CN112807363A - Traditional Chinese medicine composition for warming and activating meridians, massage cream and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for warming and activating meridians, massage cream and preparation method and application thereof Download PDFInfo
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- CN112807363A CN112807363A CN202110357051.XA CN202110357051A CN112807363A CN 112807363 A CN112807363 A CN 112807363A CN 202110357051 A CN202110357051 A CN 202110357051A CN 112807363 A CN112807363 A CN 112807363A
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- activating
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Abstract
The invention relates to a traditional Chinese medicine composition for warming and activating meridians, a massage cream, and a preparation method and application thereof. The active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 8-20 parts of eucommia bark, 10-25 parts of medicinal cyathula root, 8-18 parts of suberect spatholobus stem, 10-30 parts of garden balsam stem, 5-15 parts of cinnamon, 3-12 parts of doubleteeth pubescent angilica root, 1-10 parts of notopterygium root, 2-13 parts of gentian root, 6-18 parts of Chinese thorowax root, 5-15 parts of baical skullcap root, 4-16 parts of oriental waterplantain rhizome and 5-15 parts of largehead atractylodes rhizome. The Chinese medicinal composition and massage cream have physiotherapy effects of warming channels, dredging collaterals, dispelling pathogenic wind, eliminating dampness, dispelling cold, relieving swelling and pain, and promoting blood circulation, and can remarkably relieve and treat discomfort symptoms such as soreness, distending pain, stiffness, numbness, etc. caused by channels and collaterals obstruction.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and massage cream for warming channels and dredging collaterals, and a preparation method and application thereof.
Background
The "Ling Shu. Hai Lun" states that: the twelve main meridians belonging to fu organs are externally connected to the limbs. The internal organs of the human body, such as internal organs, limbs, bones, five sense organs, nine orifices, skin, flesh, bones and muscles, can keep relative coordination and unification, complete normal physiological activities, and are realized by the communication of the meridian system.
The book Huangdi classic on medicine has a speech: when the theory of thorns is beginning with meridians and collaterals, the measure of them is that the zang-fu organs are located at the interior and the six fu-organs are located at the exterior, and the physician wishes to smell the channels. Huangdi starts to grow, essence is formed first, essence is formed and brain is generated, bone is dry, vessels are nutrient, tendons are rigid, meat is wall, skin is firm, hair grows, and grains enter stomach, so that blood and qi circulate. Lei Gong would stroke and smell the meridians. The meridian of Huangdi can make death, treat all diseases, adjust brightness and prevent blockage.
The book journal, this book notes: the meridian passage, so they can conduct blood and qi to nourish yin and yang, nourish tendons and bones and benefit joints. Qi and blood are the material basis of life activities of human body, and normal physiological functions can be completed only by the warm nourishment and moistening of qi and blood of all tissues and organs of the whole body. The meridians and collaterals are the channels for the circulation of qi and blood of the human body, and can distribute nutrient substances to all tissues and organs of the whole body, so that the viscera and tissues are nourished, the muscles and bones are moistened, and the joints are smooth.
The reports of Su Wen Mu Ci Lun (Su Wen. Mu Nitri): the physician needs to lay the pathogenic factors in the skin and hair first, but not in the skin and hair, lay the physician in the grand pulse but in the channels, lay the physician in the five zang organs, and disperse in the intestines and stomach. The ancient medical books record the importance of meridians and collaterals to the human body, and can both resolve life and death and treat all diseases. The human body is an organic whole because the meridians criss-cross, passing in and out of the exterior and interior, connect the internal organs, and connect the limbs and joints. The meridians and collaterals are the channels for the circulation of qi and blood, and whether the circulation of qi and blood of the meridians and collaterals is normal or not is of great importance to the health of the body and the treatment and rehabilitation of diseases.
If the meridians are obstructed, different parts of the body can release different signals, such as soreness, numbness, distending pain or abnormal cooling and heating. In clinic, western medicine mainly adopts anti-inflammatory drugs to relieve swelling and pain, and the drugs have large side effects. The traditional Chinese medicine mainly adopts the way of smearing essential oil or other massage products to carry out traditional massage or applying plaster to relieve discomfort of a body caused by obstruction of channels and collaterals. The essential oil or massage products can only relax muscles to a certain degree, the discomfort of soreness, numbness, distending pain and the like caused by the obstruction of channels and collaterals cannot be really solved, and the life of a patient is greatly inconvenient because some products have too strong taste.
Therefore, the development of a massage product which has obvious effect, no toxic or side effect and convenient use and can effectively warm the channels and dredge the collaterals is very necessary.
Disclosure of Invention
Based on the above, the invention provides the traditional Chinese medicine composition for warming and activating meridians, which can effectively relieve and treat discomfort symptoms such as numbness and distending pain caused by meridian obstruction.
The specific technical scheme is as follows:
the traditional Chinese medicine composition for warming and activating meridians is prepared from the following raw materials in parts by weight: 8-20 parts of eucommia bark, 10-25 parts of medicinal cyathula root, 8-18 parts of suberect spatholobus stem, 10-30 parts of garden balsam stem, 5-15 parts of cinnamon, 3-12 parts of doubleteeth pubescent angilica root, 1-10 parts of notopterygium root, 2-13 parts of gentian root, 6-18 parts of Chinese thorowax root, 5-15 parts of baical skullcap root, 4-16 parts of oriental waterplantain rhizome and 5-15 parts of largehead atractylodes rhizome.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 10-18 parts of eucommia ulmoides, 15-20 parts of medicinal cyathula root, 10-15 parts of suberect spatholobus stem, 15-25 parts of garden balsam stem, 7-13 parts of cinnamon, 5-10 parts of radix angelicae pubescentis, 3-8 parts of notopterygium root, 5-10 parts of gentian, 10-15 parts of radix bupleuri, 8-13 parts of scutellaria baicalensis, 8-13 parts of rhizoma alismatis and 8-12 parts of bighead atractylodes rhizome.
