CA2162463C - Azolylamine derivative - Google Patents

Azolylamine derivative Download PDF

Info

Publication number
CA2162463C
CA2162463C CA002162463A CA2162463A CA2162463C CA 2162463 C CA2162463 C CA 2162463C CA 002162463 A CA002162463 A CA 002162463A CA 2162463 A CA2162463 A CA 2162463A CA 2162463 C CA2162463 C CA 2162463C
Authority
CA
Canada
Prior art keywords
compound
group
acid addition
addition salt
butane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002162463A
Other languages
English (en)
French (fr)
Other versions
CA2162463A1 (en
Inventor
Takanobu Naito
Haruhito Kobayashi
Hironobu Ogura
Kiyoshi Nagai
Tokiko Nishida
Tadashi Arika
Mamoru Yokoo
Satoko Shusse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Publication of CA2162463A1 publication Critical patent/CA2162463A1/en
Application granted granted Critical
Publication of CA2162463C publication Critical patent/CA2162463C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymerization Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002162463A 1993-05-10 1994-05-02 Azolylamine derivative Expired - Lifetime CA2162463C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13293193 1993-05-10
JP132931/1993 1993-05-10
PCT/JP1994/000737 WO1994026734A1 (fr) 1993-05-10 1994-05-02 Derive d'azolylamine

Publications (2)

Publication Number Publication Date
CA2162463A1 CA2162463A1 (en) 1994-11-24
CA2162463C true CA2162463C (en) 2006-01-03

Family

ID=15092851

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002162463A Expired - Lifetime CA2162463C (en) 1993-05-10 1994-05-02 Azolylamine derivative

Country Status (15)

Country Link
US (3) US5620994A (enExample)
EP (1) EP0698606B1 (enExample)
KR (1) KR100339166B1 (enExample)
CN (1) CN1046278C (enExample)
AT (1) ATE161257T1 (enExample)
AU (1) AU685116B2 (enExample)
CA (1) CA2162463C (enExample)
DE (1) DE69407409T2 (enExample)
DK (1) DK0698606T3 (enExample)
ES (1) ES2110749T3 (enExample)
GR (1) GR3025715T3 (enExample)
HU (1) HU225416B1 (enExample)
TW (1) TW325473B (enExample)
UA (1) UA41365C2 (enExample)
WO (1) WO1994026734A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046278C (zh) * 1993-05-10 1999-11-10 科研制药株式会社 吡咯胺衍生物
EP0881215B1 (en) * 1995-09-28 2001-09-05 Kaken Pharmaceutical Co., Ltd. Process for the preparation of 4-methylenepiperidines
EP1205559B1 (en) 1999-07-28 2009-06-24 Kaken Pharmaceutical Co., Ltd. Method for detecting pathogenic microorganisms and antimicrobial agents, method for evaluating the drug effect of antimicrobial agents, and antimicrobial agents
US20090162419A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20090162481A1 (en) * 2004-05-25 2009-06-25 Watson James B Live bacteria product
US20100080869A1 (en) * 2004-05-25 2010-04-01 Watson James B Live Bacteria product
US7625927B2 (en) * 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
PT2116243E (pt) * 2006-12-28 2010-10-26 Kaken Pharma Co Ltd Composição de gel para tratamento de micoses
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
HUE026357T2 (en) 2010-08-31 2016-06-28 Kaken Pharma Co Ltd Process for the preparation of a 1-triazole-2-butanol derivative
KR102320051B1 (ko) 2013-10-03 2021-10-29 다우 파마슈티컬 사이언시즈, 인코포레이티드 안정화된 에피나코나졸 조성물
KR102612453B1 (ko) 2013-11-22 2023-12-08 다우 파마슈티컬 사이언시즈, 인코포레이티드 항­감염 방법，조성물，및 장치
CN104292214B (zh) * 2014-09-24 2017-04-05 南京华威医药科技开发有限公司 艾氟康唑及其中间体的合成方法
CN104327047B (zh) * 2014-10-17 2016-04-06 苏州明锐医药科技有限公司 艾菲康唑的制备方法
WO2016079728A1 (en) 2014-11-23 2016-05-26 Mapi Pharma Ltd. Intermediate compounds and process for the preparation of efinaconazole
CA2974180A1 (en) * 2015-01-20 2016-07-28 Itai Adin Crystalline forms of efinaconazole
ITUB20150417A1 (it) 2015-05-08 2016-11-08 Dipharma Francis Srl Procedimento per la preparazione di composti piperidinici
AU2016261273A1 (en) * 2015-05-12 2017-12-07 Lupin Limited Process for the preparation of efinaconazole
EP3112360A1 (en) 2015-06-29 2017-01-04 Dipharma Francis S.r.l. Process for the preparation of efinaconazole
CN106565672A (zh) * 2015-10-08 2017-04-19 中美华世通生物医药科技（武汉）有限公司 制备艾氟康唑的方法
US20170129874A1 (en) * 2015-11-10 2017-05-11 Virupaksha Organics Limited Novel improved process for preparing a triazole antifungal agent
CN106810534A (zh) * 2015-11-30 2017-06-09 中美华世通生物医药科技（武汉）有限公司 艾氟康唑晶型及其制备方法
CN106928186A (zh) * 2015-12-29 2017-07-07 中美华世通生物医药科技（武汉）有限公司 化合物及其制备方法和用途
ITUB20159795A1 (it) 2015-12-30 2017-06-30 Procos Spa Processo per la sintesi di efinaconazolo
ITUA20162545A1 (it) 2016-04-13 2017-10-13 Laboratorio Chimico Int S P A Procedimento per la preparazione di intermedi utili nella sintesi di farmaci
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
IT201700048270A1 (it) 2017-05-04 2018-11-04 Seegpharm Sa Procedimento per la preparazione di un derivato azolico.
IL270691B (en) * 2017-05-19 2022-07-01 Kaken Pharma Co Ltd Production and purification methods for efinconazole
US10730861B2 (en) 2017-08-10 2020-08-04 Sumitomo Chemical Company, Limited Process for producing epoxy alcohol compound
US20210363129A1 (en) * 2018-12-29 2021-11-25 Viwit Pharmaceutical Co., Ltd. Preparation method for efinaconazole
KR102181155B1 (ko) 2019-09-26 2020-11-20 대봉엘에스 주식회사 이온성 액체를 매개로 한 에피나코나졸의 신규 제조방법
JP2021054781A (ja) 2019-09-26 2021-04-08 デボン エルエス，リミテッド 共結晶形エフィナコナゾール、及びその製造方法
KR102301743B1 (ko) * 2020-12-29 2021-09-13 대봉엘에스 주식회사 에피나코나졸 경구용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1162540A (en) * 1980-12-24 1984-02-21 Ikutaro Saji Imidazolylpropanol compounds and their acid addition salts, and production and use thereof
US4507484A (en) * 1982-07-24 1985-03-26 Pfizer Inc. Triazole antifungal agents
GB8412750D0 (en) * 1984-05-18 1984-06-27 Ici Plc Heterocyclic compounds
CN1046278C (zh) * 1993-05-10 1999-11-10 科研制药株式会社 吡咯胺衍生物

