CN104755085B - 作为pi3激酶调节剂的芳杂环化合物及其使用方法和用途 - Google Patents
作为pi3激酶调节剂的芳杂环化合物及其使用方法和用途 Download PDFInfo
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- CN104755085B CN104755085B CN201380054625.XA CN201380054625A CN104755085B CN 104755085 B CN104755085 B CN 104755085B CN 201380054625 A CN201380054625 A CN 201380054625A CN 104755085 B CN104755085 B CN 104755085B
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- compound
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- 0 CC(C#Cc1cnc2[n]1nc(-c(cc1NS(c(cc3)ccc3F)(=O)=O)cc(*)c1OC)cc2)O Chemical compound CC(C#Cc1cnc2[n]1nc(-c(cc1NS(c(cc3)ccc3F)(=O)=O)cc(*)c1OC)cc2)O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261726139P | 2012-11-14 | 2012-11-14 | |
| US61/726,139 | 2012-11-14 | ||
| PCT/US2013/069366 WO2014078211A1 (en) | 2012-11-14 | 2013-11-10 | Heteroaromatic compounds as pi3 kinase modulators and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104755085A CN104755085A (zh) | 2015-07-01 |
| CN104755085B true CN104755085B (zh) | 2018-05-01 |
Family
ID=50681898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380054625.XA Active CN104755085B (zh) | 2012-11-14 | 2013-11-10 | 作为pi3激酶调节剂的芳杂环化合物及其使用方法和用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9926324B2 (enExample) |
| EP (2) | EP2919784B1 (enExample) |
| JP (1) | JP6268183B2 (enExample) |
| KR (1) | KR102148679B1 (enExample) |
| CN (1) | CN104755085B (enExample) |
| AU (1) | AU2013345107B2 (enExample) |
| BR (1) | BR112015006726B1 (enExample) |
| CA (1) | CA2889346C (enExample) |
| ES (1) | ES2661380T3 (enExample) |
| MY (1) | MY180641A (enExample) |
| RU (1) | RU2665036C9 (enExample) |
| SG (1) | SG11201502725TA (enExample) |
| TW (1) | TWI574962B (enExample) |
| WO (1) | WO2014078211A1 (enExample) |
| ZA (1) | ZA201502575B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104496995A (zh) * | 2014-01-06 | 2015-04-08 | 广东东阳光药业有限公司 | 制备3-乙炔基咪唑并[1,2-b]哒嗪的方法 |
| RU2658912C1 (ru) * | 2014-06-17 | 2018-06-26 | Шанхай Цзя Тань Фарматек Ко. Лтд. | АНАЛОГ ПИРИДИНО[1,2-А]ПИРИМИДОНА, ИСПОЛЬЗУЕМЫЙ В КАЧЕСТВЕ ИНГИБИТОРА mTOR/PI3K |
| CN105503877A (zh) * | 2014-09-24 | 2016-04-20 | 和记黄埔医药（上海）有限公司 | 咪唑并哒嗪类化合物及其用途 |
| WO2016097359A1 (en) * | 2014-12-19 | 2016-06-23 | Janssen Pharmaceutica Nv | Heterocyclyl linked imidazopyridazine derivatives as pi3kbeta inhibitors |
| DK3233862T3 (da) | 2014-12-19 | 2019-10-07 | Janssen Pharmaceutica Nv | Imidazopyridazinderivater som pi3k-beta-inhibitorer |
| WO2017216292A1 (en) * | 2016-06-16 | 2017-12-21 | Janssen Pharmaceutica Nv | Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors |
| WO2018017633A1 (en) | 2016-07-21 | 2018-01-25 | Bristol-Myers Squibb Company | TGF Beta RECEPTOR ANTAGONISTS |
| JP2019534266A (ja) | 2016-10-14 | 2019-11-28 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ５員ヘテロアリール環の架橋した環誘導体、その製造方法およびその医学的使用 |
| EP3548033B1 (en) * | 2016-11-28 | 2024-04-10 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN108164525B (zh) * | 2016-12-08 | 2020-09-08 | 沈阳药科大学 | 一种抗肿瘤化合物的制备方法和用途 |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| FR3064364A1 (fr) * | 2017-03-27 | 2018-09-28 | S.P.C.M. Sa | Methode de dosage de polymeres cationiques |
| CA3174675A1 (en) | 2020-04-29 | 2021-11-04 | Relay Therapeutics, Inc. | Pi3k.alpha. inhibitors and methods of use thereof |
| CA3231246A1 (en) * | 2021-09-10 | 2023-03-16 | Alessandro Boezio | Pi3k-alpha inhibitors and methods of use thereof |
| WO2023220131A2 (en) * | 2022-05-10 | 2023-11-16 | Relay Therapeutics, Inc. | PI3Kα INHIBITORS AND METHODS OF USE THEREOF |