In some embodiments, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 15 parts of eucommia bark, 18 parts of medicinal cyathula root, 13 parts of suberect spatholobus stem, 20 parts of garden balsam stem, 10 parts of cinnamon, 8 parts of pubescent angelica root, 6 parts of incised notopterygium rhizome, 8 parts of gentian, 12 parts of Chinese thorowax root, 11 parts of baical skullcap root, 10 parts of oriental waterplantain rhizome and 10 parts of largehead atractylodes rhizome.
The traditional Chinese medicine composition disclosed by the invention is prepared from the following selected medicinal materials in part by pharmacological and medicinal properties:
eucommia ulmoides: sweet taste and warm nature; entering liver and kidney meridians; tonify liver and kidney, strengthen tendons and bones.
Radix cyathulae: sweet in taste, slightly bitter and neutral in nature; entering liver and kidney meridians; dispel stasis, dredge meridians, dredge joints, induce diuresis and treat stranguria.
Caulis spatholobi: bitter and sweet in taste and warm in nature; entering liver and kidney meridians; tonify blood, activate blood, dredge meridians.
Garden balsam stem: bitter taste and warm nature; entering liver and kidney meridians; dispel wind and dampness, remove toxicity and alleviate pain.
Cinnamon: pungent and sweet in flavor; heat; it enters liver, spleen, heart and kidney meridians; tonify fire, strengthen yang, guide fire to the origin, dispel cold to relieve pain, activate blood and relieve menalgia.
Radix angelicae pubescentis: bitter and pungent taste, warm nature; entering kidney and bladder meridians; dispel wind and dampness, relieve arthralgia and alleviate pain.
Notopterygium root: the taste is pungent and bitter; the nature and the temperature; entering bladder and kidney meridians; dispel cold, expel wind, remove dampness and alleviate pain.
Gentian: bitter taste and cold nature; it enters liver and gallbladder meridians; clear heat and dry dampness, purge liver and gallbladder fire.
Bupleurum root: bitter taste and slightly cold nature; it enters liver and gallbladder meridians; harmonize exterior and interior, soothe liver and raise yang.
Scutellaria baicalensis: bitter taste and cold nature; it enters lung, gallbladder, spleen, large intestine and small intestine meridians; clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion.
Rhizoma alismatis: sweet taste and cold nature; entering kidney and bladder meridians; induce diuresis, clear damp-heat.
White atractylodes rhizome: bitter taste and warm nature; spleen and kidney meridians entered; to invigorate the spleen, replenish qi, dry dampness and induce diuresis.
The traditional Chinese medicine composition has the effects of warming and activating meridian and can effectively relieve and treat discomfort symptoms such as numbness and distending pain caused by meridian obstruction by the synergistic cooperation of the medicinal materials.
The invention also provides a preparation method of the traditional Chinese medicine composition for warming and activating meridian.
The specific technical scheme is as follows:
the preparation method of the traditional Chinese medicine composition for warming and activating the channels comprises the following steps:
mixing cortex Eucommiae, radix Cyathulae, caulis Spatholobi, herba speranskiae tuberculatae, cortex Cinnamomi, radix Angelicae Pubescentis, rhizoma Et radix Notopterygii, radix Gentianae, radix bupleuri, radix Scutellariae, rhizoma Alismatis, and rhizoma Atractylodis Macrocephalae, extracting with water or ethanol water solution, filtering, and concentrating.
In some of these embodiments, the adding water to extract comprises: decocting with water;
the extraction by adding ethanol water solution comprises the following steps: ultrasonic extracting with ethanol water solution, or reflux extracting with ethanol water solution.
In some embodiments, the number of times of decoction and extraction by water is 1-3, the time of each decoction is 20-60 minutes, and the addition amount of water in each time is 1-8 times of the total amount of the medicinal materials.
In some embodiments, the number of times of extraction by adding the ethanol aqueous solution is 1-3, the time of each extraction is 20-60 minutes, the adding amount of the ethanol aqueous solution is 2-6 times of the total amount of the medicinal materials, and the volume fraction of the ethanol aqueous solution is 35-75%.
In some of these embodiments, the ultrasound conditions of the ultrasound extraction include: the temperature is 20-40 ℃, the power is 1000-1400w, and the cycle speed is 800-1200 r/min.
In some embodiments, the concentration is performed until the mass ratio of the crude drug to the concentrated solution is 1.0: 0.4-0.5.
The invention also provides application of the traditional Chinese medicine composition.
The specific technical scheme is as follows:
the application of the traditional Chinese medicine composition in preparing medicines, health-care products or cosmetics with the effects of warming channels and dredging collaterals.
The invention also provides a massage cream for warming and activating meridian.
The specific technical scheme is as follows:
a massage cream for warming and activating meridians is prepared from functional components and a carrier or an auxiliary material acceptable in the massage cream, wherein the functional components comprise the traditional Chinese medicine composition for warming and activating meridians.
In some embodiments, the weight percentage of the traditional Chinese medicine composition for warming and activating the channels in the massage cream is 30-42%.
In some embodiments, the massage cream for warming and activating meridians is prepared from the following raw materials in percentage by weight:
in some embodiments, the massage cream for warming and activating meridians is prepared from the following raw materials in percentage by weight:
the invention also provides a preparation method of the massage cream for warming and activating the channels and collaterals.
