene Solution).Experiment is undertaken in two steps.

The first step, sensitization contact: give 0.2 mL tested material solution respectively on skin of unhairing on the left of each group Cavia porcellus, and make it It is evenly distributed.After giving medicine, cover fixing with gauze and adhesive tape, it is ensured that making test sample and contact skin 6 h, warm water washes away and is subject to Reagent thing.7th day repeated to contact sensitization with the 14th day.

Second step, excites contact: 14 d after last contact sensitization, on the right side of Cavia porcellus on skin of unhairing by method smear respectively 0.2 mL respectively organizes test sample and excites contact, the 2 of positive control medicinal 0.1%, 4-dinitro-chloro-benzene solution, ibid method operation. After 6 h remove test sample, warm water washes away test medicine, at once observes, and in 24,48,72 h again observe with or without skin erythema, The anaphylaxis indications such as edema.Result is commented by Ministry of Public Health " cosmetics health specification " version allergy test dermoreaction in 2007 Divide scale.

Skin anaphylactic test medicine of the present invention and Vehicle controls group Cavia porcellus are observed in exciting contact 72 h, skin without erythema and Edema phenomenon occurs, its order of reaction meansigma methods is 0, and sensitization rate is 0；Positive controls erythema, edema and sensitization rate are 72 Different stage reaction indication is shown as in h.The results are shown in Table 3.

Table 3 skin allergy experiment appraisal result (n=8)

Embodiment 5

It is intended for single use Piglet s colibacillosis to study:

Carry out crowd with the embodiment of the present invention 1 sample and commercially available Giffarine Thailand BITONG Eight Immortals cylinder menthol ointment to try out single and make Use Comparision Test.Test separating tests group and matched group.Test group: the embodiment of the present invention 1 sample, matched group: Giffarine Thailand's BITONG Eight Immortals cylinder menthol ointment, selects more than three hours middle-long distance drivers, and men and women does not limits, totally 67 Radix Ginseng Accelerated Life, by its with Machine is divided into two groups, wherein test group 35 people, matched group 32 people.Male 27 example in test group, women 8 example；Male 25 in matched group Example, women 7 example.Test group sample and control sample are compiled blind process (Giffarine Thailand BITONG Eight Immortals cylinder menthol ointment Tear label, stick coding), participate in test driver and all do not know that oneself being the use of test drug still compares medicine, specifically Usage is all used by respective product description, solves blind, carry out statistical analysis after end to be tested.

After participating in test driver being both required to drive continuously one hour, everyone with the ball bottle equipped with medicinal liquid in people After cave, temple, forehead and ear, the position such as cervical region by specification uses, and timing immediately is observed 60 minutes.

Evaluation methodology:

A refreshment onset time: set score value as 04 points, in 0.5 min, onset remembers 4 points, and in 1 min, onset remembers 3 points, 2 min Interior onset remembers 2 points, and in 5 min, onset remembers 1 point, and after 5min, onset remembers 0 point；

B refreshment intensity: set score value as 04 points, participates in testing crew and gives a mark according to personal feeling subjectivity, effect obvious 4 Point, preferable 3 points of effect, effect still can 2 points, the most effective 1 point, numbness 0 point；

C refreshes oneself the resisting fatigue persistent period: set score value as 04 points, and persistent period 6min remembers 0 point, continues 15min and remembers 1 point, Continue 30min and remember 2 points, continue 45min and remember 3 points, continue 60min and remember 4 points；

D comfort level: set score value as 04 points, is given a mark according to personal feeling subjectivity by participating in testing crew；

E aromatic odor: set score value as 04 points, by participate in testing crew use time, according to personal like, to its aromatic odor It is evaluated marking.

Result of the test: the results are shown in Table 4.

Table 4 is intended for single use Contrast on effect experiment appraisal result

Conclusion: above five indices, test group is better than matched group comprehensively, wherein refreshment onset time, refreshment intensity and carry God's resisting fatigue persistent period, test group relatively matched group has significant advantage.

Embodiment 6

Piglet s colibacillosis is used for multiple times study:

Carry out crowd effect is used for multiple times with the embodiment of the present invention 1 sample and commercially available Giffarine Thailand BITONG Eight Immortals cylinder menthol ointment Really comparative test.Test separating tests group and matched group.Test group: the embodiment of the present invention 2 sample, matched group: Giffarine Thailand BITONG Eight Immortals cylinder menthol ointment, subjects is to participate in the student that college entrance examination anxiety is reviewed, and men and women does not limits, totally 62 people, its pilot scale Test group 31 people, matched group 31 people.Test group sample and control sample are compiled blind process (Giffarine Thailand BITONG eight Celestial cylinder menthol ointment tears label, sticks coding), participate in test student and all do not know that oneself being the use of trial target still compares Product, detailed directions is all used by products instruction, solves blind, carry out statistical analysis after end to be tested.