| CN120737113B (zh) * | 2025-09-03 | 2025-11-21 | 湖北师范大学 | 一种三唑并哒嗪类化合物区域选择性c3-h炔基化的方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090163489A1 (en) * | 2007-12-19 | 2009-06-25 | Shon Booker | Inhibitors of PI3 kinase |
| US20100204222A1 (en) * | 2007-09-17 | 2010-08-12 | GlaxoSmithKline, LLC | Pyridopyrimidine derivatives as p13 kinase inhibitors |
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|---|---|---|---|---|
| RU2036924C1 (ru) * | 1989-01-31 | 1995-06-09 | Такеда Кемикал Индастриз ЛТД | Способ получения производных имидазо (1,2-b)пиридазина или их солей и производные имидазо (1,2-b)пиридазина или их соли |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| AU1061395A (en) | 1993-11-30 | 1995-06-19 | Mcgill University | Inhibition of dna methyltransferase |
| US5578716A (en) | 1993-12-01 | 1996-11-26 | Mcgill University | DNA methyltransferase antisense oligonucleotides |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6268137B1 (en) | 1996-05-22 | 2001-07-31 | Methylgene, Inc. | Specific inhibitors of DNA methyl transferase |
| WO1998054313A2 (en) | 1997-05-30 | 1998-12-03 | Mcgill University | Dna methyltransferase genomic sequences and antisense oligonucleotides |
| US6020318A (en) | 1997-05-30 | 2000-02-01 | Methylgene, Inc. | DNA methyltransferase genomic sequences and antisense oligonucleotides |
| US6066625A (en) | 1998-02-03 | 2000-05-23 | Methylgene, Inc. | Optimized antisense oligonucleotides complementary to DNA methyltransferase sequences |
| US6953783B1 (en) | 1998-10-19 | 2005-10-11 | Methylgene, Inc. | Modulation of gene expression by combination therapy |
| KR20020007398A (ko) | 1999-05-03 | 2002-01-26 | 추후제출 | 히스톤 탈아세틸화효소의 억제 |
| KR20070053362A (ko) | 1999-11-23 | 2007-05-23 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
| EP2093292A2 (en) | 2000-03-24 | 2009-08-26 | Methylgene, Inc. | Inhibition of specific histone deacetylase isoforms |
| ATE489360T1 (de) | 2000-03-24 | 2010-12-15 | Methylgene Inc | Inhibitoren der histon-deacetylase |
| US6723733B2 (en) * | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CN1578663B (zh) | 2001-09-14 | 2011-05-25 | 梅特希尔基因公司 | 组蛋白脱乙酰化酶抑制剂 |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| JP2006503082A (ja) | 2002-10-17 | 2006-01-26 | メシルジーン、インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| EP1663953A1 (en) | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2005092899A1 (en) | 2004-03-26 | 2005-10-06 | Methylgene Inc. | Inhibitors of histone deacetylase |
| BRPI0513982A (pt) | 2004-07-30 | 2007-11-27 | Methylgene Inc | inibidores de sinalização de receptor de vegf e receptor de hgf |
| ES2761180T3 (es) | 2005-12-23 | 2020-05-19 | Ariad Pharma Inc | Compuestos bicíclicos de heteroarilo |
| RU2009107705A (ru) * | 2006-08-04 | 2010-09-10 | Такеда Фармасьютикал Компани Лимитед (Jp) | Конденсированное гетероциклическое соединение и его применение |
| EP2211615A4 (en) * | 2007-10-22 | 2010-10-13 | Glaxosmithkline Llc | PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS |
| CA2716947A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
| WO2009133127A1 (en) * | 2008-04-30 | 2009-11-05 | Merck Serono S.A. | Fused bicyclic compounds and use thereof as pi3k inhibitors |
| US9085560B2 (en) | 2009-08-17 | 2015-07-21 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
| US8604032B2 (en) * | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| UY33597A (es) * | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| PT2710018T (pt) | 2011-05-19 | 2022-03-01 | Fundacion Del Sector Publico Estatal Centro Nac De Investigaciones Oncologicas Carlos Iii F S P Cnio | Compostos macrocíclicos como inibidores de proteína quinases |