The preparation method comprises the following steps:
a preparation method of massage cream for warming channels and dredging collaterals comprises the following steps:
(1) adding water, the Chinese medicinal composition for warming and dredging channels, 1, 3-propylene glycol, betaine, sodium stearyl glutamate, xanthan gum, arginine, allantoin and bisabolol into a water pot, heating to 80-90 deg.C, stirring for dissolving to obtain water phase mixture;
(2) adding cetostearyl alcohol, isopropyl myristate, polydimethylsiloxane, PEG-100 stearate and disodium EDTA into an oil pan, heating to 80-90 ℃, and stirring for dissolving to obtain an oil phase mixture;
(3) mixing glycerol and titanium dioxide, and grinding uniformly;
(4) adding the oil phase mixture obtained in the step (2) into the water kettle obtained in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring and uniformly mixing;
(5) cooling the mixture obtained in the step (4) to 45-55 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) and (5) cooling the mixture obtained in the step (5) to room temperature, adding a preservative, and uniformly stirring and mixing to obtain the massage cream for warming channels and dredging collaterals.
According to the traditional Chinese medicine composition, the traditional Chinese medicine raw materials are selected, according to the theory of 'monarch, minister, assistant and guide' of the traditional Chinese medicine, the garden balsam stem, the eucommia bark, the medicinal cyathula root and the suberect spatholobus stem are added as monarch drugs, and the traditional Chinese medicine composition has the effects of dispelling wind, dispelling cold, relieving pain, activating blood circulation, removing stasis and stimulating the menstrual flow; cinnamon, radix angelicae pubescentis and notopterygium root are added as ministerial drugs, so that the effects of expelling wind, removing cold, removing dampness and relieving pain are enhanced; radix Gentianae, Alismatis rhizoma and Scutellariae radix are added as adjuvant drugs for clearing heat, eliminating dampness and promoting urination; the Chinese thorowax root and the largehead atractylodes rhizome are added to have the effects of promoting qi circulation, soothing liver, strengthening spleen, tonifying qi and inducing diuresis. The Chinese medicinal materials are cooperated to ensure that the obtained Chinese medicinal composition has the physical therapy effects of warming and activating meridian, dispelling wind, eliminating dampness, dispelling cold, relieving pain and swelling and activating blood circulation, and can remarkably relieve and treat discomfort symptoms such as numbness, distending pain, stiffness, numbness and the like caused by meridian obstruction.
The massage cream prepared by combining the traditional Chinese medicine composition for warming and activating the channels and collaterals and a common carrier or matrix in cosmetics has the physical therapy effects of warming and activating the channels and collaterals, dispelling wind, clearing damp, dispelling cold, relieving pain and swelling and activating blood circulation, can effectively relieve the uncomfortable symptoms of numbness, swelling pain, stiffness, numbness and the like caused by the blockage of channels and collaterals, and is mild and non-irritant to skin, safe, free of toxic and side effects, convenient to use and convenient to clean.
Detailed Description
In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The invention provides a traditional Chinese medicine composition for warming and activating meridian, which is prepared from the following raw materials in parts by weight: 8-20 parts of eucommia bark, 10-25 parts of medicinal cyathula root, 8-18 parts of suberect spatholobus stem, 10-30 parts of garden balsam stem, 5-15 parts of cinnamon, 3-12 parts of doubleteeth pubescent angilica root, 1-10 parts of notopterygium root, 2-13 parts of gentian root, 6-18 parts of Chinese thorowax root, 5-15 parts of baical skullcap root, 4-16 parts of oriental waterplantain rhizome and 5-15 parts of largehead atractylodes rhizome.
Further preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 10-18 parts of eucommia ulmoides, 15-20 parts of medicinal cyathula root, 10-15 parts of suberect spatholobus stem, 15-25 parts of garden balsam stem, 7-13 parts of cinnamon, 5-10 parts of radix angelicae pubescentis, 3-8 parts of notopterygium root, 5-10 parts of gentian, 10-15 parts of radix bupleuri, 8-13 parts of scutellaria baicalensis, 8-13 parts of rhizoma alismatis and 8-12 parts of bighead atractylodes rhizome.
More preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 14-16 parts of eucommia ulmoides, 17-19 parts of medicinal cyathula root, 12-14 parts of suberect spatholobus stem, 19-21 parts of garden balsam stem, 9-11 parts of cinnamon, 7-9 parts of radix angelicae pubescentis, 5-7 parts of notopterygium root, 7-9 parts of gentian, 11-13 parts of radix bupleuri, 10-12 parts of scutellaria baicalensis, 9-11 parts of rhizoma alismatis and 9-11 parts of bighead atractylodes rhizome.
Most preferably, the active ingredients of the traditional Chinese medicine composition for warming and activating meridians are prepared from the following raw materials in parts by weight: 15 parts of eucommia bark, 18 parts of medicinal cyathula root, 13 parts of suberect spatholobus stem, 20 parts of garden balsam stem, 10 parts of cinnamon, 8 parts of pubescent angelica root, 6 parts of incised notopterygium rhizome, 8 parts of gentian, 12 parts of Chinese thorowax root, 11 parts of baical skullcap root, 10 parts of oriental waterplantain rhizome and 10 parts of largehead atractylodes rhizome.
According to the traditional Chinese medicine composition provided by the invention, the traditional Chinese medicine raw materials are selected, and each medicinal material has a synergistic interaction effect, so that the obtained traditional Chinese medicine composition has the effects of warming and activating meridians, dispelling cold and relieving pain, and promoting blood circulation and removing blood stasis, and can be used for remarkably relieving and treating discomfort symptoms such as numbness, distending pain, stiffness, numbness and the like caused by meridian obstruction.
The traditional Chinese medicine composition for warming and activating meridians can be prepared according to a conventional method in the field of traditional Chinese medicines.
Preferably, the preparation method of the traditional Chinese medicine composition for warming and activating meridians comprises the following steps:
mixing cortex Eucommiae, radix Cyathulae, caulis Spatholobi, herba speranskiae tuberculatae, cortex Cinnamomi, radix Angelicae Pubescentis, rhizoma Et radix Notopterygii, radix Gentianae, radix bupleuri, radix Scutellariae, rhizoma Alismatis, and rhizoma Atractylodis Macrocephalae, extracting with water or ethanol water solution, filtering, and concentrating.