Participate in test student to be both required to ten o'clock of every morning, the three in the afternoon, respectively use once at nine o'clock of self-study at night, Use ten times altogether.Everyone is with the position such as cervical region after Renzhong acupoint, temple, forehead (Yintang acupoint) and ear of the ball bottle equipped with medicinal liquid By specification uses, and timing immediately is observed 60 minutes.Everyone gives a mark as requested, ten mark accumulation calculating.

Evaluation methodology:

A is refreshment onset time: set score value as 04 points, and in 0.5 min, onset remembers 4 points, and in 1 min, onset remembers 3 points, 2 In min, onset remembers 2 points, and in 5 min, onset remembers 1 point, and after 5min, onset remembers 0 point；

B refreshment intensity: set score value as 04 points, is given a mark according to personal feeling subjectivity by participating in testing crew, and effect is bright Aobvious 4 points, preferable 3 points of effect, effect still can 2 points, the most effective 1 point, numbness 0 point；

C is the resisting fatigue persistent period of refreshing oneself, and sets score value as 04 points, and persistent period 6min remembers 0 point, continues 15min note 1 Point, continue 30min and remember 2 points, continue 45min and remember 3 points, continue 60min and remember 4 points；

D comfort level, sets score value as 04 points, is given a mark according to personal feeling subjectivity by participating in testing crew；

E aromatic odor: set score value as 04 points, by participate in testing crew use time, according to personal like, to its aromatic odor It is evaluated marking.

Result of the test: the results are shown in Table 5.

Table 5 is used for multiple times Contrast on effect experiment appraisal result

Conclusion: above five indices, test group is better than matched group comprehensively, wherein refreshment onset time, refreshment intensity and carry God's resisting fatigue persistent period, test group relatively matched group has significant advantage.

Claims (8)

1. the compositions being used for driving away drowsiness, refreshment, it is characterised in that said composition is by inducing resuscitation class medicine, virtue Perfume (or spice) refresh oneself class medicine, refreshing class medicine and fragrance stomach invigorating have one's ideas straightened out class medicine composition, its weight ratio is inducing resuscitation class medicine 0.2 20, refresh oneself class medicine 0.01 25, the medicine 1 100 of refreshing class, fragrance stomach invigorating of fragrance is had one's ideas straightened out class medicine 0.01 40, and it is made into external preparation, external preparation includes varnish, tincture, liniment, gel, spray, quintessence oil, painting Membrane, emulsion, cream agent, patch and emplastrum.

A kind of compositions for driving away drowsiness, refreshment the most according to claim 1, it is characterised in that inducing resuscitation Class pharmaceutical pack is containing Styrax, Benzoinum and Camphora, its weight ratio: Storax extract 0.5 20, benzoin resin extract 0.2 10, Camphora 0.5 15；

Fragrance refreshes oneself class pharmaceutical pack containing Lemon fruit haze wax, Eucalyptus Globulus oil, Oleum Santali albi, Lignum Dalbergiae Odoriferae oil and Herba Rosmarini Officinalis leaf oil, its weight ratio: lemon Mango haze wax 1 25, Eucalyptus Globulus oil 0.1 15, Oleum Santali albi 0.5 20, Lignum Dalbergiae Odoriferae oil 0.01 5, Herba Rosmarini Officinalis leaf oil 0.01 5；

Refreshing class pharmaceutical pack containing Mentholum, Oleum menthae and Borneolum Syntheticum, its weight ratio: Mentholum 1 100, Oleum menthae 1 50, Borneolum Syntheticum 1 50；

Fragrance stomach invigorating class pharmaceutical pack of having one's ideas straightened out containing Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, perilla oil, oil of Herba Pogostemonis and Rhizoma Acori Graminei extract, its Weight ratio: Oleum Caryophylli 0.5 40, Oleum Cinnamomi 0.05 15, Oleum Anisi Stellati 0.05 5, perilla oil 0.05 15, oil of Herba Pogostemonis 0.5 15, Rhizoma Acori Graminei extract 0.01 3；

And be made into external preparation, external preparation include varnish, tincture, liniment, gel, spray, quintessence oil, liniment, Emulsion, cream agent, patch and emplastrum.

A kind of compositions for driving away drowsiness, refreshment the most according to claim 2, it is characterised in that have one's ideas straightened out awake Brain class drug weight ratio, preferably: Storax extract 1 18, benzoin resin extract 0.5 8, Camphora 1 14；

Fragrance is refreshed oneself class drug weight ratio, preferably: Lemon fruit haze wax 3 25, Eucalyptus Globulus oil 0.5 14, Oleum Santali albi 1 18, Lignum Dalbergiae Odoriferae Oil 0.05 4, Herba Rosmarini Officinalis leaf oil 0.05 4；

Refreshing class drug weight ratio, preferably: Mentholum 5 100, Oleum menthae 2 40, Borneolum Syntheticum 2 40；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, preferably: Oleum Caryophylli 1 40, Oleum Cinnamomi 0.1 15, Oleum Anisi Stellati 0.1 4, Folium Perillae Oil 0.1 14, oil of Herba Pogostemonis 1 10, Rhizoma Acori Graminei extract 0.02 2.5.

A kind of compositions for driving away drowsiness, refreshment the most according to claim 2, it is characterised in that inducing resuscitation Class drug weight ratio, further preferably: Storax extract 2 15, benzoin resin extract 17, Camphora 2 13；

Fragrance is refreshed oneself class drug weight ratio, further preferably: Lemon fruit haze wax 5 25, Eucalyptus Globulus oil 0.8 12, Oleum Santali albi 2 17, Lignum Dalbergiae Odoriferae oil 0.1 3.5, Herba Rosmarini Officinalis leaf oil 0.1 3.5；

Refreshing class drug weight ratio, further preferably: Mentholum 8 90, Oleum menthae 2 35, Borneolum Syntheticum 2 35；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, further preferably: Oleum Caryophylli 2 35, Oleum Cinnamomi 0.2 13, Oleum Anisi Stellati 0.5 3.5, perilla oil 0.2 13, oil of Herba Pogostemonis 1.5 8, Rhizoma Acori Graminei extract 0.05 2.

5. according to a kind of compositions for driving away drowsiness, refreshment described in claim 2, it is characterised in that have one's ideas straightened out awake Brain class drug weight ratio, the most preferably: Storax extract 4 12, benzoin resin extract 26, Camphora 4 12；

Fragrance is refreshed oneself class drug weight ratio, the most preferably: Lemon fruit haze wax 8 22, Eucalyptus Globulus oil 1 12, Oleum Santali albi 4 15, Lignum Dalbergiae Odoriferae oil 0.5 2, Herba Rosmarini Officinalis leaf oil 0.5 2；

Refreshing class drug weight ratio, the most most preferably: Mentholum 10 85, Oleum menthae 5 25, Borneolum Syntheticum 5 25；

Fragrance stomach invigorating is had one's ideas straightened out class drug weight ratio, the most preferably: Oleum Caryophylli 4 30, Oleum Cinnamomi 0.3 10, Oleum Anisi Stellati 1 3, perilla oil 0.5 10, oil of Herba Pogostemonis 36, Rhizoma Acori Graminei extract 0.5 1.5.

6. according to a kind of compositions for driving away drowsiness, refreshment described in claim 25, it is characterised in that add It is made into quintessence oil after corresponding adjuvant；

A, make adjuvant used by quintessence oil and weight ratio is:

(1) solvent: Oleum Vitis viniferae 2 600, liquid paraffin 5 500；

(2) skin conditioning agent: octyl dodecanol 1 60,1,2-pentanediol 0.2 10, butanediol 0.1 5；

(3) antioxidant: butylated hydroxyarisol (BHA) 0.01 1,2,6-di-t-butyl hydroxy-methylbenzene (BHT) 0.01 0.5, vitamin E 0.1 5；

B, preferred preparation method:

(1) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refresh oneself medicine, added in Oleum Vitis viniferae, be uniformly mixed；

(2) weigh Camphora, Mentholum and Borneolum Syntheticum respectively to add in above-mentioned solution, be stirred to dissolve completely；

(3) weigh skin conditioning agent, under agitation add in above-mentioned solution, be uniformly mixed；

(4) in above-mentioned solution, add antioxidant, be uniformly mixed；

(5) add liquid paraffin to 1000ml, stir evenly, filter, fill, to obtain final product.

7. according to a kind of compositions for driving away drowsiness, refreshment described in claim 25, it is characterised in that add It is made into emulsion or ointment after corresponding adjuvant；

Adjuvant used by A, ointment and weight ratio thereof be:

(1) emulsifying agent: poloxamer 1 50, Cremophor RH40 0.2 8, tween 80 0.2 10, Olivem 1000 0.2—6；

(2) thickening agent: carbomer 0.01 1, hypromellose 0.05 0.5, hyaluronate sodium 0.01 1, carboxymethyl shell Polysaccharide 0.1 1；

(3) skin conditioning agent: glycerol 1 20, propylene glycol 1 10, octyl dodecanol 0.5 20,1,2-pentanediol 0.2 10, butanediol 0.1 20；

(4) antioxidant: sodium sulfite 0.01 1, sodium sulfite 0.01 1, sodium pyrosulfite 0.01 1, sodium thiosulfate 0.01 0.5, ascorbic acid 0.1 3 etc.；

