DE69407409T2 - Azolylamin-derivat - Google Patents

Azolylamin-derivat

Info

Publication number
DE69407409T2
DE69407409T2 DE69407409T DE69407409T DE69407409T2 DE 69407409 T2 DE69407409 T2 DE 69407409T2 DE 69407409 T DE69407409 T DE 69407409T DE 69407409 T DE69407409 T DE 69407409T DE 69407409 T2 DE69407409 T2 DE 69407409T2
Authority
DE
Germany
Prior art keywords
compound
addition salt
butan
triazol
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69407409T
Other languages
German (de)
English (en)
Other versions
DE69407409D1 (de
Inventor
Tadashi Arika
Haruhito Kobayashi
Kiyoshi Nagai
Takanobu Naito
Tokiko Nishida
Hironobu Ogura
Satoko Shusse
Mamoru Yokoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69407409D1 publication Critical patent/DE69407409D1/de
Publication of DE69407409T2 publication Critical patent/DE69407409T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymerization Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69407409T 1993-05-10 1994-05-02 Azolylamin-derivat Expired - Lifetime DE69407409T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13293193 1993-05-10
PCT/JP1994/000737 WO1994026734A1 (fr) 1993-05-10 1994-05-02 Derive d'azolylamine

Publications (2)

Publication Number Publication Date
DE69407409D1 DE69407409D1 (de) 1998-01-29
DE69407409T2 true DE69407409T2 (de) 1998-04-09

Family

ID=15092851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69407409T Expired - Lifetime DE69407409T2 (de) 1993-05-10 1994-05-02 Azolylamin-derivat

Country Status (15)

