CN104837806A - 前列环素类似物的合成方法 - Google Patents
前列环素类似物的合成方法 Download PDFInfo
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- CN104837806A CN104837806A CN201380064046.3A CN201380064046A CN104837806A CN 104837806 A CN104837806 A CN 104837806A CN 201380064046 A CN201380064046 A CN 201380064046A CN 104837806 A CN104837806 A CN 104837806A
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- 0 C*C1(C)CCCCC1 Chemical compound C*C1(C)CCCCC1 0.000 description 38
- PAJMKGZZBBTTOY-ZUQLYSRVSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1OCC(O)=O)O PAJMKGZZBBTTOY-ZUQLYSRVSA-N 0.000 description 3
- WRFITGKMHGLFLM-UHFFFAOYSA-N C=CCc(c(O)ccc1)c1C(C#CCCC(CO)O)=O Chemical compound C=CCc(c(O)ccc1)c1C(C#CCCC(CO)O)=O WRFITGKMHGLFLM-UHFFFAOYSA-N 0.000 description 1
- NPAKSZUYNDRAFK-UHFFFAOYSA-N C=CCc(c(O)ccc1)c1C(C#CCCCCO)=O Chemical compound C=CCc(c(O)ccc1)c1C(C#CCCCCO)=O NPAKSZUYNDRAFK-UHFFFAOYSA-N 0.000 description 1
- WRFITGKMHGLFLM-GFCCVEGCSA-N C=CCc(c(O)ccc1)c1C(C#CCC[C@H](CO)O)=O Chemical compound C=CCc(c(O)ccc1)c1C(C#CCC[C@H](CO)O)=O WRFITGKMHGLFLM-GFCCVEGCSA-N 0.000 description 1
- QJIWETYVJNMVMP-UHFFFAOYSA-N CC(C)(C)[Si](c1ccccc1)(c1ccccc1)OC Chemical compound CC(C)(C)[Si](c1ccccc1)(c1ccccc1)OC QJIWETYVJNMVMP-UHFFFAOYSA-N 0.000 description 1
- XFGMSBXBHDQUEZ-CIIGPRGZSA-N CCCCCC(C)CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O Chemical compound CCCCCC(C)CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O XFGMSBXBHDQUEZ-CIIGPRGZSA-N 0.000 description 1
- RMNWQUAWFQTLAL-SUYXUUSGSA-N CCCCC[C@@H](CC[C@@H](CCC1Cc2c(C3)cccc2OCC(O)=O)C13N)O Chemical compound CCCCC[C@@H](CC[C@@H](CCC1Cc2c(C3)cccc2OCC(O)=O)C13N)O RMNWQUAWFQTLAL-SUYXUUSGSA-N 0.000 description 1
- PAJMKGZZBBTTOY-FBYGNRARSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)C(C2)[C@H]1Cc1c2cccc1OCC(O)=O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)C(C2)[C@H]1Cc1c2cccc1OCC(O)=O)O PAJMKGZZBBTTOY-FBYGNRARSA-N 0.000 description 1
- UTGPMEMKMRVGNE-UYBZNFNTSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)C1Cc1c2cccc1O)O UTGPMEMKMRVGNE-UYBZNFNTSA-N 0.000 description 1
- PAJMKGZZBBTTOY-ZFORQUDYSA-N CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O)O Chemical compound CCCCC[C@@H](CC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(O)=O)O PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 description 1
- BVALZCVRLDMXOQ-UHFFFAOYSA-N CCCCC[N+]([O-])=O Chemical compound CCCCC[N+]([O-])=O BVALZCVRLDMXOQ-UHFFFAOYSA-N 0.000 description 1
- YMCWCQONBKTLLK-RSUWNVLCSA-N CCC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1O Chemical compound CCC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1O YMCWCQONBKTLLK-RSUWNVLCSA-N 0.000 description 1
- GYNMAJZMNILPQR-UIBIWLFHSA-N CCC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(OCC)=O Chemical compound CCC[C@@H]([C@@H](C1)O)[C@@H](C2)[C@H]1Cc1c2cccc1OCC(OCC)=O GYNMAJZMNILPQR-UIBIWLFHSA-N 0.000 description 1
- WZAUMVLXJLXUCV-FWJOYPJLSA-N COC(c1c(CC=C)c(O)ccc1)C#CCC[C@H](CO)O Chemical compound COC(c1c(CC=C)c(O)ccc1)C#CCC[C@H](CO)O WZAUMVLXJLXUCV-FWJOYPJLSA-N 0.000 description 1
- RHMISCQZHASNSW-KRWDZBQOSA-N CO[C@H](c1c(CC=C)c(O)ccc1)C#CCCC(CO)=O Chemical compound CO[C@H](c1c(CC=C)c(O)ccc1)C#CCCC(CO)=O RHMISCQZHASNSW-KRWDZBQOSA-N 0.000 description 1
- WZAUMVLXJLXUCV-DYVFJYSZSA-N CO[C@H](c1c(CC=C)c(O)ccc1)C#CCC[C@H](CO)O Chemical compound CO[C@H](c1c(CC=C)c(O)ccc1)C#CCC[C@H](CO)O WZAUMVLXJLXUCV-DYVFJYSZSA-N 0.000 description 1
- OQOUDZFBMYRNCD-UHFFFAOYSA-N COc1cccc(C=O)c1CC=C Chemical compound COc1cccc(C=O)c1CC=C OQOUDZFBMYRNCD-UHFFFAOYSA-N 0.000 description 1
- ISHSNXMXBLGLCF-UHFFFAOYSA-N COc1cccc(CO)c1CC=C Chemical compound COc1cccc(CO)c1CC=C ISHSNXMXBLGLCF-UHFFFAOYSA-N 0.000 description 1
- IPGFEAXZBBFTFN-UHFFFAOYSA-N [O-][N+](c1cc(C(OCC2OC2)=O)cc([N+]([O-])=O)c1)=O Chemical compound [O-][N+](c1cc(C(OCC2OC2)=O)cc([N+]([O-])=O)c1)=O IPGFEAXZBBFTFN-UHFFFAOYSA-N 0.000 description 1
- XOEYAIVZJDADQJ-SECBINFHSA-N [O-][N+](c1cc(C(OC[C@@H]2OC2)=O)cc(N=O)c1)=O Chemical compound [O-][N+](c1cc(C(OC[C@@H]2OC2)=O)cc(N=O)c1)=O XOEYAIVZJDADQJ-SECBINFHSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/44—Separation; Purification; Stabilisation; Use of additives by treatments giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/32—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710389417.5A CN107098925B (zh) | 2012-12-07 | 2013-12-06 | 前列环素类似物的合成方法 |
| CN201910784017.3A CN110590547A (zh) | 2012-12-07 | 2013-12-06 | 前列环素衍生物的合成方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734672P | 2012-12-07 | 2012-12-07 | |
| US61/734,672 | 2012-12-07 | ||
| US201361777882P | 2013-03-12 | 2013-03-12 | |
| US61/777,882 | 2013-03-12 | ||
| PCT/US2013/073474 WO2014089385A2 (en) | 2012-12-07 | 2013-12-06 | Methods of synthesizing a prostacyclin analog |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710389417.5A Division CN107098925B (zh) | 2012-12-07 | 2013-12-06 | 前列环素类似物的合成方法 |
| CN201910784017.3A Division CN110590547A (zh) | 2012-12-07 | 2013-12-06 | 前列环素衍生物的合成方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104837806A true CN104837806A (zh) | 2015-08-12 |
Family
ID=49881039
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380064046.3A Pending CN104837806A (zh) | 2012-12-07 | 2013-12-06 | 前列环素类似物的合成方法 |
| CN201910784017.3A Pending CN110590547A (zh) | 2012-12-07 | 2013-12-06 | 前列环素衍生物的合成方法 |
| CN201710389417.5A Expired - Fee Related CN107098925B (zh) | 2012-12-07 | 2013-12-06 | 前列环素类似物的合成方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910784017.3A Pending CN110590547A (zh) | 2012-12-07 | 2013-12-06 | 前列环素衍生物的合成方法 |
| CN201710389417.5A Expired - Fee Related CN107098925B (zh) | 2012-12-07 | 2013-12-06 | 前列环素类似物的合成方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20150315114A1 (https=) |
| EP (2) | EP3398931B1 (https=) |
| JP (2) | JP6342414B2 (https=) |
| KR (1) | KR20150091170A (https=) |
| CN (3) | CN104837806A (https=) |
| AU (2) | AU2013355130B2 (https=) |
| BR (1) | BR112015013085A2 (https=) |
| CA (1) | CA2893604A1 (https=) |
| CL (1) | CL2015001535A1 (https=) |
| DK (1) | DK2928858T3 (https=) |
| EA (1) | EA034309B1 (https=) |
| ES (1) | ES2664026T3 (https=) |
| IL (1) | IL239172B (https=) |
| MX (2) | MX369094B (https=) |
| NZ (1) | NZ708130A (https=) |
| PE (1) | PE20160090A1 (https=) |
| PH (2) | PH12015501258A1 (https=) |
| SG (2) | SG11201504430TA (https=) |
| TW (1) | TWI634104B (https=) |
| WO (1) | WO2014089385A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115433071A (zh) * | 2021-06-02 | 2022-12-06 | 佳和桂科技股份有限公司 | 制备苯并前列环素类似物的方法和中间物，以及由其制得的苯并前列环素类似物 |
| CN117003630A (zh) * | 2022-05-05 | 2023-11-07 | 佳和桂科技股份有限公司 | 用于制备碳前列腺环素类似物的方法及中间物 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| WO2015073314A1 (en) * | 2013-11-13 | 2015-05-21 | Cayman Chemical Company Incorporated | Amine salts of a prostacyclin analog |
| HU231184B1 (hu) | 2014-10-08 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Treprostinil-nátrium-monohidrát és eljárás ennek előállítására |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| JP7220650B2 (ja) | 2016-09-26 | 2023-02-10 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| HU231296B1 (hu) * | 2018-03-09 | 2022-09-28 | Chinoin Zrt | Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására |
| JP6503508B2 (ja) * | 2018-08-03 | 2019-04-17 | Ｊｘｔｇエネルギー株式会社 | テトラカルボン酸二無水物、ポリイミド前駆体樹脂、ポリイミド、ポリイミド前駆体樹脂溶液、ポリイミド溶液及びポリイミドフィルム |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| AU2021255621A1 (en) | 2020-04-17 | 2022-10-20 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
| JP7608480B2 (ja) | 2020-06-09 | 2025-01-06 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルのフマリルジケトピペリジンプロドラッグ |
| KR20220030006A (ko) | 2020-09-02 | 2022-03-10 | 바이오플러스 주식회사 | 미용 조성물을 포함하는 마스크 및 그 제조 방법 |
| WO2022132655A1 (en) | 2020-12-14 | 2022-06-23 | United Therapeutics Corporation | Methods of treating disease with treprostinil prodrugs |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) * | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| US20020087025A1 (en) * | 1997-10-24 | 2002-07-04 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| CN1494524A (zh) * | 2001-01-05 | 2004-05-05 | �Ƹ��� | 立体选择性合成前列腺环素衍生物的方法 |
| CN101891596A (zh) * | 2009-05-22 | 2010-11-24 | 上海天伟生物制药有限公司 | 一种新化合物及其制备方法和用途 |
| US20110319641A1 (en) * | 2010-06-03 | 2011-12-29 | United Therapeutics Corporation | Treprostinil production |
| WO2012009816A1 (en) * | 2010-07-22 | 2012-01-26 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2039857A1 (en) * | 1990-04-26 | 1991-10-27 | Wilfred Po-Sum Shum | Process for producing epoxyalcohols of high optical purity |
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| CN115433071A (zh) * | 2021-06-02 | 2022-12-06 | 佳和桂科技股份有限公司 | 制备苯并前列环素类似物的方法和中间物，以及由其制得的苯并前列环素类似物 |
| CN117003630A (zh) * | 2022-05-05 | 2023-11-07 | 佳和桂科技股份有限公司 | 用于制备碳前列腺环素类似物的方法及中间物 |
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