In some embodiments, the adding water to perform the extraction comprises: decocting with water and extracting. Preferably, the number of times of decoction and extraction by water is 1-3, the time of each decoction is 20-60 minutes, and the addition amount of water in each time is 1-8 times of the total amount of the medicinal materials.
In some embodiments, the adding an aqueous ethanol solution to perform the extraction comprises: ultrasonic extracting with ethanol water solution, or reflux extracting with ethanol water solution. Preferably, the number of times of extraction by adding the ethanol aqueous solution is 1-3, the time of each extraction is 20-60 minutes, the adding amount of the ethanol aqueous solution is 2-6 times of the total amount of the medicinal materials, and the volume fraction of the ethanol aqueous solution is 35-75%. Preferably, the ultrasound conditions of the ultrasound extraction include: the temperature is 20-40 ℃, the power is 1000-1400w, and the cycle speed is 800-1200 r/min.
In some embodiments, the preparation method of the traditional Chinese medicine composition for warming and activating meridians comprises the following steps:
weighing the traditional Chinese medicinal materials according to the weight parts, fully mixing, placing in an extractor, adding water with the amount of 1-8 times of the amount of the traditional Chinese medicinal materials, soaking for 20-40 minutes, decocting and extracting for 1-3 times, each time for 20-40 minutes, combining the extract obtained after twice filtration, and concentrating until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0: 0.4-0.5.
In other embodiments, the preparation method of the traditional Chinese medicine composition for warming and activating meridians comprises the following steps:
weighing the traditional Chinese medicinal materials according to the weight parts, fully mixing, crushing into coarse powder, placing into an extractor, adding 2-6 times of ethanol water solution with the volume fraction of 35-75% of the amount of the traditional Chinese medicinal materials, uniformly stirring, standing for 20-40 minutes, carrying out ultrasonic extraction for 20-40 minutes, filtering an extracting solution, adding 2-6 times of ethanol water solution with the volume fraction of 35-75% into filter residues, carrying out ultrasonic extraction for 20-40 minutes, filtering the extracting solution, combining 2 times of filtrates, recovering ethanol, and concentrating until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0: 0.4-0.5.
In other embodiments, the preparation method of the traditional Chinese medicine composition for warming and activating meridians comprises the following steps:
weighing the traditional Chinese medicinal materials in parts by weight, fully mixing, placing into an extractor, adding 2-6 times of 35-75% ethanol water solution in volume fraction into the raw materials, performing reflux extraction for 20-40 minutes, filtering an extracting solution, adding 2-6 times of 35-75% ethanol water solution in volume fraction into filter residues, performing reflux extraction for 20-40 minutes, filtering the extracting solution, combining 2 times of filtrate, recovering ethanol, and concentrating until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0: 0.4-0.5.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines, health-care products or cosmetics for warming and activating meridians.
The traditional Chinese medicine composition provided by the invention can be prepared into massage cream for warming channels and dredging collaterals with a common carrier or matrix in cosmetics. The weight percentage of the traditional Chinese medicine composition in the massage cream is preferably 30-42%. The massage cream has the physiotherapy effects of warming and activating meridian, dispelling wind, eliminating dampness, dispelling cold, relieving pain and promoting blood circulation, can effectively relieve discomfort symptoms such as numbness, distending pain, stiffness and numbness caused by meridian obstruction, is mild and non-irritant to skin, is safe, has no toxic or side effect, is convenient to use and is convenient to clean.
The massage cream can be prepared by a conventional preparation method in the field of cosmetics.
The present invention will be described in further detail with reference to specific examples.
Example 1 Chinese medicinal composition for warming and activating meridians and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 8 parts of eucommia bark, 10 parts of medicinal cyathula root, 8 parts of suberect spatholobus stem, 10 parts of garden balsam stem, 5 parts of cinnamon, 3 parts of pubescent angelica root, 1 part of notopterygium root, 2 parts of gentian root, 6 parts of Chinese thorowax root, 5 parts of baical skullcap root, 4 parts of oriental waterplantain rhizome and 5 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the weight parts, fully mixing, placing in an extraction tank, adding water in an amount which is 2 times that of the traditional Chinese medicinal materials, soaking for 30 minutes, decocting for 30 minutes, and filtering to obtain filtrate 1 and filter residue 1; adding water 1 times the amount of the medicinal materials into the filter residue 1, decocting for 30 minutes, filtering to obtain a filtrate 2 and a filter residue 2, combining the filtrate 1 and the filtrate 2, and concentrating the mixture until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0:0.45, and then the product is obtained.
Example 2 traditional Chinese medicine composition for warming and activating meridians and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 20 parts of eucommia bark, 25 parts of medicinal cyathula root, 18 parts of suberect spatholobus stem, 30 parts of garden balsam stem, 15 parts of cinnamon, 12 parts of pubescent angelica root, 10 parts of incised notopterygium rhizome, 13 parts of Chinese gentian root, 18 parts of Chinese thorowax root, 15 parts of baical skullcap root, 16 parts of oriental waterplantain rhizome and 15 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the weight parts, fully mixing, placing in an extraction tank, adding 6 times of water, soaking for 35 minutes, decocting for 30 minutes, and filtering to obtain filtrate 1 and filter residue 1; adding water in an amount which is 3 times that of the medicinal materials into the filter residue 1, decocting for 30 minutes, filtering to obtain a filtrate 2 and a filter residue 2, combining the filtrate 1 and the filtrate 2, and concentrating the mixture until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0:0.45, and then the product is obtained.
Example 3 Chinese medicinal composition for warming channels and dredging collaterals and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 10 parts of eucommia bark, 15 parts of medicinal cyathula root, 10 parts of suberect spatholobus stem, 15 parts of garden balsam stem, 7 parts of cinnamon, 5 parts of pubescent angelica root, 3 parts of incised notopterygium rhizome, 5 parts of Chinese gentian root, 10 parts of Chinese thorowax root, 8 parts of baical skullcap root, 8 parts of oriental waterplantain rhizome and 8 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials according to the weight parts, fully mixing, placing in an extractor, adding water with the amount of 8 times of the amount of the traditional Chinese medicinal materials, soaking for 30 minutes, decocting for 30 minutes, and filtering to obtain filtrate 1 and filter residue 1; adding water 2 times the amount of the medicinal materials into the filter residue 1, decocting for 40 minutes, filtering to obtain a filtrate 2 and a filter residue 2, combining the filtrate 1 and the filtrate 2, and concentrating the mixture until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0:0.45, and then the product is obtained.
Example 4 Chinese medicinal composition for warming meridians and activating collaterals, and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 18 parts of eucommia bark, 20 parts of medicinal cyathula root, 15 parts of suberect spatholobus stem, 25 parts of garden balsam stem, 13 parts of cinnamon, 10 parts of pubescent angelica root, 8 parts of incised notopterygium rhizome, 10 parts of gentian root, 15 parts of Chinese thorowax root, 13 parts of baical skullcap root, 13 parts of oriental waterplantain rhizome and 12 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials in parts by weight, fully mixing, crushing into coarse powder, placing into an extractor, adding an ethanol water solution with the volume fraction of 35% and the amount of 2 times that of the traditional Chinese medicinal materials, uniformly stirring, placing for 30 minutes, and then performing ultrasonic extraction for 35 minutes under the extraction conditions: the temperature is 30 ℃, the power is 1200w, the circulating rotation speed is 1000 r/min, after the completion, the extracting solution is filtered, the filter residue is added with 35 percent ethanol water solution with 2 times of the amount of the medicinal materials for ultrasonic extraction for 35 min (the extraction conditions are the same as above), after the completion of the extraction, the extracting solution is filtered, 2 times of filter liquor is merged, the ethanol is recovered, and the mixture is concentrated until the mass ratio of the crude medicinal materials to the concentrated solution is 1.00: 0.45.
Example 5 Chinese medicinal composition for warming and activating meridians and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 15 parts of eucommia bark, 18 parts of medicinal cyathula root, 13 parts of suberect spatholobus stem, 20 parts of garden balsam stem, 10 parts of cinnamon, 8 parts of pubescent angelica root, 6 parts of incised notopterygium rhizome, 8 parts of gentian, 12 parts of Chinese thorowax root, 11 parts of baical skullcap root, 10 parts of oriental waterplantain rhizome and 10 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials in parts by weight, fully mixing, crushing into coarse powder, placing into an ultrasonic extractor, adding ethanol water solution with the volume fraction of 55% in an amount which is 4 times that of the traditional Chinese medicinal materials, uniformly stirring, placing for 30 minutes, then performing ultrasonic extraction for 40 minutes, wherein the extraction conditions are as follows: the temperature is 30 ℃, the power is 1200w, and the cycle speed is 1000 r/min. And filtering the extracting solution after the extraction is finished, adding an ethanol water solution with the volume fraction of 35% and the amount of 4 times of the medicinal materials into filter residues, performing ultrasonic extraction for 35 minutes under the same extraction conditions, filtering the extracting solution after the extraction is finished, combining the filtrates for 2 times, recovering ethanol, and concentrating until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0: 0.45.
Example 6 Chinese medicinal composition for warming and activating meridians and preparation method thereof
The active ingredients of the traditional Chinese medicine composition for warming and activating meridians provided by the embodiment are prepared from the following raw materials in parts by weight: 10 parts of eucommia bark, 14 parts of medicinal cyathula root, 12 parts of suberect spatholobus stem, 14 parts of garden balsam stem, 11 parts of cinnamon, 10 parts of pubescent angelica root, 5 parts of incised notopterygium rhizome, 9 parts of Chinese gentian root, 10 parts of Chinese thorowax root, 7 parts of baical skullcap root, 8 parts of oriental waterplantain rhizome and 13 parts of largehead atractylodes rhizome.
The preparation method comprises the following steps: weighing the traditional Chinese medicinal materials in parts by weight, fully mixing, placing into an extractor, adding 6 times of 75% ethanol water solution in volume fraction, extracting for 35 minutes under reflux, filtering the extracting solution, adding 6 times of 65% ethanol water solution in volume fraction into the filter residue, extracting for 30 minutes under reflux, filtering the extracting solution, combining the 2 times of filtrates, recovering ethanol, and concentrating until the mass ratio of the crude medicinal materials to the concentrated solution is 1.0: 0.45.
Example 7 massage cream for warming meridians and dredging collaterals and preparation method thereof
The massage cream for warming and activating meridians provided by the embodiment comprises the traditional Chinese medicine composition (main functional component) prepared in the embodiment 5 and a cosmetic carrier, wherein the cosmetic carrier comprises a solvent, a humectant, a thickening agent, an emollient, an emulsifier, a preservative, a masking agent, a chelating agent and a pH conditioning agent; wherein, the contents of the components are shown in table 1.
TABLE 1 (weight percent of the components in the table%)
The preparation method of the massage cream for warming and activating the channels comprises the following steps:
1. adding the components 1, 2, 3, 9, 12, 13, 14, 15 and 16 into a water kettle, heating to 85 ℃, and stirring to fully dissolve the components to obtain a water phase mixture;
2. adding the components 5, 6, 7, 8 and 17 into an oil pan, heating to 85 ℃, and stirring to completely dissolve the components to obtain an oil phase mixture;
3. mixing and grinding the components 4 and 11 uniformly in advance;
4. adding the oil phase mixture obtained in the step 2 into the water kettle obtained in the step 1, homogenizing and stirring to uniformly mix the oil phase mixture obtained in the step 2 and the water phase mixture obtained in the step 1, adding the mixture obtained in the step 3, homogenizing, stirring and uniformly mixing;
5. cooling the mixture obtained in the step (4) to 50 ℃, adding the component 18, and stirring and mixing uniformly;
6. cooling the mixture obtained in the step 5 to room temperature, adding the component 10, and stirring and mixing uniformly;
7. and (5) inspecting and storing the semi-finished product. Then filling, packaging, inspecting finished products and warehousing.
EXAMPLE 8 storage stability test of meridian warming and activating massage cream prepared in example 7-1,7-2,7-3
High temperature resistance test: adjusting a constant temperature incubator to 45 +/-1 ℃ in advance, weighing about 10g of meridian warming and vein relaxing massage cream (example 7-1, example 7-2 and example 7-3) in weighed culture dishes respectively, strickling, precisely weighing, obliquely placing on a 15-degree frame in the constant temperature incubator, sampling after 24h, placing in a dryer for cooling, weighing again, if oil seeps out, carefully wiping off the oil to leave a paste part, then weighing the culture dishes and the rest paste part, and calculating the oil seepage rate of the sample, wherein the numerical value is expressed in percentage according to a formula.
The results are shown in Table 2 below, where the results are m1-m2/m 100% (m-mass of sample in g; mass of sample plus mass of petri dish after m1-24 hours; mass of sample plus mass of petri dish after m 2-oil-permeated portion was wiped off in g): in the high temperature resistance experiment, the oil permeability of the massage creams for warming and activating meridians prepared in the examples 7-2 and 7-3 is more than 3.0%, and the massage cream for warming and activating meridians prepared in the example 7-1 is stable in property.
Low temperature resistance test: the massage creams for warming and activating meridians prepared in the examples 7-1,7-2 and 7-3 are placed at the temperature of-5 to 10 ℃ for 24 hours and then returned to the room temperature, and the massage creams for warming and activating meridians prepared in the examples 7-2 and 7-3 have the phenomenon of coarseness; the massage cream for warming meridians and activating collaterals prepared in example 7-1 did not show significant changes.
TABLE 2
Example 9 skin irritation test of massage cream for warming meridians and activating collaterals
Single and multiple skin irritation tests were performed using the meridian warming and activating massage cream of example 7-1.
1. Test drugs
Example 7-1 massage cream for warming meridians and activating collaterals
2. Test animal
Healthy white rabbits 16 (single skin irritation test), both male and female, were weighing (2.0+0.2) kg; 30 Kunming mice (multiple skin irritation tests) were used for both males and females, weighing 200-. The experimental animals are provided by southern medical university laboratory center (license number: SCXK (Yue) 2011-. The animals are all bred in a single cage, fed freely and drunk freely, and are adapted to the environment of an animal house by feeding the animals regularly for 5 days before experiments.
3. Test methods and results
3.1 methods
The skin irritation test method and procedure of single administration and multiple administration were performed according to the skin irritation test method and procedure of "cosmetic safety specification 2015", in which the test group was applied with the massage cream for warming meridians and activating collaterals of example 7-1 of the present invention, and the control group was not applied with any substance.
3.2 results
3.2.1 Single-dose skin irritation test, in which all rabbits were coated with 0.2g/kg of the test substance on the depilated skin area on one side and the skin on the other side was used as a control. The skin irritation intensity of the massage cream of example 7-1 was judged by applying the skin irritation cream for 2 hours in a closed test, removing the test substance, observing the skin reaction at the applied part for 1, 24, 48 and 72 hours, respectively, and observing the skin irritation intensity of the massage cream of example 7-1 according to the observation for 1, 24, 48 and 72 hours. The results are shown in Table 3.
TABLE 3
The results show that: 1. the skin reaction of the smearing part is observed for 24, 48 and 72 hours, and no erythema or edema, pimple, congestion and ulcer are observed. The total evaluation score and the average score of the skin irritation response are both 0, and the average response irritation intensity is less than 0.5, which indicates no irritation.
3.2.2 skin irritation test with multiple administrations, in the test process, 0.5g of the test substance is smeared on the unhaired skin area of one side of all Kunming mice, and the skin of the other side is used as a control. Applied 1 time per day for 14 days. From the next day, the hair should be cut and the residual test substance removed with water or a non-irritating solvent before each application. The results were observed for one hour. The results of judging the skin irritation intensity of the massage cream of example 7-1 by a plurality of times are shown in Table 4.
TABLE 4
The results show that 30 tested Kunming mice, 1 of which showed erythema and 1 of which showed papules, were scored on average less than 0.5 per animal per day on the first day; 30 Kunming mice were tested the following day, with one of them showing pimples with an average score per animal per day of less than 0.5; on days 3-14, all of the Kunming mice tested did not develop papules, erythema, congestion, ulcers. Multiple skin irritation levels were non-irritating according to standard evaluation criteria.
Example 10 swelling test for rabbit leg sprain
Test animals: selecting rabbits with weight of 1.5-2.0kg, which can be male and female, and each group comprises 3 rabbits, and 8 rabbits. A normal control group, a sprain control group (model group), and a drug experiment group 6 (the example 1 Chinese medicinal composition group, the example 2 Chinese medicinal composition group, the example 3 Chinese medicinal composition group, the example 4 Chinese medicinal composition group, the example 5 Chinese medicinal composition group, and the example 6 Chinese medicinal composition group, respectively.
Test drugs: the Chinese medicinal compositions for warming and activating meridians prepared in examples 1, 2, 3, 4, 5 and 6.
The test method comprises the following steps: the left hind leg and ankle of the rabbit are sprained, and the test drugs are externally applied for 1 time at intervals of 4 hours and 2 times every day, the dosage is 0.15g/kg, the test drugs are lightly applied for 1 minute and the administration is carried out for 7 days.