Country Link
US (3) US5620994A (enExample)
EP (1) EP0698606B1 (enExample)
KR (1) KR100339166B1 (enExample)
CN (1) CN1046278C (enExample)
AT (1) ATE161257T1 (enExample)
AU (1) AU685116B2 (enExample)
CA (1) CA2162463C (enExample)
DE (1) DE69407409T2 (enExample)
DK (1) DK0698606T3 (enExample)
ES (1) ES2110749T3 (enExample)
GR (1) GR3025715T3 (enExample)
HU (1) HU225416B1 (enExample)
TW (1) TW325473B (enExample)
UA (1) UA41365C2 (enExample)
WO (1) WO1994026734A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046278C (zh) * 1993-05-10 1999-11-10 科研制药株式会社 吡咯胺衍生物
EP0881215B1 (en) * 1995-09-28 2001-09-05 Kaken Pharmaceutical Co., Ltd. Process for the preparation of 4-methylenepiperidines
EP1205559B1 (en) 1999-07-28 2009-06-24 Kaken Pharmaceutical Co., Ltd. Method for detecting pathogenic microorganisms and antimicrobial agents, method for evaluating the drug effect of antimicrobial agents, and antimicrobial agents
US20090162419A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20090162481A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20100080869A1 (en) * 2004-05-25 2010-04-01 Watson James B Live Bacteria product
US7625927B2 (en) * 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
PT2116243E (pt) * 2006-12-28 2010-10-26 Kaken Pharma Co Ltd Composição de gel para tratamento de micoses
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
HUE026357T2 (en) 2010-08-31 2016-06-28 Kaken Pharma Co Ltd Process for the preparation of a 1-triazole-2-butanol derivative
KR102320051B1 (ko) 2013-10-03 2021-10-29 다우 파마슈티컬 사이언시즈, 인코포레이티드 안정화된 에피나코나졸 조성물
KR102612453B1 (ko) 2013-11-22 2023-12-08 다우 파마슈티컬 사이언시즈, 인코포레이티드 항­감염 방법，조성물，및 장치
CN104292214B (zh) * 2014-09-24 2017-04-05 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047B (zh) * 2014-10-17 2016-04-06 苏州明锐医药科技有限公司 艾菲康唑的制备方法
WO2016079728A1 (en) 2014-11-23 2016-05-26 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of efinaconazole
CA2974180A1 (en) * 2015-01-20 2016-07-28 Itai Adin Crystalline forms of efinaconazole
ITUB20150417A1 (it) 2015-05-08 2016-11-08 Dipharma Francis Srl Procedimento per la preparazione di composti piperidinici
AU2016261273A1 (en) * 2015-05-12 2017-12-07 Lupin Limited Process for the preparation of efinaconazole
EP3112360A1 (en) 2015-06-29 2017-01-04 Dipharma Francis S.r.l. Process for the preparation of efinaconazole
CN106565672A (zh) * 2015-10-08 2017-04-19 中美华世通生物医药科技（武汉）有限公司 制备艾氟康唑的方法
US20170129874A1 (en) * 2015-11-10 2017-05-11 Virupaksha Organics Limited Novel improved process for preparing a triazole antifungal agent
CN106810534A (zh) * 2015-11-30 2017-06-09 中美华世通生物医药科技（武汉）有限公司 艾氟康唑晶型及其制备方法
CN106928186A (zh) * 2015-12-29 2017-07-07 中美华世通生物医药科技（武汉）有限公司 化合物及其制备方法和用途
ITUB20159795A1 (it) 2015-12-30 2017-06-30 Procos Spa Processo per la sintesi di efinaconazolo
ITUA20162545A1 (it) 2016-04-13 2017-10-13 Laboratorio Chimico Int S P A Procedimento per la preparazione di intermedi utili nella sintesi di farmaci
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
IT201700048270A1 (it) 2017-05-04 2018-11-04 Seegpharm Sa Procedimento per la preparazione di un derivato azolico.
IL270691B (en) * 2017-05-19 2022-07-01 Kaken Pharma Co Ltd Production and purification methods for efinconazole
US10730861B2 (en) 2017-08-10 2020-08-04 Sumitomo Chemical Company, Limited Process for producing epoxy alcohol compound
US20210363129A1 (en) * 2018-12-29 2021-11-25 Viwit Pharmaceutical Co., Ltd. Preparation method for efinaconazole
KR102181155B1 (ko) 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
JP2021054781A (ja) 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法
KR102301743B1 (ko) * 2020-12-29 2021-09-13 대봉엘에스 주식회사 에피나코나졸 경구용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1162540A (en) * 1980-12-24 1984-02-21 Ikutaro Saji Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
US4507484A (en) * 1982-07-24 1985-03-26 Pfizer Inc. Triazole antifungal agents
GB8412750D0 (en) * 1984-05-18 1984-06-27 Ici Plc Heterocyclic compounds
CN1046278C (zh) * 1993-05-10 1999-11-10 科研制药株式会社 吡咯胺衍生物

Also Published As

Publication number Publication date
DK0698606T3 (da) 1998-08-24
WO1994026734A1 (fr) 1994-11-24
EP0698606A4 (enExample) 1996-04-10
CA2162463C (en) 2006-01-03
HU225416B1 (en) 2006-11-28
TW325473B (en) 1998-01-21
KR100339166B1 (ko) 2004-04-30
AU685116B2 (en) 1998-01-15
AU6689694A (en) 1994-12-12
EP0698606B1 (en) 1997-12-17
US5620994A (en) 1997-04-15
CA2162463A1 (en) 1994-11-24
ATE161257T1 (de) 1998-01-15
ES2110749T3 (es) 1998-02-16
HU9503217D0 (en) 1996-01-29
DE69407409D1 (de) 1998-01-29
CN1046278C (zh) 1999-11-10
EP0698606A1 (en) 1996-02-28
UA41365C2 (uk) 2001-09-17
GR3025715T3 (en) 1998-03-31
CN1122598A (zh) 1996-05-15
US5962476A (en) 1999-10-05
HUT75031A (en) 1997-03-28
US5716969A (en) 1998-02-10

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Legal Events

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