CN1046278C - 吡咯胺衍生物 - Google Patents

吡咯胺衍生物 Download PDF

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Publication number
CN1046278C
CN1046278C CN94192041A CN94192041A CN1046278C CN 1046278 C CN1046278 C CN 1046278C CN 94192041 A CN94192041 A CN 94192041A CN 94192041 A CN94192041 A CN 94192041A CN 1046278 C CN1046278 C CN 1046278C
Authority
CN
China
Prior art keywords
alcohol
butane
triazol
compound
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN94192041A
Other languages
English (en)
Chinese (zh)
Other versions
CN1122598A (zh
Inventor
内藤隆信
小林晴仁
小仓浩畅
永井基美
西田时子
有可正
横尾守
出世聪子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Publication of CN1122598A publication Critical patent/CN1122598A/zh
Application granted granted Critical
Publication of CN1046278C publication Critical patent/CN1046278C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymerization Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN94192041A 1993-05-10 1994-05-02 吡咯胺衍生物 Expired - Lifetime CN1046278C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13293193 1993-05-10
JP132931/93 1993-05-10

Publications (2)

Publication Number Publication Date
CN1122598A CN1122598A (zh) 1996-05-15
CN1046278C true CN1046278C (zh) 1999-11-10

Family

ID=15092851

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94192041A Expired - Lifetime CN1046278C (zh) 1993-05-10 1994-05-02 吡咯胺衍生物

Country Status (15)

Country Link
US (3) US5620994A (enExample)
EP (1) EP0698606B1 (enExample)
KR (1) KR100339166B1 (enExample)
CN (1) CN1046278C (enExample)
AT (1) ATE161257T1 (enExample)
AU (1) AU685116B2 (enExample)
CA (1) CA2162463C (enExample)
DE (1) DE69407409T2 (enExample)
DK (1) DK0698606T3 (enExample)
ES (1) ES2110749T3 (enExample)
GR (1) GR3025715T3 (enExample)
HU (1) HU225416B1 (enExample)
TW (1) TW325473B (enExample)
UA (1) UA41365C2 (enExample)
WO (1) WO1994026734A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026734A1 (fr) * 1993-05-10 1994-11-24 Kaken Pharmaceutical Co., Ltd. Derive d'azolylamine
AU7096496A (en) * 1995-09-28 1997-04-17 Kaken Pharmaceutical Co., Ltd. Process for the preparation of 4-methylenepiperidines
DE60042453D1 (de) 1999-07-28 2009-08-06 Kaken Pharma Co Ltd Verfahren zum nachweis pathogener mikroorganismen und antimikrobieller mittel, verfahren zum nachweis der arzneimittelwirkung antimikrobieller mittel und antimikrobielle mittel
US20090162481A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20090162419A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20100080869A1 (en) * 2004-05-25 2010-04-01 Watson James B Live Bacteria product
US7625927B2 (en) * 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
PT2116243E (pt) 2006-12-28 2010-10-26 Kaken Pharma Co Ltd Composição de gel para tratamento de micoses
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
ES2556782T3 (es) * 2010-08-31 2016-01-20 Kaken Pharmaceutical Co., Ltd. Procedimiento para producir derivados de 1-triazol-2-butanol
MX363386B (es) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Formulaciones de efinaconazol estabilizadas.
KR102612453B1 (ko) 2013-11-22 2023-12-08 다우 파마슈티컬 사이언시즈, 인코포레이티드 항­감염 방법，조성물，및 장치
CN104292214B (zh) * 2014-09-24 2017-04-05 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047B (zh) * 2014-10-17 2016-04-06 苏州明锐医药科技有限公司 艾菲康唑的制备方法
US9617241B2 (en) 2014-11-23 2017-04-11 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of efinaconazole
EP3247399A4 (en) * 2015-01-20 2018-09-05 Wavelength Enterprises Ltd Crystalline forms of efinaconazole
ITUB20150417A1 (it) 2015-05-08 2016-11-08 Dipharma Francis Srl Procedimento per la preparazione di composti piperidinici
US10479776B2 (en) 2015-05-12 2019-11-19 Lupin Limited Process for the preparation of Efinaconazole
EP3112360A1 (en) * 2015-06-29 2017-01-04 Dipharma Francis S.r.l. Process for the preparation of efinaconazole
CN106565672A (zh) * 2015-10-08 2017-04-19 中美华世通生物医药科技（武汉）有限公司 制备艾氟康唑的方法
US20170129874A1 (en) * 2015-11-10 2017-05-11 Virupaksha Organics Limited Novel improved process for preparing a triazole antifungal agent
CN106810534A (zh) * 2015-11-30 2017-06-09 中美华世通生物医药科技（武汉）有限公司 艾氟康唑晶型及其制备方法
CN106928186A (zh) * 2015-12-29 2017-07-07 中美华世通生物医药科技（武汉）有限公司 化合物及其制备方法和用途
ITUB20159795A1 (it) 2015-12-30 2017-06-30 Procos Spa Processo per la sintesi di efinaconazolo
ITUA20162545A1 (it) 2016-04-13 2017-10-13 Laboratorio Chimico Int S P A Procedimento per la preparazione di intermedi utili nella sintesi di farmaci
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
IT201700048270A1 (it) 2017-05-04 2018-11-04 Seegpharm Sa Procedimento per la preparazione di un derivato azolico.
TWI772425B (zh) * 2017-05-19 2022-08-01 日商科研製藥股份有限公司 艾菲康唑（ｅｆｉｎａｃｏｎａｚｏｌｅ）之製造及純化方法
EP3666762B1 (en) 2017-08-10 2022-04-06 Sumitomo Chemical Company, Limited Method for producing epoxy alcohol compound
CA3115742C (en) * 2018-12-29 2023-10-03 Viwit Pharmaceutical Co., Ltd. Preparation method for efinaconazole
KR102181155B1 (ko) 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
JP2021054781A (ja) 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法
KR102301743B1 (ko) * 2020-12-29 2021-09-13 대봉엘에스 주식회사 에피나코나졸 경구용 조성물
CN118994102B (zh) * 2024-08-27 2026-05-08 张小宇 艾氟康唑衍生物及其抗真菌活性