Observation indexes are as follows: measuring the ankle joint circumference by adopting a line-tying method, measuring the circumference of the ankle joint of the left back leg and foot of each group of rabbits before the model building and on the 1 st and 4 th days and 7 th days after the drug drying, taking an average value as the circumference after 3 times of measurement, and calculating the ankle joint swelling index according to a formula. Ankle swelling index (circumference after molding-circumference before molding)/circumference before molding.
The experimental results are as follows: comparing ankle swelling indexes of small white rabbits of each group, and on the intervention day 1, compared with a normal group, the ankle swelling indexes of the rabbits of the model group, the rabbit of the example 1 group, the rabbit of the example 2 group, the rabbit of the example 3 group, the rabbit of the example 4 group and the rabbit of the example 5 group are increased, and the difference has statistical significance; on day 4 and day 7 of intervention, the ankle swelling index of the rabbits in example 1, example 2, example 3, example 4, example 5 and example 6 decreased compared to the model group, with the ankle swelling index of example 5 being most significant (see table 5).
TABLE 5 ankle swelling index of small white rabbits in each group
| Group of | Intervention 1d | Intervention 4d | Intervention 7d |
| Normal control group | 0.081±0.007 | 0.079±0.006 | 0.080±0.005 |
| Model set | 0.297±0.015 | 0.289±0.014 | 0.265±0.015 |
| Example 1 | 0.251±0.017 | 0.234±0.016 | 0.168±0.014 |
| Example 2 | 0.247±0.016 | 0.218±0.014 | 0.148±0.016 |
| Example 3 | 0.256±0.019 | 0.228±0.017 | 0.143±0.019 |
| Example 4 | 0.241±0.017 | 0.235±0.014 | 0.136±0.015 |
| Example 5 | 0.231±0.015 | 0.203±0.013 | 0.105±0.013 |
| Example 6 | 0.251±0.015 | 0.223±0.013 | 0.129±0.013 |
Example 11 clinical efficacy test of massage cream for warming meridians and activating collaterals
Subject selection: 150 patients with one or more of the following subject inclusion criteria were selected as subjects, aged 20-50 years, 70 males, 80 females.
Subject inclusion criteria: limited movement of shoulder and neck, backward pain, discomfort of head lowering, head turning and traction pain, swelling, stiffness, soreness, etc.
The tested drugs are: massage cream prepared in example 7-1.
The application method of the massage cream comprises uniformly applying appropriate amount of the massage cream on the uncomfortable part, massaging for 30 min along the route of meridian circulation, and scrubbing with paper towel or warm water after the massage is finished, 1 time every 3 days, and 5 times as a treatment course.
Evaluation criteria for efficacy: the discomfort symptoms such as limited movement of the shoulder and neck, backward pain, discomfort of head lowering, head turning traction pain, swelling, stiffness, soreness and the like completely disappear, and the disease is cured; the discomfort symptoms such as limited activity of the shoulder and neck, backward pain, discomfort of head lowering, head turning traction pain, swelling, stiffness, soreness and the like are improved, and the effect is obvious; the discomfort symptoms such as limited movement of the shoulder and neck, backward pain, discomfort of head lowering, head turning traction pain, swelling, stiffness, soreness and distension are unchanged, and the effect is no.
The effect after one treatment course is shown in table 6.
TABLE 6
The results show that: 150 participants, wherein 65 participants completely disappear uncomfortable symptoms such as limited activity of shoulder and neck, backward pain, discomfort of head lowering, head turning traction pain, swelling, stiffness, soreness and the like; the uncomfortable symptoms of limited activity of the shoulder and neck, backward pain, discomfort of head lowering, head turning traction pain, swelling, stiffness, soreness and the like of 84 participants are improved; 1 tested person has no change in symptoms such as local pain, soreness, swelling, numbness, stiffness, limited activity and the like; the effective rate is 99.333%.
Example 12 clinical efficacy test of massage cream for warming meridians and activating collaterals
Subject selection: 30 stiff neck patients were selected and randomized into two groups of 15 patients each.
Subject inclusion criteria: neck pain and limited movement without any damage to the skin.
The tested drugs are: the massage cream prepared in example 7-1; collateral-flow-activating oil for benefiting Huangdao
The application method of the massage cream comprises uniformly applying appropriate amount of the massage cream on the uncomfortable part, massaging for 30 minutes along the route of meridian patrol, and scrubbing with paper towel or warm water after the massage is finished.
The application method of the Huangdaoyi comprises the following steps: uniformly smearing appropriate amount of collateral-activating oil on the uncomfortable part, massaging for 30 min along the route of meridian circulation, and scrubbing with paper towel or warm water after massaging.
Evaluation criteria for efficacy: neck pain and movement limitation completely disappear, and the disease is cured; neck pain and activity are improved to some extent, and are effective; neck pain and limited movement were not improved and were ineffective.
The results of observation of the effect after one treatment showed that the massage cream was effective in that the neck pain and the limitation of movement of 14 persons who had applied the massage cream of example 7-1 to 15 persons and had finished massaging along the course of the meridian passage; 1 people have limited improvement of neck pain and activity, and the medicine is effective. 15 people apply the collateral-activating oil to the collateral-activating oil, and massage the meridian-activating oil for 30 minutes along the course of the meridian patrol, so that 1 person has no neck pain and no limited activity and is cured; 2, neck pain and activity of people are relieved to some extent, and the medicine is effective; 12 people had no improvement in neck pain and limited movement, and were ineffective. The results are shown in Table 7 below.
TABLE 7
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The traditional Chinese medicine composition for warming and activating meridians is characterized in that the active ingredients are prepared from the following raw materials in parts by weight: 8-20 parts of eucommia bark, 10-25 parts of medicinal cyathula root, 8-18 parts of suberect spatholobus stem, 10-30 parts of garden balsam stem, 5-15 parts of cinnamon, 3-12 parts of doubleteeth pubescent angilica root, 1-10 parts of notopterygium root, 2-13 parts of gentian root, 6-18 parts of Chinese thorowax root, 5-15 parts of baical skullcap root, 4-16 parts of oriental waterplantain rhizome and 5-15 parts of largehead atractylodes rhizome.