(5) pH adjusting agent: triethanolamine is appropriate；

(6) antibacterial: Methylisothiazolinone 0.01 1, ethyl hydroxybenzoate 0.001 0.2, methyl hydroxybenzoate 0.001 0.2, hydroxyl Phenylpropyl alcohol ester 0.001 0.2；

B, preferred preparation method:

(1) weighing hypromellose, be the most slowly sprinkled in suitable quantity of water, temperature keeps more than 80 DEG C, is being stirred continuously Under be cooled to room temperature, (1) liquid；

(2) weigh emulsifying agent and/or thickening agent, be sprinkled into the most lentamente in (1) liquid, continue to be slowly stirred 0.5 hour, room Temperature is placed, swelling 2.5 12 hours, then is separately added into skin conditioning agent, antioxidant, antibacterial, is uniformly mixed, and filters, Obtain (2) liquid；

(3) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refreshed oneself medicine, mix homogeneously, add skin conditioning agent and stir evenly, add emulsifying agent and stir evenly, (3) liquid；

(4) weigh Camphora, Mentholum and Borneolum Syntheticum respectively, add in (3) liquid, be stirred to dissolve, obtain (4) liquid；

(5) respectively (2) liquid and (4) liquid are heated to 70 80 DEG C, under vigorous stirring, (4) liquid are slowly added in (2) liquid, Continue stirring 10 minutes after adding, add water to 1000ml, continue to stir evenly, be cooled to about 35 DEG C, adjust pH value with 10% triethanolamine To 6.0 ± 0.5；

(6) homogenizer homogenizing is used 10 minutes, froth breaking, filters, fill, to obtain final product.

8. according to a kind of compositions for driving away drowsiness, refreshment described in claim 25, it is characterised in that add It is made into liniment after corresponding adjuvant；

Adjuvant used by A, liniment and weight ratio thereof be:

(1) polyvinyl alcohol 1 60, polyvinylpyrrolidone one K30 0.1 30；

(2) emulsifying agent: poloxamer 1 50, Cremophor RH40 0.2 8, tween 80 1 20, Olivem 1000 0.2—6；

(3) thickening agent: hypromellose 0.05 0.5, hyaluronate sodium 0.01 1, carboxymethyl chitosan 0.1 1；

(4) skin conditioning agent: glycerol 1 20, propylene glycol 1 20, octyl dodecanol 0.5 20,1,2-pentanediol 0.2 10, Butanediol 0.1 20；

(5) antioxidant: sodium sulfite 0.01 1, sodium sulfite 0.01 1, sodium pyrosulfite 0.01 1, sodium thiosulfate 0.01 0.5, ascorbic acid 0.1 3；

(6) pH adjusting agent: triethanolamine is appropriate；

(7) antibacterial: Methylisothiazolinone 0.01 1, ethyl hydroxybenzoate 0.001 0.2, methyl hydroxybenzoate 0.001 0.2, hydroxyl Phenylpropyl alcohol ester 0.001 0.2；

B, preferred preparation method:

(1), during weighing polyvinyl alcohol adds suitable quantity of water, soak swelling, be placed in water-bath and be heated to 95 DEG C so that it is be completely dissolved, then Adding polyvinylpyrrolidone one K30, stirring makes it dissolve completely, adds appropriate glycerol, shake up, standby, obtains (1) liquid；

(2) weigh emulsifying agent and/or thickening agent, be sprinkled into the most lentamente in water, continue to be slowly stirred 0.5 hour, room temperature Place, swelling more than 2.5 hours, then be separately added into skin conditioning agent, antioxidant, antibacterial, be uniformly mixed, filter, (2) liquid；

(3) weigh the most camphorated inducing resuscitation class medicine respectively, fragrance refreshes oneself class medicine, refrigerant without Mentholum and Borneolum Syntheticum Refreshed oneself medicine, mix homogeneously, add skin conditioning agent, stir evenly, add emulsifying agent, stir evenly, (3) liquid；

(4) weigh Camphora, Mentholum and Borneolum Syntheticum respectively, add in (3) liquid, be stirred to dissolve, obtain (4) liquid；

(5) under agitation, (1) liquid is added in (2) liquid, continue stirring, mix homogeneously, obtain (5) liquid；

(6) respectively (4) liquid and (5) liquid are heated to 70 75 DEG C, under vigorous stirring, (4) liquid are slowly added in (5) liquid, Continue stirring 10 minutes after adding, add water to full dose, stir evenly, be cooled to about 35 DEG C, adjust pH value extremely with 10% triethanolamine 6.0—7.5；

(7) homogenizer homogenizing is used 10 minutes, froth breaking, filters, fill, to obtain final product.