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507484A (en) * 1982-07-24 1985-03-26 Pfizer Inc. Triazole antifungal agents
GB2159148A (en) * 1984-05-18 1985-11-27 Ici Plc Fungicidal imidazole and 1,2,4-triazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1162540A (en) * 1980-12-24 1984-02-21 Ikutaro Saji Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
WO1994026734A1 (fr) * 1993-05-10 1994-11-24 Kaken Pharmaceutical Co., Ltd. Derive d'azolylamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507484A (en) * 1982-07-24 1985-03-26 Pfizer Inc. Triazole antifungal agents
GB2159148A (en) * 1984-05-18 1985-11-27 Ici Plc Fungicidal imidazole and 1,2,4-triazole derivatives

Also Published As

Publication number Publication date
HU9503217D0 (en) 1996-01-29
AU6689694A (en) 1994-12-12
ATE161257T1 (de) 1998-01-15
TW325473B (en) 1998-01-21
EP0698606A1 (en) 1996-02-28
CN1122598A (zh) 1996-05-15
US5620994A (en) 1997-04-15
GR3025715T3 (en) 1998-03-31
EP0698606A4 (enExample) 1996-04-10
HU225416B1 (en) 2006-11-28
CA2162463C (en) 2006-01-03
EP0698606B1 (en) 1997-12-17
US5962476A (en) 1999-10-05
US5716969A (en) 1998-02-10
CA2162463A1 (en) 1994-11-24
HUT75031A (en) 1997-03-28
ES2110749T3 (es) 1998-02-16
WO1994026734A1 (fr) 1994-11-24
AU685116B2 (en) 1998-01-15
UA41365C2 (uk) 2001-09-17
DK0698606T3 (da) 1998-08-24
KR100339166B1 (ko) 2004-04-30
DE69407409D1 (de) 1998-01-29
DE69407409T2 (de) 1998-04-09

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20140502

Granted publication date: 19991110