Also Published As

Publication number Publication date
DK0698606T3 (da) 1998-08-24
WO1994026734A1 (fr) 1994-11-24
EP0698606A4 (enExample) 1996-04-10
HU225416B1 (en) 2006-11-28
TW325473B (en) 1998-01-21
KR100339166B1 (ko) 2004-04-30
AU685116B2 (en) 1998-01-15
AU6689694A (en) 1994-12-12
EP0698606B1 (en) 1997-12-17
US5620994A (en) 1997-04-15
CA2162463A1 (en) 1994-11-24
ATE161257T1 (de) 1998-01-15
ES2110749T3 (es) 1998-02-16
DE69407409T2 (de) 1998-04-09
HU9503217D0 (en) 1996-01-29
DE69407409D1 (de) 1998-01-29
CN1046278C (zh) 1999-11-10
EP0698606A1 (en) 1996-02-28
UA41365C2 (uk) 2001-09-17
GR3025715T3 (en) 1998-03-31
CN1122598A (zh) 1996-05-15
US5962476A (en) 1999-10-05
HUT75031A (en) 1997-03-28
US5716969A (en) 1998-02-10

Similar Documents

Publication Publication Date Title
CA2162463C (en) Azolylamine derivative
RU2114838C1 (ru) Триазольные производные, фармацевтическая композиция и промежуточные продукты
EP0973768B1 (en) Azole compounds, their production and their use
HU189143B (en) Process for preparing 2-/2,4-difluoro-phenyl/-1,3-bis/1h-1,2,4-triazol-1-yl/-propan-2-ol derivatives
SK283035B6 (sk) Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok
US6300353B1 (en) Azoles for treatment of fungal infections
WO1996038443A1 (en) Tetrahydrofuran antifungals
JPS6366835B2 (enExample)
EP1654254A4 (en) Antifungal azole derivatives having a fluorovinyl moiety and process for the preparation thereof
JPH0649033A (ja) 光学活性アゾール化合物およびその用途
IE56590B1 (en) Triazole antifungal agents
EP0958289B1 (en) Amino acid ester containing azole antifungals
RU2703997C1 (ru) Гибридные амиды на основе триазола и тиазолидина, обладающие антимикробной активностью
NZ206969A (en) 1,2,4-triazole derivatives and antifungal compositions
JP3437695B2 (ja) アゾリルアミン誘導体
SK281688B6 (sk) Regioselektívny spôsob prípravy derivátov 1-(1,2,4-triazol-1-yl)-propan-2-olu
JPH03870B2 (enExample)
JPH02172978A (ja) 置換ビスアゾール、その製造方法およびその医薬としての使用
JP2768830B2 (ja) アゾリルアミン誘導体
EP0113509B1 (en) 1,3-bis(triazolyl)-2-amino-2-aryl-propane derivatives and pharmaceutical fungicidal compositions containing them
CS228931B2 (cs) Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu
JPWO1994026734A1 (ja) アゾリルアミン誘導体
FI83777C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 1-aryl-1-(fluorhydroxialkyl eller perfluoralkanoyl)-2-(1h-1,2,4-triazol-1-yl) etanoler.
WO1997000248A1 (en) Hydroxyalkyl-substituted triazolones antifungals
JP2961538B2 (ja) イミダゾロンおよびイミダゾリジノン誘導体の合成中間体および製造法

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140502

MKEX Expiry

Effective date: 20140502