| WO2012174312A2 (en) | 2011-06-15 | 2012-12-20 | Glaxosmithkline Llc | Benzimidazole derivatives as antiviral agents |
| KR101274986B1 (ko) | 2011-07-27 | 2013-06-17 | 한국과학기술원 | 이미다조피리딘 유도체, 이를 포함하는 ＰＩ3Ｋ 및/또는 ｍＴＯＲ 저해제용 약학 조성물 및 ＰＩ3Ｋ 및/또는 ｍＴＯＲ과 연관된 질환 치료용 약학 조성물 |
| GB201205669D0 (en) | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
-
2013
- 2013-11-08 TW TW102140742A patent/TWI574962B/zh active
- 2013-11-10 CA CA2889346A patent/CA2889346C/en active Active
- 2013-11-10 KR KR1020157008264A patent/KR102148679B1/ko active Active
- 2013-11-10 BR BR112015006726-3A patent/BR112015006726B1/pt not_active IP Right Cessation
- 2013-11-10 CN CN201380054625.XA patent/CN104755085B/zh active Active
- 2013-11-10 ES ES13855522.2T patent/ES2661380T3/es active Active
- 2013-11-10 EP EP13855522.2A patent/EP2919784B1/en active Active
- 2013-11-10 US US14/076,256 patent/US9926324B2/en active Active
- 2013-11-10 EP EP17192050.7A patent/EP3299019B1/en active Active
- 2013-11-10 AU AU2013345107A patent/AU2013345107B2/en active Active
- 2013-11-10 WO PCT/US2013/069366 patent/WO2014078211A1/en not_active Ceased
- 2013-11-10 MY MYPI2015701411A patent/MY180641A/en unknown
- 2013-11-10 JP JP2015541973A patent/JP6268183B2/ja active Active
- 2013-11-10 SG SG11201502725TA patent/SG11201502725TA/en unknown
- 2013-11-10 RU RU2015116102A patent/RU2665036C9/ru active
-
2015
- 2015-04-16 ZA ZA2015/02575A patent/ZA201502575B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100204222A1 (en) * | 2007-09-17 | 2010-08-12 | GlaxoSmithKline, LLC | Pyridopyrimidine derivatives as p13 kinase inhibitors |
| US20090163489A1 (en) * | 2007-12-19 | 2009-06-25 | Shon Booker | Inhibitors of PI3 kinase |
Non-Patent Citations (1)
| Title |
|---|
| Design and Synthesis of Imidazopyridine Analogues as Inhibitors of Phosphoinositide 3-Kinase Signaling and Angiogenesis;Kim O.等;《JOURNAL OF MEDICINAL CHEMISTRY》;20110309;第54卷(第7期);第2455-2466页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1210956A1 (en) | 2016-05-13 |
| KR20150083833A (ko) | 2015-07-20 |
| CA2889346C (en) | 2018-09-25 |
| EP2919784A4 (en) | 2016-07-06 |
| RU2665036C2 (ru) | 2018-08-27 |
| AU2013345107A1 (en) | 2015-04-30 |
| SG11201502725TA (en) | 2015-05-28 |
| US20140134133A1 (en) | 2014-05-15 |
| BR112015006726B1 (pt) | 2021-11-23 |
| TWI574962B (zh) | 2017-03-21 |
| US9926324B2 (en) | 2018-03-27 |
| RU2015116102A (ru) | 2017-01-10 |
| EP2919784B1 (en) | 2017-12-20 |
| JP2015536994A (ja) | 2015-12-24 |
| WO2014078211A1 (en) | 2014-05-22 |
| JP6268183B2 (ja) | 2018-01-24 |
| KR102148679B1 (ko) | 2020-08-27 |
| EP3299019A1 (en) | 2018-03-28 |
| ZA201502575B (en) | 2016-11-30 |
| ES2661380T3 (es) | 2018-03-28 |
| CN104755085A (zh) | 2015-07-01 |
| MY180641A (en) | 2020-12-04 |
| BR112015006726A2 (pt) | 2017-08-22 |
| EP3299019B1 (en) | 2019-10-09 |
| RU2665036C9 (ru) | 2018-11-12 |
| TW201422615A (zh) | 2014-06-16 |
| EP2919784A1 (en) | 2015-09-23 |
| AU2013345107B2 (en) | 2016-02-25 |
| CA2889346A1 (en) | 2014-05-22 |
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Effective date of registration: 20210423 Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after: SUNSHINE LAKE PHARMA Co.,Ltd. Address before: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1 Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. Patentee before: CALITOR SCIENCES, LLC |
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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd. Address before: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |