ES2622716T3 - Oligonucleótido y nucleósido artificial en puente con guanidina - Google Patents
Oligonucleótido y nucleósido artificial en puente con guanidina Download PDFInfo
- Publication number
- ES2622716T3 ES2622716T3 ES13838365.8T ES13838365T ES2622716T3 ES 2622716 T3 ES2622716 T3 ES 2622716T3 ES 13838365 T ES13838365 T ES 13838365T ES 2622716 T3 ES2622716 T3 ES 2622716T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino
- nucleic acid
- compound
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012208906 | 2012-09-21 | ||
| JP2012208906 | 2012-09-21 | ||
| JP2013022360 | 2013-02-07 | ||
| JP2013022360 | 2013-02-07 | ||
| PCT/JP2013/075370 WO2014046212A1 (ja) | 2012-09-21 | 2013-09-19 | グアニジン架橋を有する人工ヌクレオシドおよびオリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2622716T3 true ES2622716T3 (es) | 2017-07-07 |
Family
ID=50341516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13838365.8T Active ES2622716T3 (es) | 2012-09-21 | 2013-09-19 | Oligonucleótido y nucleósido artificial en puente con guanidina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10377789B2 (enExample) |
| EP (1) | EP2899197B1 (enExample) |
| JP (1) | JP6048982B2 (enExample) |
| KR (1) | KR101707437B1 (enExample) |
| CN (1) | CN104768964B (enExample) |
| CA (1) | CA2885719C (enExample) |
| ES (1) | ES2622716T3 (enExample) |
| IN (1) | IN2015DN02238A (enExample) |
| WO (1) | WO2014046212A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9315535B2 (en) | 2013-02-18 | 2016-04-19 | Shionogi & Co., Ltd. | Nucleoside and nucleotide having nitrogen-containing heterocycle structure |
| TW201718618A (zh) * | 2015-09-18 | 2017-06-01 | 田邊三菱製藥股份有限公司 | 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物 |
| EP3415524A4 (en) | 2016-01-07 | 2019-09-04 | Osaka University | INHIBITOR OF α-SYNNUCLEINE EXPRESSION |
| JP7095893B2 (ja) | 2017-02-21 | 2022-07-05 | 国立大学法人大阪大学 | アンチセンスオリゴ核酸 |
| US11286275B2 (en) | 2017-02-21 | 2022-03-29 | Osaka University | Nucleic acid compound and oligonucleotide |
| WO2019009298A1 (ja) * | 2017-07-05 | 2019-01-10 | 国立大学法人大阪大学 | α－シヌクレイン発現抑制剤 |
| TWI850773B (zh) | 2017-08-31 | 2024-08-01 | 日商田邊三菱製藥股份有限公司 | 可溶性il-33受體的用途 |
| JP7394749B2 (ja) * | 2018-05-10 | 2023-12-08 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| EP3831837A4 (en) | 2018-07-31 | 2023-06-14 | Osaka University | OLIGONUCLEOTIDE THERAPEUTIC AGENT FOR SMALL CELL LUNG CANCER |
| JP7396577B2 (ja) | 2018-09-05 | 2023-12-12 | 国立大学法人大阪大学 | Ａｒｌ４ｃを標的分子とするアンチセンスオリゴヌクレオチド、及び当該アンチセンスオリゴヌクレオチドを使用した核酸医薬 |
| KR102886120B1 (ko) | 2018-11-12 | 2025-11-14 | 미쓰비시 타나베 파마 코퍼레이션 | 가교형 인공 핵산 alna |
| CA3198199A1 (en) | 2019-03-29 | 2020-10-08 | Mitsubishi Tanabe Pharma Corporation | Compound, method and pharmaceutical composition for modulating expression of dux4 |
| WO2020203896A1 (ja) | 2019-03-29 | 2020-10-08 | シスメックス株式会社 | 新規人工核酸、その製造方法及び用途 |
| AU2020282828A1 (en) | 2019-05-31 | 2022-01-27 | Aligos Therapeutics, Inc. | Modified gapmer oligonucleotides and methods of use |
| JPWO2020256084A1 (enExample) * | 2019-06-19 | 2020-12-24 | ||
| US20230087946A1 (en) * | 2019-06-20 | 2023-03-23 | Hoffmann-La Roche Inc. | Radiolabeled moem type oligonucleotides and process for their preparation |
| WO2021230286A1 (ja) | 2020-05-12 | 2021-11-18 | 田辺三菱製薬株式会社 | Ａｔａｘｉｎ ３発現を調節するための化合物、方法及び医薬組成物 |
| JP7725490B2 (ja) | 2020-09-25 | 2025-08-19 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| JPWO2022097727A1 (enExample) | 2020-11-06 | 2022-05-12 | ||
| WO2022181807A1 (ja) | 2021-02-25 | 2022-09-01 | 国立大学法人大阪大学 | ＲＥＳＴ ｍＲＮＡ前駆体のプロセシングにおけるＮエキソンのスキッピングを誘導するオリゴヌクレオチド |
| JP2024105742A (ja) * | 2021-05-26 | 2024-08-07 | ルクサナバイオテク株式会社 | 心疾患治療薬 |
| CA3221758A1 (en) | 2021-05-28 | 2022-12-01 | Sumitomo Pharma Co., Ltd. | Antisense nucleic acid |
| CN113552198B (zh) * | 2021-05-31 | 2024-03-26 | 武汉维尔博生物科技有限公司 | 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法 |
| JPWO2023026994A1 (enExample) | 2021-08-21 | 2023-03-02 | ||
| WO2023093960A1 (en) * | 2021-11-26 | 2023-06-01 | Syddansk Universitet | Modified peptide-oligonucleotide conjugate |
| WO2023127857A1 (ja) | 2021-12-27 | 2023-07-06 | 株式会社理研ジェネシス | 新規人工核酸、その製造方法及び用途 |
