CN104583390B - 用于生产b型流感嗜血杆菌抗原的方法 - Google Patents

用于生产b型流感嗜血杆菌抗原的方法 Download PDF

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CN104583390B
CN104583390B CN201380035582.0A CN201380035582A CN104583390B CN 104583390 B CN104583390 B CN 104583390B CN 201380035582 A CN201380035582 A CN 201380035582A CN 104583390 B CN104583390 B CN 104583390B
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medium
toxoid
combining
prp
sigma
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CN104583390A (zh
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J.勒希尔
P.卢比埃
F.巴比拉托
N.林德利
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Sanofi Pasteur Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380035582.0A 2012-07-02 2013-07-02 用于生产b型流感嗜血杆菌抗原的方法 Active CN104583390B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1256329 2012-07-02
FR1256329A FR2992656B1 (fr) 2012-07-02 2012-07-02 Procede de production d'antigenes haemophilus influenzae type b
PCT/FR2013/051549 WO2014006318A1 (fr) 2012-07-02 2013-07-02 Procédé de production d'antigènes haemophilus influenzae type b

Publications (2)

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CN104583390A CN104583390A (zh) 2015-04-29
CN104583390B true CN104583390B (zh) 2018-07-10

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US (2) US9556464B2 (https=)
EP (1) EP2885397B1 (https=)
JP (1) JP6347778B2 (https=)
KR (1) KR102051482B1 (https=)
CN (1) CN104583390B (https=)
AU (1) AU2013285306B2 (https=)
BR (1) BR112014033082B1 (https=)
CA (1) CA2878053C (https=)
CR (1) CR20140559A (https=)
CY (1) CY1120465T1 (https=)
DK (1) DK2885397T3 (https=)
ES (1) ES2681993T3 (https=)
FR (1) FR2992656B1 (https=)
GE (1) GEP201706788B (https=)
HR (1) HRP20181206T1 (https=)
HU (1) HUE038865T2 (https=)
IL (1) IL236208A0 (https=)
LT (1) LT2885397T (https=)
MX (1) MX358953B (https=)
NZ (1) NZ702471A (https=)
PE (1) PE20150192A1 (https=)
PH (1) PH12014502730A1 (https=)
PL (1) PL2885397T3 (https=)
PT (1) PT2885397T (https=)
RS (1) RS57495B1 (https=)
RU (1) RU2644246C2 (https=)
SG (1) SG11201408194SA (https=)
SI (1) SI2885397T1 (https=)
SM (1) SMT201800389T1 (https=)
TR (1) TR201810678T4 (https=)
UA (1) UA115787C2 (https=)
WO (1) WO2014006318A1 (https=)
ZA (2) ZA201500028B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2624014C1 (ru) * 2016-04-08 2017-06-30 Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства России (ФГУП СПбНИИВС ФМБА России) Штамм haemophilus influenzae spb тип в - высокоактивный продуцент капсульного полисахарида полирибозилрибитолфосфата
CN109922828A (zh) 2016-10-20 2019-06-21 Km生物医药股份公司 使用具有降低了的分子量的PRP的Hib结合疫苗的制造方法
WO2018193475A2 (en) * 2017-04-22 2018-10-25 Biological E Limited An improved method for high level production of crm
RU2704452C1 (ru) * 2019-04-22 2019-10-28 Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства Способ получения вакцины гемофильной тип b конъюгированной
CN109975559B (zh) * 2019-04-29 2023-07-11 厦门稀土材料研究所 一种时间分辨荧光定量检测25羟基维生素d的试剂盒及方法
CN111000994A (zh) * 2019-12-26 2020-04-14 北京科兴中维生物技术有限公司 一种液体疫苗组合物及其制备方法与应用
CN112212779B (zh) * 2020-09-04 2022-05-17 厦门大学 一种水凝胶柔性应变传感器的制备方法
WO2022114735A1 (ko) * 2020-11-25 2022-06-02 주식회사 엘지화학 헤모필루스 인플루엔자 타입 b의 prp 항원 정제 공정의 품질 평가 방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056365A1 (fr) * 1999-03-23 2000-09-28 Aventis Pasteur Utilisation de trehalose pour stabiliser un vaccin liquide
CN101688174A (zh) * 2007-07-10 2010-03-31 赛诺菲巴斯德有限公司 B型流感嗜血杆菌的培养介质
CN101932698A (zh) * 2007-12-20 2010-12-29 诺华有限公司 培养链球菌的发酵工艺以及从中提取cps的纯化工艺
CN102196818A (zh) * 2008-10-24 2011-09-21 万能药生物有限公司 具有无细胞百日咳的联合疫苗

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03183416A (ja) * 1989-12-12 1991-08-09 Shozo Oyama 菌根菌を培養する方法、およびその子実体を取得する方法
RU2258737C2 (ru) * 2003-09-01 2005-08-20 Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН Питательная среда для культивирования бактерий haemophilus influenzae типа b
FR2914302A1 (fr) * 2007-03-30 2008-10-03 Sanofi Pasteur Sa Procede de preparation de derives de porphyrine, telle que la protoporphyrine (ix) et intermediaire de synthese
TW201129698A (en) * 2009-12-10 2011-09-01 Jgc Corp New cell culture method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056365A1 (fr) * 1999-03-23 2000-09-28 Aventis Pasteur Utilisation de trehalose pour stabiliser un vaccin liquide
CN101688174A (zh) * 2007-07-10 2010-03-31 赛诺菲巴斯德有限公司 B型流感嗜血杆菌的培养介质
CN101932698A (zh) * 2007-12-20 2010-12-29 诺华有限公司 培养链球菌的发酵工艺以及从中提取cps的纯化工艺
CN102196818A (zh) * 2008-10-24 2011-09-21 万能药生物有限公司 具有无细胞百日咳的联合疫苗

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PE20150192A1 (es) 2015-02-27
GEP201706788B (en) 2017-12-11
EP2885397B1 (fr) 2018-05-30
CY1120465T1 (el) 2019-07-10
SG11201408194SA (en) 2015-01-29
KR102051482B1 (ko) 2019-12-03
JP6347778B2 (ja) 2018-06-27
WO2014006318A1 (fr) 2014-01-09
RS57495B1 (sr) 2018-10-31
US20170211111A1 (en) 2017-07-27
PL2885397T3 (pl) 2018-10-31
PT2885397T (pt) 2018-07-27
KR20150036311A (ko) 2015-04-07
MX2014014607A (es) 2015-02-12
PH12014502730B1 (en) 2015-02-02
UA115787C2 (uk) 2017-12-26
TR201810678T4 (tr) 2018-08-27
CN104583390A (zh) 2015-04-29
MX358953B (es) 2018-09-10
EP2885397A1 (fr) 2015-06-24
SMT201800389T1 (it) 2018-09-13
LT2885397T (lt) 2018-08-27
BR112014033082A2 (pt) 2017-06-27
PH12014502730A1 (en) 2015-02-02
HK1208493A1 (en) 2016-03-04
ZA201500028B (en) 2016-10-26
NZ702471A (en) 2017-08-25
HUE038865T2 (hu) 2018-12-28
US20150167036A1 (en) 2015-06-18
DK2885397T3 (en) 2018-08-06
RU2644246C2 (ru) 2018-02-08
ZA201500014B (en) 2016-10-26
CA2878053A1 (fr) 2014-01-09
IL236208A0 (en) 2015-01-29
BR112014033082B1 (pt) 2022-02-15
AU2013285306A1 (en) 2015-01-15
HRP20181206T1 (hr) 2018-10-05
RU2015103140A (ru) 2016-08-27
JP2015522272A (ja) 2015-08-06
FR2992656A1 (fr) 2014-01-03
CA2878053C (fr) 2021-07-06
ES2681993T3 (es) 2018-09-17
US9556464B2 (en) 2017-01-31
AU2013285306B2 (en) 2018-10-04
SI2885397T1 (sl) 2018-09-28
CR20140559A (es) 2015-04-06
FR2992656B1 (fr) 2016-10-07
US10144940B2 (en) 2018-12-04

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