2. The traditional Chinese medicine composition for warming channels and dredging collaterals as claimed in claim 1, wherein the active ingredients are prepared from the following raw materials in parts by weight: 10-18 parts of eucommia ulmoides, 15-20 parts of medicinal cyathula root, 10-15 parts of suberect spatholobus stem, 15-25 parts of garden balsam stem, 7-13 parts of cinnamon, 5-10 parts of radix angelicae pubescentis, 3-8 parts of notopterygium root, 5-10 parts of gentian, 10-15 parts of radix bupleuri, 8-13 parts of scutellaria baicalensis, 8-13 parts of rhizoma alismatis and 8-12 parts of bighead atractylodes rhizome.
3. The traditional Chinese medicine composition for warming channels and dredging collaterals as claimed in claim 2, characterized in that the active ingredients are prepared from the following raw materials in parts by weight: 15 parts of eucommia bark, 18 parts of medicinal cyathula root, 13 parts of suberect spatholobus stem, 20 parts of garden balsam stem, 10 parts of cinnamon, 8 parts of pubescent angelica root, 6 parts of incised notopterygium rhizome, 8 parts of gentian, 12 parts of Chinese thorowax root, 11 parts of baical skullcap root, 10 parts of oriental waterplantain rhizome and 10 parts of largehead atractylodes rhizome.
4. A method for preparing the traditional Chinese medicine composition for warming and activating meridians according to any one of claims 1 to 3, which is characterized by comprising the following steps:
mixing cortex Eucommiae, radix Cyathulae, caulis Spatholobi, herba speranskiae tuberculatae, cortex Cinnamomi, radix Angelicae Pubescentis, rhizoma Et radix Notopterygii, radix Gentianae, radix bupleuri, radix Scutellariae, rhizoma Alismatis, and rhizoma Atractylodis Macrocephalae, extracting with water or ethanol water solution, filtering, and concentrating.
5. The method for preparing a Chinese medicinal composition for warming meridians and activating collaterals as claimed in claim 4, wherein the extracting with water comprises: decocting with water;
the extraction by adding ethanol water solution comprises the following steps: ultrasonic extracting with ethanol water solution, or reflux extracting with ethanol water solution;
preferably, the number of times of decoction and extraction by water is 1-3, the time of each decoction is 20-60 minutes, and the addition amount of water in each time is 1-8 times of the total amount of the medicinal materials;
preferably, the number of times of adding the ethanol aqueous solution for extraction is 1-3, the time of each extraction is 20-60 minutes, the adding amount of the ethanol aqueous solution is 2-6 times of the total amount of the medicinal raw materials, and the volume fraction of the ethanol aqueous solution is 35-75%;
preferably, the ultrasound conditions of the ultrasound extraction include: the temperature is 20-40 ℃, the power is 1000-;
preferably, the concentration is carried out until the mass ratio of the crude drug to the concentrated solution is 1.0: 0.4-0.5.
6. Use of the Chinese medicinal composition of any one of claims 1 to 3 for preparing a medicament, health product or cosmetic having the effects of warming and activating meridians and/or relieving pain and swelling.
7. A massage cream for warming and activating meridians is characterized by being prepared from functional components and acceptable carriers or auxiliary materials in the massage cream, wherein the functional components comprise the traditional Chinese medicine composition for warming and activating meridians according to any one of claims 1 to 3.
8. The massage cream for warming the channels and dredging the collaterals as claimed in claim 7, wherein the weight percentage of the traditional Chinese medicine composition for warming the channels and dredging the collaterals in the massage cream is 30-42%.
9. The massage cream for warming and activating the channels and collaterals as claimed in claim 8, is characterized in that the massage cream for warming and activating the channels and collaterals is prepared from the following raw materials in percentage by weight:
preferably, the massage cream for warming and activating meridians is prepared from the following raw materials in percentage by weight:
10. the preparation method of the massage cream for warming the meridians and activating the collaterals as claimed in claim 9, which is characterized by comprising the following steps:
(1) adding water, the Chinese medicinal composition for warming and dredging channels, 1, 3-propylene glycol, betaine, sodium stearyl glutamate, xanthan gum, arginine, allantoin and bisabolol into a water pot, heating to 80-90 deg.C, stirring for dissolving to obtain water phase mixture;
(2) adding cetostearyl alcohol, isopropyl myristate, polydimethylsiloxane, PEG-100 stearate and disodium EDTA into an oil pan, heating to 80-90 ℃, and stirring for dissolving to obtain an oil phase mixture;
(3) mixing glycerol and titanium dioxide, and grinding uniformly;
(4) adding the oil phase mixture obtained in the step (2) into the water kettle obtained in the step (1), stirring to uniformly mix the oil phase mixture and the water phase mixture, adding the mixture obtained in the step (3), and stirring and uniformly mixing;
(5) cooling the mixture obtained in the step (4) to 45-55 ℃, adding tetrahydropiperine, and stirring and mixing uniformly;
(6) and (5) cooling the mixture obtained in the step (5) to room temperature, adding a preservative, and uniformly stirring and mixing to obtain the massage cream for warming channels and dredging collaterals.
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|---|---|---|---|---|
| CN114225003A (en) * | 2022-01-25 | 2022-03-25 | 深圳前海惠馀堂健康管理咨询有限公司 | Traditional Chinese medicine composition for tonifying fire, supporting yang, warming middle-jiao and dispelling cold and preparation method and application thereof |
| CN114225003B (en) * | 2022-01-25 | 2024-03-01 | 深圳前海惠馀堂健康管理咨询有限公司 | Traditional Chinese medicine composition for tonifying fire and yang, warming middle-jiao and dispelling cold, and preparation method and application thereof |
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