| EP4493694A1 (en) * | 2022-03-17 | 2025-01-22 | Aligos Therapeutics, Inc. | Modified gapmer oligomers and methods of use thereof |
| EP4617279A1 (en) | 2022-11-10 | 2025-09-17 | Luxna Biotech Co., Ltd. | Modified nucleoside having guanidino structure in bridged part and method for producing oligonucleotide using same |
| JPWO2024181416A1 (enExample) | 2023-02-28 | 2024-09-06 | ||
| CN120813558A (zh) | 2023-03-06 | 2025-10-17 | 斯佩拉制药株式会社 | 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法 |
| CN121311591A (zh) | 2023-06-16 | 2026-01-09 | 住友制药株式会社 | 调节rps25基因的表达和/或其功能的反义寡核苷酸 |
| WO2025240506A1 (en) | 2024-05-14 | 2025-11-20 | Aligos Therapeutics, Inc. | Modified antisense oligonucleotides for treating hepatitis b virus |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) * | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) * | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) * | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4973679A (en) * | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US5696253A (en) * | 1994-06-30 | 1997-12-09 | The Regents Of The University Of California | Polynucleoside chain with 3'→5' guanidyl linkages |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| JP4151751B2 (ja) * | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| JP4383176B2 (ja) | 2002-02-13 | 2009-12-16 | 武 今西 | ヌクレオシド類縁体およびそのヌクレオチド類縁体を含むオリゴヌクレオチド誘導体 |
| JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | Ｎ−ｏ結合性架橋構造型新規人工核酸 |
| WO2007026824A1 (ja) * | 2005-08-31 | 2007-03-08 | Osaka University | オリゴヌクレオチド類縁体 |
| CN102596983B (zh) * | 2009-10-29 | 2016-06-15 | 国立大学法人大阪大学 | 交联型人工核苷和核苷酸 |
| US8536323B2 (en) * | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
| US9206216B2 (en) * | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
-
2013
- 2013-09-19 JP JP2014536921A patent/JP6048982B2/ja active Active
- 2013-09-19 EP EP13838365.8A patent/EP2899197B1/en active Active
- 2013-09-19 WO PCT/JP2013/075370 patent/WO2014046212A1/ja not_active Ceased
- 2013-09-19 US US14/428,646 patent/US10377789B2/en active Active
- 2013-09-19 ES ES13838365.8T patent/ES2622716T3/es active Active
- 2013-09-19 KR KR1020157010144A patent/KR101707437B1/ko active Active
- 2013-09-19 CN CN201380057335.0A patent/CN104768964B/zh active Active
- 2013-09-19 CA CA2885719A patent/CA2885719C/en active Active
- 2013-09-19 IN IN2238DEN2015 patent/IN2015DN02238A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2899197A1 (en) | 2015-07-29 |
| WO2014046212A1 (ja) | 2014-03-27 |
| US10377789B2 (en) | 2019-08-13 |
| CA2885719C (en) | 2017-07-11 |
| KR20150056647A (ko) | 2015-05-26 |
| EP2899197A4 (en) | 2016-03-09 |
| JP6048982B2 (ja) | 2016-12-21 |
| EP2899197B1 (en) | 2017-03-22 |
| IN2015DN02238A (enExample) | 2015-08-21 |
| KR101707437B1 (ko) | 2017-02-16 |
| JPWO2014046212A1 (ja) | 2016-08-18 |
| US20150266917A1 (en) | 2015-09-24 |
| CN104768964B (zh) | 2017-03-29 |
| CN104768964A (zh) | 2015-07-08 |
| CA2885719A1 (en) | 2014-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2622716T3 (es) | Oligonucleótido y nucleósido artificial en puente con guanidina | |
| JP7485642B2 (ja) | 治療化合物用の標的化リガンド | |
| ES2382807T3 (es) | Nuevos ácidos nucleicos artificiales del tipo de enlace N-O con reticulación | |
| US9611479B2 (en) | Crosslinked nucleoside and nucleotide | |
| JP5669073B2 (ja) | 架橋型人工ヌクレオシドおよびヌクレオチド | |
| AU2018359515B2 (en) | Integrin ligands and uses thereof | |
| AU2023255025A1 (en) | Targeting ligands | |
| JP5030998B2 (ja) | ヌクレオシド類縁体およびそのヌクレオチド類縁体を含むオリゴヌクレオチド誘導体 | |
| JPWO2010113937A1 (ja) | ヌクレオシドの製造方法 | |
| WO2016017422A1 (ja) | 架橋型ヌクレオシドおよびヌクレオチド | |
| JPWO2020158910A1 (ja) | ５’位修飾ヌクレオシドおよびそれを用いたヌクレオチド | |
| JPWO2020166551A1 (ja) | ５’位修飾ヌクレオシドおよびそれを用いたヌクレオチド | |
| WO2015125845A1 (ja) | 含窒素非芳香族複素環を含む核酸のリン酸部位修飾 | |
| US20250136613A1 (en) | Phenoxazine derivative and drug delivery system formulation using same | |
| EP4617279A1 (en) | Modified nucleoside having guanidino structure in bridged part and method for producing oligonucleotide using same | |
| WO2023167094A1 (ja) | ５'位修飾ヌクレオシドおよびそれを用いたヌクレオチド | |
| CN118946575A (zh) | 5'位修饰核苷和使用其的核苷酸 |