CN104837831B - 新的吡啶衍生物 - Google Patents

新的吡啶衍生物 Download PDF

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Publication number
CN104837831B
CN104837831B CN201380063475.9A CN201380063475A CN104837831B CN 104837831 B CN104837831 B CN 104837831B CN 201380063475 A CN201380063475 A CN 201380063475A CN 104837831 B CN104837831 B CN 104837831B
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China
Prior art keywords
pyridine
bases
cyclo propyl
azetidin
formic acid
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Expired - Fee Related
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CN201380063475.9A
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English (en)
Chinese (zh)
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CN104837831A (zh
Inventor
比特·弗赖
罗卡·戈比
尤伟·格雷瑟
金原笃
马蒂亚斯·内特科文
斯蒂芬·勒韦尔
马克·罗杰斯-埃文斯
坦贾·舒尔兹-加施
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CN201710932324.2A priority Critical patent/CN107674061A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201380063475.9A 2012-12-07 2013-12-02 新的吡啶衍生物 Expired - Fee Related CN104837831B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710932324.2A CN107674061A (zh) 2012-12-07 2013-12-02 吡啶衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12196022.3 2012-12-07
EP12196022 2012-12-07
PCT/EP2013/075225 WO2014086705A1 (en) 2012-12-07 2013-12-02 Novel pyridine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710932324.2A Division CN107674061A (zh) 2012-12-07 2013-12-02 吡啶衍生物

Publications (2)

Publication Number Publication Date
CN104837831A CN104837831A (zh) 2015-08-12
CN104837831B true CN104837831B (zh) 2017-10-31

Family

ID=47290804

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380063475.9A Expired - Fee Related CN104837831B (zh) 2012-12-07 2013-12-02 新的吡啶衍生物
CN201710932324.2A Pending CN107674061A (zh) 2012-12-07 2013-12-02 吡啶衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201710932324.2A Pending CN107674061A (zh) 2012-12-07 2013-12-02 吡啶衍生物

Country Status (33)

Country Link
US (1) US9522886B2 (https=)
EP (2) EP3357918A1 (https=)
JP (1) JP6426618B2 (https=)
KR (1) KR20150092282A (https=)
CN (2) CN104837831B (https=)
AR (1) AR093843A1 (https=)
AU (2) AU2013354278B2 (https=)
BR (1) BR112015012919A2 (https=)
CA (1) CA2890100A1 (https=)
CL (1) CL2015001536A1 (https=)
CO (1) CO7350620A2 (https=)
CR (1) CR20150250A (https=)
DK (1) DK2928881T3 (https=)
EA (1) EA026669B1 (https=)
ES (1) ES2668690T3 (https=)
HR (1) HRP20180672T1 (https=)
HU (1) HUE036911T2 (https=)
IL (1) IL239075B (https=)
LT (1) LT2928881T (https=)
MA (1) MA38239A1 (https=)
MX (1) MX2015007155A (https=)
NO (1) NO2928881T3 (https=)
PE (1) PE20151025A1 (https=)
PH (1) PH12015501083B1 (https=)
PL (1) PL2928881T3 (https=)
PT (1) PT2928881T (https=)
RS (1) RS57143B1 (https=)
SG (2) SG10201800170YA (https=)
SI (1) SI2928881T1 (https=)
TW (1) TWI600645B (https=)
UA (1) UA114656C2 (https=)
WO (1) WO2014086705A1 (https=)
ZA (1) ZA201503969B (https=)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
AU2014224784B2 (en) 2013-03-07 2018-03-08 F. Hoffmann-La Roche Ag Novel pyrazol derivatives
CN105121436B (zh) 2013-03-26 2018-07-27 豪夫迈·罗氏有限公司 新的吡啶衍生物
AU2014261585B2 (en) 2013-05-02 2018-03-08 F. Hoffmann-La Roche Ag Purine derivatives as CB2 receptor agonists
WO2014177527A1 (en) 2013-05-02 2014-11-06 F. Hoffmann-La Roche Ag Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists
JP6441356B2 (ja) 2013-09-06 2018-12-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規トリアゾロ［４，５−ｄ］ピリミジン誘導体
CN111170938A (zh) * 2014-04-04 2020-05-19 豪夫迈·罗氏有限公司 作为大麻素受体激动剂的5,6-双取代的吡啶-2-甲酰胺
WO2015190564A1 (ja) * 2014-06-13 2015-12-17 武田薬品工業株式会社 含窒素複素環化合物
EP3386951B1 (en) * 2015-12-09 2020-02-26 H. Hoffnabb-La Roche Ag Phenyl derivatives as cannabinoid receptor 2 agonists
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
AR112199A1 (es) 2017-06-20 2019-10-02 Hoffmann La Roche Derivados de piridina como agonistas inversos del receptor cannabinoide 2
JP2021521228A (ja) * 2018-04-18 2021-08-26 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ Ｄ−グルカロ−６，３−ラクトンモノエステル及びその製造方法
JP7456948B2 (ja) 2018-06-27 2024-03-27 エフ． ホフマン－ラ ロシュ アーゲー 放射性標識カンナビノイド受容体２リガンド
EP3814337B1 (en) * 2018-06-27 2025-05-14 F. Hoffmann-La Roche AG Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
CN112119068A (zh) * 2018-06-27 2020-12-22 豪夫迈·罗氏有限公司 作为大麻素受体2的抑制剂的新型氮杂环丁烷-取代的吡啶和吡嗪化合物
PE20210368A1 (es) 2018-06-27 2021-02-26 Eth Zuerich Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2
CN114502538A (zh) * 2019-09-30 2022-05-13 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的经取代的3,4-二氢喹唑啉
JP2023541601A (ja) 2020-09-10 2023-10-03 プレシリックス・ナームローゼ・ベンノートシヤープ Ｆａｐに対する抗体フラグメント
MX2023012365A (es) * 2021-04-19 2023-11-27 Chemocentryx Inc Azetidinil-acetamidas como inhibidores de cxcr7.
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
CA3251753A1 (en) 2022-05-02 2023-11-09 Precirix N.V. PRE-TARGETTING

Citations (3)

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CN101522644A (zh) * 2006-10-04 2009-09-02 霍夫曼-拉罗奇有限公司 作为cb2受体调节剂的吡嗪-2-羧酰胺衍生物
US20120065212A1 (en) * 2010-09-09 2012-03-15 Paul Hebeisen Heteroarylmethyl amides
WO2012168350A1 (en) * 2011-06-10 2012-12-13 F. Hoffmann-La Roche Ag Pyridin- 2 -amides useful as cb2 agonists

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AR085013A1 (es) * 2011-01-26 2013-08-07 Sanofi Aventis Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN101522644A (zh) * 2006-10-04 2009-09-02 霍夫曼-拉罗奇有限公司 作为cb2受体调节剂的吡嗪-2-羧酰胺衍生物
US20120065212A1 (en) * 2010-09-09 2012-03-15 Paul Hebeisen Heteroarylmethyl amides
WO2012168350A1 (en) * 2011-06-10 2012-12-13 F. Hoffmann-La Roche Ag Pyridin- 2 -amides useful as cb2 agonists

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HK1208031A1 (en) 2016-02-19
JP6426618B2 (ja) 2018-11-21
IL239075A0 (en) 2015-07-30
EP3357918A1 (en) 2018-08-08
AU2017279648A1 (en) 2018-01-18
CL2015001536A1 (es) 2015-10-23
KR20150092282A (ko) 2015-08-12
DK2928881T3 (en) 2018-05-28
HUE036911T2 (hu) 2018-08-28
EP2928881A1 (en) 2015-10-14
WO2014086705A1 (en) 2014-06-12
CN104837831A (zh) 2015-08-12
IL239075B (en) 2018-11-29
HRP20180672T1 (hr) 2018-06-01
SG11201504416XA (en) 2015-07-30
SG10201800170YA (en) 2018-02-27
AU2013354278B2 (en) 2017-10-12
MX2015007155A (es) 2015-10-14
RS57143B1 (sr) 2018-07-31
CR20150250A (es) 2015-06-11
JP2016501240A (ja) 2016-01-18
AU2013354278A1 (en) 2015-05-14
CO7350620A2 (es) 2015-08-10
LT2928881T (lt) 2018-06-11
US9522886B2 (en) 2016-12-20
BR112015012919A2 (pt) 2017-07-11
PH12015501083A1 (en) 2015-08-03
NO2928881T3 (https=) 2018-08-11
UA114656C2 (uk) 2017-07-10
TWI600645B (zh) 2017-10-01
TW201427951A (zh) 2014-07-16
MA38239A1 (fr) 2017-03-31
EP2928881B1 (en) 2018-03-14
PE20151025A1 (es) 2015-07-15
PT2928881T (pt) 2018-05-07
EA201591064A1 (ru) 2015-09-30
CA2890100A1 (en) 2014-06-12
SI2928881T1 (en) 2018-07-31
PL2928881T3 (pl) 2018-07-31
ZA201503969B (en) 2016-04-28
CN107674061A (zh) 2018-02-09
US20150307452A1 (en) 2015-10-29
ES2668690T3 (es) 2018-05-21
PH12015501083B1 (en) 2015-08-03
EA026669B1 (ru) 2017-05-31
AR093843A1 (es) 2015-06-24

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