CN104768964B - 具有胍桥的人工核苷和寡核苷酸 - Google Patents

具有胍桥的人工核苷和寡核苷酸 Download PDF

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Publication number
CN104768964B
CN104768964B CN201380057335.0A CN201380057335A CN104768964B CN 104768964 B CN104768964 B CN 104768964B CN 201380057335 A CN201380057335 A CN 201380057335A CN 104768964 B CN104768964 B CN 104768964B
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carbon atoms
amino
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nucleic acid
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CN104768964A (zh
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小比贺聪
寿悠太朗
胁玲子
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University of Osaka NUC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
CN201380057335.0A 2012-09-21 2013-09-19 具有胍桥的人工核苷和寡核苷酸 Active CN104768964B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012208906 2012-09-21
JP2012-208906 2012-09-21
JP2013022360 2013-02-07
JP2013-022360 2013-02-07
PCT/JP2013/075370 WO2014046212A1 (ja) 2012-09-21 2013-09-19 グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド

Publications (2)

Publication Number Publication Date
CN104768964A CN104768964A (zh) 2015-07-08
CN104768964B true CN104768964B (zh) 2017-03-29

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US (1) US10377789B2 (enExample)
EP (1) EP2899197B1 (enExample)
JP (1) JP6048982B2 (enExample)
KR (1) KR101707437B1 (enExample)
CN (1) CN104768964B (enExample)
CA (1) CA2885719C (enExample)
ES (1) ES2622716T3 (enExample)
IN (1) IN2015DN02238A (enExample)
WO (1) WO2014046212A1 (enExample)

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US9315535B2 (en) 2013-02-18 2016-04-19 Shionogi & Co., Ltd. Nucleoside and nucleotide having nitrogen-containing heterocycle structure
TW201718618A (zh) * 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物
US11234995B2 (en) 2016-01-07 2022-02-01 Osaka University α-synuclein expression inhibitor
US11286275B2 (en) * 2017-02-21 2022-03-29 Osaka University Nucleic acid compound and oligonucleotide
WO2018155450A1 (ja) 2017-02-21 2018-08-30 国立大学法人大阪大学 アンチセンスオリゴ核酸
WO2019009298A1 (ja) * 2017-07-05 2019-01-10 国立大学法人大阪大学 α－シヌクレイン発現抑制剤
CN115920031A (zh) 2017-08-31 2023-04-07 田边三菱制药株式会社 含有il-33拮抗剂的子宫内膜异位症治疗剂
US11560401B2 (en) * 2018-05-10 2023-01-24 Nippon Shinyaku Co., Ltd. Method for preparing oligonucleic acid compound
US11866705B2 (en) 2018-07-31 2024-01-09 Osaka Univerity Small cell lung cancer therapeutic agent containing oligonucleotide
JP7396577B2 (ja) 2018-09-05 2023-12-12 国立大学法人大阪大学 Ａｒｌ４ｃを標的分子とするアンチセンスオリゴヌクレオチド、及び当該アンチセンスオリゴヌクレオチドを使用した核酸医薬
SG11202104901VA (en) * 2018-11-12 2021-06-29 Mitsubishi Tanabe Pharma Corp Crosslinked artificial nucleic acid alna
JP7413362B2 (ja) 2019-03-29 2024-01-15 シスメックス株式会社 新規人工核酸、その製造方法及び用途
CN120290561A (zh) 2019-03-29 2025-07-11 田边三菱制药株式会社 用于调节dux4的表达的化合物、方法和医药组合物
SG11202112741XA (en) 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
CA3140410A1 (en) * 2019-06-20 2020-12-24 Martin Edelmann Radiolabeled moem type oligonucleotides and process for their preparation
EP4151237A4 (en) 2020-05-12 2024-08-14 Mitsubishi Tanabe Pharma Corporation Compound, method and pharmaceutical composition for regulating expression of ataxin 3
JP7725490B2 (ja) 2020-09-25 2025-08-19 株式会社理研ジェネシス 新規人工核酸、その製造方法及び用途
TW202233838A (zh) 2020-11-06 2022-09-01 日商住友製藥股份有限公司 Ｒｐｓ２５基因之表現及／或功能調節劑
WO2022181807A1 (ja) 2021-02-25 2022-09-01 国立大学法人大阪大学 ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド
JP2024105742A (ja) * 2021-05-26 2024-08-07 ルクサナバイオテク株式会社 心疾患治療薬
CA3221758A1 (en) 2021-05-28 2022-12-01 Sumitomo Pharma Co., Ltd. Antisense nucleic acid
CN113552198B (zh) * 2021-05-31 2024-03-26 武汉维尔博生物科技有限公司 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法
JPWO2023026994A1 (enExample) 2021-08-21 2023-03-02
WO2023093960A1 (en) * 2021-11-26 2023-06-01 Syddansk Universitet Modified peptide-oligonucleotide conjugate
EP4458836A4 (en) 2021-12-27 2025-05-21 Riken Genesis Co., Ltd. Novel artificial nucleic acid, method for producing same, and use of same
JP2025509552A (ja) * 2022-03-17 2025-04-11 アリゴス セラピューティクス，インコーポレーテッド 修飾ギャップマーオリゴマー及びその使用方法
CN120187739A (zh) 2022-11-10 2025-06-20 璐库萨那生物技术株式会社 桥联部具有胍基结构的修饰核苷和使用其的寡核苷酸的制造方法
US20250368996A1 (en) 2024-05-14 2025-12-04 Aligos Therapeutics, Inc. Modified antisense oligonucleotides for treating hepatitis b virus

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WO1996000575A1 (en) * 1994-06-30 1996-01-11 The Regents Of The University Of California Polynucleoside chain having multiple nucleosides, the nucleosides coupled by guanidyl linkages
CN1376161A (zh) * 1999-07-22 2002-10-23 三共株式会社 新型双环核苷类似物
CN102596983A (zh) * 2009-10-29 2012-07-18 国立大学法人大阪大学 交联型人工核苷和核苷酸

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CN1376161A (zh) * 1999-07-22 2002-10-23 三共株式会社 新型双环核苷类似物
CN102596983A (zh) * 2009-10-29 2012-07-18 国立大学法人大阪大学 交联型人工核苷和核苷酸

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IN2015DN02238A (enExample) 2015-08-21
EP2899197B1 (en) 2017-03-22
US20150266917A1 (en) 2015-09-24
WO2014046212A1 (ja) 2014-03-27
EP2899197A1 (en) 2015-07-29
ES2622716T3 (es) 2017-07-07
KR101707437B1 (ko) 2017-02-16
EP2899197A4 (en) 2016-03-09
CA2885719C (en) 2017-07-11
CN104768964A (zh) 2015-07-08
JP6048982B2 (ja) 2016-12-21
KR20150056647A (ko) 2015-05-26
CA2885719A1 (en) 2014-03-27
JPWO2014046212A1 (ja) 2016-08-18
US10377789B2 (en) 2019-08-13

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